BRPI0607995A2 - imidazóis substituìdos com heterociclamida - Google Patents

imidazóis substituìdos com heterociclamida

Info

Publication number
BRPI0607995A2
BRPI0607995A2 BRPI0607995-4A BRPI0607995A BRPI0607995A2 BR PI0607995 A2 BRPI0607995 A2 BR PI0607995A2 BR PI0607995 A BRPI0607995 A BR PI0607995A BR PI0607995 A2 BRPI0607995 A2 BR PI0607995A2
Authority
BR
Brazil
Prior art keywords
substituted imidazoles
heterocycamide
heterocyclamide
prophylaxis
diseases
Prior art date
Application number
BRPI0607995-4A
Other languages
English (en)
Inventor
Holger Zimmermann
David Brueeckner
Kerstin Henninger
Ulrich Rosentreter
Martin Hendrix
Joerg Keldenich
Dieter Lang
Martin Radtke
Daniela Paulsen
Armin Kern
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36675125&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0607995(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of BRPI0607995A2 publication Critical patent/BRPI0607995A2/pt
Publication of BRPI0607995B1 publication Critical patent/BRPI0607995B1/pt
Publication of BRPI0607995B8 publication Critical patent/BRPI0607995B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Imidazóis substituìdos com heterociclamida. O presente invento se refere a imidazóis substituidos com heterociclamidas e métodos para a sua preparação, seu uso para o tratamento e/ou profilaxia de doenças bem como seu uso para a produção de medicamentos para o tratamento e/ou profilaxia de doenças, em particular para o uso como agentes antivirais, especialmente contra citomegalovírus.
BRPI0607995A 2005-02-23 2006-02-14 composto de fórmula (i), método para preparar o composto de fórmula (i) e uso do composto de fórmula (i) BRPI0607995B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005008183.5 2005-02-23
DE102005008183A DE102005008183A1 (de) 2005-02-23 2005-02-23 Heterocyclylamid-substituierte Imidazole
PCT/EP2006/001325 WO2006089664A2 (de) 2005-02-23 2006-02-14 Heterocyclylamid-substituierte imidazole

Publications (3)

Publication Number Publication Date
BRPI0607995A2 true BRPI0607995A2 (pt) 2009-10-27
BRPI0607995B1 BRPI0607995B1 (pt) 2019-07-16
BRPI0607995B8 BRPI0607995B8 (pt) 2021-05-25

Family

ID=36675125

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607995A BRPI0607995B8 (pt) 2005-02-23 2006-02-14 composto de fórmula (i), método para preparar o composto de fórmula (i) e uso do composto de fórmula (i)

Country Status (28)

Country Link
US (1) US7919489B2 (pt)
EP (1) EP1853582B1 (pt)
JP (1) JP5208522B2 (pt)
KR (1) KR101276003B1 (pt)
CN (1) CN101128455B (pt)
AR (1) AR053141A1 (pt)
AT (1) ATE446292T1 (pt)
AU (1) AU2006218276C1 (pt)
BR (1) BRPI0607995B8 (pt)
CA (1) CA2598521C (pt)
DE (2) DE102005008183A1 (pt)
DK (1) DK1853582T3 (pt)
ES (1) ES2333249T3 (pt)
GT (1) GT200600077A (pt)
HN (2) HN2006007774A (pt)
IL (1) IL185050A (pt)
MX (1) MX2007010308A (pt)
MY (1) MY140543A (pt)
NO (1) NO338997B1 (pt)
NZ (1) NZ560811A (pt)
PE (2) PE20061141A1 (pt)
PL (1) PL1853582T3 (pt)
PT (1) PT1853582E (pt)
RU (1) RU2415851C2 (pt)
TW (1) TWI388553B (pt)
UY (1) UY29387A1 (pt)
WO (1) WO2006089664A2 (pt)
ZA (1) ZA200707412B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004015007A1 (de) 2004-03-26 2005-10-13 Bayer Healthcare Ag Substituierte Imidazole
DE102005008183A1 (de) 2005-02-23 2006-08-31 Bayer Healthcare Ag Heterocyclylamid-substituierte Imidazole
DE102011101446A1 (de) * 2011-05-10 2012-11-15 Aicuris Gmbh & Co. Kg Herstellung von "Dense Bodies" (DB)
DE102011113749A1 (de) * 2011-09-14 2013-03-14 Aicuris Gmbh & Co. Kg Sulfonsäuresalze Heterocyclylamid-substituiertr Imidazole
CN104610160A (zh) * 2013-11-04 2015-05-13 南京大学 含哌嗪环的5-硝基咪唑类衍生物及其制备与在抗菌药物中的应用
CN104016925B (zh) * 2014-06-17 2016-03-30 遵义医学院 4-烷基咪唑-2-羧酸的合成方法
AU2016284398C1 (en) * 2015-06-22 2021-01-07 Sumitomo Dainippon Pharma Co., Ltd. 1,4-disubstituted imidazole derivative
JP6507976B2 (ja) * 2015-09-30 2019-05-08 東レ株式会社 イミダゾール−２−カルボン酸エステル誘導体又はその塩の製造方法
CN116120238B (zh) * 2023-03-01 2023-09-22 山东梅奥华卫科技有限公司 一种咪唑衍生物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342501B1 (en) 1994-02-25 2002-01-29 The Regents Of The University Of Michigan Pyrrolo[2,3-d] pyrimidines as antiviral agents
EP1019040B1 (en) * 1997-05-23 2004-09-29 Bayer Corporation Aryl ureas for the treatment of inflammatory or immunomodulatory diseases
AU1367599A (en) 1997-11-03 1999-05-24 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as anti-inflammatory agents
HK1041264B (zh) * 1998-07-23 2007-08-17 安斯泰来制药有限公司 咪唑化合物及其作为腺苷脱氨酶抑制剂的用途
CN1367785A (zh) 1998-12-09 2002-09-04 美国家庭用品有限公司 含取代的苯二胺基团的含杂环羧酰胺的疱疹病毒硫脲抑制剂
DE10257358A1 (de) 2002-12-09 2004-07-08 Bayer Healthcare Ag Substituierte Pyrrole
DE102004015007A1 (de) * 2004-03-26 2005-10-13 Bayer Healthcare Ag Substituierte Imidazole
CN1984899B (zh) * 2004-05-12 2011-07-27 先灵公司 Cxcr1和cxcr2趋化因子拮抗剂
DE102005008183A1 (de) 2005-02-23 2006-08-31 Bayer Healthcare Ag Heterocyclylamid-substituierte Imidazole

Also Published As

Publication number Publication date
PL1853582T3 (pl) 2010-03-31
KR101276003B1 (ko) 2013-06-20
PE20100233A1 (es) 2010-04-22
HN2010000128A (es) 2010-03-29
AU2006218276A1 (en) 2006-08-31
HK1110857A1 (zh) 2008-07-25
MY140543A (en) 2009-12-31
PT1853582E (pt) 2009-11-13
WO2006089664A3 (de) 2006-11-02
DE502006005182D1 (de) 2009-12-03
WO2006089664A2 (de) 2006-08-31
CA2598521C (en) 2012-11-27
AU2006218276C1 (en) 2012-06-28
MX2007010308A (es) 2007-10-17
ATE446292T1 (de) 2009-11-15
AU2006218276B2 (en) 2011-04-07
RU2007135277A (ru) 2009-03-27
JP2008531508A (ja) 2008-08-14
ES2333249T3 (es) 2010-02-18
NO338997B1 (no) 2016-11-07
DE102005008183A1 (de) 2006-08-31
EP1853582B1 (de) 2009-10-21
US20080176859A1 (en) 2008-07-24
UY29387A1 (es) 2006-10-02
BRPI0607995B8 (pt) 2021-05-25
NO20074780L (no) 2007-11-01
HN2006007774A (es) 2010-03-29
CN101128455B (zh) 2013-01-16
PE20061141A1 (es) 2006-12-29
ZA200707412B (en) 2008-12-31
TWI388553B (zh) 2013-03-11
GT200600077A (es) 2006-10-03
NZ560811A (en) 2010-07-30
IL185050A0 (en) 2007-12-03
AR053141A1 (es) 2007-04-25
BRPI0607995B1 (pt) 2019-07-16
EP1853582A2 (de) 2007-11-14
JP5208522B2 (ja) 2013-06-12
KR20080002772A (ko) 2008-01-04
DK1853582T3 (da) 2010-01-18
TW200700411A (en) 2007-01-01
CA2598521A1 (en) 2006-08-31
RU2415851C2 (ru) 2011-04-10
CN101128455A (zh) 2008-02-20
IL185050A (en) 2013-01-31
US7919489B2 (en) 2011-04-05

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/07/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/07/2019, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/02/2006 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 17A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2709 DE 06-12-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.