PL1843770T3 - Tadafil w postaci cząstek stałych mający dwumodalny rozkład wielkości ziaren - Google Patents
Tadafil w postaci cząstek stałych mający dwumodalny rozkład wielkości ziarenInfo
- Publication number
- PL1843770T3 PL1843770T3 PL06802484T PL06802484T PL1843770T3 PL 1843770 T3 PL1843770 T3 PL 1843770T3 PL 06802484 T PL06802484 T PL 06802484T PL 06802484 T PL06802484 T PL 06802484T PL 1843770 T3 PL1843770 T3 PL 1843770T3
- Authority
- PL
- Poland
- Prior art keywords
- particle size
- size distribution
- solid particulate
- bimodal particle
- particulate tadalafil
- Prior art date
Links
- 230000002902 bimodal effect Effects 0.000 title abstract 2
- 239000002245 particle Substances 0.000 title abstract 2
- 239000007787 solid Substances 0.000 title abstract 2
- IEHKWSGCTWLXFU-IIBYNOLFSA-N tadalafil Chemical compound C1=C2OCOC2=CC([C@@H]2C3=C([C]4C=CC=CC4=N3)C[C@H]3N2C(=O)CN(C3=O)C)=C1 IEHKWSGCTWLXFU-IIBYNOLFSA-N 0.000 title abstract 2
- 229960000835 tadalafil Drugs 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Packages (AREA)
- Medicinal Preparation (AREA)
- Detergent Compositions (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Secondary Cells (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71258905P | 2005-08-29 | 2005-08-29 | |
| EP06802484A EP1843770B1 (en) | 2005-08-29 | 2006-08-29 | Solid particulate tadalafil having a bimodal particle size distribution |
| PCT/US2006/033541 WO2007027612A2 (en) | 2005-08-29 | 2006-08-29 | Solid particulate tadalafil having a bimodal particle size distribution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1843770T3 true PL1843770T3 (pl) | 2008-10-31 |
Family
ID=37809413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06802484T PL1843770T3 (pl) | 2005-08-29 | 2006-08-29 | Tadafil w postaci cząstek stałych mający dwumodalny rozkład wielkości ziaren |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20070098804A1 (pl) |
| EP (1) | EP1843770B1 (pl) |
| JP (1) | JP2008518041A (pl) |
| KR (1) | KR20070067173A (pl) |
| AT (1) | ATE398451T1 (pl) |
| BR (1) | BRPI0606122A2 (pl) |
| CA (1) | CA2610668A1 (pl) |
| DE (1) | DE602006001510D1 (pl) |
| ES (1) | ES2308750T3 (pl) |
| IL (1) | IL185938A0 (pl) |
| PL (1) | PL1843770T3 (pl) |
| PT (1) | PT1843770E (pl) |
| WO (1) | WO2007027612A2 (pl) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7638138B2 (en) | 2003-02-21 | 2009-12-29 | Translational Research, Ltd. | Compositions for nasal administration of pharmaceuticals |
| AU2003220808B2 (en) | 2003-03-27 | 2008-08-21 | Bioactis Limited | Powder medicine applicator for nasal cavity |
| US8337817B2 (en) | 2006-12-26 | 2012-12-25 | Shin Nippon Biomedical Laboratories, Ltd. | Preparation for transnasal application |
| GB0712316D0 (en) * | 2007-06-26 | 2007-08-01 | Entripneur Ltd | A novel powder and its method of manufacture |
| EP2238979A1 (en) | 2009-04-06 | 2010-10-13 | LEK Pharmaceuticals d.d. | Active pharmaceutical ingredient adsorbed on solid support |
| WO2010131486A1 (en) * | 2009-05-15 | 2010-11-18 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
| WO2011013003A2 (en) * | 2009-07-31 | 2011-02-03 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal granisetron and nasal applicator |
| WO2011030351A2 (en) | 2009-09-03 | 2011-03-17 | Rubicon Research Private Limited | Taste - masked pharmaceutical compositions |
| WO2013109223A1 (en) * | 2012-01-18 | 2013-07-25 | Mahmut Bilgic | Particulate formulations of tadalafil in effervescent form |
| WO2014092661A1 (en) * | 2012-01-18 | 2014-06-19 | Mahmut Bilgic | Particulate formulations of tadalafil in effervescent form |
| US20160136282A1 (en) | 2014-11-18 | 2016-05-19 | Genovate Biotechnology Co., Ltd. | Novel formulation of cilostazol, a quinolinone-derivative used for alleviating the symptom of intermittent claudication in patients with peripheral vascular disease |
| MX379254B (es) * | 2016-02-26 | 2025-03-10 | Apotex Inc | Formulaciones farmacéuticas novedosas que comprenden un inhibidor de pde5. |
| MX385370B (es) * | 2016-03-31 | 2025-03-18 | Immutrix Therapeutics Inc | Metodo para el tratamiento extracorporeo de preeclampsia y trastornos relacionados. |
| US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
| US20200405693A1 (en) * | 2019-06-25 | 2020-12-31 | Primus Pharmaceuticals, Inc. | Reduced dose metaxalone formulations |
| WO2026068588A1 (en) * | 2024-09-30 | 2026-04-02 | Synthon B.V. | Improved azacitidine composition |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI223598B (en) * | 1998-06-22 | 2004-11-11 | Pfizer Ireland Pharmaceuticals | An intranasal pharmaceutical composition for the treatment of male erectile dysfunction or female sexual disorders, an intranasal delivery system or device and sildenafil mesylate |
| US6821975B1 (en) * | 1999-08-03 | 2004-11-23 | Lilly Icos Llc | Beta-carboline drug products |
| US6465465B1 (en) * | 2000-03-14 | 2002-10-15 | Arzneimittelwerk Dresden Gmbh | Process for the treatment of erectile dysfunction and product therefor |
| CN1638739A (zh) * | 2000-08-18 | 2005-07-13 | 法玛西雅厄普约翰美国公司 | 治疗成瘾性障碍的化合物 |
| JP4969761B2 (ja) * | 2000-08-31 | 2012-07-04 | オバン・エナジー・リミテッド | 所望粒度を持つ固体基材の小粒子および第一材料の小粒状物を含む相乗作用性混合物を製造する方法 |
| AU2002310086B2 (en) * | 2001-05-24 | 2008-09-04 | Alexza Pharmaceuticals, Inc. | Delivery of erectile dysfunction drugs through an inhalation route |
| IL159326A0 (en) * | 2001-07-31 | 2004-06-01 | Lundbeck & Co As H | Crystalline composition containing escitalopram |
| US20050042177A1 (en) * | 2003-07-23 | 2005-02-24 | Elan Pharma International Ltd. | Novel compositions of sildenafil free base |
-
2006
- 2006-08-29 EP EP06802484A patent/EP1843770B1/en not_active Not-in-force
- 2006-08-29 WO PCT/US2006/033541 patent/WO2007027612A2/en not_active Ceased
- 2006-08-29 DE DE602006001510T patent/DE602006001510D1/de not_active Expired - Fee Related
- 2006-08-29 JP JP2007539382A patent/JP2008518041A/ja active Pending
- 2006-08-29 ES ES06802484T patent/ES2308750T3/es active Active
- 2006-08-29 US US11/512,679 patent/US20070098804A1/en not_active Abandoned
- 2006-08-29 KR KR1020077009473A patent/KR20070067173A/ko not_active Ceased
- 2006-08-29 CA CA002610668A patent/CA2610668A1/en not_active Abandoned
- 2006-08-29 BR BRPI0606122-2A patent/BRPI0606122A2/pt not_active IP Right Cessation
- 2006-08-29 AT AT06802484T patent/ATE398451T1/de not_active IP Right Cessation
- 2006-08-29 PT PT06802484T patent/PT1843770E/pt unknown
- 2006-08-29 PL PL06802484T patent/PL1843770T3/pl unknown
-
2007
- 2007-09-11 IL IL185938A patent/IL185938A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE398451T1 (de) | 2008-07-15 |
| KR20070067173A (ko) | 2007-06-27 |
| US20070098804A1 (en) | 2007-05-03 |
| PT1843770E (pt) | 2008-08-05 |
| WO2007027612A3 (en) | 2007-08-02 |
| EP1843770B1 (en) | 2008-06-18 |
| CA2610668A1 (en) | 2007-03-08 |
| JP2008518041A (ja) | 2008-05-29 |
| IL185938A0 (en) | 2008-08-07 |
| BRPI0606122A2 (pt) | 2009-06-02 |
| EP1843770A2 (en) | 2007-10-17 |
| DE602006001510D1 (de) | 2008-07-31 |
| ES2308750T3 (es) | 2008-12-01 |
| WO2007027612A2 (en) | 2007-03-08 |
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