BRPI0607926A2 - compostos espiro-oxindol e seus usos como agentes terapêuticos - Google Patents

compostos espiro-oxindol e seus usos como agentes terapêuticos

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Publication number
BRPI0607926A2
BRPI0607926A2 BRPI0607926-1A BRPI0607926A BRPI0607926A2 BR PI0607926 A2 BRPI0607926 A2 BR PI0607926A2 BR PI0607926 A BRPI0607926 A BR PI0607926A BR PI0607926 A2 BRPI0607926 A2 BR PI0607926A2
Authority
BR
Brazil
Prior art keywords
compounds
spiro
therapeutic agents
oxindole compounds
oxindole
Prior art date
Application number
BRPI0607926-1A
Other languages
English (en)
Inventor
Sultan Chowdhury
Robert Fraser
Rajender Kamboj
Duanjie Hou
Shifeng Liu
Mehran Seid Bagherzadeh
Serguei Sviridov
Shaoyi Sun
Nagasree Chakka
Vandna Raina
Mikhail Chafeev
Jianmin Fu
Jianyu Sun
Tom Hsieh
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of BRPI0607926A2 publication Critical patent/BRPI0607926A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

COMPOSTOS ESPIRO-OXINDOL E SEUS USOS COMO AGENTES TERAPêUTICOS. Esta invenção é direcionada aos compostos espiro-oxindol da fórmula (I) em que k, j, Q, R^ 1^, R^ 2a^, R^ 2b^, R^ 2c^, R^ 2d^, R^ 3a^, R^ 3b^, R^ 3c^, e R^ 3d^ são da maneira aqui definida, na forma de um estereoisâmero, enatiómero, tautómero destes ou suas misturas; ou um sal, solvato ou promedicamento farmaceuticamente aceitáveis destes, que são usados para o tratamento e/ou prevenção de doenças ou condiçoes mediadas pelo canal de sódio, tal como dor. Composições farmacêuticas compreendendo os compostos e métodos de preparar e usar os compostos também são revelados.
BRPI0607926-1A 2005-04-11 2006-04-11 compostos espiro-oxindol e seus usos como agentes terapêuticos BRPI0607926A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67089605P 2005-04-11 2005-04-11
PCT/US2006/014352 WO2006110917A2 (en) 2005-04-11 2006-04-11 Spiro-oxindole compounds and their uses as therapeutic agents

Publications (1)

Publication Number Publication Date
BRPI0607926A2 true BRPI0607926A2 (pt) 2009-11-24

Family

ID=36952847

Family Applications (1)

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BRPI0607926-1A BRPI0607926A2 (pt) 2005-04-11 2006-04-11 compostos espiro-oxindol e seus usos como agentes terapêuticos

Country Status (30)

Country Link
US (4) US7700641B2 (pt)
EP (4) EP1888595B1 (pt)
JP (4) JP5118627B2 (pt)
KR (5) KR20160130864A (pt)
CN (2) CN102153562B (pt)
AR (1) AR056968A1 (pt)
AT (1) ATE543825T1 (pt)
AU (1) AU2006235593B2 (pt)
BR (1) BRPI0607926A2 (pt)
CA (3) CA2604115C (pt)
DK (1) DK1888595T3 (pt)
EC (1) ECSP077852A (pt)
ES (2) ES2488618T3 (pt)
HK (1) HK1199874A1 (pt)
HR (1) HRP20070505B1 (pt)
IL (1) IL186616A (pt)
MA (1) MA29684B1 (pt)
MX (1) MX2007012636A (pt)
MY (2) MY144968A (pt)
NO (1) NO20074619L (pt)
NZ (1) NZ561210A (pt)
PL (1) PL1888595T3 (pt)
PT (1) PT1888595E (pt)
RS (1) RS52295B (pt)
RU (1) RU2415143C2 (pt)
SG (1) SG161262A1 (pt)
SI (1) SI1888595T1 (pt)
TN (1) TNSN07382A1 (pt)
TW (1) TWI374141B (pt)
WO (1) WO2006110917A2 (pt)

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