BRPI0619153B8 - derivados de 4-amino-pirroltriazina substituída, e composição farmacêutica - Google Patents

derivados de 4-amino-pirroltriazina substituída, e composição farmacêutica

Info

Publication number
BRPI0619153B8
BRPI0619153B8 BRPI0619153A BRPI0619153A BRPI0619153B8 BR PI0619153 B8 BRPI0619153 B8 BR PI0619153B8 BR PI0619153 A BRPI0619153 A BR PI0619153A BR PI0619153 A BRPI0619153 A BR PI0619153A BR PI0619153 B8 BRPI0619153 B8 BR PI0619153B8
Authority
BR
Brazil
Prior art keywords
pyrroltriazine
amino
substituted
derivatives
pharmaceutical composition
Prior art date
Application number
BRPI0619153A
Other languages
English (en)
Inventor
Phillips Barton
Chandler Brent
Kluender Harold
Newcom Jason
Dixon Julie
Allegue Kristen
Parcella Kyle
Magnuson Steven
Li Tandy
Wang Yamin
Liu Zheng
Hong Zhenqiu
Zhang Zhonghua
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of BRPI0619153A2 publication Critical patent/BRPI0619153A2/pt
Publication of BRPI0619153A8 publication Critical patent/BRPI0619153A8/pt
Publication of BRPI0619153B1 publication Critical patent/BRPI0619153B1/pt
Publication of BRPI0619153B8 publication Critical patent/BRPI0619153B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

derivados de 4-amino-pirroltriazina substituída úteis para o tratamento de distúrbios e doenças hiperproliferativos associados à angiogênese. a presente invenção refere-se a novos compostos de pirrozolotriazina, a composições farmacêuticas contendo tais compostos e ao uso desses compostos e composições para a prevenção e/ou o tratamento de distúrbios e doenças hiperproliferativos associados à angiogênese.
BRPI0619153A 2005-12-02 2006-11-30 derivados de 4-amino-pirroltriazina substituída, e composição farmacêutica BRPI0619153B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74215105P 2005-12-02 2005-12-02
US60/742,151 2005-12-02
PCT/US2006/045996 WO2007064883A2 (en) 2005-12-02 2006-11-30 Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis

Publications (4)

Publication Number Publication Date
BRPI0619153A2 BRPI0619153A2 (pt) 2011-09-20
BRPI0619153A8 BRPI0619153A8 (pt) 2019-11-12
BRPI0619153B1 BRPI0619153B1 (pt) 2020-01-28
BRPI0619153B8 true BRPI0619153B8 (pt) 2021-05-25

Family

ID=38092821

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0619153A BRPI0619153B8 (pt) 2005-12-02 2006-11-30 derivados de 4-amino-pirroltriazina substituída, e composição farmacêutica

Country Status (17)

Country Link
US (2) US8133995B2 (pt)
EP (2) EP1957077B1 (pt)
JP (1) JP5199882B2 (pt)
KR (1) KR101404290B1 (pt)
CN (2) CN105732634A (pt)
AR (1) AR057991A1 (pt)
AU (1) AU2006320480B2 (pt)
BR (1) BRPI0619153B8 (pt)
CA (1) CA2631775C (pt)
DO (1) DOP2006000269A (pt)
ES (1) ES2459016T3 (pt)
IL (1) IL191864A (pt)
PE (1) PE20070855A1 (pt)
TW (1) TWI388560B (pt)
UY (1) UY29983A1 (pt)
WO (1) WO2007064883A2 (pt)
ZA (1) ZA200805694B (pt)

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CN101365454A (zh) 2009-02-11
US20090281079A1 (en) 2009-11-12
WO2007064883A3 (en) 2007-10-25
TWI388560B (zh) 2013-03-11
JP5199882B2 (ja) 2013-05-15
UY29983A1 (es) 2007-06-29
JP2009519905A (ja) 2009-05-21
US8829185B2 (en) 2014-09-09
EP2465505A1 (en) 2012-06-20
AU2006320480B2 (en) 2011-11-10
CA2631775C (en) 2015-02-03
US20120165314A1 (en) 2012-06-28
PE20070855A1 (es) 2007-10-14
CA2631775A1 (en) 2007-06-07
EP1957077A2 (en) 2008-08-20
BRPI0619153B1 (pt) 2020-01-28
IL191864A0 (en) 2009-08-03
WO2007064883A2 (en) 2007-06-07
EP1957077A4 (en) 2010-01-13
DOP2006000269A (es) 2007-07-31
CN101365454B (zh) 2016-03-30
BRPI0619153A2 (pt) 2011-09-20
US8133995B2 (en) 2012-03-13
AR057991A1 (es) 2008-01-09
KR101404290B1 (ko) 2014-06-20
KR20080083651A (ko) 2008-09-18
BRPI0619153A8 (pt) 2019-11-12
ES2459016T3 (es) 2014-05-07
HK1129305A1 (zh) 2009-11-27
ZA200805694B (en) 2009-11-25
TW200738724A (en) 2007-10-16
CN105732634A (zh) 2016-07-06
IL191864A (en) 2017-03-30
EP1957077B1 (en) 2014-01-22

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