BRPI0608100A2 - materiais poliméricos altamente porosos compreendendo moléculas biologicamente ativas através de enxerto covalente - Google Patents

materiais poliméricos altamente porosos compreendendo moléculas biologicamente ativas através de enxerto covalente

Info

Publication number
BRPI0608100A2
BRPI0608100A2 BRPI0608100-2A BRPI0608100A BRPI0608100A2 BR PI0608100 A2 BRPI0608100 A2 BR PI0608100A2 BR PI0608100 A BRPI0608100 A BR PI0608100A BR PI0608100 A2 BRPI0608100 A2 BR PI0608100A2
Authority
BR
Brazil
Prior art keywords
biologically active
highly porous
species
porous polymeric
polymeric materials
Prior art date
Application number
BRPI0608100-2A
Other languages
English (en)
Inventor
Sebastien Pierre
Neil Ronald Cameron
Hest Jan Cornelis Maria Van
Paul WYMAN
Jens Christoph Thies
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of BRPI0608100A2 publication Critical patent/BRPI0608100A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2/00—Processes of polymerisation
    • C08F2/32—Polymerisation in water-in-oil emulsions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/087—Acrylic polymers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Graft Or Block Polymers (AREA)
  • Materials For Medical Uses (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

MATERIAIS POLIMêRICOS ALTAMENTE POROSOS COMPREENDENDO MOLéCULAS BIOLOGICAMENTE ATIVAS ATRAVéS DE ENXERTO COVALENTE. A presente invenção se refere aos materiais poliméricos altamente porosos, compreendendo espécies biologicamente ativas, enxertadas covalentemente. A invenção também se refere a um processo para a preparação de materiais altamente porosos, compreendendo monómeros funcionais capazes de enxerto em espécies moleculares biologicamente ativas compreendendo as etapas de: (a) preparação de uma composição em emulsão compreendendo uma fase em gotícula e uma fase contínua e contendo monómeros, (b) cura da emulsão e (c) remoção opcional da fase aquosa/em gotículas. A invenção se refere adicionalmente a um processo para enxerto de espécies biologicamente ativas em tal material polimérico altamente poroso compreendendo as etapas de: (i) exposição do material altamente poroso a uma solução de espécies moleculares biologicamente ativas em um meio solvente apropriado, (ii) adição opcional de um agente de ativação, (iii) aquecimento opcional e (iv) enxágúe do material poroso com um meio solvente para remover espécies não enxertadas. Os materiais poliméricos altamente porosos compreendendo espécies biologicamente ativas covalentemente enxertadas podem ser usados, por exemplo, como um catalisador heterogêneo, em biosensores, para cromatograf ia, em dispositivos biomédicos e em implantes.
BRPI0608100-2A 2005-04-22 2006-04-21 materiais poliméricos altamente porosos compreendendo moléculas biologicamente ativas através de enxerto covalente BRPI0608100A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05075957 2005-04-22
PCT/EP2006/003677 WO2006111399A2 (en) 2005-04-22 2006-04-21 Highly porous polymeric materials comprising biologically active molecules via covalent grafting

Publications (1)

Publication Number Publication Date
BRPI0608100A2 true BRPI0608100A2 (pt) 2009-11-03

Family

ID=36974715

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0608100-2A BRPI0608100A2 (pt) 2005-04-22 2006-04-21 materiais poliméricos altamente porosos compreendendo moléculas biologicamente ativas através de enxerto covalente

Country Status (7)

Country Link
US (1) US20090215913A1 (pt)
EP (1) EP1871878A2 (pt)
JP (1) JP2008536986A (pt)
KR (1) KR20080010402A (pt)
CN (1) CN101163789A (pt)
BR (1) BRPI0608100A2 (pt)
WO (1) WO2006111399A2 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102131593A (zh) * 2008-08-13 2011-07-20 长持续创新-L2I(有限责任公司) 用于结合活性分子到一个载体上的方法、通过所述方法获得的活性构件以及用于实施所述方法的化学组合物
EP2544664A1 (en) 2010-03-11 2013-01-16 Danmarks Tekniske Universitet Supported biologically active compounds
EP2552927B1 (en) * 2010-03-30 2019-03-13 SurModics, Inc. Degradable photo-crosslinkers
US9062245B2 (en) 2011-02-09 2015-06-23 Technion Research & Development Foundation Limited Liquid-retaining elastomeric compositions
US9180094B2 (en) 2011-10-12 2015-11-10 The Texas A&M University System High porosity materials, scaffolds, and method of making
US20160243277A1 (en) * 2013-09-23 2016-08-25 The Texas A & M University System Fast curing porous materials and control thereof
WO2015070074A2 (en) 2013-11-08 2015-05-14 The Texas A &M University System Porous microparticles with high loading efficiencies
IL245656B (en) 2016-05-16 2018-02-28 Technion Res & Dev Foundation Polymer structures with high absorption capacity
WO2018002916A1 (en) 2016-06-26 2018-01-04 Technion Research & Development Foundation Limited Hhh
IL247302B (en) 2016-08-16 2019-03-31 Technion Res & Dev Foundation Systems for releasing materials based on polymer emulsions
CN107164359B (zh) * 2017-06-30 2020-03-17 鲁东大学 一种具有良好热稳定性的葡萄糖氧化酶纳米凝胶的制备方法
IL253431A0 (en) 2017-07-11 2017-09-28 Technion Res & Dev Foundation Flexible compounds store liquids, their preparation processes and their uses
WO2019016816A1 (en) 2017-07-19 2019-01-24 Technion Research & Development Foundation Limited HYDROGELS WITH EMULSION MATRIX DOUBLELY RETICULATED BY REVERSIBLE METAL COORDINATION
IL255404B (en) 2017-11-02 2018-10-31 Technion Res & Dev Foundation A zwitterionic hydrogel in the configuration of an internal multiphase emulsion

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3130924A1 (de) * 1981-08-05 1983-02-17 Röhm GmbH, 6100 Darmstadt Oberflaechenreiche systeme zur fixierung von nucleophile gruppen enthaltenden substraten
DE3629177A1 (de) * 1986-08-28 1988-03-17 Hoechst Ag Vernetzte polymerisate und verfahren zu ihrer herstellung
GB8729889D0 (en) * 1987-12-22 1988-02-03 Unilever Plc Bio-catalysts support systems
JPH08322915A (ja) * 1995-05-29 1996-12-10 Synbolon Corp 病原体の失活方法
JPH11322997A (ja) * 1998-05-14 1999-11-26 Dainippon Ink & Chem Inc 多孔質ビーズの製造方法
KR101113201B1 (ko) * 2003-02-19 2012-04-12 나트릭스 세퍼레이션즈, 인코포레이티드 지지된 다공성 젤을 함유하는 복합재

Also Published As

Publication number Publication date
US20090215913A1 (en) 2009-08-27
EP1871878A2 (en) 2008-01-02
WO2006111399A3 (en) 2007-02-08
WO2006111399A2 (en) 2006-10-26
JP2008536986A (ja) 2008-09-11
KR20080010402A (ko) 2008-01-30
CN101163789A (zh) 2008-04-16
WO2006111399A8 (en) 2006-12-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012.

B15K Others concerning applications: alteration of classification

Ipc: C12N 11/06 (2006.01), C12N 11/08 (2006.01)