BRPI0519598A2 - derivados de cromano éteis como antagonistas de bomba de Ácido, composiÇço farmacÊutica e uso dos mesmos - Google Patents
derivados de cromano éteis como antagonistas de bomba de Ácido, composiÇço farmacÊutica e uso dos mesmosInfo
- Publication number
- BRPI0519598A2 BRPI0519598A2 BRPI0519598-5A BRPI0519598A BRPI0519598A2 BR PI0519598 A2 BRPI0519598 A2 BR PI0519598A2 BR PI0519598 A BRPI0519598 A BR PI0519598A BR PI0519598 A2 BRPI0519598 A2 BR PI0519598A2
- Authority
- BR
- Brazil
- Prior art keywords
- disease
- acid pump
- compounds
- pharmaceutical composition
- chroman derivatives
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 2
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical class C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 208000021302 gastroesophageal reflux disease Diseases 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000006549 dyspepsia Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000019505 Deglutition disease Diseases 0.000 abstract 1
- 208000007882 Gastritis Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 241000589989 Helicobacter Species 0.000 abstract 1
- 206010028813 Nausea Diseases 0.000 abstract 1
- 206010030216 Oesophagitis Diseases 0.000 abstract 1
- 208000008469 Peptic Ulcer Diseases 0.000 abstract 1
- 206010039424 Salivary hypersecretion Diseases 0.000 abstract 1
- 208000008630 Sialorrhea Diseases 0.000 abstract 1
- 208000007107 Stomach Ulcer Diseases 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000010643 digestive system disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000000718 duodenal ulcer Diseases 0.000 abstract 1
- 208000006881 esophagitis Diseases 0.000 abstract 1
- 201000005917 gastric ulcer Diseases 0.000 abstract 1
- 201000000052 gastrinoma Diseases 0.000 abstract 1
- 208000029493 gastroesophageal disease Diseases 0.000 abstract 1
- 208000018685 gastrointestinal system disease Diseases 0.000 abstract 1
- 208000024798 heartburn Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000008693 nausea Effects 0.000 abstract 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 1
- 208000011906 peptic ulcer disease Diseases 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
- 208000009935 visceral pain Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
DERIVADOS DE CROMANO éTEIS COMO ANTAGONISTAS DE BOMBA DE ÁCIDO, COMPOSIÇçO FARMACÊUTICA E JSO DOS MESMOS. A presente invenção refere-se a compostos da fórmula (1): ou um sal farmaceuticamente aceitável dos mesmos, em que: R¹, R², Rü, R^ 4^, R^ 5^, R^ 6^, R^ 7^, R^ 8^ A e B são cada como descrito aqui ou um sal farmaceuticamente aceitável, e composições contendo tais compostos e o método de tratamento e o uso, compreendendo tais compostos para o tratamento de uma condição mediada por atividade antagonística de bomba de ácido tal como, porém não limitado a, como doença gastrointestinal, doença gastroesofágica, doença de refluxo gastroesofágica (GERD), úlcera péptica, úlcera gástrica, úlcera duodenal, úlceras induzidas por NSAID, gastrites, infecção de Helicobacter piloris, dispepsia, dispepsia funcional, síndrome de Zollinger-Ellison, doença de refluxo não erosiva (NERD), dor visceral, azia, náusea, esofagite, disfagia, hipersalivação, distúrbios da via aérea ou asma.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63696304P | 2004-12-17 | 2004-12-17 | |
| US69577205P | 2005-06-29 | 2005-06-29 | |
| PCT/IB2005/003758 WO2006064339A1 (en) | 2004-12-17 | 2005-12-07 | Chromane derivatives useful as acid pump antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0519598A2 true BRPI0519598A2 (pt) | 2009-03-10 |
Family
ID=35995811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0519598-5A BRPI0519598A2 (pt) | 2004-12-17 | 2005-12-07 | derivados de cromano éteis como antagonistas de bomba de Ácido, composiÇço farmacÊutica e uso dos mesmos |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20090291977A1 (pt) |
| EP (1) | EP1838309B1 (pt) |
| JP (1) | JP2008524199A (pt) |
| KR (1) | KR20070086294A (pt) |
| AP (1) | AP2007004023A0 (pt) |
| AT (1) | ATE405262T1 (pt) |
| AU (1) | AU2005315303A1 (pt) |
| BR (1) | BRPI0519598A2 (pt) |
| CA (1) | CA2591412A1 (pt) |
| DE (1) | DE602005009257D1 (pt) |
| EA (1) | EA011512B1 (pt) |
| ES (1) | ES2313444T3 (pt) |
| IL (1) | IL183602A0 (pt) |
| MA (1) | MA29095B1 (pt) |
| MX (1) | MX2007007010A (pt) |
| NO (1) | NO20072764L (pt) |
| TN (1) | TNSN07227A1 (pt) |
| WO (1) | WO2006064339A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007026218A2 (en) * | 2005-09-01 | 2007-03-08 | Pfizer Japan Inc. | Chromane substituted 2-alkyl imidazopyridine derivatives and use thereof as acid pump antagonists |
| EP1996589A1 (en) * | 2006-03-17 | 2008-12-03 | RaQualia Pharma Inc | Chromane derivatives |
| WO2008059373A1 (en) * | 2006-11-17 | 2008-05-22 | Raqualia Pharma Inc. | Imidazo [1, 2-a] pyrazine derivatives and their use as acid pump antagonists |
| KR102254957B1 (ko) | 2013-11-22 | 2021-05-25 | 씨엘 바이오사이언시즈 엘엘씨 | 골다공증 치료 및 예방을 위한 가스트린 길항제(ｅｇ ｙｆ476, 네타제피드) |
| JP6315708B2 (ja) * | 2015-06-22 | 2018-04-25 | 日本電信電話株式会社 | リチウム空気二次電池、リチウム空気二次電池の製造方法及びリチウム空気二次電池を備えた装置 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9801526D0 (sv) * | 1998-04-29 | 1998-04-29 | Astra Ab | New compounds |
| SE0102808D0 (sv) * | 2001-08-22 | 2001-08-22 | Astrazeneca Ab | New compounds |
| RS20050377A (sr) * | 2002-11-19 | 2007-11-15 | Altana Pharma Ag., | 8-supstituisani imidazopiridini |
-
2005
- 2005-12-07 AU AU2005315303A patent/AU2005315303A1/en not_active Abandoned
- 2005-12-07 ES ES05818222T patent/ES2313444T3/es not_active Expired - Lifetime
- 2005-12-07 WO PCT/IB2005/003758 patent/WO2006064339A1/en not_active Ceased
- 2005-12-07 AP AP2007004023A patent/AP2007004023A0/xx unknown
- 2005-12-07 US US11/721,453 patent/US20090291977A1/en not_active Abandoned
- 2005-12-07 MX MX2007007010A patent/MX2007007010A/es unknown
- 2005-12-07 EA EA200701087A patent/EA011512B1/ru not_active IP Right Cessation
- 2005-12-07 BR BRPI0519598-5A patent/BRPI0519598A2/pt not_active IP Right Cessation
- 2005-12-07 AT AT05818222T patent/ATE405262T1/de not_active IP Right Cessation
- 2005-12-07 EP EP05818222A patent/EP1838309B1/en not_active Expired - Lifetime
- 2005-12-07 JP JP2007546218A patent/JP2008524199A/ja active Pending
- 2005-12-07 CA CA002591412A patent/CA2591412A1/en not_active Abandoned
- 2005-12-07 DE DE602005009257T patent/DE602005009257D1/de not_active Expired - Fee Related
- 2005-12-07 KR KR1020077013608A patent/KR20070086294A/ko not_active Abandoned
-
2007
- 2007-05-31 IL IL183602A patent/IL183602A0/en unknown
- 2007-05-31 NO NO20072764A patent/NO20072764L/no not_active Application Discontinuation
- 2007-06-15 MA MA29996A patent/MA29095B1/fr unknown
- 2007-06-15 TN TNP2007000227A patent/TNSN07227A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AP2007004023A0 (en) | 2007-06-30 |
| IL183602A0 (en) | 2007-09-20 |
| EA011512B1 (ru) | 2009-04-28 |
| EA200701087A1 (ru) | 2008-02-28 |
| CA2591412A1 (en) | 2006-06-22 |
| ATE405262T1 (de) | 2008-09-15 |
| EP1838309B1 (en) | 2008-08-20 |
| US20090291977A1 (en) | 2009-11-26 |
| JP2008524199A (ja) | 2008-07-10 |
| EP1838309A1 (en) | 2007-10-03 |
| NO20072764L (no) | 2007-07-03 |
| TNSN07227A1 (fr) | 2008-11-21 |
| KR20070086294A (ko) | 2007-08-27 |
| DE602005009257D1 (de) | 2008-10-02 |
| MA29095B1 (fr) | 2007-12-03 |
| AU2005315303A1 (en) | 2006-06-22 |
| WO2006064339A1 (en) | 2006-06-22 |
| ES2313444T3 (es) | 2009-03-01 |
| MX2007007010A (es) | 2007-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: RAQUALIA PHARMA INC. (JP) Free format text: TRANSFERIDO DE: PFIZER INC. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 5A E 6A ANUIDADES. |