BRPI0607769A2 - pró-fármacos nucleosìdeo-tricìclicos para tratamento de infecções virais - Google Patents

pró-fármacos nucleosìdeo-tricìclicos para tratamento de infecções virais

Info

Publication number
BRPI0607769A2
BRPI0607769A2 BRPI0607769-2A BRPI0607769A BRPI0607769A2 BR PI0607769 A2 BRPI0607769 A2 BR PI0607769A2 BR PI0607769 A BRPI0607769 A BR PI0607769A BR PI0607769 A2 BRPI0607769 A2 BR PI0607769A2
Authority
BR
Brazil
Prior art keywords
viral infections
treatment
tricyclic
nucleoside
prodrugs
Prior art date
Application number
BRPI0607769-2A
Other languages
English (en)
Inventor
Jesse D Keicher
Christopher Don Roberts
Original Assignee
Genelabs Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genelabs Tech Inc filed Critical Genelabs Tech Inc
Publication of BRPI0607769A2 publication Critical patent/BRPI0607769A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/22—Pteridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PRó-FáRMACOS NUCLEOSìDEO-TRICìCLICOS PARA TRATAMENTO DE INFECçõES VIRAIS. Esta invenção é direcionada a novos compostos que São úteis nas infecções virais em mamíferos, mediadas, pelo menos em parte, por um vírus da família de vírus Flaviviridae. Em um dos aspectos da composição, a presente invenção é direcionada aos compostos de Fórmula (I).
BRPI0607769-2A 2005-02-28 2006-02-28 pró-fármacos nucleosìdeo-tricìclicos para tratamento de infecções virais BRPI0607769A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65746305P 2005-02-28 2005-02-28
PCT/US2006/007131 WO2006093986A1 (en) 2005-02-28 2006-02-28 Tricyclic-nucleoside prodrugs for treating viral infections

Publications (1)

Publication Number Publication Date
BRPI0607769A2 true BRPI0607769A2 (pt) 2009-10-06

Family

ID=36570903

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0607770-6A BRPI0607770A2 (pt) 2005-02-28 2006-02-28 compostos de nucleosideo tricìclico para tratamento de infecções virais
BRPI0607769-2A BRPI0607769A2 (pt) 2005-02-28 2006-02-28 pró-fármacos nucleosìdeo-tricìclicos para tratamento de infecções virais

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0607770-6A BRPI0607770A2 (pt) 2005-02-28 2006-02-28 compostos de nucleosideo tricìclico para tratamento de infecções virais

Country Status (18)

Country Link
US (4) US7534771B2 (pt)
EP (2) EP1853617A1 (pt)
JP (2) JP2008531704A (pt)
KR (2) KR20070106781A (pt)
CN (2) CN101128474A (pt)
AP (2) AP2007004128A0 (pt)
AR (1) AR058419A1 (pt)
AU (2) AU2006218704A1 (pt)
BR (2) BRPI0607770A2 (pt)
CA (2) CA2597685A1 (pt)
EA (2) EA200701850A1 (pt)
HR (2) HRP20070435A9 (pt)
IL (2) IL184954A0 (pt)
MX (2) MX2007010460A (pt)
NO (2) NO20074613L (pt)
TW (1) TW200640474A (pt)
WO (2) WO2006093986A1 (pt)
ZA (1) ZA200707410B (pt)

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Also Published As

Publication number Publication date
EP1853618A1 (en) 2007-11-14
US7524825B2 (en) 2009-04-28
WO2006093986A1 (en) 2006-09-08
CN101142226A (zh) 2008-03-12
KR20070106781A (ko) 2007-11-05
CA2597685A1 (en) 2006-09-08
MX2007010460A (es) 2007-11-08
AU2006218704A1 (en) 2006-09-08
AP2007004118A0 (en) 2007-08-31
HRP20070435A2 (hr) 2008-02-29
BRPI0607770A2 (pt) 2009-06-13
NO20074915L (no) 2007-11-20
AU2006218705A1 (en) 2006-09-08
EA200701849A1 (ru) 2008-02-28
JP2008531704A (ja) 2008-08-14
EP1853617A1 (en) 2007-11-14
CN101128474A (zh) 2008-02-20
HRP20070435A9 (en) 2008-09-30
MX2007010463A (es) 2007-11-08
AP2007004128A0 (en) 2007-08-31
AR058419A1 (es) 2008-02-06
KR20070106767A (ko) 2007-11-05
HRP20070436A2 (hr) 2008-02-29
IL184955A0 (en) 2007-12-03
US7534771B2 (en) 2009-05-19
US20090208457A1 (en) 2009-08-20
WO2006093987A1 (en) 2006-09-08
US20060252715A1 (en) 2006-11-09
EA200701850A1 (ru) 2008-02-28
JP2008531703A (ja) 2008-08-14
IL184954A0 (en) 2007-12-03
ZA200707410B (en) 2008-10-29
US20060194749A1 (en) 2006-08-31
US20090253648A1 (en) 2009-10-08
NO20074613L (no) 2007-11-27
CA2597683A1 (en) 2006-09-08
TW200640474A (en) 2006-12-01

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012.