CR8698A - Anticuerpos monoclonales al factor de crecimiento de hepatocito - Google Patents
Anticuerpos monoclonales al factor de crecimiento de hepatocitoInfo
- Publication number
- CR8698A CR8698A CR8698A CR8698A CR8698A CR 8698 A CR8698 A CR 8698A CR 8698 A CR8698 A CR 8698A CR 8698 A CR8698 A CR 8698A CR 8698 A CR8698 A CR 8698A
- Authority
- CR
- Costa Rica
- Prior art keywords
- growth factor
- hepatocite
- monoclonal antibodies
- pharmaceutical composition
- administering
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La presente invencion es concerniente con un anticuerpo monoclonal neutralizante al factor crecimiento de hepatocito, una composicion farmaceutica que comprende el mismo y metodo de tratamiento que comprenden administrar tal composicion farmaceutica a un paciente, tal como para inhibir glioblastoma.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/825,060 US20040208876A1 (en) | 2003-04-18 | 2004-04-15 | Monoclonal antibodies to hepatocyte growth factor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR8698A true CR8698A (es) | 2007-12-17 |
Family
ID=35320045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR8698A CR8698A (es) | 2004-04-15 | 2006-10-19 | Anticuerpos monoclonales al factor de crecimiento de hepatocito |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US20040208876A1 (es) |
| EP (2) | EP1734995B1 (es) |
| JP (2) | JP4594381B2 (es) |
| KR (1) | KR101072736B1 (es) |
| CN (1) | CN1964738A (es) |
| AT (1) | ATE473760T1 (es) |
| AU (1) | AU2004319276C1 (es) |
| BR (1) | BRPI0418745A (es) |
| CA (1) | CA2563080C (es) |
| CR (1) | CR8698A (es) |
| CY (1) | CY1110783T1 (es) |
| DE (1) | DE602004028168D1 (es) |
| DK (1) | DK1734995T3 (es) |
| ES (1) | ES2346886T3 (es) |
| HR (1) | HRP20100521T1 (es) |
| IL (1) | IL178474A (es) |
| MX (1) | MXPA06011822A (es) |
| NO (1) | NO20065227L (es) |
| NZ (1) | NZ550324A (es) |
| PL (1) | PL1734995T3 (es) |
| PT (1) | PT1734995E (es) |
| RU (1) | RU2361879C2 (es) |
| SI (1) | SI1734995T1 (es) |
| WO (1) | WO2005107800A1 (es) |
| ZA (1) | ZA200609407B (es) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040208876A1 (en) * | 2003-04-18 | 2004-10-21 | Kim Kyung Jin | Monoclonal antibodies to hepatocyte growth factor |
| MXPA06000508A (es) * | 2003-07-18 | 2006-04-05 | Amgen Inc | Agentes de union especifica al factor del crecimiento de los hepatocitos. |
| AU2005267720B2 (en) * | 2004-08-05 | 2012-02-23 | Genentech, Inc. | Humanized anti-cmet antagonists |
| MX2007015056A (es) * | 2005-06-02 | 2008-03-11 | Galaxy Biotech Llc | Metodos para el tratamiento de tumores de cerebro con anticuerpos. |
| RU2446826C2 (ru) | 2005-10-14 | 2012-04-10 | Фукуока Юниверсити | Агенты для подавления повреждения трансплантированных островков после трансплантации островков |
| JP5191235B2 (ja) | 2005-10-21 | 2013-05-08 | 中外製薬株式会社 | 心疾患治療剤 |
| AR057582A1 (es) | 2005-11-15 | 2007-12-05 | Nat Hospital Organization | Agentes para suprimir la induccion de linfocitos t citotoxicos |
| AR057941A1 (es) * | 2005-11-25 | 2007-12-26 | Univ Keio | Agentes terapeuticos para el cancer de prostata |
| AR059213A1 (es) | 2006-01-27 | 2008-03-19 | Univ Keio | Agentes terapeuticos para enfermedades que involucran neovascularizacion coroidal |
| AR059922A1 (es) * | 2006-04-01 | 2008-05-07 | Galaxy Biotech Llc | Anticuerpos monoclonales humanizados para el factor de crecimiento de hepatocitos |
| CA2648644C (en) | 2006-04-07 | 2016-01-05 | Osaka University | Muscle regeneration promoter |
| ES2378097T3 (es) | 2006-06-02 | 2012-04-04 | Aveo Pharmaceuticals, Inc. | ProteÃnas de unión al factor de crecimiento de hepatocitos (HGF) |
| ATE495195T1 (de) | 2006-06-02 | 2011-01-15 | Aveo Pharmaceuticals Inc | Hepatocytenwachstumsfaktor-(hgf-)bindungsprotei e |
| KR101508019B1 (ko) | 2007-01-23 | 2015-04-06 | 고쿠리츠 다이가쿠 호우징 신슈 다이가쿠 | 만성 거부반응 억제제 |
| WO2009002521A2 (en) * | 2007-06-25 | 2008-12-31 | Amgen Inc. | Compositions of specific binding agents to hepatocyte growth factor |
| TW201002346A (en) * | 2008-04-11 | 2010-01-16 | Galaxy Biotech Llc | Combination of HGF inhibitor and EGF inhibitor to treat cancer |
| MX2010012290A (es) * | 2008-05-14 | 2011-02-21 | Amgen Inc | Combinaciones de inhibidores del receptor del factor de crecimiento endotelial vascular e inhibidores del factor de crecimiento de hepatocito para el tratamiento de cancer. |
| US10717781B2 (en) | 2008-06-05 | 2020-07-21 | National Cancer Center | Neuroinvasion inhibitor |
| PA8849001A1 (es) | 2008-11-21 | 2010-06-28 | Lilly Co Eli | Anticuerpos de c-met |
| US8545839B2 (en) * | 2008-12-02 | 2013-10-01 | Pierre Fabre Medicament | Anti-c-Met antibody |
| WO2010119991A2 (en) | 2009-04-17 | 2010-10-21 | Takeda Pharmaceutical Company Limited | Novel method of treating cancer |
| CN101555912B (zh) * | 2009-04-29 | 2012-10-03 | 深圳市特辰科技股份有限公司 | 一种转轮式自锁安全制动装置及其工作方法 |
| EP2287197A1 (en) * | 2009-08-21 | 2011-02-23 | Pierre Fabre Medicament | Anti-cMET antibody and its use for the detection and the diagnosis of cancer |
| EP4115906A1 (en) | 2010-05-28 | 2023-01-11 | Chugai Seiyaku Kabushiki Kaisha | Antitumor t cell response enhancer |
| EP2588107A1 (en) | 2010-07-01 | 2013-05-08 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| JP2013537918A (ja) | 2010-09-27 | 2013-10-07 | エクセリクシス, インク. | 去勢抵抗性前立腺癌および骨芽細胞骨転移の治療のためのmetおよびvegfの二元阻害薬 |
| BR112013030472A2 (pt) | 2011-06-30 | 2019-09-24 | Genentech Inc | formulação farmacêutica, artigo de fabricação e método |
| CZ303636B6 (cs) * | 2011-08-19 | 2013-01-23 | Invos, Spol. S R. O. | Biokontejner pro sber bioodpadu a komunálního odpadu |
| US20140234328A1 (en) | 2011-09-09 | 2014-08-21 | Amgen Inc. | Use of c-met protein for predicting the efficacy of anti-hepatocyte growth factor ("hgf") antibodies in esophageal and gastric cancer patients |
| WO2013043452A1 (en) | 2011-09-20 | 2013-03-28 | Eli Lilly And Company | Anti-c-met antibodies |
| WO2014010586A1 (ja) | 2012-07-10 | 2014-01-16 | 武田薬品工業株式会社 | 注射用製剤 |
| EP2708556B1 (en) | 2012-09-12 | 2018-11-07 | Samsung Electronics Co., Ltd | Pharmaceutical composition for the use in a combination therapy for prevention or treatment of c-met or angiogenesis factor induced diseases |
| US9481725B2 (en) | 2013-03-14 | 2016-11-01 | Alderbio Holdings, Llc | Antibodies to HGF and compositions containing |
| WO2014153166A2 (en) * | 2013-03-14 | 2014-09-25 | Alder Biopharmaceuticals, Inc. | Therapeutic use of antibodies to hgf |
| WO2015031578A1 (en) * | 2013-08-28 | 2015-03-05 | Abbvie Inc. | Hgf assay |
| EP3620531A4 (en) | 2017-05-02 | 2021-03-17 | National Center of Neurology and Psychiatry | METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS |
| US11692037B2 (en) | 2017-10-20 | 2023-07-04 | Hyogo College Of Medicine | Anti-IL-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion |
| CN121358764A (zh) * | 2023-05-05 | 2026-01-16 | 布坦坦研究所 | 人抗FGF2单克隆抗体(mAb)、包含其的药物组合物、其用途和用于检测包含所述mAb的生物样品中的癌症的试剂盒 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US722041A (en) * | 1902-11-24 | 1903-03-03 | Mail Belting Company | Conveyer-belt. |
| JP2564486B2 (ja) | 1986-07-14 | 1996-12-18 | 修治 橋本 | 肝細胞増殖因子 |
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| ES2087997T3 (es) | 1990-01-12 | 1996-08-01 | Cell Genesys Inc | Generacion de anticuerpos xenogenicos. |
| GB9003621D0 (en) | 1990-02-16 | 1990-04-11 | Imp Cancer Res Tech | Protein factor |
| GB9009548D0 (en) * | 1990-04-27 | 1990-06-20 | Celltech Ltd | Chimeric antibody and method |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| JPH06508511A (ja) | 1990-07-10 | 1994-09-29 | ケンブリッジ アンティボディー テクノロジー リミティド | 特異的な結合ペアーの構成員の製造方法 |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| GB9110202D0 (en) * | 1991-05-10 | 1991-07-03 | Erba Carlo Spa | Truncated forms of the hepatocyte growth factor(hgf)receptor |
| EP0940468A1 (en) | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Humanized antibody variable domain |
| EP0746609A4 (en) | 1991-12-17 | 1997-12-17 | Genpharm Int | NON-HUMAN TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGOUS ANTIBODIES |
| US5837676A (en) | 1993-10-18 | 1998-11-17 | Long Island Jewish Medical Center | Use of scatter factor to enhance angiogenesis |
| US6498144B1 (en) | 1993-10-18 | 2002-12-24 | North Shore - Long Island Jewish Research Institute | Use of scatter factor to enhance angiogenesis |
| US5707624A (en) | 1994-06-03 | 1998-01-13 | The Regents Of The University Of Michigan | Treatment of Kaposi's sarcoma by inhibition of scatter factor |
| US5686292A (en) * | 1995-06-02 | 1997-11-11 | Genentech, Inc. | Hepatocyte growth factor receptor antagonist antibodies and uses thereof |
| US6214344B1 (en) * | 1995-06-02 | 2001-04-10 | Genetech, Inc. | Hepatocyte growth factor receptor antagonists and uses thereof |
| US5646036A (en) | 1995-06-02 | 1997-07-08 | Genentech, Inc. | Nucleic acids encoding hepatocyte growth factor receptor antagonist antibodies |
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| JP2000515735A (ja) * | 1996-07-03 | 2000-11-28 | ジェネンテック インコーポレーテッド | 肝細胞成長因子レセプターアゴニスト |
| WO2000012560A1 (en) | 1998-08-28 | 2000-03-09 | Dendreon Corporation | Selective apoptosis of neoplastic cells by an hla-dr specific monoclonal antibody |
| WO2001034650A1 (en) | 1999-11-09 | 2001-05-17 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Heatlh And Human Services | Hgf-sf monoclonal antibody combinations |
| AU2002355249A1 (en) | 2001-07-26 | 2003-02-17 | Eli Lilly And Company | Interleukin-1 beta antibodies |
| AU2002357388A1 (en) | 2001-12-27 | 2003-07-24 | The United States Of America, As Represented By The Department Of Veterans Affairs | Monoclonal antibody imaging and therapy of tumors that express met and bind hepatocyte growth factor |
| AU2003270118A1 (en) * | 2002-08-30 | 2004-03-19 | F. Hoffmann-La Roche Ag | Scatter factor/hepatocyte growth factor antagonist nk4 for the treatment of glioma |
| US7220410B2 (en) | 2003-04-18 | 2007-05-22 | Galaxy Biotech, Llc | Monoclonal antibodies to hepatocyte growth factor |
| US20040208876A1 (en) | 2003-04-18 | 2004-10-21 | Kim Kyung Jin | Monoclonal antibodies to hepatocyte growth factor |
| EP1636593B9 (en) | 2003-06-06 | 2009-12-16 | Genentech, Inc. | Modulating the interaction between hgf beta chain and c-met |
| DE602004024536D1 (de) | 2003-07-07 | 2010-01-21 | Van Andel Res Inst | Hemmung der tumor-angiogenese durch eine kombination von thrombospondin-1 und hemmern des vaskulären endothel-wachstumsfaktors |
| MXPA06000508A (es) * | 2003-07-18 | 2006-04-05 | Amgen Inc | Agentes de union especifica al factor del crecimiento de los hepatocitos. |
| KR100556660B1 (ko) | 2003-11-11 | 2006-03-10 | 국립암센터 | Hgf의 중화가능 에피토프 및 이에 결합하는 중화 항체 |
| MX2007015056A (es) * | 2005-06-02 | 2008-03-11 | Galaxy Biotech Llc | Metodos para el tratamiento de tumores de cerebro con anticuerpos. |
| AR059922A1 (es) * | 2006-04-01 | 2008-05-07 | Galaxy Biotech Llc | Anticuerpos monoclonales humanizados para el factor de crecimiento de hepatocitos |
-
2004
- 2004-04-15 US US10/825,060 patent/US20040208876A1/en not_active Abandoned
- 2004-08-13 KR KR1020067023964A patent/KR101072736B1/ko not_active Expired - Fee Related
- 2004-08-13 BR BRPI0418745-8A patent/BRPI0418745A/pt not_active IP Right Cessation
- 2004-08-13 JP JP2007508323A patent/JP4594381B2/ja not_active Expired - Fee Related
- 2004-08-13 SI SI200431468T patent/SI1734995T1/sl unknown
- 2004-08-13 RU RU2006140257/13A patent/RU2361879C2/ru not_active IP Right Cessation
- 2004-08-13 PT PT04781281T patent/PT1734995E/pt unknown
- 2004-08-13 AT AT04781281T patent/ATE473760T1/de active
- 2004-08-13 ZA ZA200609407A patent/ZA200609407B/xx unknown
- 2004-08-13 DK DK04781281.3T patent/DK1734995T3/da active
- 2004-08-13 AU AU2004319276A patent/AU2004319276C1/en not_active Ceased
- 2004-08-13 EP EP04781281A patent/EP1734995B1/en not_active Expired - Lifetime
- 2004-08-13 CN CNA200480042750XA patent/CN1964738A/zh active Pending
- 2004-08-13 HR HR20100521T patent/HRP20100521T1/hr unknown
- 2004-08-13 EP EP10160203A patent/EP2204191A1/en not_active Withdrawn
- 2004-08-13 CA CA2563080A patent/CA2563080C/en not_active Expired - Fee Related
- 2004-08-13 NZ NZ550324A patent/NZ550324A/en not_active IP Right Cessation
- 2004-08-13 PL PL04781281T patent/PL1734995T3/pl unknown
- 2004-08-13 MX MXPA06011822A patent/MXPA06011822A/es active IP Right Grant
- 2004-08-13 ES ES04781281T patent/ES2346886T3/es not_active Expired - Lifetime
- 2004-08-13 DE DE602004028168T patent/DE602004028168D1/de not_active Expired - Lifetime
- 2004-08-13 WO PCT/US2004/026565 patent/WO2005107800A1/en not_active Ceased
-
2006
- 2006-10-05 IL IL178474A patent/IL178474A/en not_active IP Right Cessation
- 2006-10-19 CR CR8698A patent/CR8698A/es unknown
- 2006-11-14 NO NO20065227A patent/NO20065227L/no not_active Application Discontinuation
-
2007
- 2007-02-23 US US11/710,009 patent/US7494650B2/en not_active Expired - Fee Related
- 2007-06-13 US US11/818,305 patent/US7687063B2/en not_active Expired - Fee Related
-
2008
- 2008-12-22 US US12/342,059 patent/US20090104192A1/en not_active Abandoned
-
2010
- 2010-08-03 JP JP2010174810A patent/JP2011012067A/ja not_active Withdrawn
- 2010-08-30 CY CY20101100789T patent/CY1110783T1/el unknown
-
2011
- 2011-06-14 US US13/160,444 patent/US20120064066A1/en not_active Abandoned
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