BRPI0608453A2 - compostos tendo atividade na correção de processamento de cftr mutante e usos destes - Google Patents

compostos tendo atividade na correção de processamento de cftr mutante e usos destes

Info

Publication number
BRPI0608453A2
BRPI0608453A2 BRPI0608453-2A BRPI0608453A BRPI0608453A2 BR PI0608453 A2 BRPI0608453 A2 BR PI0608453A2 BR PI0608453 A BRPI0608453 A BR PI0608453A BR PI0608453 A2 BRPI0608453 A2 BR PI0608453A2
Authority
BR
Brazil
Prior art keywords
containing compounds
compounds
activity
correction
processing
Prior art date
Application number
BRPI0608453-2A
Other languages
English (en)
Inventor
Nicoletta Pedemonte
Luis J V Galietta
Alan Verkman
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of BRPI0608453A2 publication Critical patent/BRPI0608453A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPOSTOS TENDO ATIVIDADE NA CORREçãO DE PROCESSAMENTO DE CFTR MUTANTE E USOS DESTES. A presente invenção refere-se a composições, preparações farmacêuticas e métodos para corrigir o processamento celular (por exemplo, duplicação, tráfico, ou modificação pós-transiacional) de uma proteína reguladora da condutância de transmembrana cística de fibrose mutante (por exemplo, <30>F508 CFTR) que são úteis para o tratamento de fibrose cística (CF). As composições e preparações farmacêuticas da invenção podem compreender um ou mais compostos contendo aminobenzotiazol, compostos contendo aminoariltiazol, compostos contendo quinazolinilaminopirimidinona, compostos contendo bisaminometilbitiazol, ou compostos da invenção contendo fenilaminoquinolina, ou um análogo ou derivado destes.
BRPI0608453-2A 2005-03-18 2006-03-08 compostos tendo atividade na correção de processamento de cftr mutante e usos destes BRPI0608453A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66350105P 2005-03-18 2005-03-18
PCT/US2006/008267 WO2006101740A2 (en) 2005-03-18 2006-03-08 Compounds having activity in correcting mutant-cftr processing and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0608453A2 true BRPI0608453A2 (pt) 2009-12-29

Family

ID=37024308

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0608453-2A BRPI0608453A2 (pt) 2005-03-18 2006-03-08 compostos tendo atividade na correção de processamento de cftr mutante e usos destes

Country Status (12)

Country Link
US (1) US8143295B2 (pt)
EP (1) EP1863522A4 (pt)
JP (1) JP2008538107A (pt)
KR (1) KR20070114820A (pt)
CN (1) CN101605543A (pt)
AU (1) AU2006227833A1 (pt)
BR (1) BRPI0608453A2 (pt)
CA (1) CA2600869A1 (pt)
IL (1) IL185999A0 (pt)
MX (1) MX2007011512A (pt)
RU (1) RU2007138584A (pt)
WO (1) WO2006101740A2 (pt)

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Also Published As

Publication number Publication date
US8143295B2 (en) 2012-03-27
KR20070114820A (ko) 2007-12-04
US20080318984A1 (en) 2008-12-25
CA2600869A1 (en) 2006-09-28
EP1863522A2 (en) 2007-12-12
JP2008538107A (ja) 2008-10-09
IL185999A0 (en) 2008-08-07
MX2007011512A (es) 2007-12-07
RU2007138584A (ru) 2009-04-27
EP1863522A4 (en) 2010-11-10
CN101605543A (zh) 2009-12-16
AU2006227833A1 (en) 2006-09-28
WO2006101740A3 (en) 2009-06-04
WO2006101740A2 (en) 2006-09-28

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