BRPI0607350A2 - método para detecção da presença ou quantidade de uma proteìna erroneamente duplicada em uma amostra e kit - Google Patents

método para detecção da presença ou quantidade de uma proteìna erroneamente duplicada em uma amostra e kit

Info

Publication number
BRPI0607350A2
BRPI0607350A2 BRPI0607350-6A BRPI0607350A BRPI0607350A2 BR PI0607350 A2 BRPI0607350 A2 BR PI0607350A2 BR PI0607350 A BRPI0607350 A BR PI0607350A BR PI0607350 A2 BRPI0607350 A2 BR PI0607350A2
Authority
BR
Brazil
Prior art keywords
sample
protein
kit
detecting
duplicated
Prior art date
Application number
BRPI0607350-6A
Other languages
English (en)
Inventor
Cindy S Orser
Tao Pan
Jasmeet Sethi
Original Assignee
Adlyfe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adlyfe Inc filed Critical Adlyfe Inc
Publication of BRPI0607350A2 publication Critical patent/BRPI0607350A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

MéTODO PARA DETECçAO DA PRESENçA OU QUANTIDADE DE UMA PROTEìNA ERRONEAMENTE DUPLICADA EM UMA AMOSTRA E KIT. A invenção proporciona métodos e kits para detecção de proteínas contormacionalmente alteradas, tais como prions ou outras proteínas associadas a estados doentios, em uma amostra. Os métodos compreendem captura seletiva e separação de complexos de peptídeo e proteína conformacionalmente alterada de substâncias que interferem com a detecção de tais complexos e, de preferência, amplificação do sinal de detecção quando de adição de um segundo peptídeo duplamente rotulado.
BRPI0607350-6A 2005-02-15 2006-02-14 método para detecção da presença ou quantidade de uma proteìna erroneamente duplicada em uma amostra e kit BRPI0607350A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65273305P 2005-02-15 2005-02-15
PCT/US2006/005095 WO2006088823A2 (en) 2005-02-15 2006-02-14 Method for detecting misfolded proteins and prions

Publications (1)

Publication Number Publication Date
BRPI0607350A2 true BRPI0607350A2 (pt) 2009-09-01

Family

ID=36916969

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607350-6A BRPI0607350A2 (pt) 2005-02-15 2006-02-14 método para detecção da presença ou quantidade de uma proteìna erroneamente duplicada em uma amostra e kit

Country Status (10)

Country Link
US (1) US8372593B2 (pt)
EP (1) EP1853915B1 (pt)
JP (1) JP5048522B2 (pt)
CN (1) CN101156068B (pt)
AT (1) ATE528649T1 (pt)
AU (1) AU2006214463B2 (pt)
BR (1) BRPI0607350A2 (pt)
CA (1) CA2597912C (pt)
MX (1) MX2007009819A (pt)
WO (1) WO2006088823A2 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002320045B2 (en) 2001-05-31 2008-05-08 Adlyfe, Inc. Misfolded protein sensor method
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
DK1931695T3 (da) 2005-09-09 2013-07-01 Novartis Ag Prionspecifikke peptoidreagenser
US8673579B2 (en) 2006-07-28 2014-03-18 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
JP2010515879A (ja) * 2007-01-12 2010-05-13 オールプリオン・アーゲー プリオンタンパク質を取り出すための方法
CN102014967A (zh) * 2008-03-21 2011-04-13 阿德利夫股份有限公司 芘携带肽穿过血脑屏障的用途
WO2010062377A2 (en) * 2008-10-31 2010-06-03 Yale University Methods and compositions for the detection and treatment of preeclampsia
EP2391644B1 (en) 2009-01-30 2016-04-13 System of Systems Analytics, Inc. Conformationally dynamic peptides
WO2011149917A1 (en) 2010-05-25 2011-12-01 Adlyfe, Inc. STABILIZED AMYLOID- β OLIGOMERS AND USES THEREOF
JP2014514576A (ja) 2011-04-27 2014-06-19 エイディーライフ インコーポレイティッド アミロイドタンパク質の眼における検出法
CN102901825A (zh) * 2011-07-29 2013-01-30 中国科学院生物物理研究所 丙二醛修饰蛋白质作为错误折叠蛋白质荧光探剂的应用
DE102012104504B4 (de) * 2012-05-24 2021-10-07 Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Wirtschaft und Technologie, dieses vertreten durch den Präsidenten der BAM, Bundesanstalt für Materialforschung und -prüfung Polypeptidmarker
JP6178586B2 (ja) 2013-02-20 2017-08-09 サヴィッド・セラピューティックス株式会社 ビオチン改変体、ストレプトアビジン変異体およびそれらの利用
CN105092854A (zh) * 2014-05-07 2015-11-25 湖州数问生物技术有限公司 体外诊断装置和试剂盒
JP6980953B2 (ja) * 2014-09-11 2021-12-15 ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム ミスフォールディングタンパク質の検出
WO2022105923A1 (zh) * 2020-11-21 2022-05-27 浙江数问生物技术有限公司 用于检测生物样本中的错误折叠蛋白质的装置和方法

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444879A (en) * 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
US5434050A (en) 1991-08-13 1995-07-18 Regents Of The University Of Minnesota Labelled β-amyloid peptide and methods of screening for Alzheimer's disease
ATE177754T1 (de) 1991-12-03 1999-04-15 Proteus Molecular Design Fragmente von prion proteinen.
US5955343A (en) 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US5565186A (en) 1994-05-13 1996-10-15 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US5854215A (en) 1995-03-14 1998-12-29 Praecis Pharmaceuticals Incorporated Modulators of β-amyloid peptide aggregation
CA2231409C (en) 1995-09-14 2003-02-11 The Regents Of The University Of California Antibodies specific for native prpsc
US5750361A (en) 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
EP0914614B1 (en) 1996-05-14 2003-09-03 Winnacker, Ernst-Ludwig, Prof. CHARPERONES CAPABLE OF BINDING TO PRION PROTEINS AND DISTINGUISHING THE ISOFORMS PrPc AND PrPsc
US20060178302A1 (en) 1997-02-05 2006-08-10 Northwestern University & The University Of Southern California Amyloid beta protein (globular assembly and uses thereof)
US5891641A (en) 1997-02-21 1999-04-06 The Regents Of The University Of California Assay for disease related conformation of a protein
US20010001061A1 (en) 1997-02-21 2001-05-10 Prusiner Stanley B. Assay for disease related conformation of a protein
CA2301142A1 (en) 1997-08-14 1999-02-25 The Regents Of The University Of California Fluorescent amyloid a.beta. peptides and uses thereof
DE59805338D1 (de) 1997-09-19 2002-10-02 Evotec Ag Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen
WO1999041279A2 (en) 1998-02-13 1999-08-19 Arch Development Corporation Methods and compositions comprising the use of blocked b-amyloid peptide
US5977324A (en) 1998-02-20 1999-11-02 The Regents Of The University Of California Process for concentrating protein with disease-related conformation
US6214565B1 (en) 1998-10-09 2001-04-10 The Regents Of The University Of California Assay for disease related conformation of a protein and isolating same
US6211149B1 (en) 1998-08-03 2001-04-03 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors of formation of protease resistant prion protein
US6750025B1 (en) 1998-07-09 2004-06-15 V.I. Technologies, Inc. Method of detecting and isolating prion protein and variants thereof
GB2348203B (en) 1998-11-04 2002-06-19 Imp College Innovations Ltd Solube beta-forms of prion proteins, methods of preparation and use
WO2000043791A2 (en) 1999-01-25 2000-07-27 Minerva Biotechnologies Corporation Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases
US20050112607A1 (en) 1999-01-23 2005-05-26 Bamdad Cynthia C. Rapid and sensitive detection of protein aggregation
US6166187A (en) 1999-03-05 2000-12-26 The Regents Of The University Of California Method of concentrating prion proteins in blood samples
SI1105409T1 (sl) 1999-05-17 2006-06-30 Conjuchem Inc Zascita endogenih peptidov pred peptidazno ucinkovitostjo s konjugacijo na krvne komponente
EP1200469A2 (en) 1999-07-27 2002-05-02 Imperial College Innovations Limited Fragments of cellular prion protein and methods useful in the diagnosis and treatment of prion diseases
GB9917724D0 (en) 1999-07-28 1999-09-29 Medical Res Council Peptides
WO2001014412A1 (en) 1999-08-23 2001-03-01 The Regents Of The University Of California Compounds useful to mimic peptide beta-strands
US6399314B1 (en) 1999-12-29 2002-06-04 American Cyanamid Company Methods of detection of amyloidogenic proteins
CA2405568A1 (en) * 2000-04-05 2001-10-18 North Carolina State University Prion-binding peptidic ligands and methods of using same
DK1712920T3 (da) 2000-07-07 2009-05-11 Merck Serono Sa Tidlig diagnose af konformationelle sygdomme
US6780641B2 (en) 2000-07-10 2004-08-24 University Of British Columbia Immortalized human microglia cell line
US7303907B2 (en) 2001-01-08 2007-12-04 Health Protection Agency Degradation and detection of TSE infectivity
WO2002053723A2 (en) 2001-01-08 2002-07-11 Health Protection Agency Degradation and detection of tse infectivity
AR035956A1 (es) 2001-04-17 2004-07-28 Femtolink Biotechnologies Llc Deteccion y cuantificacion de isoformas de prion en enfermedades neurodegenerativas mediante espectrometria de masas.
AU2002314794A1 (en) 2001-05-23 2002-12-03 New York University Detection of alzheimer's amyloid by magnetic resonance imaging
AU2002320045B2 (en) 2001-05-31 2008-05-08 Adlyfe, Inc. Misfolded protein sensor method
US20050026165A1 (en) 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
CA2451795A1 (en) 2001-06-26 2003-01-09 Paul M. Mathews Cell-based high-throughput screening methods
CA2467914A1 (en) 2001-12-10 2003-06-19 Applied Research Systems Ars Holding N.V. Prion inhibiting peptides and derivatives thereof
US20040052928A1 (en) 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
EP1572937B1 (en) 2002-04-09 2012-02-08 The Scripps Research Institute Motif-grafted hybrid polypeptides and uses thereof
JP2004155688A (ja) 2002-04-30 2004-06-03 Biofrontier Kenkyusho:Kk シャペロン活性を有する合成ペプチド、脱炭酸活性の測定方法、伝達性海綿状脳症用薬剤及びその探索方法
FR2842303B1 (fr) * 2002-07-09 2004-09-24 Commissariat Energie Atomique Methode de detection automatisable de la prpres et ses applications
WO2004018511A2 (en) 2002-08-23 2004-03-04 Copenhagen Biotech Assets Aps Composite peptide compounds for diagnosis and treatment of diseases caused by prion proteins
US20040072236A1 (en) 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
MXPA05005920A (es) 2002-12-03 2006-03-17 American Nat Red Cross Ligandos de proteina prion y metodos de uso.
US7510848B2 (en) 2003-04-04 2009-03-31 North Carolina State University Prion protein binding materials and methods of use
JP2004361227A (ja) 2003-06-04 2004-12-24 Tohoku Univ アミロイドβ結合蛋白質の同定方法
US20070054322A1 (en) 2003-07-31 2007-03-08 Hadasit Medical Research Services & Development Lt Methods and kits for the detection of prion diseases
US20060035242A1 (en) 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
NZ545385A (en) 2003-08-13 2010-12-24 Novartis Vaccines & Diagnostic Prion-specific peptide reagents
JP3910569B2 (ja) 2003-08-19 2007-04-25 独立行政法人科学技術振興機構 アミロイドβ蛋白質のアミロイド線維化を増幅するための試薬
US20060057671A1 (en) 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
US8673579B2 (en) 2006-07-28 2014-03-18 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics

Also Published As

Publication number Publication date
JP2008530565A (ja) 2008-08-07
HK1110936A1 (en) 2008-07-25
WO2006088823A2 (en) 2006-08-24
US8372593B2 (en) 2013-02-12
ATE528649T1 (de) 2011-10-15
US20110081660A1 (en) 2011-04-07
WO2006088823A3 (en) 2007-03-29
EP1853915A2 (en) 2007-11-14
CN101156068A (zh) 2008-04-02
CA2597912A1 (en) 2006-08-24
CA2597912C (en) 2013-06-04
JP5048522B2 (ja) 2012-10-17
EP1853915B1 (en) 2011-10-12
AU2006214463B2 (en) 2012-08-30
MX2007009819A (es) 2007-11-07
CN101156068B (zh) 2015-03-18
EP1853915A4 (en) 2008-09-03
AU2006214463A1 (en) 2006-08-24

Similar Documents

Publication Publication Date Title
BRPI0607350A2 (pt) método para detecção da presença ou quantidade de uma proteìna erroneamente duplicada em uma amostra e kit
ATE556030T1 (de) Ultrasensitiver nachweis von analyten
WO2012035296A3 (en) Assay for prions
BRPI0720707A2 (pt) Sistema de teste para uso com um tampão para testar a presença de moléculas alvo de um ou mais tipos de alvo em uma amostra de teste biológico; sistema de teste para testar a presença de moléculas alvo de um ou mais tipos de alvo em uma amostra de teste biológico; e método de focalização de moléculas para facilitar um teste da presença de moléculas alvo de um ou mais tipos de alvo de uma amostra de teste biológico.
DE602006019858D1 (de) Verfahren und vorrichtung zur erkennung und behebung von defekten in einem inline-strom-fähigen ethernetsystem
BRPI0618713B8 (pt) cardiolipina modificada e seus usos
NO20070599L (no) Anvendelse av C3a og derivater derav som biomarkor for colorektal adenom og/eller karsinom, samt diagnosemetoder og testsytem som anvender samme.
EP2472258A3 (en) Highly sensitive system and methods for analysis of troponin
WO2008041953A3 (en) Dengue diagnosis and treatment
WO2008021290A9 (en) Organ-specific proteins and methods of their use
ATE541054T1 (de) Bio-barcode erkennung für zielmoleküle
ATE423972T1 (de) Vorrichtung und verfahren um gleichzeitig verschiedene antikörper und antigene nachzuweisen in klinischen, nahrungsmittel- und umwelt-proben
WO2005114218A3 (en) Cross-screening system and methods for detecting a molecule having binding affinity for a target molecule
DE60315715D1 (de) Verwendung von nicotinamide n-methyltransferase zur diagnose von kolorektalem krebs
EA202191931A1 (ru) Способ характеризации видимых и/или невидимых частиц в биологических препаратах
WO2008152528A3 (en) Method for the diagnosis or the screening of an arbovirus infection, reagents useful in said method and their applications
EP2312313A3 (en) Immobilized probes and methods of detecting conformationally altered prion proteins
EA201491411A1 (ru) Растворимый manf при поражениях бета-клеток поджелудочной железы
WO2011109112A3 (en) Method of detecting tau protein and tau fragments in serum
WO2007147141A3 (en) Methods for detecting molecular complexes
BRPI0607692A2 (pt) peptìdeos para detecção de anticorpo para o vìrus da sìndrome reprodutiva e respiratória suìna
TW200702981A (en) Exception analysis methods and systems
BRPI0716767A2 (pt) mÉtodos para identificar uma proteÍna em uma amostra de proteÍna, e para isolar os peptÍdeos de terminal-c de uma amostra de proteÍna, base de dados, uso da mesma, e, dispositivo para identificar proteÍnas em uma ou mais amostras baseadas em seus peptÍdeos de terminal-c
DE60138192D1 (de) Verfahren zur quantifizierung der akt-protein-expression
ATE520028T1 (de) Test zum nachweis von proteinbindung

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]