BRPI0610087A2 - composto para resfriamento - Google Patents
composto para resfriamentoInfo
- Publication number
- BRPI0610087A2 BRPI0610087A2 BRPI0610087-2A BRPI0610087A BRPI0610087A2 BR PI0610087 A2 BRPI0610087 A2 BR PI0610087A2 BR PI0610087 A BRPI0610087 A BR PI0610087A BR PI0610087 A2 BRPI0610087 A2 BR PI0610087A2
- Authority
- BR
- Brazil
- Prior art keywords
- nhch
- och
- formula
- cooling
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000001816 cooling Methods 0.000 title abstract 4
- 241000208125 Nicotiana Species 0.000 abstract 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 235000013361 beverage Nutrition 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 235000009508 confectionery Nutrition 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000000551 dentifrice Substances 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002324 mouth wash Substances 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/20—Synthetic spices, flavouring agents or condiments
- A23L27/204—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q9/00—Preparations for removing hair or for aiding hair removal
- A61Q9/02—Shaving preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/24—Thermal properties
- A61K2800/244—Endothermic; Cooling; Cooling sensation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Confectionery (AREA)
- Seasonings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
COMPOSTOS PARA RESFRIAMENTO. A presente invenção refere-se a método para conferir um efeito de resfriamento para a pele ou para as membranas mucosas através da a- plicação as mesmas de pelo menos de um composto da fórmula I (a) na qual B é selecionado a partir de H, CH~ 3~, C~ 2~H~ 5~, OCH~ 3~, OC~ 2~H~ 5~; e OH; e (b) na qual A é uma porção da fórmula -CO-D, na qual D é selecionado a partir das seguinte porçóes:(i) -NR¹R², na qual R¹ e R² são independentemente selecionados a partir de H e grupos alifáticos de cadeia linear ou ramificada de C~ 1~-C~ 8~ alcoxialquila, hidroxialquila, grupos aralifáticos e de cicloalquila, ou R¹ e R² em conjunto com o átomo de nitrogénio ao qual eles estão ligados formam parte de anel heterocíclico de cinco ou seis elementos opcionalmente substituidos; (ii) -NHCH~ 2~COOCH~ 2~CH~ 3~, -NHCH~ 2~CONH~ 2~, -NHCH~ 2~CH~ 2~OCH~ 3~, -NHCH~ 2~CH2OH, -NHCH~ 2~ CH(OH)CH~ 2~OH e (iii) uma porção selecionada a partir do grupo que consiste em: Os compostos são úteis para prover efeitos de resfriamento em uma variedade de produtos tais como produtos alimentícios, confeitos, produtos de tabaco, bebidas, cosméticos, dentifrícios, preparações medicinais, líquidos para lavagem bucal ou produ- tos de toucador.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68554805P | 2005-05-27 | 2005-05-27 | |
| PCT/CH2006/000270 WO2006125334A1 (en) | 2005-05-27 | 2006-05-24 | Cooling compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0610087A2 true BRPI0610087A2 (pt) | 2008-12-02 |
Family
ID=36751575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0610087-2A BRPI0610087A2 (pt) | 2005-05-27 | 2006-05-24 | composto para resfriamento |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20090105237A1 (pt) |
| EP (1) | EP1885327A1 (pt) |
| JP (1) | JP2009501132A (pt) |
| KR (1) | KR20080020609A (pt) |
| CN (1) | CN101184470A (pt) |
| BR (1) | BRPI0610087A2 (pt) |
| MX (1) | MX2007014456A (pt) |
| WO (1) | WO2006125334A1 (pt) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100582089C (zh) | 2003-11-21 | 2010-01-20 | 吉万奥丹股份有限公司 | N-取代的对-薄荷烷甲酰胺 |
| US20070148284A1 (en) | 2004-08-25 | 2007-06-28 | Cadbury Adams Usa Llc. | Liquid-filled chewing gum |
| US7772266B2 (en) | 2006-02-15 | 2010-08-10 | Dendreon Corporation | Small-molecule modulators of TRP-P8 activity |
| SI1986622T1 (sl) * | 2006-02-15 | 2014-02-28 | Dendreon Corporation | Malomolekulski modulatorji aktivnosti Trp-p8 |
| US20100056636A1 (en) * | 2006-12-20 | 2010-03-04 | Stefan Michael Furrer | N-Substituted-P-Menthane-3-Carboxamide and Uses Thereof |
| GB0704163D0 (en) | 2007-03-02 | 2007-04-11 | Quest Int Serv Bv | Compositions comprising a physiological coolant |
| WO2008141469A2 (en) | 2007-05-23 | 2008-11-27 | Givaudan Sa | Butone derivatives useful as cooling agents |
| PL2219467T3 (pl) | 2007-11-29 | 2015-02-27 | Intercontinental Great Brands Llc | Guma do żucia z wieloma obszarami z substancjami czynnymi |
| US8377422B2 (en) | 2007-12-07 | 2013-02-19 | Givaudan S.A. | Carboxamide derivatives having cooling properties |
| EP2250154A1 (en) * | 2008-01-17 | 2010-11-17 | Givaudan SA | Benzimidazole derivatives and their use as cooling agents |
| RU2492695C2 (ru) | 2008-02-27 | 2013-09-20 | КРАФТ ФУДЗ ГЛОБАЛ БРЭНДЗ ЭлЭлСи | Многозональное кондитерское изделие |
| EP2271227B1 (en) | 2008-05-02 | 2012-12-26 | Kraft Foods Global Brands LLC | Multilayered sugar free isomalt confectionery and methods of making same |
| US9060526B2 (en) | 2009-01-22 | 2015-06-23 | Intercontinental Great Brands Llc | Confectionery processing |
| US8487130B2 (en) * | 2009-04-27 | 2013-07-16 | International Flavors & Fragrances Inc. | Menthylcarboxamides and their use as cooling agents |
| US7923577B2 (en) * | 2009-04-27 | 2011-04-12 | International Flavors & Fragrances Inc. | Menthylcarboxamides and their use as cooling agents |
| WO2010128026A2 (en) | 2009-05-05 | 2010-11-11 | Givaudan Sa | Organic compounds |
| US8920856B2 (en) | 2009-10-08 | 2014-12-30 | Intercontinental Great Brands Llc | Co-extruded layered candy and gum apparatus and methods |
| ES2441738T3 (es) | 2009-10-30 | 2014-02-06 | Intercontinental Great Brands Llc | Dulces sin azúcar, métodos para su preparación y utilización en la preparación de productos de confitería multicapa |
| ES2744577T3 (es) | 2009-12-21 | 2020-02-25 | Intercontinental Great Brands Llc | Composiciones de recubrimiento en forma de partículas, producto de confitería recubierto, y métodos para elaborar el mismo |
| MX2012014392A (es) | 2010-06-25 | 2013-02-26 | Cadbury Adams Mexico S De R L De C V | Liberacion mejorada de ingredientes lipofilos de gomas de mascar con hidrocoloides. |
| EP2675283B1 (en) | 2011-02-14 | 2018-11-14 | Intercontinental Great Brands LLC | Confectionary with multiple flavors and textures |
| GB201103103D0 (en) | 2011-02-23 | 2011-04-06 | Givaudan Sa | Organic compounds |
| EP2677878B1 (en) | 2011-02-23 | 2016-02-17 | Intercontinental Great Brands LLC | Flavor pre-blends for chewing gum, methods of making flavor pre-blends and chewing gum compositions thereof |
| US10973238B2 (en) | 2011-03-11 | 2021-04-13 | Intercontinental Great Brands Llc | System and method of forming multilayer confectionery |
| BR112014001361A2 (pt) | 2011-07-21 | 2017-02-14 | Intercontinental Great Brands Llc | formação e resfriamento de goma avançada |
| JP2013195289A (ja) | 2012-03-21 | 2013-09-30 | Takasago Internatl Corp | 感覚刺激成分の評価方法 |
| MX386990B (es) | 2012-06-19 | 2025-03-19 | Intercontinental Great Brands Llc | Goma de mascar sin recubrir, empacada a granel |
| RU2015106110A (ru) | 2012-08-22 | 2016-10-20 | Интэрконтинентал Грэйт Брэндс Ллс | Составы жевательной резинки и методы их изготовления |
| WO2014128566A2 (en) | 2013-02-21 | 2014-08-28 | Mondelez International | Chewing gum and methods of making thereof field |
| PL3009004T3 (pl) | 2013-03-29 | 2020-03-31 | Intercontinental Great Brands Llc | Przezroczyste i półprzezroczyste cukierki z płynnym nadzieniem; bezcukrowa, płynna, jadalna kompozycja |
| WO2014194198A1 (en) | 2013-05-31 | 2014-12-04 | Intercontinental Great Brands Llc | Chewing gum with hard, amorphous inclusions; and methods of making thereof |
| WO2015051056A1 (en) | 2013-10-02 | 2015-04-09 | Intercontinental Great Brands Llc | Particulate coated chewing gum and confectionery; and methods of making the same |
| CN106028827A (zh) | 2014-02-28 | 2016-10-12 | 洲际大品牌有限责任公司 | 用于可食用芯的包衣；包衣的系统和方法；以及由此制得的包覆的产品 |
| EP3131405A1 (en) | 2014-03-03 | 2017-02-22 | Intercontinental Great Brands LLC | Method for manufacturing a comestible |
| RU2016138746A (ru) | 2014-04-23 | 2018-05-24 | Дзе Проктер Энд Гэмбл Компани | Циклогексанкарбоксамид с охлаждающими свойствами |
| WO2015175885A1 (en) | 2014-05-15 | 2015-11-19 | Intercontinental Great Brands Llc | Multi-textured chewing gum and methods of making thereof |
| EP3356356B1 (en) | 2015-10-01 | 2021-05-26 | Firmenich Incorporated | Compounds useful as modulators of trpm8 |
| KR102493173B1 (ko) | 2017-01-10 | 2023-01-27 | 다카사고 고료 고교 가부시키가이샤 | 메틸멘톨 유도체 및 그것을 함유하는 냉감제 조성물 |
| US11896028B2 (en) | 2017-02-06 | 2024-02-13 | Intercontinental Great Brands Llc | Dual-textured confectionery; and methods of making the same |
| PL3634143T3 (pl) | 2017-06-05 | 2021-08-30 | Intercontinental Great Brands Llc | Kompozycja gumy do żucia i sposoby jej wytwarzania |
| WO2019036590A1 (en) | 2017-08-18 | 2019-02-21 | Intercontinental Great Brands Llc | CHEWING-GUM COMPOSITIONS AND METHODS OF MAKING SAME |
| CA3078909A1 (en) | 2017-10-16 | 2019-04-25 | Takasago International Corporation | Cool-sensation imparter composition containing 2,2,6-trimethylcyclohexanecarboxylic acid derivative |
| EP4566459A3 (en) | 2018-08-10 | 2025-08-20 | Firmenich Incorporated | Antagonists of t2r54 and compositions and uses thereof |
| EP4364577A3 (en) | 2018-10-26 | 2024-06-19 | Intercontinental Great Brands LLC | Center-filled confectionery product; coated product; and methods of making |
| EP4013233B1 (en) | 2019-08-14 | 2024-10-02 | Intercontinental Great Brands LLC | Confectionery chip product and methods of making the same |
| EP4225042A2 (en) | 2020-10-09 | 2023-08-16 | Intercontinental Great Brands LLC | Unwrapped hard candy product; isomalt confectionery; method of making and use thereof |
| CN115872881B (zh) * | 2022-11-14 | 2025-02-14 | 云南中烟工业有限责任公司 | 一种薄荷醇胺类化合物的合成方法及其在卷烟中的应用 |
| JP2026506814A (ja) | 2023-03-01 | 2026-02-26 | ペルフェッティ ヴァン メレ ベネルクス ベー．フェー． | 歯を白くするチューインガム、及びそれを作製する方法 |
| GB202303792D0 (en) | 2023-03-15 | 2023-04-26 | Givaudan Sa | Cosmetic composition |
| WO2025032120A1 (en) | 2023-08-10 | 2025-02-13 | Perfetti Van Melle Benelux Bv | Chewing gum comprising fiber; methods of making the same; and methods of use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4193936A (en) * | 1971-02-04 | 1980-03-18 | Wilkinson Sword Limited | N-substituted paramenthane carboxamides |
| PH10359A (en) * | 1971-02-04 | 1977-01-05 | Wilkinson Sword Ltd | N-substituted-p-methane-3-carboxamides having physiological cooling activity and compositions containing them |
| CA2535265C (en) * | 2003-08-22 | 2014-01-28 | Dendreon Corporation | Compositions and methods for the treatment of disease associated with trp-p8 expression |
| US7169377B2 (en) * | 2003-10-15 | 2007-01-30 | Wei Edward T | Radioligands for the TRP-M8 receptor and methods therewith |
| CN100582089C (zh) * | 2003-11-21 | 2010-01-20 | 吉万奥丹股份有限公司 | N-取代的对-薄荷烷甲酰胺 |
-
2006
- 2006-05-24 MX MX2007014456A patent/MX2007014456A/es not_active Application Discontinuation
- 2006-05-24 US US11/920,813 patent/US20090105237A1/en not_active Abandoned
- 2006-05-24 BR BRPI0610087-2A patent/BRPI0610087A2/pt not_active IP Right Cessation
- 2006-05-24 JP JP2008512666A patent/JP2009501132A/ja active Pending
- 2006-05-24 WO PCT/CH2006/000270 patent/WO2006125334A1/en not_active Ceased
- 2006-05-24 CN CNA2006800185961A patent/CN101184470A/zh active Pending
- 2006-05-24 KR KR1020077027503A patent/KR20080020609A/ko not_active Withdrawn
- 2006-05-24 EP EP06721969A patent/EP1885327A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| KR20080020609A (ko) | 2008-03-05 |
| EP1885327A1 (en) | 2008-02-13 |
| CN101184470A (zh) | 2008-05-21 |
| JP2009501132A (ja) | 2009-01-15 |
| MX2007014456A (es) | 2008-02-07 |
| WO2006125334A1 (en) | 2006-11-30 |
| US20090105237A1 (en) | 2009-04-23 |
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