ATE540051T1 - Age-inhibitoren - Google Patents

Age-inhibitoren

Info

Publication number: ATE540051T1
Authority: AT; Austria
Prior art keywords: halogen atoms; groups; group; amino acid; optionally substituted
Prior art date: 2005-03-31

Application number

AT06725441T

Other languages

English (en)

Inventor

Nobumichi Sasaki

Garcia Alvarez Maria Achab

Qian Wang-Zhu

Lioudmila Ermolenko

Joanna Bakala

Gisele Franck

Nhiri Naima Bakrim

Pierre Potier

Original Assignee

Centre Nat Rech Scient

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-03-31

Filing date

2006-03-30

Publication date

2012-01-15

2006-03-30 Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient

2012-01-15 Application granted granted Critical

2012-01-15 Publication of ATE540051T1 publication Critical patent/ATE540051T1/de

Links

239000003112 inhibitor Substances 0.000 title 1
150000001413 amino acids Chemical class 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
229910018830 PO3H Inorganic materials 0.000 abstract 1
229910006069 SO3H Inorganic materials 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Ophthalmology & Optometry (AREA)
Hematology (AREA)
Obesity (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Nutrition Science (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)

AT06725441T 2005-03-31 2006-03-30 Age-inhibitoren ATE540051T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0503176A FR2883873B1 (fr)	2005-03-31	2005-03-31	Inhibiteurs d'age
PCT/EP2006/061191 WO2006103274A1 (fr)	2005-03-31	2006-03-30	Inhibiteurs d'age

Publications (1)

Publication Number	Publication Date
ATE540051T1 true ATE540051T1 (de)	2012-01-15

Family

ID=34955359

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06725441T ATE540051T1 (de)	2005-03-31	2006-03-30	Age-inhibitoren

Country Status (16)

Country	Link
US (2)	US20080249030A1 (de)
EP (1)	EP1863832B1 (de)
JP (1)	JP4695186B2 (de)
KR (2)	KR101536839B1 (de)
CN (1)	CN101268093B (de)
AT (1)	ATE540051T1 (de)
AU (1)	AU2006228163A1 (de)
BR (1)	BRPI0609783A8 (de)
CA (1)	CA2603386C (de)
EA (1)	EA200702104A1 (de)
FR (1)	FR2883873B1 (de)
GE (1)	GEP20104882B (de)
MA (1)	MA29416B1 (de)
MX (1)	MX2007012238A (de)
WO (1)	WO2006103274A1 (de)
ZA (1)	ZA200708835B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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CN101646416B (zh) *	2007-03-20	2011-08-17	株式会社资生堂	皮肤外用组合物
EP2435465B1 (de) *	2009-05-29	2016-03-09	Ruprecht-Karls-Universität Heidelberg	Methylglyoxal-absorbierende verbindungen und zusammensetzungen zur verwendung zur prävention und behandlung von schmerz und/oder hyperalgesie
JP5787339B2 (ja) *	2009-12-28	2015-09-30	学校法人福岡大学	糖尿病前症の検査方法
FR2981073B1 (fr) *	2011-10-07	2013-12-27	Pharmamens	Composes piegeurs d'alpha-oxoaldehydes et d'aldehydes alpha, beta-insatures, compositions les contenant et leurs utilisations dans des traitements de maladies liees a l'accumulation des age et ale.
HK1220607A1 (zh) *	2013-03-15	2017-05-12	Genzyme Corporation	晚期糖化终产物(age)前体的螯合剂
JP6674455B2 (ja) *	2014-10-22	2020-04-01	アモーレパシフィックコーポレーションＡｍｏｒｅｐａｃｉｆｉｃＣｏｒｐｏｒａｔｉｏｎ	ラテックス発泡フォームを含む化粧料組成物担体
FR3038605B1 (fr)	2015-07-06	2018-08-24	Universite Amiens Picardie Jules Verne	Diamines primaires vicinales associees a des motifs chelateurs de metaux et/ou de radicaux libres, actives contre les stress carbonyle et oxydant et leur utilisation
JP6553491B2 (ja) *	2015-11-26	2019-07-31	オリエンタル酵母工業株式会社	最終糖化産物（ＡＧＥｓ）が関連する疾患の罹患又はそのリスクを予測する方法
CN109111478B (zh) *	2017-06-26	2021-02-26	上海日馨生物科技有限公司	苯磷硫胺衍生物、制备方法及其药物组合物
TWI685338B (zh) *	2017-12-14	2020-02-21	柯瑞伊里阿斯Ｊ	使用非可吸收性口服投予之化合物之包括第2型糖尿病、脂肪肝炎及相關病況之人類代謝症候群之預防及治療
WO2020071258A1 (ja) *	2018-10-03	2020-04-09	味の素株式会社	タンパク質糖化抑制剤
CN112881581B (zh) *	2021-01-15	2022-04-01	中国海洋大学	一种定量检测水产品中吡咯素和甲基乙二醛氢咪唑酮的方法
WO2022159473A1 (en)	2021-01-20	2022-07-28	New York University	Methods and compositions for treating 4-hydroxyphenylpyruvate dioxygenase-like (hpdl)-related diseases or disorders
WO2025137572A1 (en) *	2023-12-20	2025-06-26	New York University	Coq10 repletion using 4-hma

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US4908446A (en) *	1985-11-14	1990-03-13	The Rockefeller University	Inhibitors of nonenzymatic cross-linking
US4758583A (en) *	1984-03-19	1988-07-19	The Rockefeller University	Method and agents for inhibiting protein aging
US4900747A (en) *	1984-03-19	1990-02-13	The Rockefeller University	Method and agents for removing advanced glycosylation endproducts
FI890918A7 (fi) *	1988-03-11	1989-09-12	Eisai Co Ltd	Polypeptider.
US5232735A (en)	1990-06-01	1993-08-03	Bioresearch, Inc.	Ingestibles containing substantially tasteless sweetness inhibitors as bitter taste reducers or substantially tasteless bitter inhibitors as sweet taste reducers
EP0572560B1 (de) *	1991-02-22	2003-01-29	SHAPIRO, Howard, K.	Verwendung von pharmazeutischen wirkstoffen zur behandlung von krankheitssymptomen neurologischer erkrankungen und etiologisch verwandter symptomenkomplexe
US5561110A (en) *	1991-09-09	1996-10-01	Peptide Technology Limited	Method for the treatment of the complications and pathology of diabetes
HUT68764A (en) *	1991-11-27	1995-07-28	Bioresearch Inc	Eatable taste modifiers
GB9200415D0 (en) *	1992-01-09	1992-02-26	Bagshawe Kenneth D	Inactivation of cytotoxic drugs
US5780588A (en) *	1993-01-26	1998-07-14	Arizona Board Of Regents	Elucidation and synthesis of selected pentapeptides
US5629174A (en)	1993-07-26	1997-05-13	Cor Therapeutics, Inc.	Recombinant C140 receptor
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DK61695A (da) *	1995-06-01	1996-12-02	Aarhus Oliefabrik As	Kakaoflavouraktive peptider, DNA som koder for dem, fremgangsmåder til fremstilling af peptiderne og deres anvendelse til frembringelse af kakaoflavour
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DE10048260A1 (de) *	2000-09-29	2002-04-11	Beiersdorf Ag	Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an Aminoguanidin und/oder dessen Derivaten und Strukturanaloga zur Hautaufhellung von Altersflecken und/oder zur Verhinderung der Hautbräunung, insbesondere der durch UV-Strahlung hervorgerufenen Hautbräunung
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US20030135023A1 (en) *	2001-06-27	2003-07-17	Hans-Ulrich Demuth	Peptide structures useful for competitive modulation of dipeptidyl peptidase IV catalysis
JP2005514919A (ja) *	2001-10-15	2005-05-26	バーンズ−ジューイッシュホスピタル	骨抗吸収化合物
AU2002333155A1 (en) *	2001-10-30	2003-05-12	Pentapharm Ag	Dermopharmaceutically and cosmetically active oligopeptides
CA2481334A1 (en) *	2002-04-01	2003-10-16	Anthony C. Stevens	Tissue-specific endothelial membrane proteins
WO2004002418A2 (en) *	2002-06-26	2004-01-08	Entremed, Inc	Compositions and methods comprising protein activated receptor antagonists

2005
- 2005-03-31 FR FR0503176A patent/FR2883873B1/fr not_active Expired - Fee Related
2006
- 2006-03-30 EA EA200702104A patent/EA200702104A1/ru unknown
- 2006-03-30 EP EP06725441A patent/EP1863832B1/de not_active Expired - Lifetime
- 2006-03-30 US US11/909,761 patent/US20080249030A1/en not_active Abandoned
- 2006-03-30 MX MX2007012238A patent/MX2007012238A/es unknown
- 2006-03-30 KR KR1020137021845A patent/KR101536839B1/ko not_active Expired - Fee Related
- 2006-03-30 AT AT06725441T patent/ATE540051T1/de active
- 2006-03-30 CA CA2603386A patent/CA2603386C/fr not_active Expired - Fee Related
- 2006-03-30 GE GEAP200610342A patent/GEP20104882B/en unknown
- 2006-03-30 AU AU2006228163A patent/AU2006228163A1/en not_active Abandoned
- 2006-03-30 BR BRPI0609783A patent/BRPI0609783A8/pt not_active Application Discontinuation
- 2006-03-30 JP JP2008503523A patent/JP4695186B2/ja not_active Expired - Fee Related
- 2006-03-30 CN CN2006800149170A patent/CN101268093B/zh not_active Expired - Fee Related
- 2006-03-30 WO PCT/EP2006/061191 patent/WO2006103274A1/fr not_active Ceased
2007
- 2007-10-16 KR KR1020077023743A patent/KR101343929B1/ko not_active Expired - Fee Related
- 2007-10-16 ZA ZA200708835A patent/ZA200708835B/xx unknown
- 2007-10-30 MA MA30340A patent/MA29416B1/fr unknown
2012
- 2012-04-02 US US13/437,491 patent/US9512176B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1863832A1 (de)	2007-12-12
WO2006103274A1 (fr)	2006-10-05
WO2006103274A9 (fr)	2007-01-18
CA2603386A1 (fr)	2006-10-05
JP2008534557A (ja)	2008-08-28
FR2883873A1 (fr)	2006-10-06
FR2883873B1 (fr)	2009-07-10
GEP20104882B (en)	2010-01-11
MX2007012238A (es)	2008-03-18
KR20080006557A (ko)	2008-01-16
AU2006228163A1 (en)	2006-10-05
KR101343929B1 (ko)	2013-12-24
ZA200708835B (en)	2009-09-30
EP1863832B1 (de)	2012-01-04
CA2603386C (fr)	2018-03-06
KR101536839B1 (ko)	2015-07-14
BRPI0609783A8 (pt)	2018-03-13
CN101268093A (zh)	2008-09-17
WO2006103274A8 (fr)	2007-05-03
KR20130110222A (ko)	2013-10-08
US20120252866A1 (en)	2012-10-04
EA200702104A1 (ru)	2008-02-28
CN101268093B (zh)	2013-04-03
MA29416B1 (fr)	2008-04-01
US9512176B2 (en)	2016-12-06
JP4695186B2 (ja)	2011-06-08
US20080249030A1 (en)	2008-10-09
BRPI0609783A2 (pt)	2011-10-11

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MA29416B1 (fr)	2008-04-01	Inhibiteurs d'age
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MY148953A (en)	2013-06-14	Substituted biphenyl carboxylic acids and derivatives thereof
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