ECSP045420A - Derivados de benzoxazina como moduladores 5-ht6 y usos de los mismos - Google Patents

Derivados de benzoxazina como moduladores 5-ht6 y usos de los mismos

Info

Publication number
ECSP045420A
ECSP045420A EC2004005420A ECSP045420A ECSP045420A EC SP045420 A ECSP045420 A EC SP045420A EC 2004005420 A EC2004005420 A EC 2004005420A EC SP045420 A ECSP045420 A EC SP045420A EC SP045420 A ECSP045420 A EC SP045420A
Authority
EC
Ecuador
Prior art keywords
modulators
same
benzoxazine derivatives
formula
methods
Prior art date
Application number
EC2004005420A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ECSP045420A publication Critical patent/ECSP045420A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención proporciona un compuesto de la fórmula una sal farmacéuticamente aceptable o un pro fármaco de las mismas, donde R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, Z1, m, n, y p son como se define aquí. La presente invención también proporciona composiciones que comprenden, métodos para usar, y métodos para preparar Compuestos de la Fórmula I.
EC2004005420A 2002-05-13 2004-11-10 Derivados de benzoxazina como moduladores 5-ht6 y usos de los mismos ECSP045420A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37800302P 2002-05-13 2002-05-13

Publications (1)

Publication Number Publication Date
ECSP045420A true ECSP045420A (es) 2005-01-03

Family

ID=29420358

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005420A ECSP045420A (es) 2002-05-13 2004-11-10 Derivados de benzoxazina como moduladores 5-ht6 y usos de los mismos

Country Status (36)

Country Link
US (4) US6867204B2 (es)
EP (1) EP1506179B1 (es)
JP (1) JP4307377B2 (es)
KR (1) KR100636475B1 (es)
CN (1) CN100429206C (es)
AR (1) AR039988A1 (es)
AT (1) ATE316523T1 (es)
AU (1) AU2003233231B2 (es)
BR (1) BRPI0310032B8 (es)
CA (1) CA2485136C (es)
DE (1) DE60303376T2 (es)
DK (1) DK1506179T3 (es)
EA (1) EA009982B1 (es)
EC (1) ECSP045420A (es)
EG (1) EG25683A (es)
ES (1) ES2256744T3 (es)
GT (1) GT200300108A (es)
HR (1) HRP20041030B1 (es)
IL (1) IL164928A0 (es)
JO (1) JO2413B1 (es)
MA (1) MA27118A1 (es)
MX (1) MXPA04011254A (es)
MY (1) MY139612A (es)
NO (1) NO329380B1 (es)
NZ (1) NZ536230A (es)
PA (1) PA8573501A1 (es)
PE (1) PE20040757A1 (es)
PL (1) PL211057B1 (es)
PT (1) PT1506179E (es)
RS (1) RS51042B (es)
TN (1) TNSN04225A1 (es)
TW (1) TWI258479B (es)
UA (1) UA76877C2 (es)
UY (1) UY27803A1 (es)
WO (1) WO2003095434A1 (es)
ZA (1) ZA200408783B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1408976T5 (da) * 2001-07-20 2011-01-10 Psychogenics Inc Behandling af ADHD (Attention deficit hyperactivity disorder)
ES2386828T3 (es) 2002-03-27 2012-08-31 Glaxo Group Limited Derivados de quinolina y su uso como ligandos 5-HT6
KR100636475B1 (ko) * 2002-05-13 2006-10-18 에프. 호프만-라 로슈 아게 5-ｈｔ6 조절제로서 벤족사진 유도체 및 이의 용도
PT1562918E (pt) 2002-11-08 2008-03-12 Hoffmann La Roche Benzoxazinonas substituídas e as suas utilizações
US8754238B2 (en) 2003-07-22 2014-06-17 Arena Pharmaceuticals, Inc. Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
AU2004299201B2 (en) 2003-12-09 2009-12-03 F. Hoffmann-La Roche Ag Benzoxazine derivatives and uses thereof
AU2005205016B2 (en) * 2004-01-16 2010-07-15 F. Hoffmann-La Roche Ag 1-benzyl-5-piperazin-1-yl-3,4 dihydro-1H-quinazolin-2-one derivatives and the respective 1H-benzo(1,2,6)thiadiazine-2,2-dioxide and 1,4-dihydro-benzo(D) (1,3)oxazin-2-one derivatives as modulators of the 5-hydroxytryptamine receptor (5-HT) for the treatment of diseases of the central nervous system
CN100540546C (zh) * 2004-05-05 2009-09-16 弗·哈夫曼-拉罗切有限公司 用于调节5-ht6受体、5-ht2a受体或两者的芳基磺酰基苯并二烷
US7378415B2 (en) * 2004-09-30 2008-05-27 Roche Palo Alto Llc Benzoxazine and quinoxaline derivatives and uses thereof
RU2382036C2 (ru) * 2004-09-30 2010-02-20 Ф.Хоффманн-Ля Рош Аг Производные бензоксазина и хиноксалина и их применение
US7713954B2 (en) * 2004-09-30 2010-05-11 Roche Palo Alto Llc Compositions and methods for treating cognitive disorders
ES2359725T3 (es) * 2004-09-30 2011-05-26 F. Hoffmann-La Roche Ag Composiciones y métodos para el tratamiento de trastornos cognitivos.
US9084742B2 (en) 2007-12-12 2015-07-21 Axovant Sciences Ltd. Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-Quinoline
US20110021538A1 (en) 2008-04-02 2011-01-27 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
WO2010062321A1 (en) 2008-10-28 2010-06-03 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
AR078770A1 (es) * 2009-10-27 2011-11-30 Elara Pharmaceuticals Gmbh Derivados de dihidrobenzo oxacinas y tiazinas, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades inflamatorias e hiperproliferativas.
KR101293384B1 (ko) * 2010-10-13 2013-08-05 주식회사 대웅제약 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도
US9403800B2 (en) * 2012-01-24 2016-08-02 Chemregen, Inc. Compounds for inhibition of cancer cell proliferation
WO2015106025A1 (en) * 2014-01-09 2015-07-16 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Substituted benzoxazine and related compounds
RU2017145976A (ru) 2015-06-12 2019-07-15 Аксовант Сайенсиз Гмбх Производные диарил- и арилгетероарилмочевины, применимые для профилактики и лечения нарушения поведения во время REM-фазы сна
TW201720439A (zh) 2015-07-15 2017-06-16 Axovant Sciences Gmbh 用於預防及治療與神經退化性疾病相關的幻覺之作為５－ｈｔ２ａ血清素受體的二芳基及芳基雜芳基脲衍生物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1029479C (zh) * 1989-11-08 1995-08-09 山之内制药株式会社 新型苯并噁嗪衍生物的制备方法
US5492914A (en) * 1994-07-28 1996-02-20 Syntex (U.S.A.) Inc. 2-(1-azabicyclo[2.2.2]oct-3 s-yl)-6-hydroxy-2,4,5,6-tetrahydro-1H-benz[DE]is[2.2.2]oct-3's-yl)-6-hydroxy-2,3,3a,4,5,6-hexahydro-1h-benz [DE]isoquinolin-1-one and individual stereoisomers thereof
GB9507203D0 (en) 1995-04-07 1995-05-31 Smithkline Beecham Plc Novel compounds
DZ2376A1 (fr) * 1996-12-19 2002-12-28 Smithkline Beecham Plc Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
AU732863B2 (en) 1997-04-18 2001-05-03 Smithkline Beecham Plc Indole derivatives having combined 5HT1A, 5HT1B and 5HT1D receptor antagonist activity
JP2002511097A (ja) 1997-07-11 2002-04-09 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ▲下６▼レセプターアンタゴニストであるスルホンアミド誘導体およびその製造方法
ATE252575T1 (de) * 1997-07-25 2003-11-15 Lundbeck & Co As H Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendung
GB9801392D0 (en) 1998-01-22 1998-03-18 Smithkline Beecham Plc Novel compounds
HRP20000847A2 (en) * 1998-06-19 2001-12-31 Lundbeck & Co As H 4,5,6 i 7 - INDOLE AND INDOLINE DERIVATIVES, THEIR PREPARATION AND USE
GB9818916D0 (en) * 1998-08-28 1998-10-21 Smithkline Beecham Plc Use
US6380235B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Benzimidazolones and analogues
ATE299142T1 (de) * 1999-08-23 2005-07-15 Solvay Pharm Bv Phenylpiperazin-derivate als inhibitoren der serotonin-wiederaufnahme
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
WO2001057003A1 (en) 2000-02-01 2001-08-09 Cor Therapeutics, Inc. 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE INHIBITORS OF FACTOR Xa
KR100636475B1 (ko) * 2002-05-13 2006-10-18 에프. 호프만-라 로슈 아게 5-ｈｔ6 조절제로서 벤족사진 유도체 및 이의 용도

Also Published As

Publication number Publication date
UY27803A1 (es) 2003-11-28
CA2485136A1 (en) 2003-11-20
ZA200408783B (en) 2005-12-28
NO329380B1 (no) 2010-10-04
HRP20041030A2 (en) 2005-06-30
IL164928A0 (en) 2005-12-18
EP1506179B1 (en) 2006-01-25
US20030232825A1 (en) 2003-12-18
JP4307377B2 (ja) 2009-08-05
US6867204B2 (en) 2005-03-15
JP2005530774A (ja) 2005-10-13
ES2256744T3 (es) 2006-07-16
AU2003233231B2 (en) 2009-02-26
AR039988A1 (es) 2005-03-09
DE60303376T2 (de) 2006-11-16
TW200400188A (en) 2004-01-01
DE60303376D1 (de) 2006-04-13
RS97004A (sr) 2006-10-27
BRPI0310032B1 (pt) 2019-01-08
PE20040757A1 (es) 2004-11-06
PA8573501A1 (es) 2003-12-10
EA009982B1 (ru) 2008-04-28
US8377931B2 (en) 2013-02-19
CN100429206C (zh) 2008-10-29
UA76877C2 (uk) 2006-09-15
US20050130962A1 (en) 2005-06-16
AU2003233231A1 (en) 2003-11-11
EG25683A (en) 2012-05-16
CN1653054A (zh) 2005-08-10
US20090325950A1 (en) 2009-12-31
KR100636475B1 (ko) 2006-10-18
JO2413B1 (en) 2007-11-11
KR20040106538A (ko) 2004-12-17
PL374019A1 (en) 2005-09-19
PT1506179E (pt) 2006-06-30
CA2485136C (en) 2011-12-20
TNSN04225A1 (fr) 2007-03-12
BR0310032A (pt) 2005-02-15
PL211057B1 (pl) 2012-04-30
DK1506179T3 (da) 2006-06-06
ATE316523T1 (de) 2006-02-15
BRPI0310032B8 (pt) 2021-05-25
GT200300108A (es) 2004-03-15
TWI258479B (en) 2006-07-21
NZ536230A (en) 2007-05-31
MXPA04011254A (es) 2005-01-25
US20130123251A1 (en) 2013-05-16
MA27118A1 (fr) 2004-12-20
HK1080846A1 (zh) 2006-05-04
EA200401455A1 (ru) 2005-06-30
HRP20041030B1 (hr) 2013-03-31
MY139612A (en) 2009-10-30
NO20044665L (no) 2004-12-03
WO2003095434A1 (en) 2003-11-20
RS51042B (sr) 2010-10-31
EP1506179A1 (en) 2005-02-16

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