BRPI0607487A2 - virus rna deficientes em replicação como vacinas - Google Patents

virus rna deficientes em replicação como vacinas

Info

Publication number
BRPI0607487A2
BRPI0607487A2 BRPI0607487-1A BRPI0607487A BRPI0607487A2 BR PI0607487 A2 BRPI0607487 A2 BR PI0607487A2 BR PI0607487 A BRPI0607487 A BR PI0607487A BR PI0607487 A2 BRPI0607487 A2 BR PI0607487A2
Authority
BR
Brazil
Prior art keywords
vaccines
rna virus
replication deficient
deficient rna
replication
Prior art date
Application number
BRPI0607487-1A
Other languages
English (en)
Inventor
Wolfgang J Neubert
Sasha Bossow
Sabine Schlecht
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Publication of BRPI0607487A2 publication Critical patent/BRPI0607487A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/115—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18811—Sendai virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141—Use of virus, viral particle or viral elements as a vector
    • C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

VìRUS RNA DEFICIENTES EM REPLICAçãO COMO VACINAS. A presente invenção refere-se a um vírus RNA deficiente em replicação de genoma e competente em transcrição de feixe negativo que pode ser empregado para a expressão de transgênicos e particularmente para o campo do desenvolvimento de vacinas, O genoma viral contém uma mutação em pelo menos um dos genes N, L ou P.
BRPI0607487-1A 2005-02-11 2006-02-10 virus rna deficientes em replicação como vacinas BRPI0607487A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005006388A DE102005006388A1 (de) 2005-02-11 2005-02-11 Replikationsdefiziente RNA-Viren als Impfstoffe
PCT/EP2006/001251 WO2006084746A1 (de) 2005-02-11 2006-02-10 Replikationsdefiziente rna-viren als impfstoffe

Publications (1)

Publication Number Publication Date
BRPI0607487A2 true BRPI0607487A2 (pt) 2009-09-08

Family

ID=36353666

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607487-1A BRPI0607487A2 (pt) 2005-02-11 2006-02-10 virus rna deficientes em replicação como vacinas

Country Status (22)

Country Link
US (2) US20090041725A1 (pt)
EP (2) EP1851239B1 (pt)
JP (2) JP5679620B2 (pt)
KR (1) KR101279636B1 (pt)
CN (1) CN101155826B (pt)
AT (1) ATE421529T1 (pt)
AU (1) AU2006212385B2 (pt)
BR (1) BRPI0607487A2 (pt)
CA (1) CA2599036C (pt)
DE (2) DE102005006388A1 (pt)
DK (1) DK1851239T3 (pt)
EA (1) EA015013B1 (pt)
ES (1) ES2321651T3 (pt)
HR (1) HRP20090230T1 (pt)
IL (1) IL185147A (pt)
MX (1) MX2007009628A (pt)
PL (1) PL1851239T3 (pt)
PT (1) PT1851239E (pt)
RS (1) RS50977B (pt)
SI (1) SI1851239T1 (pt)
WO (1) WO2006084746A1 (pt)
ZA (1) ZA200707216B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005006388A1 (de) 2005-02-11 2006-08-24 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Replikationsdefiziente RNA-Viren als Impfstoffe
SI2604695T1 (sl) 2007-12-27 2023-03-31 Universitaet Zuerich Prorektorat Forschung Replikacijsko defektni arenavirusni vektorji
EP2085479A1 (en) 2008-01-31 2009-08-05 Institut Pasteur Reverse genetics of negative-strand rna viruses in yeast
JP5633075B2 (ja) * 2009-05-18 2014-12-03 独立行政法人産業技術総合研究所 多能性幹細胞作成用ベクター材料及びこれを用いた多能性幹細胞作成方法
US9365866B2 (en) 2009-06-03 2016-06-14 National Institute Of Advanced Industrial Science And Technology Vectors for generating pluripotent stem cells and methods of producing pluripotent stem cells using the same
DE102010018961B4 (de) * 2010-04-23 2012-09-20 Eberhard-Karls-Universität Tübingen Universitätsklinikum Genetisch modifiziertes Paramyxovirus zur Behandlung von Tumorerkrankungen
JP5807917B2 (ja) 2011-02-08 2015-11-10 国立大学法人三重大学 遺伝子導入用ウイルスベクターの製造方法
CN103987726B (zh) * 2011-10-05 2017-10-03 金维克有限公司 猴(大猩猩)腺病毒或腺病毒载体及其使用方法
EP2669381A1 (en) 2012-05-30 2013-12-04 AmVac AG Method for expression of heterologous proteins using a recombinant negative-strand RNA virus vector comprising a mutated P protein
EP2968506B1 (en) 2013-03-15 2019-07-31 Université de Genève Anti-mycobacterial vaccines
EA201592298A1 (ru) * 2013-06-10 2016-06-30 Амвак Аг Полуживая вирусная вакцина против респираторно-синцитиального вируса
EP2813574B1 (en) * 2013-06-10 2019-02-20 RSV Genius GmbH Semi-live respiratory syncytial virus vaccine
EP4531903A1 (en) 2022-05-25 2025-04-09 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Vaccine with reduced anti-vector antigenicity

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE257175T1 (de) 1994-07-18 2004-01-15 Conzelmann Karl Klaus Prof Dr Rekombinantes infektiöses nicht-in-segmente- geteiltes, negativ-strange-rns-virus
DK0863202T3 (da) 1995-11-01 2010-09-27 Dnavec Research Inc Rekombinant Sendai-virus
AU785148B2 (en) 1999-12-10 2006-10-05 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Use of recombinant parainfluenza viruses (PIVs) as vectors to protect against infection and disease caused by PIV and other human pathogens
JP4791651B2 (ja) * 2000-05-18 2011-10-12 株式会社ディナベック研究所 外来遺伝子導入用パラミクソウイルスベクター
US20050130123A1 (en) 2001-09-18 2005-06-16 Makoto Inoue Methods of examining (-) strand rna virus vectors having lowered ability to form grains and method of constructing the same
JP2004344001A (ja) * 2003-03-07 2004-12-09 Dnavec Research Inc 胚性幹細胞に遺伝子を導入する方法
JP2004357689A (ja) * 2003-06-03 2004-12-24 Dnavec Research Inc 遺伝子導入ベクターの非侵襲的インビボ評価方法
EP1633860A2 (en) * 2003-06-09 2006-03-15 Wyeth IMPROVED METHOD FOR THE RECOVERY OF NON-SEGMENTED, NEGATIVE-STRANDED RNA VIRUSES FROM cDNA
DE102005006388A1 (de) 2005-02-11 2006-08-24 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Replikationsdefiziente RNA-Viren als Impfstoffe

Also Published As

Publication number Publication date
US20180142256A1 (en) 2018-05-24
DE502006002711D1 (de) 2009-03-12
KR20070110345A (ko) 2007-11-16
SI1851239T1 (sl) 2009-08-31
PT1851239E (pt) 2009-04-28
EP2045260A1 (de) 2009-04-08
WO2006084746A1 (de) 2006-08-17
CA2599036A1 (en) 2006-08-17
PL1851239T3 (pl) 2009-07-31
CN101155826A (zh) 2008-04-02
ES2321651T3 (es) 2009-06-09
US11028409B2 (en) 2021-06-08
HRP20090230T1 (hr) 2009-05-31
EP1851239A1 (de) 2007-11-07
AU2006212385A1 (en) 2006-08-17
RS50977B (sr) 2010-10-31
CN101155826B (zh) 2011-10-12
US20090041725A1 (en) 2009-02-12
IL185147A0 (en) 2007-12-03
JP2012213407A (ja) 2012-11-08
IL185147A (en) 2011-12-29
CA2599036C (en) 2014-11-04
ATE421529T1 (de) 2009-02-15
EP1851239B1 (de) 2009-01-21
AU2006212385B2 (en) 2011-12-15
ZA200707216B (en) 2008-05-28
MX2007009628A (es) 2007-11-15
EA015013B1 (ru) 2011-04-29
EA200701695A1 (ru) 2008-02-28
JP2008529508A (ja) 2008-08-07
KR101279636B1 (ko) 2013-06-28
JP5679620B2 (ja) 2015-03-04
DK1851239T3 (da) 2009-05-18
DE102005006388A1 (de) 2006-08-24
HK1118297A1 (en) 2009-02-06

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Legal Events

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time