BRPI0520806A2 - derivados pirrólicos, processos para a preparação de compostos, seu uso e composição farmacêutica que os contém - Google Patents

derivados pirrólicos, processos para a preparação de compostos, seu uso e composição farmacêutica que os contém

Info

Publication number
BRPI0520806A2
BRPI0520806A2 BRPI0520806-8A BRPI0520806A BRPI0520806A2 BR PI0520806 A2 BRPI0520806 A2 BR PI0520806A2 BR PI0520806 A BRPI0520806 A BR PI0520806A BR PI0520806 A2 BRPI0520806 A2 BR PI0520806A2
Authority
BR
Brazil
Prior art keywords
compounds
processes
preparation
pharmaceutical composition
composition containing
Prior art date
Application number
BRPI0520806-8A
Other languages
English (en)
Inventor
Mora Fernando Pedro Cossio
Manel Esteller Badosa
Aizpea Zubia Olascoaga
Dorleta Otaegui Ansa
Original Assignee
Ct Nac De Investigaciones Oncologicas
Univ Pais Vasco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Nac De Investigaciones Oncologicas, Univ Pais Vasco filed Critical Ct Nac De Investigaciones Oncologicas
Publication of BRPI0520806A2 publication Critical patent/BRPI0520806A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/42—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

DERIVADOS PIRRóLICOS, PROCESSOS PARA A PREPARAçãO DE COMPOSTOS, SEU USO E COMPOSIçãO FARMACêUTICA QUE OS CONTêM. A invenção descreve novos compostos derivados de pirroles da fórmula (1), métodos para a sua obtenção e sua aplicação como drogas em composições farmacêuticas para o tratamento de câncer graças à sua atividade inibitória em determinados desacetilazos de histonas.
BRPI0520806-8A 2005-12-27 2005-12-27 derivados pirrólicos, processos para a preparação de compostos, seu uso e composição farmacêutica que os contém BRPI0520806A2 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/ES2005/000708 WO2007074176A1 (es) 2005-12-27 2005-12-27 Nuevos derivados pirrólicos con actividad inhibidora de desacetilasas de histonas

Publications (1)

Publication Number Publication Date
BRPI0520806A2 true BRPI0520806A2 (pt) 2009-06-09

Family

ID=38217700

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0520806-8A BRPI0520806A2 (pt) 2005-12-27 2005-12-27 derivados pirrólicos, processos para a preparação de compostos, seu uso e composição farmacêutica que os contém

Country Status (17)

Country Link
US (1) US7638550B2 (pt)
EP (1) EP1975158B9 (pt)
JP (1) JP4975758B2 (pt)
CN (1) CN101351444B (pt)
AT (1) ATE516268T1 (pt)
AU (1) AU2005339535B2 (pt)
BR (1) BRPI0520806A2 (pt)
CA (1) CA2635392C (pt)
CY (1) CY1111899T1 (pt)
DK (1) DK1975158T3 (pt)
ES (1) ES2369705T3 (pt)
MX (1) MX2008008470A (pt)
PL (1) PL1975158T3 (pt)
PT (1) PT1975158E (pt)
RU (1) RU2416600C2 (pt)
SI (1) SI1975158T1 (pt)
WO (1) WO2007074176A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006108864A2 (en) * 2005-04-15 2006-10-19 Dominion Pharmakine S.L. New nitrogenated trans-stilbene analogs, method for the obtention and medical applications thereof
EP2305643A1 (en) 2009-10-02 2011-04-06 Ikerchem, S.L. New histone deacetylase inhibitors based simultaneously on trisubstituted 1h-pyrroles and aromatic and heteroaromatic spacers
EP2508510A1 (en) * 2011-04-06 2012-10-10 Ikerchem, S.L. Hydroxyphenyl pyrrole compounds containing an hydroxamic acid as hdac inhibitors and medicinal applications thereof
CN103373969B (zh) * 2012-04-27 2015-09-16 中国科学院上海有机化学研究所 苯基唑环取代酰胺类化合物及其制备方法和用途
MY195058A (en) 2015-05-22 2023-01-05 Chong Kun Dang Pharmaceutical Corp Heterocyclicalkyl Derivative Compounds as Selective Histone Deacetylase Inhibitors and Pharmaceutical Compositions Comprising the Same
CN106565583A (zh) * 2016-11-15 2017-04-19 淮阴师范学院 多取代吡咯衍生物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2208964T3 (es) * 1996-12-10 2004-06-16 G.D. SEARLE & CO. Compuestos de pirrolilo substituidos para el tratamiento de la inflamacion.
JP4191825B2 (ja) * 1998-09-10 2008-12-03 あすか製薬株式会社 ５−アミノイソキサゾール誘導体
BR0014254A (pt) * 1999-09-08 2002-08-27 Sloan Kettering Inst Cancer Nova classe de agentes de citodiferenciação e inibidores de desacetilase de histona, e métodos de uso dos mesmos
DE60134626D1 (de) * 2000-01-31 2008-08-14 Ishihara Sangyo Kaisha Heilmittel und vorbeugende mittel für verdauungserkrankungen die diaminotrifluoromethylpyridinverbindungen enthalten
CA2423868C (en) * 2000-09-29 2011-06-07 Prolifix Limited Carbamic acid compounds comprising an amide linkage as hdac inhibitors
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives
US7612064B2 (en) 2003-05-26 2009-11-03 Takeda Pharmaceutical Company Limited Sulfopyrroles
CA2547573A1 (en) 2003-12-05 2005-06-23 Warner-Lambert Company Llc N-alkyl pyrroles as hmg-coa reductase inhibitors
US7842820B2 (en) * 2004-03-11 2010-11-30 4Sc Ag Sulfonylpyrroles

Also Published As

Publication number Publication date
CN101351444A (zh) 2009-01-21
EP1975158A4 (en) 2009-11-11
HK1125926A1 (en) 2009-08-21
DK1975158T3 (da) 2011-10-24
JP2009521519A (ja) 2009-06-04
MX2008008470A (es) 2008-09-26
CA2635392A1 (en) 2007-07-05
PT1975158E (pt) 2011-09-23
ES2369705T3 (es) 2011-12-05
EP1975158B1 (en) 2011-07-13
CA2635392C (en) 2013-07-23
PL1975158T3 (pl) 2011-12-30
SI1975158T1 (sl) 2011-10-28
US7638550B2 (en) 2009-12-29
ATE516268T1 (de) 2011-07-15
US20080262073A1 (en) 2008-10-23
WO2007074176A1 (es) 2007-07-05
AU2005339535B2 (en) 2012-02-23
CN101351444B (zh) 2011-07-13
AU2005339535A1 (en) 2007-07-05
RU2008130876A (ru) 2010-02-10
EP1975158B9 (en) 2012-02-29
EP1975158A1 (en) 2008-10-01
CY1111899T1 (el) 2015-11-04
RU2416600C2 (ru) 2011-04-20
JP4975758B2 (ja) 2012-07-11

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.