CL2008001005A1 - Compuestos derivados de azufre, inhibidores de la serina proteasa ns3 del virus de la hepatitis c; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de trastornos asociados a la proteasa de hcv. - Google Patents

Compuestos derivados de azufre, inhibidores de la serina proteasa ns3 del virus de la hepatitis c; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de trastornos asociados a la proteasa de hcv.

Info

Publication number: CL2008001005A1
Authority: CL; Chile
Prior art keywords: compound; hepatitis; virus; inhibitors; sulfur
Prior art date: 2007-04-10

Application number

CL200801005A

Other languages

English (en)

Inventor

Francisco Velazquez

Stephane L. Bogen

Ashok Arasappan

Srikanth Venkatraman

F. George Njoroge

Neng-Yang. Shih

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-04-10

Filing date

2008-04-09

Publication date

2008-10-17

2008-04-09 Application filed by Schering Corp filed Critical Schering Corp

2008-10-17 Publication of CL2008001005A1 publication Critical patent/CL2008001005A1/es

Links

150000001875 compounds Chemical class 0.000 title 3
108091005804 Peptidases Proteins 0.000 title 1
239000004365 Protease Substances 0.000 title 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title 1
241000700605 Viruses Species 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
208000006454 hepatitis Diseases 0.000 title 1
231100000283 hepatitis Toxicity 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
229910052717 sulfur Inorganic materials 0.000 title 1
239000011593 sulfur Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Virology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Crystallography & Structural Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CL200801005A 2007-04-10 2008-04-09 Compuestos derivados de azufre, inhibidores de la serina proteasa ns3 del virus de la hepatitis c; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de trastornos asociados a la proteasa de hcv. CL2008001005A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US11/733,479 US7816326B2 (en)	2004-02-27	2007-04-10	Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease

Publications (1)

Publication Number	Publication Date
CL2008001005A1 true CL2008001005A1 (es)	2008-10-17

Family

ID=39743035

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL200801005A CL2008001005A1 (es)	2007-04-10	2008-04-09	Compuestos derivados de azufre, inhibidores de la serina proteasa ns3 del virus de la hepatitis c; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de trastornos asociados a la proteasa de hcv.

Country Status (22)

Country	Link
US (1)	US7816326B2 (es)
EP (1)	EP2134739B1 (es)
JP (1)	JP2010523666A (es)
KR (1)	KR20100016185A (es)
CN (1)	CN101679484A (es)
AR (1)	AR065984A1 (es)
AT (1)	ATE490265T1 (es)
AU (1)	AU2008236644A1 (es)
BR (1)	BRPI0810851A2 (es)
CA (1)	CA2683639A1 (es)
CL (1)	CL2008001005A1 (es)
CO (1)	CO6231036A2 (es)
DE (1)	DE602008003777D1 (es)
EC (1)	ECSP099685A (es)
ES (1)	ES2355015T3 (es)
IL (1)	IL201427A0 (es)
MX (1)	MX2009011064A (es)
PE (1)	PE20090228A1 (es)
RU (1)	RU2009141187A (es)
TW (1)	TW200902044A (es)
WO (1)	WO2008124148A2 (es)
ZA (1)	ZA200907353B (es)

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MY145081A (en) *	2004-02-27	2011-12-15	Schering Corp	Sulfur compounds as inhibitors of hepatitis c virus ns3 serine protease
US7816326B2 (en) *	2004-02-27	2010-10-19	Schering Corporation	Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease
JP5249028B2 (ja) *	2005-07-25	2013-07-31	インターミューン・インコーポレーテッド	Ｃ型肝炎ウイルス複製の新規大環状阻害剤
GEP20104956B (en) *	2005-10-11	2010-04-12	Array Biopharma Inc	Compounds for inhibiting hepatitis c viral replication and use thereof
KR20110005869A (ko) *	2008-04-15	2011-01-19	인터뮨, 인크.	Ｃ형 간염 바이러스 복제의 신규한 마크로사이클릭 억제제
CN102216321A (zh) *	2008-10-15	2011-10-12	因特蒙公司	治疗性抗病毒肽
AR075584A1 (es)	2009-02-27	2011-04-20	Intermune Inc	COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO.
CA2763140A1 (en)	2009-05-29	2010-12-02	Schering Corporation	Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c
AU2010324871A1 (en)	2009-11-25	2012-06-14	Merck Sharp & Dohme Corp.	Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases
CA2785488A1 (en)	2009-12-22	2011-07-21	Merck Sharp & Dohme Corp.	Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases
EP2545060B1 (en)	2010-03-09	2015-11-25	Merck Sharp & Dohme Corp.	Fused tricyclic silyl compounds and methods of use thereof for the treatment of viral diseases
WO2012018534A2 (en)	2010-07-26	2012-02-09	Schering Corporation	Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases
EP2621279B1 (en)	2010-09-29	2018-04-04	Merck Sharp & Dohme Corp.	Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases
US9156872B2 (en)	2011-04-13	2015-10-13	Merck Sharp & Dohme Corp.	2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
EP2696681B1 (en)	2011-04-13	2018-10-03	Merck Sharp & Dohme Corp.	2'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2013033900A1 (en)	2011-09-08	2013-03-14	Merck Sharp & Dohme Corp.	Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
WO2013033901A1 (en)	2011-09-08	2013-03-14	Merck Sharp & Dohme Corp.	Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases
WO2013033899A1 (en)	2011-09-08	2013-03-14	Merck Sharp & Dohme Corp.	Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
WO2013039876A1 (en)	2011-09-14	2013-03-21	Merck Sharp & Dohme Corp.	Silyl-containing heterocyclic compounds and methods of use thereof for the treatment of viral diseases
US8889159B2 (en)	2011-11-29	2014-11-18	Gilead Pharmasset Llc	Compositions and methods for treating hepatitis C virus
BR112014012739A8 (pt) *	2011-11-29	2017-06-20	Gilead Pharmasset Llc	composições e métodos para o tratamento do vírus da hepatite c
US10167298B2 (en)	2013-10-30	2019-01-01	Merck Sharp & Dohme Corp.	Pseudopolymorphs of an HCV NS5A inhibitor and uses thereof
WO2017059446A1 (en)	2015-10-01	2017-04-06	Memorial Sloan-Kettering Cancer Center	Anthranilyl-adenosinemonosulfamate analogs and uses thereof
CA3000709A1 (en) *	2015-10-01	2017-04-06	Memorial Sloan-Kettering Cancer Center	Inhibitors of menaquinone biosynthesis
EP3897667A4 (en)	2018-12-21	2023-04-19	Memorial Sloan Kettering Cancer Center	SALICYL ADENOSIN MONOSULFAMATE ANALOGUES AND THEIR USES
WO2022013684A1 (en)	2020-07-11	2022-01-20	Pfizer Inc.	Antiviral heteroaryl ketone derivatives
US11351149B2 (en)	2020-09-03	2022-06-07	Pfizer Inc.	Nitrile-containing antiviral compounds
US12083099B2 (en)	2020-10-28	2024-09-10	Accencio LLC	Methods of treating symptoms of coronavirus infection with viral protease inhibitors

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US7244721B2 (en) *	2000-07-21	2007-07-17	Schering Corporation	Peptides as NS3-serine protease inhibitors of hepatitis C virus
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AR029851A1 (es)	2000-07-21	2003-07-16	Dendreon Corp	Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c
HUP0303436A2 (hu) *	2000-12-12	2004-01-28	Schering Corp.	Diaril-peptidek mint a hepatitis C vírus NS3-szerin proteáz inhibitorai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
US7816326B2 (en)	2004-02-27	2010-10-19	Schering Corporation	Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease
MY145081A (en)	2004-02-27	2011-12-15	Schering Corp	Sulfur compounds as inhibitors of hepatitis c virus ns3 serine protease
CN101212970B (zh)	2005-06-02	2010-07-21	先灵公司	Hcv蛋白酶抑制剂与表面活性剂的组合物

2007
- 2007-04-10 US US11/733,479 patent/US7816326B2/en active Active
2008
- 2008-04-08 AR ARP080101450A patent/AR065984A1/es unknown
- 2008-04-08 WO PCT/US2008/004549 patent/WO2008124148A2/en not_active Ceased
- 2008-04-08 AU AU2008236644A patent/AU2008236644A1/en not_active Abandoned
- 2008-04-08 ES ES08742663T patent/ES2355015T3/es active Active
- 2008-04-08 EP EP08742663A patent/EP2134739B1/en not_active Not-in-force
- 2008-04-08 BR BRPI0810851-0A2A patent/BRPI0810851A2/pt not_active Application Discontinuation
- 2008-04-08 CN CN200880019227A patent/CN101679484A/zh active Pending
- 2008-04-08 AT AT08742663T patent/ATE490265T1/de not_active IP Right Cessation
- 2008-04-08 DE DE602008003777T patent/DE602008003777D1/de active Active
- 2008-04-08 JP JP2010503039A patent/JP2010523666A/ja not_active Withdrawn
- 2008-04-08 PE PE2008000629A patent/PE20090228A1/es not_active Application Discontinuation
- 2008-04-08 CA CA002683639A patent/CA2683639A1/en not_active Abandoned
- 2008-04-08 RU RU2009141187/04A patent/RU2009141187A/ru not_active Application Discontinuation
- 2008-04-08 MX MX2009011064A patent/MX2009011064A/es active IP Right Grant
- 2008-04-08 KR KR1020097022983A patent/KR20100016185A/ko not_active Withdrawn
- 2008-04-09 CL CL200801005A patent/CL2008001005A1/es unknown
- 2008-04-09 TW TW097112895A patent/TW200902044A/zh unknown
2009
- 2009-10-08 EC EC2009009685A patent/ECSP099685A/es unknown
- 2009-10-09 CO CO09112538A patent/CO6231036A2/es not_active Application Discontinuation
- 2009-10-11 IL IL201427A patent/IL201427A0/en unknown
- 2009-10-20 ZA ZA200907353A patent/ZA200907353B/xx unknown

Also Published As

Publication number	Publication date
ECSP099685A (es)	2009-11-30
MX2009011064A (es)	2009-10-29
US7816326B2 (en)	2010-10-19
ZA200907353B (en)	2010-07-28
KR20100016185A (ko)	2010-02-12
WO2008124148A3 (en)	2009-05-07
JP2010523666A (ja)	2010-07-15
EP2134739A2 (en)	2009-12-23
EP2134739B1 (en)	2010-12-01
CA2683639A1 (en)	2008-10-16
BRPI0810851A2 (pt)	2014-10-29
CO6231036A2 (es)	2010-12-20
DE602008003777D1 (de)	2011-01-13
ES2355015T3 (es)	2011-03-22
IL201427A0 (en)	2010-05-31
AU2008236644A1 (en)	2008-10-16
PE20090228A1 (es)	2009-03-28
US20070197448A1 (en)	2007-08-23
CN101679484A (zh)	2010-03-24
WO2008124148A2 (en)	2008-10-16
ATE490265T1 (de)	2010-12-15
RU2009141187A (ru)	2011-05-20
TW200902044A (en)	2009-01-16
AR065984A1 (es)	2009-07-15

Publication	Publication Date	Title
CL2007003299A1 (es)	2008-08-22	Compuestos derivados de macrociclos, inhibidores del virus de la hepatitis c; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la hepatitis c.
CL2007003540A1 (es)	2008-06-13	Compuestos derivados de macrociclos, inhibidores de la proteasa serina de hepatitis c; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la hepatitis c.
ECSP099685A (es)	2009-11-30	Compuestos de azufre como inhibidores de la serina proteasa ns3 del virus de la hepatitis c
CL2008003511A1 (es)	2010-02-19	Compuestos derivados nucleotidicos, inhibidores de polimerasa ns5b del virus de la hepatitis c; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la hepatitis c.
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CL2009000305A1 (es)	2010-02-19	Compuestos derivados de 2-aril-sustituido-1-benzofurano-3-carboxamida, inhibidores de la polimerasa ns5b; composicion farmaceutica; y su uso en el tratamiento de una enfermedad causada por el virus de la hepatitis c (hcv).
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CL2007002234A1 (es)	2008-06-13	Compuestos derivados de heterociclos de nitrogeno; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de enfermedades proliferativas.
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