BRPI0604577B8 - formulação farmacêutica para administração intraocular de fármacos e processo de obtenção - Google Patents

formulação farmacêutica para administração intraocular de fármacos e processo de obtenção

Info

Publication number
BRPI0604577B8
BRPI0604577B8 BRPI0604577A BRPI0604577A BRPI0604577B8 BR PI0604577 B8 BRPI0604577 B8 BR PI0604577B8 BR PI0604577 A BRPI0604577 A BR PI0604577A BR PI0604577 A BRPI0604577 A BR PI0604577A BR PI0604577 B8 BRPI0604577 B8 BR PI0604577B8
Authority
BR
Brazil
Prior art keywords
extraction
alkaloids
indole alkaloids
fluids
supercritical
Prior art date
Application number
BRPI0604577A
Other languages
English (en)
Inventor
Da Silva Cunha Junior Armando
Camargo Siqueira Rubens
Ligório Fialho Silvia
Original Assignee
Univ Minas Gerais
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minas Gerais filed Critical Univ Minas Gerais
Priority to BRPI0604577A priority Critical patent/BRPI0604577B8/pt
Priority to PCT/BR2007/000222 priority patent/WO2008025111A2/en
Publication of BRPI0604577A publication Critical patent/BRPI0604577A/pt
Publication of BRPI0604577B1 publication Critical patent/BRPI0604577B1/pt
Publication of BRPI0604577B8 publication Critical patent/BRPI0604577B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

processo dr extração de alcalóides indólicos e frações alcoídicas utilizando fluidos supercríticos a presente invenção relata o processo de extração de alcalóides indólicos e frações alcaloídicas utilizando fluidos supercríticos e parâmetros diferenciados que aumentam eficiência da extração, obtendo fluidos mais ricos e mais puros. esta invenção apresenta a otimização do processo de extração supercrítica de alcalóides indólicos pelo ajuste das condições de temperatura, pressão, teor e tipo de co-solvente para elaboração de alimentos enriquecidos, fitoterápicos e medica-mentos. os alcalóides em questão apresentam importante atividade terapêutica, tais como, ativi-dades anti-tumoral, anti-inflamátoria, analgésica, antioxidante, antimicobacteriano, anticancerí-gena, tripanomicida e leishmanicida. com o processo aqui apresentado, verifica-se um aumento no rendimento da fração de alcalói-des indólicos pelo uso da melhor condição de extração. apresenta-se também a obtenção dos componentes desejados com mínimos riscos ambientais devido à redução do uso de solventes orgânicos e das etapas de purificação presentes nos processos convencionais.
BRPI0604577A 2006-08-31 2006-08-31 formulação farmacêutica para administração intraocular de fármacos e processo de obtenção BRPI0604577B8 (pt)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BRPI0604577A BRPI0604577B8 (pt) 2006-08-31 2006-08-31 formulação farmacêutica para administração intraocular de fármacos e processo de obtenção
PCT/BR2007/000222 WO2008025111A2 (en) 2006-08-31 2007-08-31 Biodegradable device for intraocular drug delivery

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0604577A BRPI0604577B8 (pt) 2006-08-31 2006-08-31 formulação farmacêutica para administração intraocular de fármacos e processo de obtenção

Publications (3)

Publication Number Publication Date
BRPI0604577A BRPI0604577A (pt) 2008-04-22
BRPI0604577B1 BRPI0604577B1 (pt) 2020-11-24
BRPI0604577B8 true BRPI0604577B8 (pt) 2021-05-25

Family

ID=38987981

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0604577A BRPI0604577B8 (pt) 2006-08-31 2006-08-31 formulação farmacêutica para administração intraocular de fármacos e processo de obtenção

Country Status (2)

Country Link
BR (1) BRPI0604577B8 (pt)
WO (1) WO2008025111A2 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10588855B2 (en) * 2008-05-12 2020-03-17 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US9877973B2 (en) 2008-05-12 2018-01-30 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US10064819B2 (en) 2008-05-12 2018-09-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
BR102012009316A2 (pt) * 2012-04-20 2013-11-26 Univ Minas Gerais Dispositivo de liberação prolongada de talidomida e uso em doenças oculares causadoras de neovascularização
JP6543431B2 (ja) * 2013-10-10 2019-07-10 ユニバーシティー オブ ユタ リサーチ ファウンデーションＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｕｔａｈ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ 眼内薬物送達デバイスおよび付随する方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6726918B1 (en) * 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
US20050244469A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments

Also Published As

Publication number Publication date
WO2008025111A3 (en) 2008-04-17
BRPI0604577A (pt) 2008-04-22
WO2008025111A8 (en) 2008-05-29
WO2008025111A2 (en) 2008-03-06
BRPI0604577B1 (pt) 2020-11-24

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/11/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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B22L Other matters related to patents and certificates of addition of invention: notification of licence offer (art 64 par 1 of lpi)

Free format text: REFERENTE A PETICAO NO 870230033311 DE 20.04.2023 - O INTERESSADO PODERA OBTER COPIA NA INTEGRA DAS CONDICOES CONTRATUAIS OFERECIDAS PELO TITULAR (INSTRUCAO NORMATIVA NO 17/2013 ITEM 8), MEDIANTE PETICIONAMENTO ELETRONICO AO INPI - OBS: CONSULTA A CARTA PATENTE PODERA SER FEITA ATRAVES DO ENDERECO ELETRONICO WWW.INPI.GOV.BR - NO ACESSO RAPIDO = BUSCA DE PROCESSOS = FACA LOGIN COM SENHA OU TECLE CONTINUAR = PATENTE = DIGITE O NUMERO DO PROCESSO = PESQUISAR. PARA ACESSAR, CADASTRE-SE NO PORTAL DO INPI

B22L Other matters related to patents and certificates of addition of invention: notification of licence offer (art 64 par 1 of lpi)

Free format text: OFERTA DE LICENCA DE PATENTE - REFERENTE A PETICAO NO 870230033311 DE 20.04.2023 - O INTERESSADO PODERA OBTER COPIA NA INTEGRA DAS CONDICOES CONTRATUAIS OFERECIDAS PELO TITULAR (INSTRUCAO NORMATIVA NO 17/2013 ITEM 8), MEDIANTE PETICIONAMENTO ELETRONICO AO INPI - OBS: CONSULTA A CARTA PATENTE PODERA SER FEITA ATRAVES DO ENDERECO ELETRONICO WWW.INPI.GOV.BR - NO ACESSO RAPIDO = BUSCA DE PROCESSOS = FACA LOGIN COM SENHA OU TECLE CONTINUAR = PATENTE = DIGITE O NUMERO DO PROCESSO = PESQUISAR. PARA ACESSAR, CADASTRE-SE NO PORTAL DO INPI.