BRPI0606476A2 - compostos para inflamação e usos imuno-relacionados e suas composições farmacêuticas - Google Patents

compostos para inflamação e usos imuno-relacionados e suas composições farmacêuticas

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Publication number
BRPI0606476A2
BRPI0606476A2 BRPI0606476-0A BRPI0606476A BRPI0606476A2 BR PI0606476 A2 BRPI0606476 A2 BR PI0606476A2 BR PI0606476 A BRPI0606476 A BR PI0606476A BR PI0606476 A2 BRPI0606476 A2 BR PI0606476A2
Authority
BR
Brazil
Prior art keywords
compounds
inflammation
pharmaceutical compositions
related uses
immune related
Prior art date
Application number
BRPI0606476-0A
Other languages
English (en)
Inventor
Lijun Sun
Shoujun Chen
Zhi Qiang Xia
Jun Jiang
Yu Xie
Junyi Zhang
Original Assignee
Synta Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synta Pharmaceuticals Corp filed Critical Synta Pharmaceuticals Corp
Publication of BRPI0606476A2 publication Critical patent/BRPI0606476A2/pt

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
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Abstract

COMPOSTOS PARA INFLAMAçãO E USOS IMUNO-RELACIONADOS E SUAS COMPOSIçõES FARMACêUTICAS. A presente invenção refere-se a compostos de fórmulas estruturais (I), (VII) e (Xl): ou um sal, solvato, clatrato, ou pró-fármaco farmaceuticamente aceitável destes, em que X~ 1~, X~ 2~, X~ 3~, Y, Z, L, R~ 1~, R~ 2~, R~ 3~, R~ 18~ e n são definidos aqui. Estes compostos são úteis como agentes imunossupressivos e para tratar e prevenir condições inflamatórias, distúrbios alérgicos, e distúrbios imunes.
BRPI0606476-0A 2005-01-07 2006-01-06 compostos para inflamação e usos imuno-relacionados e suas composições farmacêuticas BRPI0606476A2 (pt)

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PCT/US2006/000296 WO2006083477A2 (en) 2005-01-07 2006-01-06 Compounds for inflammation and immune-related uses

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