BRPI0819916A2 - Proteína de ligação a antígeno, composição farmacêutica, método para tratar um paciente humano afligido com uma doença, anticorpo ou fragmento do mesmo, e, proteína de ligação a antígeno. - Google Patents

Proteína de ligação a antígeno, composição farmacêutica, método para tratar um paciente humano afligido com uma doença, anticorpo ou fragmento do mesmo, e, proteína de ligação a antígeno.

Info

Publication number: BRPI0819916A2
Authority: BR; Brazil
Prior art keywords: antigen binding; binding protein; antibody; fragment; disease
Prior art date: 2007-12-11

Application number

BRPI0819916-7A

Other languages

English (en)

Inventor

Philippe Marc Louis Alard

Jonathan Henry Ellis

Susannah Karen Ford

Volker Germaschewski

Peter Ernest Soden

Pamela Joan Thomas

Trevor Anthony Kenneth Wattam

Ian Richard Catchpole

Gerald Wayne Gough

Alan Peter Lewis

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-11

Filing date

2008-12-09

Publication date

2015-05-19

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40547800&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0819916(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-12-11 Priority claimed from GB0724185A external-priority patent/GB0724185D0/en

2008-04-04 Priority claimed from GB0806230A external-priority patent/GB0806230D0/en

2008-12-09 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2015-05-19 Publication of BRPI0819916A2 publication Critical patent/BRPI0819916A2/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
Ophthalmology & Optometry (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Neurosurgery (AREA)
Cell Biology (AREA)
Hematology (AREA)
Microbiology (AREA)
General Physics & Mathematics (AREA)
Biotechnology (AREA)
Hospice & Palliative Care (AREA)
Food Science & Technology (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Pathology (AREA)
Psychiatry (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BRPI0819916-7A 2007-12-11 2008-12-09 Proteína de ligação a antígeno, composição farmacêutica, método para tratar um paciente humano afligido com uma doença, anticorpo ou fragmento do mesmo, e, proteína de ligação a antígeno. BRPI0819916A2 (pt)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB0724185A GB0724185D0 (en)	2007-12-11	2007-12-11	Antibodies
GB0806230A GB0806230D0 (en)	2008-04-04	2008-04-04	Antibodies
US4383908P	2008-04-10	2008-04-10
PCT/EP2008/067138 WO2009074583A1 (en)	2007-12-11	2008-12-09	Antigen binding proteins

Publications (1)

Publication Number	Publication Date
BRPI0819916A2 true BRPI0819916A2 (pt)	2015-05-19

Family

ID=40547800

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0819916-7A BRPI0819916A2 (pt)	2007-12-11	2008-12-09	Proteína de ligação a antígeno, composição farmacêutica, método para tratar um paciente humano afligido com uma doença, anticorpo ou fragmento do mesmo, e, proteína de ligação a antígeno.

Country Status (24)

Country	Link
US (2)	US8921523B2 (pt)
EP (1)	EP2222705B1 (pt)
JP (2)	JP5512537B2 (pt)
KR (2)	KR101629365B1 (pt)
CN (1)	CN101970484B (pt)
AR (1)	AR069610A1 (pt)
AU (1)	AU2008334637B2 (pt)
BR (1)	BRPI0819916A2 (pt)
CA (1)	CA2707859A1 (pt)
CL (1)	CL2008003655A1 (pt)
CO (1)	CO6280540A2 (pt)
CR (1)	CR11561A (pt)
DO (1)	DOP2010000170A (pt)
EA (1)	EA022913B1 (pt)
ES (1)	ES2525704T3 (pt)
IL (1)	IL206188A0 (pt)
MA (1)	MA31999B1 (pt)
MX (1)	MX2010006422A (pt)
NZ (1)	NZ586003A (pt)
PE (1)	PE20091449A1 (pt)
TW (1)	TWI388334B (pt)
UY (1)	UY31520A1 (pt)
WO (1)	WO2009074583A1 (pt)
ZA (1)	ZA201004133B (pt)

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US8048420B2 (en)	2007-06-12	2011-11-01	Ac Immune S.A.	Monoclonal antibody
US8613923B2 (en)	2007-06-12	2013-12-24	Ac Immune S.A.	Monoclonal antibody
AU2008311367B2 (en)	2007-10-05	2014-11-13	Ac Immune S.A.	Use of anti-amyloid beta antibody in ocular diseases
WO2011106702A2 (en)	2010-02-25	2011-09-01	The Johns Hopkins University	Sustained delivery of therapeutic agents to an eye compartment
EP2598882B1 (en)	2010-07-30	2017-07-26	AC Immune S.A.	Safe and functional humanized antibodies for use in treating an amyloidosis
AR085302A1 (es)	2011-02-24	2013-09-18	Sanofi Sa	Metodo de produccion de anticuerpos sialilados
WO2012139069A2 (en) *	2011-04-07	2012-10-11	Neotope Biosciences Limited	Compositions and methods for treating diseases of protein aggregation involving ic3b deposition
GB201113570D0 (en)	2011-08-05	2011-09-21	Glaxosmithkline Biolog Sa	Vaccine
US10112988B2 (en)	2012-01-09	2018-10-30	Icb International, Inc.	Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide
US10112987B2 (en) *	2012-01-09	2018-10-30	Icb International, Inc.	Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide
WO2013106572A1 (en)	2012-01-11	2013-07-18	Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University	Bispecific antibody fragments for neurological disease proteins and methods of use
DK3019240T3 (da)	2013-07-09	2024-06-03	Annexon Inc	Anti-komplementfaktor C1Q antistoffer og anvendelser deraf
EP3060581A4 (en) *	2013-10-25	2017-06-07	Dana-Farber Cancer Institute, Inc.	Anti-pd-l1 monoclonal antibodies and fragments thereof
EP3105250B1 (en) *	2014-02-10	2020-08-05	IGM Biosciences, Inc.	Iga multi-specific binding molecules
SI3215527T1 (sl) *	2014-11-05	2025-04-30	Annexon, Inc.	Humanizirana protitelesa proti komplementnemu faktorju C1q in njihova uporaba
WO2017035401A1 (en)	2015-08-26	2017-03-02	Achillion Pharmaceuticals, Inc.	Amide compounds for treatment of immune and inflammatory disorders
AR106018A1 (es)	2015-08-26	2017-12-06	Achillion Pharmaceuticals Inc	Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
WO2017035405A1 (en)	2015-08-26	2017-03-02	Achillion Pharmaceuticals, Inc.	Amino compounds for treatment of immune and inflammatory disorders
WO2017035409A1 (en)	2015-08-26	2017-03-02	Achillion Pharmaceuticals, Inc.	Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders
EP3380518B1 (en)	2015-11-24	2026-03-25	Annexon, Inc.	Anti-complement factor c1q fab fragments and uses thereof
WO2017127761A1 (en)	2016-01-20	2017-07-27	Vitrisa Therapeutics, Inc.	Compositions and methods for inhibiting factor d
CN105542005B (zh) *	2016-02-03	2018-11-09	大连理工大学	一种抗人淀粉样β肽的纳米抗体及其应用
WO2018075758A1 (en) *	2016-10-19	2018-04-26	Alexion Pharmaceuticals, Inc.	A method of quantitating unbound c5 in a sample
EP3529619B1 (en) *	2016-10-19	2021-06-30	Alexion Pharmaceuticals, Inc.	A method of quantitating unbound c5a in a sample
WO2018136827A1 (en)	2017-01-20	2018-07-26	Vitrisa Therapeutics, Inc.	Stem-loop compositions and methods for inhibiting factor d
WO2018160891A1 (en)	2017-03-01	2018-09-07	Achillion Pharmaceutical, Inc.	Pharmaceutical compounds for treatment of medical disorders
US20200330592A1 (en) *	2017-10-09	2020-10-22	Keith Black	Compositions and methods of treating alzheimer's and other amyloid related diseases
WO2020051538A1 (en)	2018-09-06	2020-03-12	Achillion Pharmaceuticals, Inc.	Morphic forms of complement factor d inhibitors
WO2020131974A1 (en)	2018-12-17	2020-06-25	Achillion Pharmaceuticals, Inc.	Targeted dosing for the treatment of complement mediated disorders
BR112021018456A2 (pt)	2019-03-22	2021-11-23	Achillion Pharmaceuticals Inc	Compostos farmacêuticos para o tratamento de distúrbios mediados por complemento
US12496279B2 (en)	2019-04-11	2025-12-16	The Johns Hopkins University	Nanoparticles for drug delivery to brain
US20230126447A1 (en) *	2020-03-10	2023-04-27	Achillion Pharmaceuticals, Inc.	Ocular drug depot for complement-mediated disorders
JP2021141861A (ja) *	2020-03-13	2021-09-24	富士フイルム和光純薬株式会社	抗原に対する親和力が向上した抗体のスクリーニング方法および製造方法
CN113929748B (zh) *	2020-07-13	2023-10-20	中国科学技术大学	检测bace1酶活性的试剂盒及用途
US12486322B2 (en)	2021-12-13	2025-12-02	Annexon, Inc.	Anti-complement factor C1q antibodies with single binding arms and uses thereof
JP2026507222A (ja) *	2023-03-03	2026-02-27	ケースウエスタンリザーブユニバーシティ	細胞接着分子を標的とする免疫療法
CN117131608B (zh) *	2023-10-23	2024-03-15	南京航空航天大学	一种基于最佳环量分布的激励盘方法
CN118258998B (zh) *	2024-05-31	2024-08-09	北京大学人民医院	一种抗原特异性b细胞检测探针及其制备方法和应用

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ATE239797T1 (de) *	1993-01-25	2003-05-15	Takeda Chemical Industries Ltd	Antikörper gegen beta-amyloid oder derivative davon und seine verwendung
US6972125B2 (en) *	1999-02-12	2005-12-06	Genetics Institute, Llc	Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith
AU5286999A (en) *	1999-07-23	2001-02-13	Glaxo Group Limited	Combination of an anti-ep-cam antibody with a chemotherapeutic agent
WO2003076455A2 (en)	2002-03-05	2003-09-18	Ramot At Tel-Aviv University Ltd.	Immunizing composition and method for inducing an immune response against the ss-secretase cleavage site of amyloid precursor protein
US20040146512A1 (en) *	2002-10-09	2004-07-29	Arnon Rosenthal	Methods of treating Alzheimer's disease using antibodies directed against amyloid beta peptide and compositions thereof
ATE468886T1 (de)	2003-02-10	2010-06-15	Applied Molecular Evolution	Abeta-bindende moleküle
UY29504A1 (es) *	2005-04-29	2006-10-31	Rinat Neuroscience Corp	Anticuerpos dirigidos contra el péptido amiloide beta y métodos que utilizan los mismos.
US20070196367A1 (en) *	2006-02-22	2007-08-23	Valentin Dinu	Methods of preventing and treating Alzheimer's disease, age related macular degeneration and other diseases involving extra-cellular debris through the inhibition of the complement system
JP5103466B2 (ja) *	2006-03-30	2012-12-19	グラクソグループリミテッド	アミロイド‐βペプチドに対する抗体
US20090022728A1 (en)	2007-03-09	2009-01-22	Rinat Neuroscience Corporation	Methods of treating ophthalmic diseases

2008
- 2008-12-09 US US12/330,541 patent/US8921523B2/en not_active Expired - Fee Related
- 2008-12-09 JP JP2010537424A patent/JP5512537B2/ja not_active Expired - Fee Related
- 2008-12-09 NZ NZ586003A patent/NZ586003A/xx not_active IP Right Cessation
- 2008-12-09 CA CA2707859A patent/CA2707859A1/en not_active Abandoned
- 2008-12-09 MX MX2010006422A patent/MX2010006422A/es active IP Right Grant
- 2008-12-09 BR BRPI0819916-7A patent/BRPI0819916A2/pt not_active IP Right Cessation
- 2008-12-09 ES ES08860577.9T patent/ES2525704T3/es active Active
- 2008-12-09 TW TW097147856A patent/TWI388334B/zh not_active IP Right Cessation
- 2008-12-09 UY UY31520A patent/UY31520A1/es not_active Application Discontinuation
- 2008-12-09 KR KR1020107015248A patent/KR101629365B1/ko not_active Expired - Fee Related
- 2008-12-09 KR KR1020157022610A patent/KR101657637B1/ko not_active Expired - Fee Related
- 2008-12-09 AU AU2008334637A patent/AU2008334637B2/en not_active Ceased
- 2008-12-09 WO PCT/EP2008/067138 patent/WO2009074583A1/en not_active Ceased
- 2008-12-09 CN CN200880126884.8A patent/CN101970484B/zh not_active Expired - Fee Related
- 2008-12-09 EA EA201000787A patent/EA022913B1/ru not_active IP Right Cessation
- 2008-12-09 AR ARP080105335A patent/AR069610A1/es not_active Application Discontinuation
- 2008-12-09 CL CL2008003655A patent/CL2008003655A1/es unknown
- 2008-12-09 US US12/746,837 patent/US20110014182A1/en not_active Abandoned
- 2008-12-09 PE PE2008002026A patent/PE20091449A1/es not_active Application Discontinuation
- 2008-12-09 EP EP08860577.9A patent/EP2222705B1/en active Active
2010
- 2010-06-06 IL IL206188A patent/IL206188A0/en unknown
- 2010-06-08 CO CO10068844A patent/CO6280540A2/es not_active Application Discontinuation
- 2010-06-09 DO DO2010000170A patent/DOP2010000170A/es unknown
- 2010-06-09 ZA ZA2010/04133A patent/ZA201004133B/en unknown
- 2010-07-05 MA MA32987A patent/MA31999B1/fr unknown
- 2010-07-09 CR CR11561A patent/CR11561A/es not_active Application Discontinuation
2014
- 2014-03-26 JP JP2014062826A patent/JP2014177462A/ja active Pending

Also Published As

Publication number	Publication date
CA2707859A1 (en)	2009-06-18
CR11561A (es)	2010-09-23
EA022913B1 (ru)	2016-03-31
EA201000787A1 (ru)	2010-12-30
EP2222705A1 (en)	2010-09-01
US8921523B2 (en)	2014-12-30
JP5512537B2 (ja)	2014-06-04
NZ586003A (en)	2012-08-31
TW200932267A (en)	2009-08-01
IL206188A0 (en)	2010-12-30
WO2009074583A1 (en)	2009-06-18
US20090162358A1 (en)	2009-06-25
JP2014177462A (ja)	2014-09-25
CL2008003655A1 (es)	2010-04-16
AU2008334637A1 (en)	2009-06-18
PE20091449A1 (es)	2009-10-07
DOP2010000170A (es)	2010-08-15
KR101629365B1 (ko)	2016-06-14
KR101657637B1 (ko)	2016-09-19
AU2008334637B2 (en)	2014-08-07
MA31999B1 (fr)	2011-01-03
CO6280540A2 (es)	2011-05-20
UY31520A1 (es)	2009-08-03
JP2011506387A (ja)	2011-03-03
US20110014182A1 (en)	2011-01-20
CN101970484A (zh)	2011-02-09
ES2525704T3 (es)	2014-12-29
TWI388334B (zh)	2013-03-11
AR069610A1 (es)	2010-02-03
KR20150100964A (ko)	2015-09-02
ZA201004133B (en)	2011-11-30
KR20100099277A (ko)	2010-09-10
MX2010006422A (es)	2010-06-25
CN101970484B (zh)	2014-10-01
EP2222705B1 (en)	2014-10-22

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