CR9377A - Un metodo de cromatografia de particion debil - Google Patents
Un metodo de cromatografia de particion debilInfo
- Publication number
- CR9377A CR9377A CR9377A CR9377A CR9377A CR 9377 A CR9377 A CR 9377A CR 9377 A CR9377 A CR 9377A CR 9377 A CR9377 A CR 9377A CR 9377 A CR9377 A CR 9377A
- Authority
- CR
- Costa Rica
- Prior art keywords
- partition chromatography
- chromatography method
- weak partition
- weak
- medium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/30—Partition chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/325—Reversed phase
- B01D15/327—Reversed phase with hydrophobic interaction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
- B01D15/3828—Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
Esta invencion se relaciona con metodos para usar cromatografia de particion debil para la purificacion de un producto desde un fluido de carga que contiene unas o mas impurezas. Adicionalmente la invencion se relaciona con metodos de cromatografia de particion debil definidos mediante las condiciones operativas que causan que un medio ligue por lo menos 1mg de producto por ml de medio, o alternativamente definido, por un coeficiente de particion de por lo menos 0,1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66043705P | 2005-03-11 | 2005-03-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR9377A true CR9377A (es) | 2008-02-21 |
Family
ID=36992346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR9377A CR9377A (es) | 2005-03-11 | 2007-09-12 | Un metodo de cromatografia de particion debil |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US8067182B2 (es) |
| EP (1) | EP1869065B1 (es) |
| JP (1) | JP5199063B2 (es) |
| KR (2) | KR101482791B1 (es) |
| CN (2) | CN104610422A (es) |
| AU (1) | AU2006223180B2 (es) |
| BR (1) | BRPI0608584B8 (es) |
| CA (1) | CA2601062C (es) |
| CR (1) | CR9377A (es) |
| DK (1) | DK1869065T3 (es) |
| ES (1) | ES2797480T3 (es) |
| HK (1) | HK1210476A1 (es) |
| HU (1) | HUE049797T2 (es) |
| IL (1) | IL185687A (es) |
| MX (1) | MX2007011129A (es) |
| NO (1) | NO20074443L (es) |
| PL (1) | PL1869065T3 (es) |
| PT (1) | PT1869065T (es) |
| RU (1) | RU2457214C2 (es) |
| SI (1) | SI1869065T1 (es) |
| WO (1) | WO2006099308A2 (es) |
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| EP1869065B1 (en) * | 2005-03-11 | 2020-05-06 | Wyeth LLC | A method of weak partitioning chromatography |
| JP2010510963A (ja) * | 2006-06-14 | 2010-04-08 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | セラミックヒドロキシアパタイトを使用する抗体の精製方法 |
| SI2061803T2 (sl) | 2006-08-28 | 2023-01-31 | Ares Trading S.A. | Postopek za čiščenje proteinov, ki vsebujejo FC |
| CN101511387A (zh) * | 2006-09-08 | 2009-08-19 | 惠氏公司 | 使用亲和色谱法纯化蛋白质的精氨酸洗涤液 |
| AU2007294731B2 (en) | 2006-09-13 | 2014-04-17 | Abbvie Inc. | Cell culture improvements |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| SI2078071T1 (sl) | 2006-11-08 | 2015-05-29 | Wyeth Llc | Racionalno zasnovana gojišča za celično kulturo |
| ES2533266T5 (es) | 2007-10-30 | 2018-04-18 | Genentech, Inc. | Purificación de anticuerpos mediante cromatografía de intercambio catiónico |
| EP2238154B1 (en) | 2008-01-18 | 2015-09-16 | Bio-Rad Laboratories, Inc. | Enhanced purification of phosphorylated and non-phosphorylated biomolecules by apatite chromatography |
| BRPI0823046B1 (pt) | 2008-08-14 | 2021-12-14 | Genentech, Inc | Método para purificar um anticorpo monoclonal de uma composição compreendendo o anticorpo monoclonal e pelo menos uma proteína de ovário de hamster chinês (chop) |
| US20100069617A1 (en) * | 2008-09-12 | 2010-03-18 | Ge Healthcare Bio-Sciences Ab | Enhanced protein aggregate removal by mixed mode chromatography on hydrophobic interaction media in the presence of protein-excluded zwitterions |
| US20110166332A1 (en) * | 2008-09-12 | 2011-07-07 | Ge Healthcare Bio-Sciences Ab | Enhanced antibody aggregate removal with capto adhere in the presence of protein-excluded zwitterions |
| NZ592095A (en) | 2008-10-20 | 2013-01-25 | Abbott Lab | Isolation and purification of il-12 and tnf-alpha antibodies using protein a affinity chromatography |
| BRPI0920572A8 (pt) | 2008-10-20 | 2015-10-27 | Abbott Lab | Inativação viral durante a purificação dos anticorpos |
| BRPI0919879A2 (pt) | 2008-10-29 | 2016-02-16 | Wyeth Llc | métodos para purificação de moléculas de ligação a antígeno de domínio único |
| CA2738243C (en) | 2008-10-29 | 2020-09-29 | Wyeth Llc | Formulations of single domain antigen binding molecules |
| JP2012513425A (ja) | 2008-12-22 | 2012-06-14 | エフ.ホフマン−ラ ロシュ アーゲー | 免疫グロブリンの精製 |
| ES2982297T3 (es) * | 2009-12-18 | 2024-10-15 | Novartis Ag | Método de cromatografía de afinidad |
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| KR101976853B1 (ko) * | 2010-05-25 | 2019-05-09 | 제넨테크, 인크. | 폴리펩티드의 정제 방법 |
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| US8895707B2 (en) | 2010-08-18 | 2014-11-25 | Bio-Rad Laboratories, Inc. | Elution of proteins from hydroxyapatite resins without resin deterioration |
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| EP2670704B1 (en) | 2011-02-02 | 2018-12-12 | Bio-Rad Laboratories, Inc. | Apatite surface neutralization with alkali solutions |
| US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| CN103827134A (zh) | 2011-07-20 | 2014-05-28 | 泽普泰恩股份有限公司 | 多肽分离方法 |
| HUE035685T2 (en) | 2011-11-02 | 2018-05-28 | Hoffmann La Roche | Overload and elute chromatography |
| SG10201701224UA (en) | 2012-03-12 | 2017-04-27 | Merck Patent Gmbh | Removal of protein aggregates from biopharmaceutical preparations in a flowthrough mode |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
| WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
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| SG11201407809QA (en) * | 2012-05-31 | 2014-12-30 | Agency Science Tech & Res | Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities |
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| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
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| JP6326499B2 (ja) | 2013-12-12 | 2018-05-16 | イー・エム・デイー・ミリポア・コーポレイシヨン | アクリルアミド含有フィルターを使用したタンパク質分離 |
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| EP4096802A4 (en) * | 2020-01-29 | 2024-07-03 | Merck Sharp & Dohme LLC | METHOD FOR SEPARATION OF HOST CELL LIPASES FROM ANTI-LAG3 ANTIBODY PRODUCTION |
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-
2006
- 2006-03-10 EP EP06738028.7A patent/EP1869065B1/en not_active Revoked
- 2006-03-10 WO PCT/US2006/008919 patent/WO2006099308A2/en not_active Ceased
- 2006-03-10 PT PT67380287T patent/PT1869065T/pt unknown
- 2006-03-10 CA CA2601062A patent/CA2601062C/en not_active Expired - Lifetime
- 2006-03-10 CN CN201410849296.4A patent/CN104610422A/zh active Pending
- 2006-03-10 KR KR20077020848A patent/KR101482791B1/ko not_active Expired - Lifetime
- 2006-03-10 JP JP2008501028A patent/JP5199063B2/ja not_active Expired - Lifetime
- 2006-03-10 HU HUE06738028A patent/HUE049797T2/hu unknown
- 2006-03-10 SI SI200632376T patent/SI1869065T1/sl unknown
- 2006-03-10 BR BRPI0608584A patent/BRPI0608584B8/pt active IP Right Grant
- 2006-03-10 US US11/372,054 patent/US8067182B2/en active Active
- 2006-03-10 ES ES06738028T patent/ES2797480T3/es not_active Expired - Lifetime
- 2006-03-10 AU AU2006223180A patent/AU2006223180B2/en not_active Expired
- 2006-03-10 KR KR1020137028820A patent/KR101660575B1/ko not_active Expired - Lifetime
- 2006-03-10 RU RU2007132851/10A patent/RU2457214C2/ru not_active Application Discontinuation
- 2006-03-10 DK DK06738028.7T patent/DK1869065T3/da active
- 2006-03-10 MX MX2007011129A patent/MX2007011129A/es active IP Right Grant
- 2006-03-10 CN CNA200680016391XA patent/CN101175765A/zh active Pending
- 2006-03-10 PL PL06738028T patent/PL1869065T3/pl unknown
- 2006-08-28 US US11/510,634 patent/US20070054390A1/en not_active Abandoned
-
2007
- 2007-09-03 IL IL185687A patent/IL185687A/en active IP Right Grant
- 2007-09-03 NO NO20074443A patent/NO20074443L/no not_active Application Discontinuation
- 2007-09-12 CR CR9377A patent/CR9377A/es not_active Application Discontinuation
-
2011
- 2011-11-28 US US13/305,045 patent/US9144755B2/en active Active
-
2015
- 2015-11-12 HK HK15111155.1A patent/HK1210476A1/xx unknown
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