BRPI0606596A2 - derivado de ácido hialurÈnico e células-tronco neurais para regeneração de sci e pnt - Google Patents

derivado de ácido hialurÈnico e células-tronco neurais para regeneração de sci e pnt

Info

Publication number
BRPI0606596A2
BRPI0606596A2 BRPI0606596-1A BRPI0606596A BRPI0606596A2 BR PI0606596 A2 BRPI0606596 A2 BR PI0606596A2 BR PI0606596 A BRPI0606596 A BR PI0606596A BR PI0606596 A2 BRPI0606596 A2 BR PI0606596A2
Authority
BR
Brazil
Prior art keywords
hyaluronic acid
pnt
regeneration
sci
acid derivative
Prior art date
Application number
BRPI0606596-1A
Other languages
English (en)
Inventor
Alessandra Pavesio
Angelo Vescovi
Fabrizio Gelain
Maurizio Verga
Original Assignee
Fidia Advanced Biopolymers Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl
Publication of BRPI0606596A2 publication Critical patent/BRPI0606596A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/383—Nerve cells, e.g. dendritic cells, Schwann cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3878—Nerve tissue, brain, spinal cord, nerves, dura mater
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polymers & Plastics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)

Abstract

DERIVADO DE áCIDO HIALURONICO E CéLULAS-TRONCO NEURAIS PARA REGENERAçãO DE SCI E PNT. A presente invenção refere-se a um biomaterial para o tratamento de lesão do nervo periférico ou medula espinhal, obtenível por: a) tratamento de um derivado de ácido hialurónico com uma solução de revestimento promovendo adesão de Células-tronco Neuronais, ramificação e diferenciação; b) contato das Células-Tronco Neuronais isoladas com o derivado de ácido hialurónico obtido a partir da etapa a) e cultivo e expansão das células absorvidas na presença de fatores neurotróficos ou de crescimento selecionados de beta FGF (fator de crescimento de fibroblasto básico), CNTF (fator neurotrófico ciliar), BDNF (fator neurotrófico derivado do cérebro) e GDNF (fator neurotrófico derivado glial) ou misturas dos mesmos.
BRPI0606596-1A 2005-01-19 2006-01-18 derivado de ácido hialurÈnico e células-tronco neurais para regeneração de sci e pnt BRPI0606596A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64458705P 2005-01-19 2005-01-19
PCT/EP2006/000398 WO2006077085A2 (en) 2005-01-19 2006-01-18 Hyaluronic acid derivative and neural stem cells for sci and pnt regeneration

Publications (1)

Publication Number Publication Date
BRPI0606596A2 true BRPI0606596A2 (pt) 2009-07-07

Family

ID=36463348

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606596-1A BRPI0606596A2 (pt) 2005-01-19 2006-01-18 derivado de ácido hialurÈnico e células-tronco neurais para regeneração de sci e pnt

Country Status (15)

Country Link
US (3) US20090202495A1 (pt)
EP (1) EP1838240B1 (pt)
JP (1) JP2008526916A (pt)
KR (1) KR20070097065A (pt)
CN (1) CN101106955A (pt)
AU (1) AU2006207618A1 (pt)
BR (1) BRPI0606596A2 (pt)
CA (1) CA2604394A1 (pt)
DK (1) DK1838240T3 (pt)
ES (1) ES2668355T3 (pt)
MX (1) MX2007008668A (pt)
PL (1) PL1838240T3 (pt)
RU (1) RU2007127416A (pt)
SI (1) SI1838240T1 (pt)
WO (1) WO2006077085A2 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201103572A (en) * 2009-05-04 2011-02-01 Neostem Inc Method and composition for restoration of age-related tissue loss in the face or selected areas of the body
JP5867797B2 (ja) * 2011-05-27 2016-02-24 国立大学法人京都大学 ドーパミン産生神経の分化誘導用の細胞培養基材
ES2577883B2 (es) * 2014-12-16 2016-11-21 Universitat Politècnica De València Biohíbrido para su uso en la regeneración de tractos neurales
KR101865781B1 (ko) * 2016-11-10 2018-06-11 (주)헵틸와이 산화 다당류 및 아민 변성 히알루론산을 포함하는 창상피복재용 히드로겔 및 그 제조방법
WO2019135216A1 (en) 2018-01-02 2019-07-11 Cartiheal (2009) Ltd. Implantation tool and protocol for optimized solid substrates promoting cell and tissue growth
WO2019180454A1 (en) 2018-03-22 2019-09-26 Queen Mary University Of London Implantable cell dressing for treatment of disease
CN115770324B (zh) * 2022-11-30 2024-01-16 苏州大学附属第一医院 一种促进神经再生的活体静电纺丝支架的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2207992A1 (en) * 1995-01-16 1996-07-25 Genevieve Krack Self-supporting sheet-like material of cross-linked fibrin for preventing post operative adhesions
US6482231B1 (en) * 1995-11-20 2002-11-19 Giovanni Abatangelo Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative
US6361996B1 (en) * 1997-05-07 2002-03-26 University Of Utah Research Foundation Neuroepithelial stem cells and glial-restricted intermediate precursors
EP1073420A4 (en) * 1998-05-14 2004-09-08 Abraham Shahar SPECIFICALLY DESIGNED NEURONAL IMPLANT TO RECONSTRUCT FROM THE DAMAGED CENTRAL SYSTEM
AU2001273992B2 (en) * 2000-05-03 2005-08-04 Fidia Advanced Biopolymers S.R.L. Biomaterials comprised of preadipocyte cells for soft tissue repair

Also Published As

Publication number Publication date
EP1838240A2 (en) 2007-10-03
EP1838240B1 (en) 2018-04-11
CN101106955A (zh) 2008-01-16
JP2008526916A (ja) 2008-07-24
ES2668355T3 (es) 2018-05-17
WO2006077085A2 (en) 2006-07-27
MX2007008668A (es) 2008-02-11
SI1838240T1 (en) 2018-07-31
US20180140741A1 (en) 2018-05-24
KR20070097065A (ko) 2007-10-02
RU2007127416A (ru) 2009-01-27
US20100136081A1 (en) 2010-06-03
US20090202495A1 (en) 2009-08-13
CA2604394A1 (en) 2006-07-27
PL1838240T3 (pl) 2018-09-28
US10702628B2 (en) 2020-07-07
DK1838240T3 (en) 2018-06-18
WO2006077085A3 (en) 2006-09-21
AU2006207618A1 (en) 2006-07-27

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012.