BRPI0606122A2 - tadalafil particulado sólido que tem uma distribuição de tamanho de partìcula bimodal - Google Patents

tadalafil particulado sólido que tem uma distribuição de tamanho de partìcula bimodal

Info

Publication number
BRPI0606122A2
BRPI0606122A2 BRPI0606122-2A BRPI0606122A BRPI0606122A2 BR PI0606122 A2 BRPI0606122 A2 BR PI0606122A2 BR PI0606122 A BRPI0606122 A BR PI0606122A BR PI0606122 A2 BRPI0606122 A2 BR PI0606122A2
Authority
BR
Brazil
Prior art keywords
particle size
size distribution
solid particulate
bimodal particle
particulate tadalafil
Prior art date
Application number
BRPI0606122-2A
Other languages
English (en)
Inventor
Judith Aronhime
Guy Samburski
Yhoshoa Ovadya
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of BRPI0606122A2 publication Critical patent/BRPI0606122A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Packages (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Secondary Cells (AREA)

Abstract

TADALAFIL PARTICULADO SóLIDO QUE TEM UMA DISTRIBUIçãO DE TAMANHO DE PARTìCULA BIMODAL é fornecido um tadalafil particulado sólido que tem uma distribuição de tamanho de partícula bimodal.
BRPI0606122-2A 2005-08-29 2006-08-29 tadalafil particulado sólido que tem uma distribuição de tamanho de partìcula bimodal BRPI0606122A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71258905P 2005-08-29 2005-08-29
PCT/US2006/033541 WO2007027612A2 (en) 2005-08-29 2006-08-29 Solid particulate tadalafil having a bimodal particle size distribution

Publications (1)

Publication Number Publication Date
BRPI0606122A2 true BRPI0606122A2 (pt) 2009-06-02

Family

ID=37809413

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606122-2A BRPI0606122A2 (pt) 2005-08-29 2006-08-29 tadalafil particulado sólido que tem uma distribuição de tamanho de partìcula bimodal

Country Status (13)

Country Link
US (1) US20070098804A1 (pt)
EP (1) EP1843770B1 (pt)
JP (1) JP2008518041A (pt)
KR (1) KR20070067173A (pt)
AT (1) ATE398451T1 (pt)
BR (1) BRPI0606122A2 (pt)
CA (1) CA2610668A1 (pt)
DE (1) DE602006001510D1 (pt)
ES (1) ES2308750T3 (pt)
IL (1) IL185938A0 (pt)
PL (1) PL1843770T3 (pt)
PT (1) PT1843770E (pt)
WO (1) WO2007027612A2 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004073729A1 (ja) 2003-02-21 2004-09-02 Translational Research Ltd. 薬物の経鼻投与用組成物
US7278982B2 (en) 2003-03-27 2007-10-09 Bioactis Limited Powder medicine applicator for nasal cavity
CN101668544B (zh) 2006-12-26 2013-04-24 株式会社新日本科学 经鼻投用制剂
GB0712316D0 (en) * 2007-06-26 2007-08-01 Entripneur Ltd A novel powder and its method of manufacture
EP2238979A1 (en) * 2009-04-06 2010-10-13 LEK Pharmaceuticals d.d. Active pharmaceutical ingredient adsorbed on solid support
EP2429495A4 (en) * 2009-05-15 2014-01-22 Shin Nippon Biomedical Lab Ltd INTRANASAL PHARMACEUTICAL COMPOSITION WITH IMPROVED PHARMACOKINETICS
US8827946B2 (en) * 2009-07-31 2014-09-09 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator
WO2011030351A2 (en) 2009-09-03 2011-03-17 Rubicon Research Private Limited Taste - masked pharmaceutical compositions
WO2014092661A1 (en) * 2012-01-18 2014-06-19 Mahmut Bilgic Particulate formulations of tadalafil in effervescent form
WO2013109223A1 (en) * 2012-01-18 2013-07-25 Mahmut Bilgic Particulate formulations of tadalafil in effervescent form
US20160136282A1 (en) 2014-11-18 2016-05-19 Genovate Biotechnology Co., Ltd. Novel formulation of cilostazol, a quinolinone-derivative used for alleviating the symptom of intermittent claudication in patients with peripheral vascular disease
MX379254B (es) * 2016-02-26 2025-03-10 Apotex Inc Formulaciones farmacéuticas novedosas que comprenden un inhibidor de pde5.
CN108883193A (zh) * 2016-03-31 2018-11-23 伊穆特丽克斯治疗股份有限公司 先兆子痫和有关障碍的体外治疗方法
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
US20200405693A1 (en) * 2019-06-25 2020-12-31 Primus Pharmaceuticals, Inc. Reduced dose metaxalone formulations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI223598B (en) * 1998-06-22 2004-11-11 Pfizer Ireland Pharmaceuticals An intranasal pharmaceutical composition for the treatment of male erectile dysfunction or female sexual disorders, an intranasal delivery system or device and sildenafil mesylate
US6821975B1 (en) * 1999-08-03 2004-11-23 Lilly Icos Llc Beta-carboline drug products
US6465465B1 (en) * 2000-03-14 2002-10-15 Arzneimittelwerk Dresden Gmbh Process for the treatment of erectile dysfunction and product therefor
CN1638739A (zh) * 2000-08-18 2005-07-13 法玛西雅厄普约翰美国公司 治疗成瘾性障碍的化合物
US6634576B2 (en) * 2000-08-31 2003-10-21 Rtp Pharma Inc. Milled particles
AU2002310086B2 (en) * 2001-05-24 2008-09-04 Alexza Pharmaceuticals, Inc. Delivery of erectile dysfunction drugs through an inhalation route
EA006213B1 (ru) * 2001-07-31 2005-10-27 Х. Лундбекк А/С Кристаллическая композиция, содержащая эсциталопрам
US20050042177A1 (en) * 2003-07-23 2005-02-24 Elan Pharma International Ltd. Novel compositions of sildenafil free base

Also Published As

Publication number Publication date
ES2308750T3 (es) 2008-12-01
US20070098804A1 (en) 2007-05-03
EP1843770B1 (en) 2008-06-18
IL185938A0 (en) 2008-08-07
CA2610668A1 (en) 2007-03-08
ATE398451T1 (de) 2008-07-15
PT1843770E (pt) 2008-08-05
PL1843770T3 (pl) 2008-10-31
DE602006001510D1 (de) 2008-07-31
KR20070067173A (ko) 2007-06-27
WO2007027612A2 (en) 2007-03-08
WO2007027612A3 (en) 2007-08-02
JP2008518041A (ja) 2008-05-29
EP1843770A2 (en) 2007-10-17

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A E 5A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012.