BRPI0607817A2 - processo para a preparação de compostos macrocìclicos - Google Patents

processo para a preparação de compostos macrocìclicos

Info

Publication number
BRPI0607817A2
BRPI0607817A2 BRPI0607817-6A BRPI0607817A BRPI0607817A2 BR PI0607817 A2 BRPI0607817 A2 BR PI0607817A2 BR PI0607817 A BRPI0607817 A BR PI0607817A BR PI0607817 A2 BRPI0607817 A2 BR PI0607817A2
Authority
BR
Brazil
Prior art keywords
formula
preparation
macrocyclic
macrocyclic compounds
compounds
Prior art date
Application number
BRPI0607817-6A
Other languages
English (en)
Inventor
Fabrice Gallou
Azad Hossain
Suresh R Kapadia
Jianxiu Liu
Chris Hug Senanayake
Carl Alan Busacca
Nizar Haddad
Xudong Wei
Nathan K Yee
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BRPI0607817A2 publication Critical patent/BRPI0607817A2/pt
Publication of BRPI0607817B1 publication Critical patent/BRPI0607817B1/pt
Publication of BRPI0607817B8 publication Critical patent/BRPI0607817B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCESSO PARA A PREPARAçãO DE COMPOSTOS MACROCìCLICOS. A presente invenção refere-se a um processo para preparar um composto macrocíclico de fórmula (I) onde um composto macrocíclico hidroxil-substituído de fórmula (3) é reagido com um composto sulfonil-substituído de fórmula QUIN: Os compostos de fórmula (I) são agentes ativos potentes para o tratamento de infecção pelo vírus da hepatite O (HCV).
BRPI0607817A 2005-03-08 2006-03-06 compostos macrocíclicos e seu processo de preparação BRPI0607817B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65969605P 2005-03-08 2005-03-08
PCT/US2006/007954 WO2006096652A2 (en) 2005-03-08 2006-03-06 Process for preparing macrocyclic compounds

Publications (3)

Publication Number Publication Date
BRPI0607817A2 true BRPI0607817A2 (pt) 2009-10-06
BRPI0607817B1 BRPI0607817B1 (pt) 2019-11-26
BRPI0607817B8 BRPI0607817B8 (pt) 2021-05-25

Family

ID=36570780

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0607817A BRPI0607817B8 (pt) 2005-03-08 2006-03-06 compostos macrocíclicos e seu processo de preparação

Country Status (17)

Country Link
US (2) US7608614B2 (pt)
EP (2) EP1863833B1 (pt)
JP (2) JP5667745B2 (pt)
KR (2) KR101514953B1 (pt)
CN (2) CN103172697A (pt)
AU (1) AU2006220708B9 (pt)
BR (1) BRPI0607817B8 (pt)
CA (1) CA2600367C (pt)
DK (1) DK1863833T3 (pt)
ES (1) ES2439732T3 (pt)
IL (2) IL185779A (pt)
MX (1) MX2007010879A (pt)
NZ (1) NZ562167A (pt)
PL (1) PL1863833T3 (pt)
RU (2) RU2456296C2 (pt)
WO (1) WO2006096652A2 (pt)
ZA (1) ZA200706560B (pt)

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Also Published As

Publication number Publication date
US20060205638A1 (en) 2006-09-14
ZA200706560B (en) 2008-09-25
PL1863833T3 (pl) 2014-03-31
AU2006220708B2 (en) 2012-09-27
EP2332963A3 (en) 2011-11-16
EP1863833A2 (en) 2007-12-12
US8222369B2 (en) 2012-07-17
WO2006096652A3 (en) 2006-11-23
EP2332963A2 (en) 2011-06-15
IL228977A (en) 2015-11-30
BRPI0607817B8 (pt) 2021-05-25
IL185779A0 (en) 2008-01-06
RU2456296C2 (ru) 2012-07-20
KR101514953B1 (ko) 2015-04-24
KR20140059308A (ko) 2014-05-15
CA2600367A1 (en) 2006-09-14
JP2012255030A (ja) 2012-12-27
CN101160317A (zh) 2008-04-09
NZ562167A (en) 2011-01-28
WO2006096652A2 (en) 2006-09-14
JP2008533014A (ja) 2008-08-21
DK1863833T3 (da) 2013-12-02
JP5667745B2 (ja) 2015-02-12
KR20070117664A (ko) 2007-12-12
IL185779A (en) 2014-02-27
MX2007010879A (es) 2007-11-23
IL228977A0 (en) 2013-12-31
RU2012113243A (ru) 2013-10-10
RU2007136964A (ru) 2009-04-20
AU2006220708A1 (en) 2006-09-14
BRPI0607817B1 (pt) 2019-11-26
ES2439732T3 (es) 2014-01-24
EP1863833B1 (en) 2013-09-18
US7608614B2 (en) 2009-10-27
CN103172697A (zh) 2013-06-26
CA2600367C (en) 2014-08-12
CN101160317B (zh) 2013-03-27
US20090326194A1 (en) 2009-12-31
AU2006220708B9 (en) 2013-01-17

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B09Y Publication of grant cancelled [chapter 9.1.2 patent gazette]

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B06A Patent application procedure suspended [chapter 6.1 patent gazette]
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B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2661 DE 04-01-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.