BRPI0606148A2 - anticorpos monoclonais neutralizantes contra a sìndrome respiratória aguda grave associada com o coronavìrus - Google Patents

anticorpos monoclonais neutralizantes contra a sìndrome respiratória aguda grave associada com o coronavìrus

Info

Publication number
BRPI0606148A2
BRPI0606148A2 BRPI0606148-6A BRPI0606148A BRPI0606148A2 BR PI0606148 A2 BRPI0606148 A2 BR PI0606148A2 BR PI0606148 A BRPI0606148 A BR PI0606148A BR PI0606148 A2 BRPI0606148 A2 BR PI0606148A2
Authority
BR
Brazil
Prior art keywords
sars
cov
acute respiratory
respiratory syndrome
coronavirus
Prior art date
Application number
BRPI0606148-6A
Other languages
English (en)
Inventor
Shibo Jiang
Yuxian He
Original Assignee
New York Blood Ct Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York Blood Ct Inc filed Critical New York Blood Ct Inc
Publication of BRPI0606148A2 publication Critical patent/BRPI0606148A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/102—Coronaviridae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

ANTICORPOS MONOCLONAIS NEUTRALIZANTES CONTRA A SìNDROME RESPIRATóRIA AGUDA GRAVE ASSOCIADA COM O CORONAVìRUS. A presente invenção fornece um anticorpo isolado capaz de ligar-se ao domínio de ligação do receptor da proteína spike da síndrome respiratória aguda grave - associada com o coronavírus (SARS-CoV) de forma a inibir competitivamente a ligação da SARS-CoV para as células principais. Estes mAbs ou substâncias podem ser usadas: 1) como agents imunizantes passivos para a prevenção da infecção da SARS-CoV; 2) como reagentes biológicos para o diagnóstico da infecção da SARS-CoV; 3) como imunoterapêuticos para tratamento inicial da infecção da SARS-CoV; e 4) como provas para estudar a imunogenicidade, antigenicidade, estrutura, e função da proteína S da SARS-CoV.
BRPI0606148-6A 2005-02-08 2006-02-08 anticorpos monoclonais neutralizantes contra a sìndrome respiratória aguda grave associada com o coronavìrus BRPI0606148A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65104605P 2005-02-08 2005-02-08
US14192505A 2005-05-31 2005-05-31
PCT/US2006/004599 WO2006086561A2 (en) 2005-02-08 2006-02-08 Neutralizing monoclonal antibodies against severe acute respiratory syndrome-associated coronavirus

Publications (1)

Publication Number Publication Date
BRPI0606148A2 true BRPI0606148A2 (pt) 2009-06-02

Family

ID=36793717

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606148-6A BRPI0606148A2 (pt) 2005-02-08 2006-02-08 anticorpos monoclonais neutralizantes contra a sìndrome respiratória aguda grave associada com o coronavìrus

Country Status (10)

Country Link
EP (1) EP1855719A4 (pt)
JP (1) JP2008529504A (pt)
AT (1) ATE556717T1 (pt)
AU (1) AU2006213775C1 (pt)
BR (1) BRPI0606148A2 (pt)
CA (1) CA2595780A1 (pt)
ES (1) ES2384497T3 (pt)
MX (1) MX2007009512A (pt)
NZ (1) NZ560328A (pt)
WO (1) WO2006086561A2 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA39957B1 (fr) 2014-06-12 2021-04-30 Univ Do Porto Reitoria Vaccin néonatal
KR20220166787A (ko) * 2020-02-06 2022-12-19 브이아이비 브이지더블유 코로나 바이러스 결합제
PH12022552164A1 (en) * 2020-02-19 2023-11-29 United Biomedical Inc Designer peptides and proteins for the detection, prevention and treatment of coronavirus disease, 2019 (covid-19)
CN113292649B (zh) * 2020-02-24 2022-08-12 中国科学院微生物研究所 新型冠状病毒的人源单克隆抗体及其应用
CN113292650B (zh) * 2020-02-24 2022-08-12 中国科学院微生物研究所 新型冠状病毒的人源单克隆抗体及其应用
JP2023517234A (ja) * 2020-03-09 2023-04-24 アブセレラ バイオロジクス インコーポレイテッド 抗コロナウイルス抗体および使用の方法
CN113391064B (zh) * 2020-03-13 2024-11-22 科美诊断技术股份有限公司 用于检测新型冠状病毒中和抗体的受体试剂及其应用
CN111560074B (zh) * 2020-03-20 2021-07-09 中山大学 一种基于幽门螺旋杆菌铁蛋白的新型冠状病毒s蛋白单区域亚单位纳米疫苗
CN111983226A (zh) * 2020-03-25 2020-11-24 新加坡国立大学 SARSr-CoV抗体的检测
WO2021202893A1 (en) * 2020-04-03 2021-10-07 Nonigenex, Inc. Detecting adaptive immunity to coronavirus
JP7174961B2 (ja) * 2020-05-01 2022-11-18 花王株式会社 抗ＳＡＲＳ－ＣｏＶ－２抗体を用いた医薬品及び検査キット
WO2021229270A1 (es) 2020-05-13 2021-11-18 Laboratorio Avi-Mex, S.A. De C.V. Vacuna recombinante contra covid-19 en vector viral
CN112010966B (zh) * 2020-05-15 2021-03-19 潍坊医学院 一种针对新冠病毒棘突蛋白非rbd区的单克隆抗体及其应用
WO2021238910A1 (en) * 2020-05-25 2021-12-02 Guo Bingshi Anti-coronavirus spike protein antibodies and uses thereof
CN112017782A (zh) * 2020-06-01 2020-12-01 北京松果天目健康管理有限公司 SARS-CoV-2易感性的检测方法及新冠病毒重症风险预测方法
CA3179834A1 (en) * 2020-06-25 2021-12-30 David S. Block Ace2-fc fusion proteins and methods of use
CN113945714B (zh) * 2020-07-16 2023-01-31 南京蓬勃生物科技有限公司 新型冠状病毒中和抗体类药物中和能力的检测方法
BR112023000503A2 (pt) 2020-07-16 2023-01-31 Caregen Co Ltd Peptídeo com atividade neutralizante contra a síndrome respiratória aguda grave do coronavírus-2
CN112010984B (zh) * 2020-08-04 2021-10-12 广州千扬生物医药技术有限公司 一种基于幽门螺旋杆菌铁蛋白的新型冠状病毒s蛋白多聚体纳米疫苗
US20230312689A1 (en) 2020-08-26 2023-10-05 National University Corporation Kumamoto University Human antibody or antigen-binding fragment thereof against coronavirus spike protein
CN114181301B (zh) * 2020-09-14 2023-04-28 复旦大学 针对SARS-CoV-2的无ADE效应的中和抗体
CN113156129B (zh) * 2021-01-13 2022-04-05 广东菲鹏生物有限公司 中和抗体高敏检测方法及产品
US20240158477A1 (en) * 2021-01-27 2024-05-16 Bioduro (Jiangsu) Co., Ltd. Antibody against sars-cov-2
CN115109151B (zh) * 2021-01-31 2024-06-11 中南大学湘雅医院 新型冠状病毒单克隆抗体xy6及其应用
CN114859042B (zh) * 2021-02-03 2023-11-03 广东菲鹏生物有限公司 一种鉴别结合突变型抗原的抗体的方法及试剂
EP4089112A1 (en) * 2021-05-14 2022-11-16 Ustav organicke chemie a biochemie AV CR, v.v.i. Antibody binding to rbd of spike protein of sars-cov-2 and a method for quantifying protective antibodies against sars-cov-2
WO2023148641A1 (en) * 2022-02-02 2023-08-10 Translational Health Science And Technology Institute Monoclonal antibodies specific to receptor binding domain of sars-cov2 and uses thereof

Also Published As

Publication number Publication date
EP1855719A2 (en) 2007-11-21
CA2595780A1 (en) 2006-08-17
AU2006213775A1 (en) 2006-08-17
AU2006213775B2 (en) 2010-11-11
EP1855719A4 (en) 2009-11-04
NZ560328A (en) 2010-05-28
WO2006086561A3 (en) 2009-04-23
AU2006213775C1 (en) 2011-11-03
MX2007009512A (es) 2008-02-21
ES2384497T3 (es) 2012-07-05
WO2006086561A2 (en) 2006-08-17
JP2008529504A (ja) 2008-08-07
ATE556717T1 (de) 2012-05-15

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]