BRPI0607130A2 - copolihidroxi-alquil-glutaminas funcionalizadas por grupamentos hidrofóbicos e as respectivas aplicações, notadamente terapêuticas - Google Patents

copolihidroxi-alquil-glutaminas funcionalizadas por grupamentos hidrofóbicos e as respectivas aplicações, notadamente terapêuticas

Info

Publication number
BRPI0607130A2
BRPI0607130A2 BRPI0607130-9A BRPI0607130A BRPI0607130A2 BR PI0607130 A2 BRPI0607130 A2 BR PI0607130A2 BR PI0607130 A BRPI0607130 A BR PI0607130A BR PI0607130 A2 BRPI0607130 A2 BR PI0607130A2
Authority
BR
Brazil
Prior art keywords
novel
hydrophobic groups
glutamines
vectorization
notably
Prior art date
Application number
BRPI0607130-9A
Other languages
English (en)
Inventor
Remi Soula
You-Ping Chan
Original Assignee
Flamel Techonologies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flamel Techonologies filed Critical Flamel Techonologies
Publication of BRPI0607130A2 publication Critical patent/BRPI0607130A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G23/00—Compounds of titanium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/88—Polyamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/48—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
    • C08L77/04—Polyamides derived from alpha-amino carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Birds (AREA)
  • Environmental & Geological Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Geology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)

Abstract

COPOLIHIDROXI -ALQUIL-GLUTAMINAS FUNCIONALIZADAS POR GRUPAMENTOS HIDRóFOBOS E AS RESPECTIVAS APLICAçõES, NOTADAMENTE TERAPêUTICAS. A presente invenção se refere aos novos materiais biodegradáveis à base de poliaminoácidos modificados, biodegradáveis, úteis notadamente para a vetorização de princípio(s) ativo(s) (DA) . A invenção visa também novas composições farmacêuticas, cosméticas, dietéticas ou fitossanitárias à base desses poliaminoácidos. A finalidade da invenção é fornecer uma nova matéria-prima de polímero, capaz de ser utilizada para a vetorização de DA e permitindo satisfazer de maneira ótima a todas as especificações requeridas na espécie: biocompatibilidade, biodegradabilidade, aptidão para se associar facilmente com numerosos princípios ativos ou a solubilizá-lo, e a liberar esses princípios ativos in vivo. Essa finalidade é atingida pela presente invenção que se refere a novas copolibidroxi-alquil-glutaminas, compreendendo unidades glutaminas e eventualmente unidades glutamatos e que são portadoras de grupamentos hidrófobos, comportando de 8 a 30 átomos de carbono. Essas copolihidroxi-alquil-glutamínas sao anfifílicas e estão aptas a se transformarem de modo fácil e económico em partículas de vetorização de princípios ativos, essas partículas sendo próprias para formarem suspensões coloidais aquosas estáveis.
BRPI0607130-9A 2005-01-27 2006-01-23 copolihidroxi-alquil-glutaminas funcionalizadas por grupamentos hidrofóbicos e as respectivas aplicações, notadamente terapêuticas BRPI0607130A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0550231A FR2881140B1 (fr) 2005-01-27 2005-01-27 Copolyhydroxyalkylglutamines fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
PCT/EP2006/050369 WO2006079614A2 (fr) 2005-01-27 2006-01-23 Copolyhydroxyalkylglutamines fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques

Publications (1)

Publication Number Publication Date
BRPI0607130A2 true BRPI0607130A2 (pt) 2009-08-04

Family

ID=34955198

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607130-9A BRPI0607130A2 (pt) 2005-01-27 2006-01-23 copolihidroxi-alquil-glutaminas funcionalizadas por grupamentos hidrofóbicos e as respectivas aplicações, notadamente terapêuticas

Country Status (13)

Country Link
US (1) US20110044930A1 (pt)
EP (1) EP1848411A2 (pt)
JP (1) JP2008528543A (pt)
KR (1) KR20070101337A (pt)
CN (1) CN101151023A (pt)
AU (1) AU2006208739A1 (pt)
BR (1) BRPI0607130A2 (pt)
CA (1) CA2596147A1 (pt)
FR (1) FR2881140B1 (pt)
IL (1) IL184863A0 (pt)
MX (1) MX2007009029A (pt)
WO (1) WO2006079614A2 (pt)
ZA (1) ZA200707079B (pt)

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* Cited by examiner, † Cited by third party
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FR2822834B1 (fr) 2001-04-02 2005-02-25 Flamel Tech Sa Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation
FR2840614B1 (fr) 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
FR2862536B1 (fr) 2003-11-21 2007-11-23 Flamel Tech Sa Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
CN100443547C (zh) * 2007-03-15 2008-12-17 上海交通大学 聚(酰胺-胺)-聚(l-苄基-谷氨酸酯)纳米粒子的制备方法
FR2915683B1 (fr) * 2007-05-03 2009-08-07 Flamel Technologies Sa Formulations pharmaceutiques auto-precipitantes pour la liberation modifiee de principe actif
FR2915684B1 (fr) * 2007-05-03 2011-01-14 Flamel Tech Sa Particules a base de polyelectrolytes et de principe actif a liberation modifiee et formulations pharmaceutiques contenant ces particules
FR2968993B1 (fr) 2010-12-17 2012-12-28 Flamel Tech Sa Nanoparticules comportant au moins un actif et au moins deux polyelectrolytes
FR2968994B1 (fr) 2010-12-17 2012-12-28 Flamel Tech Sa Procede de preparation de nanoparticules
FR2975912B1 (fr) 2011-05-30 2013-06-14 Flamel Tech Sa Composition a liberation controlee de buprenorphine
CN107583039A (zh) * 2012-01-09 2018-01-16 阿道恰公司 Ph为7且至少含pi为5.8至8.5之基础胰岛素和取代共聚(氨基酸)的可注射溶液
BR112018075250A2 (pt) * 2016-06-07 2019-03-12 Adocia composição na forma de uma solução aquosa injetável, cujo ph é de 6,0 a 8,0
CN108623802B (zh) * 2018-05-08 2021-01-08 四川大学 一种功能性聚氨基酸衍生物及其制备方法和应用
CN109730081A (zh) * 2019-02-26 2019-05-10 南京轩凯生物科技有限公司 一种农用杀菌剂组合物
CN113896236A (zh) * 2021-09-13 2022-01-07 常州市妇幼保健院 一种基于谷氨酰胺修饰的二氧化钛合成方法

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US4351337A (en) * 1973-05-17 1982-09-28 Arthur D. Little, Inc. Biodegradable, implantable drug delivery device, and process for preparing and using the same
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
DE3581471D1 (de) * 1984-10-19 1991-02-28 Battelle Memorial Institute Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten.
CH667874A5 (fr) * 1985-12-19 1988-11-15 Battelle Memorial Institute Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments.
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FR2732218B1 (fr) * 1995-03-28 1997-08-01 Flamel Tech Sa Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s) et leurs procedes de preparation
FR2786098B1 (fr) * 1998-11-20 2003-05-30 Flamel Tech Sa Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s), suspension colloidale les comprenant et leurs procedes de fabrication
FR2801226B1 (fr) * 1999-11-23 2002-01-25 Flamel Tech Sa Suspension colloidale de particules submicroniques de vectorisation de principes actifs et son mode de preparation
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JP4585114B2 (ja) * 2000-12-27 2010-11-24 三井化学株式会社 重合体及びその製造方法
JP4775985B2 (ja) * 2000-12-27 2011-09-21 三井化学株式会社 重合体及びその製造方法
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FR2840614B1 (fr) * 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
FR2843117B1 (fr) * 2002-07-30 2004-10-15 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
FR2855521B1 (fr) * 2003-05-28 2005-08-05 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques.

Also Published As

Publication number Publication date
FR2881140B1 (fr) 2007-04-06
CA2596147A1 (fr) 2006-08-03
KR20070101337A (ko) 2007-10-16
AU2006208739A1 (en) 2006-08-03
JP2008528543A (ja) 2008-07-31
WO2006079614A2 (fr) 2006-08-03
US20110044930A1 (en) 2011-02-24
ZA200707079B (en) 2008-12-31
FR2881140A1 (fr) 2006-07-28
IL184863A0 (en) 2007-12-03
EP1848411A2 (fr) 2007-10-31
CN101151023A (zh) 2008-03-26
MX2007009029A (es) 2007-10-02
WO2006079614A3 (fr) 2007-06-21

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUI DADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2210 DE 14/05/2013.