BRPI0608136A2 - base livre de lercanidipina - Google Patents

base livre de lercanidipina

Info

Publication number
BRPI0608136A2
BRPI0608136A2 BRPI0608136-3A BRPI0608136A BRPI0608136A2 BR PI0608136 A2 BRPI0608136 A2 BR PI0608136A2 BR PI0608136 A BRPI0608136 A BR PI0608136A BR PI0608136 A2 BRPI0608136 A2 BR PI0608136A2
Authority
BR
Brazil
Prior art keywords
free base
lercanidipine free
lercanidipine
purity
formulation
Prior art date
Application number
BRPI0608136-3A
Other languages
English (en)
Inventor
Amedeo Leonardi
Gianni Motta
Ilaria Candiani
Francesco Corcella
Fabio Berlati
Original Assignee
Recordati Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Ireland Ltd filed Critical Recordati Ireland Ltd
Publication of BRPI0608136A2 publication Critical patent/BRPI0608136A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)

Abstract

BASE LIVRE DE LERCANIDIPINA. A invenção fornece base livre de lercanidipina substancialmente pura, que tem uma pureza de pelo menos 95%, preferivelmente pelo menos cerca de 97%, mais preferivelmente pelo menos cerca de 99%, e ainda mais preferivelmente pelo menos cerca de 99,5%. A base livre de lercanidipina da presente invenção é formada como um sólido amorfo que é facilmente manuseado e particularmente bem adequado para a formulação de composições farmacêuticas.
BRPI0608136-3A 2005-02-25 2006-02-24 base livre de lercanidipina BRPI0608136A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65674105P 2005-02-25 2005-02-25
PCT/EP2006/001783 WO2006089788A1 (en) 2005-02-25 2006-02-24 Lercanidipine free base

Publications (1)

Publication Number Publication Date
BRPI0608136A2 true BRPI0608136A2 (pt) 2009-11-17

Family

ID=36587241

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0608136-3A BRPI0608136A2 (pt) 2005-02-25 2006-02-24 base livre de lercanidipina

Country Status (18)

Country Link
US (1) US20060199849A1 (pt)
EP (1) EP1853562A1 (pt)
JP (1) JP2008531516A (pt)
KR (1) KR20070105978A (pt)
CN (1) CN101142186A (pt)
AR (1) AR053023A1 (pt)
AU (1) AU2006218027A1 (pt)
BR (1) BRPI0608136A2 (pt)
CA (1) CA2597992A1 (pt)
EA (1) EA200701686A1 (pt)
IL (1) IL184348A0 (pt)
MX (1) MX2007010362A (pt)
NO (1) NO20074873L (pt)
PE (1) PE20061393A1 (pt)
TW (1) TW200640860A (pt)
UY (1) UY29400A1 (pt)
WO (1) WO2006089788A1 (pt)
ZA (1) ZA200708126B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100651212B1 (ko) * 2004-10-27 2006-12-01 제일약품주식회사 무정형 레르카니디핀의 제조방법
WO2008040367A1 (en) * 2006-08-01 2008-04-10 Union Quimico-Farmaceutica S.A. Lercanidipine hydrobromide, a process for its preparation, crystalline forms and compositions thereof
DE102010005124A1 (de) * 2010-01-19 2012-03-01 Stada Arzneimittel Ag Feste pharmazeutische Zusammensetzung umfassend Lercanidipin
CN102531999B (zh) * 2011-12-16 2014-02-26 华润赛科药业有限责任公司 无定形盐酸乐卡地平及其制备方法
CN102558032B (zh) * 2011-12-16 2014-02-26 华润赛科药业有限责任公司 一种无定形盐酸乐卡地平及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8403866D0 (en) * 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters
US5696139A (en) * 1995-05-12 1997-12-09 Recordati S.A., Chemical And Pharmaceutical Company Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure
US5767136A (en) * 1995-05-12 1998-06-16 Recordati, S.A. Chemical And Pharmaceutical Company 1,4-Dihydropyridines useful for prevention or reduction of atherosclerotic lesions on arterial walls
IT1275532B (it) * 1995-07-14 1997-08-07 Recordati Chem Pharm Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa
IT1298732B1 (it) * 1998-03-13 2000-02-02 Recordati Chem Pharm Composizioni farmaceutiche orali assumibili senza liquidi,contenenti complessi di inclusione
US20030069285A1 (en) * 2001-08-06 2003-04-10 Recordati Ireland Limited Novel solvate and crystalline forms of lercanidipine hydrochloride
US6852737B2 (en) * 2001-08-06 2005-02-08 Recordati Ireland Limited Crude and crystalline forms of lercanidipine hydrochloride
US20030180355A1 (en) * 2001-10-16 2003-09-25 Amedeo Leonardi Combination therapy for hypertension
US20040147566A1 (en) * 2002-10-16 2004-07-29 Amedeo Leonardi Lisinopril/lercanidipine combination therapy
JP2006504800A (ja) * 2002-10-16 2006-02-09 レコーダチ アイルランド リミテッド リシノプリル／レルカニジピンの組み合わせ治療
US20040198789A1 (en) * 2003-02-28 2004-10-07 Recordati Ireland Limited Lercanidipine/ARB/diuretic therapeutic combinations
KR20060125824A (ko) * 2003-12-01 2006-12-06 라이프사이클 파마 에이/에스 레르카니디핀을 포함한 약학적 조성물
TW200613275A (en) * 2004-08-24 2006-05-01 Recordati Ireland Ltd Lercanidipine salts
TW200616681A (en) * 2004-10-05 2006-06-01 Recordati Ireland Ltd Lercanidipine capsules

Also Published As

Publication number Publication date
WO2006089788A1 (en) 2006-08-31
JP2008531516A (ja) 2008-08-14
PE20061393A1 (es) 2007-01-16
KR20070105978A (ko) 2007-10-31
NO20074873L (no) 2007-11-22
AU2006218027A1 (en) 2006-08-31
AR053023A1 (es) 2007-04-18
CN101142186A (zh) 2008-03-12
EP1853562A1 (en) 2007-11-14
ZA200708126B (en) 2008-11-26
MX2007010362A (es) 2007-10-17
US20060199849A1 (en) 2006-09-07
EA200701686A1 (ru) 2008-02-28
IL184348A0 (en) 2007-10-31
CA2597992A1 (en) 2006-08-31
UY29400A1 (es) 2006-06-30
TW200640860A (en) 2006-12-01

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]