BRPI0607562A2 - derivados da diosmetina para o tratamento e a prevenção das patologias trombóticas - Google Patents

derivados da diosmetina para o tratamento e a prevenção das patologias trombóticas

Info

Publication number
BRPI0607562A2
BRPI0607562A2 BRPI0607562-2A BRPI0607562A BRPI0607562A2 BR PI0607562 A2 BRPI0607562 A2 BR PI0607562A2 BR PI0607562 A BRPI0607562 A BR PI0607562A BR PI0607562 A2 BRPI0607562 A2 BR PI0607562A2
Authority
BR
Brazil
Prior art keywords
prevention
treatment
derivatives
diosmetine
thrombotic disorders
Prior art date
Application number
BRPI0607562-2A
Other languages
English (en)
Inventor
Tony Verbeuren
Alain Rupin
Patricia Sansilvestri-Morel
Marie-Francoise Boussard
Marie-Odile Vallez
Michel Wierzbicki
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BRPI0607562A2 publication Critical patent/BRPI0607562A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

DERIVADOS DA DIOSMETINA PARA O TRATAMENTO E A PREVENçãO DAS PATOLOGIAS TROMBóTICAS. A presente invenção refere-se a utilização de derivados da diosmetina, para a obtenção de composições farmacêuticas destinadas à prevenção e/ou ao tratamento das patologias trombóticas, assim como às patologias de risco trombótico.
BRPI0607562-2A 2005-03-01 2006-02-28 derivados da diosmetina para o tratamento e a prevenção das patologias trombóticas BRPI0607562A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0502044A FR2882654B1 (fr) 2005-03-01 2005-03-01 Utilisation de derives de la diosmetine pour le traitement et la prevention des pathologies thrombotiques
PCT/FR2006/000441 WO2006092490A1 (fr) 2005-03-01 2006-02-28 Utilisation de derives de la diosmetine pour le traitement et la prevention des pathologies thrombotiques

Publications (1)

Publication Number Publication Date
BRPI0607562A2 true BRPI0607562A2 (pt) 2009-09-15

Family

ID=35134198

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607562-2A BRPI0607562A2 (pt) 2005-03-01 2006-02-28 derivados da diosmetina para o tratamento e a prevenção das patologias trombóticas

Country Status (18)

Country Link
US (1) US20080176934A1 (pt)
EP (1) EP1853253A1 (pt)
JP (1) JP2008531660A (pt)
KR (2) KR20090128581A (pt)
CN (1) CN101132788A (pt)
AR (1) AR053149A1 (pt)
AU (1) AU2006219853B2 (pt)
BR (1) BRPI0607562A2 (pt)
CA (1) CA2599658A1 (pt)
EA (1) EA013078B1 (pt)
FR (1) FR2882654B1 (pt)
MA (1) MA29316B1 (pt)
MX (1) MX2007010364A (pt)
NO (1) NO20074941L (pt)
NZ (1) NZ560749A (pt)
UA (1) UA91848C2 (pt)
WO (1) WO2006092490A1 (pt)
ZA (1) ZA200707472B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2002835A1 (en) 2007-06-04 2008-12-17 GenKyo Tex Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
KR101162816B1 (ko) * 2008-04-01 2012-07-09 르 라보레또레 쎄르비에르 디오스메틴 화합물，이의 제조 방법 및 이를 함유하는 약제학적 조성물
FR2929276B1 (fr) * 2008-04-01 2010-04-23 Servier Lab Nouveaux derives de diosmetine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2165707A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166009A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as nadph oxidase inhibitors
EP2166010A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
WO2010062681A2 (en) * 2008-10-30 2010-06-03 University Of South Florida Luteolin and diosmin/diosmetin as novel stat3 inhibitors for treating autism
EP2305679A1 (en) 2009-09-28 2011-04-06 GenKyoTex SA Pyrazoline dione derivatives as nadph oxidase inhibitors
WO2013076580A2 (en) 2011-11-23 2013-05-30 Bioven 3 Limited Recombinant proteins and their therapeutic uses
EP3034500A1 (en) 2014-12-17 2016-06-22 Genkyotex Sa Amido thiazole derivatives as NADPH oxidase inhibitors
US20200115358A1 (en) * 2016-03-11 2020-04-16 H. Lee Moffitt Cancer Center And Research Institute, Inc. Icariin and icaritin derivatives
TWI750189B (zh) * 2016-12-15 2021-12-21 大陸商深圳瑞健生命科學研究院有限公司 一種治療冠狀動脈粥樣硬化及其併發症的方法
TWI677348B (zh) * 2016-12-15 2019-11-21 大陸商深圳瑞健生命科學研究院有限公司 一種改善心臟病變的方法
WO2018107689A1 (zh) * 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种预防和治疗脂质肾损伤的方法
CN108210915A (zh) * 2016-12-15 2018-06-29 深圳瑞健生命科学研究院有限公司 改善心脏病变的药物及其用途
JP7168990B2 (ja) 2016-12-15 2022-11-10 タレンゲン インターナショナル リミテッド 肥満症を予防および治療するための方法および薬物
CN106822087A (zh) * 2017-01-12 2017-06-13 西南大学 香叶木素在制备治疗ⅱ型糖尿病的药物中的应用
CN109280067B (zh) * 2017-07-21 2022-07-05 南京正大天晴制药有限公司 香叶木苷衍生物、其制备方法以及医药用途
EP3479843A1 (en) 2017-11-01 2019-05-08 GenKyoTex Suisse SA Use of nox inhibitors for treatment of cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2701261B1 (fr) * 1993-02-05 1995-03-31 Adir Nouveaux composés glucuronides de la diosmétine, leur procédé de préparation et les compositions pharmaceutiques les renfermant.
FR2726273B1 (fr) * 1994-10-26 1996-12-06 Adir Nouveaux derives de la diosmetine, leur procede de preparation et les compositions pharmaceutiques les contenant
FR2748025B1 (fr) * 1996-04-25 1998-10-30 Adir Nouveaux acides et esters de la diosmetine, et les compositions pharmaceutiques les contenant
EP1124815B1 (de) * 1998-10-30 2004-05-26 MERCK PATENT GmbH Verfahren zur herstellung von luteolin und luteolin-derivaten

Also Published As

Publication number Publication date
KR100971589B1 (ko) 2010-07-20
FR2882654B1 (fr) 2007-04-27
FR2882654A1 (fr) 2006-09-08
EA200701820A1 (ru) 2008-02-28
ZA200707472B (en) 2008-11-26
AR053149A1 (es) 2007-04-25
NO20074941L (no) 2007-10-01
CN101132788A (zh) 2008-02-27
EP1853253A1 (fr) 2007-11-14
NZ560749A (en) 2010-11-26
MX2007010364A (es) 2007-09-25
EA013078B1 (ru) 2010-02-26
KR20090128581A (ko) 2009-12-15
WO2006092490A1 (fr) 2006-09-08
KR20070110395A (ko) 2007-11-16
US20080176934A1 (en) 2008-07-24
AU2006219853A1 (en) 2006-09-08
AU2006219853B2 (en) 2011-06-09
UA91848C2 (ru) 2010-09-10
JP2008531660A (ja) 2008-08-14
CA2599658A1 (fr) 2006-09-08
MA29316B1 (fr) 2008-03-03

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUI DADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2211 DE 21/05/2013.