BRPI0606367A2 - derivados espirocetais e composições farmacêuticas compreendendo os mesmos - Google Patents
derivados espirocetais e composições farmacêuticas compreendendo os mesmosInfo
- Publication number
- BRPI0606367A2 BRPI0606367A2 BRPI0606367-5A BRPI0606367A BRPI0606367A2 BR PI0606367 A2 BRPI0606367 A2 BR PI0606367A2 BR PI0606367 A BRPI0606367 A BR PI0606367A BR PI0606367 A2 BRPI0606367 A2 BR PI0606367A2
- Authority
- BR
- Brazil
- Prior art keywords
- optionally substituted
- group
- derivatives
- pharmaceutical compositions
- same
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/153—Ortho-condensed systems the condensed system containing two rings with oxygen as ring hetero atom and one ring with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
DERIVADOS ESPIROCETAIS E COMPOSIçõES FARMACêUTICAS COMPREENDENDO OS MESMOS. A presente invenção refere-se a um composto de Fórmula (1): [Fórmula 1] em que R^ 1^, R^ 2^, R^ 3^ e R^ 4^ são cada qual independentemente selecionados de um átomo de hidrogênio, um grupo 01-06 alquila opcionaímente substituida, um grupo C~ 7~-C~ 1-4~ aralquila opcionalmente substituida e -C(=O)Rx; Rx representa um grupo C~ 1~-C~ 6~ alquila opcionalmente substituida, um grupo arila opcionaímente substituida, um grupo heteroarila opcionalmente substituida, um grupo C~ 1~-C~ 6~ alcóxi opcionaímente substituído ou -NReRf; Ar^ 1^ representa um anel carbocíclico aromático opcionalmente substituído ou um anel heterociclico aromático opcionalmente monossubstituído; O representa (CH~ 2~)m(L)p-ou (L)~ p~(CH~ 2~)m; m representa um número inteiro selecionado de O a 2, n representa um número inteiro selecionado de 1 e 2, e p representa um número inteiro selecionado de O e 1; L representa -O-, -S- ou -NR^ 5^-; e A representa um grupo arila opcionalmente substituida ou um grupo heteroarila opcionalmente substituida, um pró-fármaco do mesmo e um saí farmaceuticamente aceitável do mesmo, bem como uma preparação farmacêutica ou composição farmacêutica compreendendo tal composto.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005020901 | 2005-01-28 | ||
| JP2005-020901 | 2005-01-28 | ||
| JP2005176690 | 2005-06-16 | ||
| JP2005-176690 | 2005-06-16 | ||
| PCT/JP2006/301284 WO2006080421A1 (ja) | 2005-01-28 | 2006-01-27 | スピロケタール誘導体、およびその糖尿病治療薬としての使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0606367A2 true BRPI0606367A2 (pt) | 2009-06-23 |
| BRPI0606367B1 BRPI0606367B1 (pt) | 2023-03-21 |
Family
ID=36740445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0606367-5A BRPI0606367B1 (pt) | 2005-01-28 | 2006-01-27 | Compostos derivados espirocetais, bem como composições farmacêuticas e uso dos mesmos |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7767651B2 (pt) |
| EP (2) | EP1852439B1 (pt) |
| JP (1) | JP4093587B2 (pt) |
| KR (2) | KR20130102648A (pt) |
| AR (1) | AR054612A1 (pt) |
| AU (1) | AU2006209523B2 (pt) |
| BR (1) | BRPI0606367B1 (pt) |
| CA (1) | CA2596235C (pt) |
| CR (1) | CR9314A (pt) |
| DK (1) | DK1852439T3 (pt) |
| ES (1) | ES2567439T3 (pt) |
| HR (1) | HRP20160333T1 (pt) |
| HU (1) | HUE027078T2 (pt) |
| IL (1) | IL184838A (pt) |
| MA (1) | MA29272B1 (pt) |
| MY (1) | MY140528A (pt) |
| NO (1) | NO341263B1 (pt) |
| NZ (1) | NZ556343A (pt) |
| PL (1) | PL1852439T3 (pt) |
| RU (1) | RU2416617C2 (pt) |
| SI (1) | SI1852439T1 (pt) |
| TW (1) | TW200637869A (pt) |
| WO (1) | WO2006080421A1 (pt) |
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| US7803778B2 (en) | 2006-05-23 | 2010-09-28 | Theracos, Inc. | Glucose transport inhibitors and methods of use |
| TWI403516B (zh) * | 2006-07-27 | 2013-08-01 | Chugai Pharmaceutical Co Ltd | To replace spirocyclic alcohol derivatives, and its use as a therapeutic agent for diabetes |
| TWI432446B (zh) * | 2006-07-27 | 2014-04-01 | Chugai Pharmaceutical Co Ltd | 稠環螺酮縮醇衍生物、及其做為糖尿病治療藥之使用 |
| EP2072522A4 (en) * | 2006-10-13 | 2010-01-06 | Chugai Pharmaceutical Co Ltd | THIOGLUCOSE SPIRKETAL DERIVATIVE AND ITS USE AS DIABETES THERAPEUTIC |
| US7795228B2 (en) | 2006-12-28 | 2010-09-14 | Theracos, Inc. | Spiroheterocyclic glycosides and methods of use |
| CL2008002427A1 (es) | 2007-08-16 | 2009-09-11 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2. |
| US7838499B2 (en) * | 2007-08-23 | 2010-11-23 | Theracos, Inc. | Benzylbenzene derivatives and methods of use |
| UA101004C2 (en) | 2007-12-13 | 2013-02-25 | Теракос, Инк. | Derivatives of benzylphenylcyclohexane and use thereof |
| JP5820269B2 (ja) | 2008-05-22 | 2015-11-24 | アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ | Ｓｇｌｔ２阻害剤を使用する高尿酸血症の治療方法およびｓｇｌｔ２阻害剤を含有する組成物 |
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| WO2011153712A1 (en) | 2010-06-12 | 2011-12-15 | Theracos, Inc. | Crystalline form of benzylbenzene sglt2 inhibitor |
| SG188548A1 (en) | 2010-09-22 | 2013-04-30 | Arena Pharm Inc | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
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| JP6294665B2 (ja) * | 2011-02-25 | 2018-03-14 | 中外製薬株式会社 | スピロケタール誘導体の結晶 |
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- 2006-01-27 AU AU2006209523A patent/AU2006209523B2/en not_active Ceased
- 2006-01-27 US US11/815,074 patent/US7767651B2/en active Active
- 2006-01-27 KR KR1020137020138A patent/KR20130102648A/ko not_active Ceased
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