BRPI0609783A8 - composto, utilização do mesmo, composição farmacêutica ou cosmética, e, utilização cosmética de um composto - Google Patents

composto, utilização do mesmo, composição farmacêutica ou cosmética, e, utilização cosmética de um composto

Info

Publication number
BRPI0609783A8
BRPI0609783A8 BRPI0609783A BRPI0609783A BRPI0609783A8 BR PI0609783 A8 BRPI0609783 A8 BR PI0609783A8 BR PI0609783 A BRPI0609783 A BR PI0609783A BR PI0609783 A BRPI0609783 A BR PI0609783A BR PI0609783 A8 BRPI0609783 A8 BR PI0609783A8
Authority
BR
Brazil
Prior art keywords
compound
cosmetic
halogen atoms
pharmaceutical
groups
Prior art date
Application number
BRPI0609783A
Other languages
English (en)
Inventor
Franck Gisèle
Bakala Joanna
Ermolenko Lioudmila
Concepcion Achab Garcia Alvarez Maria
Bakrim Nhiri Naïma
André Sasaki Nobumichi
Potier Pierre
Wang-Zhu Qian
Original Assignee
Centre Nat Rech Scient
Pharmamens
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Pharmamens filed Critical Centre Nat Rech Scient
Publication of BRPI0609783A2 publication Critical patent/BRPI0609783A2/pt
Publication of BRPI0609783A8 publication Critical patent/BRPI0609783A8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Nutrition Science (AREA)

Abstract

composto, utilização do mesmo, composição farmacêutica ou cosmética, e, utilização cosmética de um composto. a presente invenção refere-se a um composto de fórmula geral seguinte i, em que x representa ch~2~, c=o, c=s ou choh, x representa ch~2~, c=o, c=s, choh, r~1~ representa um aminoácido, eventualmente substituído por um ou vários átomos de halogênio, vantajosamente flúor, ou por um ou vários grupos cf~3~, e n=0, 1 ou 2 ou x representa ch~2~, c=o, c=s, choh, r~1~ representa um peptídeo contendo dois aminoácidos, cada aminoácido sendo eventualmente substituído por um ou vários átomos de halogênio, com vantagem flúor, ou por um ou vários grupos cf~3~, e n=o ou 1, ou xr~1~ representando po~3~h ou so~3~h e n=0,1 ou 2; r~2~ representa h, xr1, um grupo alquila em c~1~-c~6~, um grupo aralquila em c~1~-c~6~, ou um grupo arila, os grupos alquilas, aralquilas e arilas podendo ser substituidos por uma amina nh~2~, um grupo carboxílico cooh, ou um ou vários átomos de halogênio, com vantagem flúor, ou um ou vários grupos cf~3~, ou seus sais de adição farmaceuticamente aceitáveis, isômeros, enantiômeros, diastereoisômeros, assim como suas misturas, e as composições farmacêuticas ou cosméticas compreendendo os mesmos e sua utilização como um medicamento captador de compostos carbonila reativos inibidor de ages.
BRPI0609783A 2005-03-31 2006-03-30 composto, utilização do mesmo, composição farmacêutica ou cosmética, e, utilização cosmética de um composto BRPI0609783A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0503176A FR2883873B1 (fr) 2005-03-31 2005-03-31 Inhibiteurs d'age
FR0503176 2005-03-31
PCT/EP2006/061191 WO2006103274A1 (fr) 2005-03-31 2006-03-30 Inhibiteurs d'age

Publications (2)

Publication Number Publication Date
BRPI0609783A2 BRPI0609783A2 (pt) 2011-10-11
BRPI0609783A8 true BRPI0609783A8 (pt) 2018-03-13

Family

ID=34955359

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0609783A BRPI0609783A8 (pt) 2005-03-31 2006-03-30 composto, utilização do mesmo, composição farmacêutica ou cosmética, e, utilização cosmética de um composto

Country Status (16)

Country Link
US (2) US20080249030A1 (pt)
EP (1) EP1863832B1 (pt)
JP (1) JP4695186B2 (pt)
KR (2) KR101536839B1 (pt)
CN (1) CN101268093B (pt)
AT (1) ATE540051T1 (pt)
AU (1) AU2006228163A1 (pt)
BR (1) BRPI0609783A8 (pt)
CA (1) CA2603386C (pt)
EA (1) EA200702104A1 (pt)
FR (1) FR2883873B1 (pt)
GE (1) GEP20104882B (pt)
MA (1) MA29416B1 (pt)
MX (1) MX2007012238A (pt)
WO (1) WO2006103274A1 (pt)
ZA (1) ZA200708835B (pt)

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WO2008126652A1 (ja) * 2007-03-20 2008-10-23 Shiseido Company, Ltd. 皮膚外用組成物
JP5875190B2 (ja) * 2009-05-29 2016-03-02 ルプレヒト−カールス−ウニヴェルジテート ハイデルベルクＲｕｐｒｅｃｈｔ−Ｋａｒｌｓ−Ｕｎｉｖｅｒｓｉｔａｅｔ Ｈｅｉｄｅｌｂｅｒｇ メチルグリオキサール−スカベンジング化合物ならびに疼痛および／または痛覚過敏の予防および治療のためのその使用
JP5787339B2 (ja) * 2009-12-28 2015-09-30 学校法人福岡大学 糖尿病前症の検査方法
FR2981073B1 (fr) * 2011-10-07 2013-12-27 Pharmamens Composes piegeurs d'alpha-oxoaldehydes et d'aldehydes alpha, beta-insatures, compositions les contenant et leurs utilisations dans des traitements de maladies liees a l'accumulation des age et ale.
CA2906501A1 (en) * 2013-03-15 2014-09-25 Genzyme Corporation Sequestrants of advanced glycation end product (age) precursors
JP6674455B2 (ja) * 2014-10-22 2020-04-01 アモーレパシフィック コーポレーションＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ ラテックス発泡フォームを含む化粧料組成物担体
FR3038605B1 (fr) * 2015-07-06 2018-08-24 Universite Amiens Picardie Jules Verne Diamines primaires vicinales associees a des motifs chelateurs de metaux et/ou de radicaux libres, actives contre les stress carbonyle et oxydant et leur utilisation
JP6553491B2 (ja) * 2015-11-26 2019-07-31 オリエンタル酵母工業株式会社 最終糖化産物（ＡＧＥｓ）が関連する疾患の罹患又はそのリスクを予測する方法
CN112898342A (zh) * 2017-06-26 2021-06-04 上海日馨生物科技有限公司 苯磷硫胺衍生物、制备方法及其药物组合物
TWI685338B (zh) * 2017-12-14 2020-02-21 柯瑞 伊里阿斯 Ｊ 使用非可吸收性口服投予之化合物之包括第2型糖尿病、脂肪肝炎及相關病況之人類代謝症候群之預防及治療
JPWO2020071258A1 (ja) * 2018-10-03 2021-09-02 味の素株式会社 タンパク質糖化抑制剤
CN112881581B (zh) * 2021-01-15 2022-04-01 中国海洋大学 一种定量检测水产品中吡咯素和甲基乙二醛氢咪唑酮的方法
WO2022159473A1 (en) 2021-01-20 2022-07-28 New York University Methods and compositions for treating 4-hydroxyphenylpyruvate dioxygenase-like (hpdl)-related diseases or disorders
IL328643A (en) * 2023-12-20 2026-07-01 Univ New York COQ10 supplementation using 4-HMA
WO2026085537A1 (en) * 2024-10-18 2026-04-23 Research Foundation Of The City University Of New York Nanoligands for affinity chromatography and methods of use therefore

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Also Published As

Publication number Publication date
CN101268093A (zh) 2008-09-17
KR101343929B1 (ko) 2013-12-24
JP4695186B2 (ja) 2011-06-08
EA200702104A1 (ru) 2008-02-28
AU2006228163A1 (en) 2006-10-05
FR2883873A1 (fr) 2006-10-06
KR20080006557A (ko) 2008-01-16
ZA200708835B (en) 2009-09-30
CA2603386A1 (fr) 2006-10-05
MX2007012238A (es) 2008-03-18
BRPI0609783A2 (pt) 2011-10-11
WO2006103274A1 (fr) 2006-10-05
MA29416B1 (fr) 2008-04-01
WO2006103274A9 (fr) 2007-01-18
WO2006103274A8 (fr) 2007-05-03
GEP20104882B (en) 2010-01-11
CA2603386C (fr) 2018-03-06
US20080249030A1 (en) 2008-10-09
EP1863832B1 (fr) 2012-01-04
KR20130110222A (ko) 2013-10-08
FR2883873B1 (fr) 2009-07-10
KR101536839B1 (ko) 2015-07-14
ATE540051T1 (de) 2012-01-15
CN101268093B (zh) 2013-04-03
JP2008534557A (ja) 2008-08-28
EP1863832A1 (fr) 2007-12-12
US9512176B2 (en) 2016-12-06
US20120252866A1 (en) 2012-10-04

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