BRPI0610092A2 - mÉtodos para a detecÇço de um analito e de um Ácido nucleico em uma amostra, e para sintetizaÇço de uma molÉcula de Ácido nucleico ou de anÁlago de Ácido nucleico, kit reagente, usos do mesmo, de um composto, e de um mÉtodo, molÉcula de Ácido nucleico ou de anÁlogo de Ácido nucleico, produto de metalizaÇço, produto associado, e, composto - Google Patents
mÉtodos para a detecÇço de um analito e de um Ácido nucleico em uma amostra, e para sintetizaÇço de uma molÉcula de Ácido nucleico ou de anÁlago de Ácido nucleico, kit reagente, usos do mesmo, de um composto, e de um mÉtodo, molÉcula de Ácido nucleico ou de anÁlogo de Ácido nucleico, produto de metalizaÇço, produto associado, e, compostoInfo
- Publication number
- BRPI0610092A2 BRPI0610092A2 BRPI0610092-9A BRPI0610092A BRPI0610092A2 BR PI0610092 A2 BRPI0610092 A2 BR PI0610092A2 BR PI0610092 A BRPI0610092 A BR PI0610092A BR PI0610092 A2 BRPI0610092 A2 BR PI0610092A2
- Authority
- BR
- Brazil
- Prior art keywords
- nucleic acid
- compound
- product
- methods
- synthesizing
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
MÉTODOS PARA A DETECÇçO DE UM ANALITO E DE UM ÁCIDO NUCLEICO EM UMA AMOSTRA, E PARA SINTETIZAÇçO DE UMA MOLÉCULA DE ÁCIDO NUCLEICO OU DE ANÁLOGO DE ÁCIDO NUCLEICO, KIT REAGENTE, USOS DO MESMO, DE UM COMPOSTO, E DE UM MÉTODO, MOLÉCULA DE ÁCIDO NUCLEICO OU DE ANÁLOGO DE ÁCIDO NUCLEICO, PRODUTO DE METALIZAÇçO, PRODUTO ASSOCIADO, E, COMPOSTO. A invenção refere-se a métodos e reagentes para a detecção de analitos, e.g., ácidos nucleicos. Os novos métodos e reagentes permitem uma detecção simples e sensível mesmo em amostras biológicas complexas.
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67678505P | 2005-05-02 | 2005-05-02 | |
| EP05009618 | 2005-05-02 | ||
| US60/676,785 | 2005-05-02 | ||
| EP05009618.9 | 2005-05-02 | ||
| US75010005P | 2005-12-14 | 2005-12-14 | |
| EP05027370.5 | 2005-12-14 | ||
| US60/750,100 | 2005-12-14 | ||
| EP05027370 | 2005-12-14 | ||
| PCT/EP2006/004017 WO2006117161A2 (en) | 2005-05-02 | 2006-04-28 | New labelling strategies for the sensitive detection of analytes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0610092A2 true BRPI0610092A2 (pt) | 2008-12-09 |
| BRPI0610092B1 BRPI0610092B1 (pt) | 2018-03-27 |
| BRPI0610092B8 BRPI0610092B8 (pt) | 2021-07-27 |
Family
ID=42676666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0610092A BRPI0610092B8 (pt) | 2005-05-02 | 2006-04-28 | métodos para a detecção de um analito e de um ácido nucleico em uma amostra, e de sintetização de uma molécula de ácido nucleico ou de análogo de ácido nucleico, kit reagente, uso do mesmo, molécula de ácido nucleico ou de análogo de ácido nucleico e produto associado |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8129315B2 (pt) |
| EP (4) | EP2256126B1 (pt) |
| JP (1) | JP4944098B2 (pt) |
| AR (1) | AR053251A1 (pt) |
| AT (1) | ATE479699T1 (pt) |
| AU (1) | AU2006243370B2 (pt) |
| BR (1) | BRPI0610092B8 (pt) |
| CA (1) | CA2607530C (pt) |
| DE (1) | DE602006016589D1 (pt) |
| DK (1) | DK1877415T3 (pt) |
| MX (1) | MX2007013296A (pt) |
| PL (1) | PL1877415T3 (pt) |
| PT (1) | PT1877415E (pt) |
| SI (1) | SI1877415T1 (pt) |
| TW (1) | TWI406952B (pt) |
| WO (1) | WO2006117161A2 (pt) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0205455D0 (en) | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
| HRP20100659T1 (hr) * | 2005-05-02 | 2011-01-31 | Baseclick Gmbh | Nove strategije obiljezavanja za osjetljivo otkrivanje analita |
| AU2006243370B2 (en) | 2005-05-02 | 2012-06-28 | Basf Aktiengesellschaft | New labelling strategies for the sensitive detection of analytes |
| EP1937849B1 (en) | 2005-10-27 | 2019-05-29 | The President and Fellows of Harvard College | Methods and compositions for labeling nucleic acids |
| US8114636B2 (en) * | 2006-02-10 | 2012-02-14 | Life Technologies Corporation | Labeling and detection of nucleic acids |
| US20070249014A1 (en) | 2006-02-10 | 2007-10-25 | Invitrogen Corporation | Labeling and detection of post translationally modified proteins |
| TW200808975A (en) * | 2006-04-28 | 2008-02-16 | Basf Ag | Molecular beacons for DNA-photography |
| ES2369299T3 (es) * | 2006-10-31 | 2011-11-29 | Baseclick Gmbh | Química de click para la producción de moléculas informadoras. |
| TW200827703A (en) * | 2006-11-09 | 2008-07-01 | Basf Ag | Photographic determination of analytes |
| GB0718255D0 (en) * | 2007-09-19 | 2007-10-31 | Univ Edinburgh | Nucleobase characterisation |
| EP2053131A1 (en) * | 2007-10-19 | 2009-04-29 | Ludwig-Maximilians-Universität München | Method for determining methylation at deoxycytosine residues |
| EP2907525B1 (en) | 2007-11-21 | 2018-05-16 | University Of Georgia Research Foundation, Inc. | Dibenzocyclooctene-compounds for bioorthogonal reactions |
| CN104263816B (zh) * | 2008-05-16 | 2018-10-19 | 生命技术公司 | 用于测量细胞增殖的双标记法 |
| US8618297B2 (en) | 2008-07-25 | 2013-12-31 | Basf Se | Azide substituted naphthylene or rylene imide derivatives and their use as reagents in click-reactions |
| EP2307507B1 (en) | 2008-07-25 | 2016-04-20 | Basf Se | New azide substituted naphthylene or rylene imide derivatives and their use as reagents in click-reactions |
| WO2010039548A2 (en) * | 2008-09-23 | 2010-04-08 | Alnylam Pharmaceuticals, Inc. | Chemical modifications of monomers and oligonucleotides with cycloaddition |
| EP2239053A1 (en) | 2009-04-09 | 2010-10-13 | baseclick GmbH | Click chemistry on heterogeneous catalysts |
| EP2435461B1 (en) | 2009-05-29 | 2017-08-09 | Life Technologies Corporation | Scaffolded nucleic acid polymer particles and methods of making and using |
| US11435358B2 (en) | 2011-06-23 | 2022-09-06 | Board Of Regents, The University Of Texas System | Single molecule peptide sequencing |
| BR112015000236A2 (pt) | 2012-07-10 | 2017-06-27 | Baseclick Gmbh | moléculas de ácidos nucleicos modificadas por anandamida |
| US9797011B2 (en) | 2013-09-13 | 2017-10-24 | Life Technologies Corporation | Device preparation using condensed nucleic acid particles |
| US20190154696A1 (en) * | 2015-08-31 | 2019-05-23 | Life Technologies Corporation | Colorimetric Labeling and Detection Methods and Compositions |
| WO2020072907A1 (en) | 2018-10-05 | 2020-04-09 | Board Of Regents, The University Of Texas System | Solid-phase n-terminal peptide capture and release |
| US20240052391A1 (en) | 2020-10-29 | 2024-02-15 | Dna Script | Enzymatic Synthesis of Polynucleotide Probes |
| EP4655411A2 (en) | 2023-01-26 | 2025-12-03 | DNA Script | Enzymatic synthesis of polynucleotide probes |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2209754A (en) * | 1987-09-17 | 1989-05-24 | Thomas Lee Mattson | Polyaldehydic polynucleotides in use as probes,their preparation and use |
| JP2681061B2 (ja) | 1988-06-08 | 1997-11-19 | ロンドン・ダイアグノスティック・インコーポレーテッド | 検出可能なシグナルのセンシタイザー誘導発生を利用したアッセイ |
| US5723289A (en) | 1990-06-11 | 1998-03-03 | Nexstar Pharmaceuticals, Inc. | Parallel selex |
| US5843650A (en) | 1995-05-01 | 1998-12-01 | Segev; David | Nucleic acid detection and amplification by chemical linkage of oligonucleotides |
| EP2319854B1 (en) | 1997-01-08 | 2016-11-30 | Sigma-Aldrich Co. LLC | Bioconjugation Of Macromolecules |
| US7427678B2 (en) | 1998-01-08 | 2008-09-23 | Sigma-Aldrich Co. | Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method |
| US6727356B1 (en) * | 1999-12-08 | 2004-04-27 | Epoch Pharmaceuticals, Inc. | Fluorescent quenching detection reagents and methods |
| US7205105B2 (en) * | 1999-12-08 | 2007-04-17 | Epoch Biosciences, Inc. | Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis |
| DE10013600A1 (de) * | 2000-03-18 | 2002-01-10 | Aventis Res & Tech Gmbh & Co | Reaktive Monomere für die Oligonucleotid- und Polynucleotidsynthese, modifizierte Oligonucleotide und Polynucleotiden und ein Verfahren zu deren Herstellung |
| NZ535592A (en) * | 2002-02-28 | 2006-07-28 | Astrazeneca Ab | 3-cyclyl-5-(nitrogen-containing 5-membered ring) methyl-oxazolidinone derivatives and their use as antibacterial agents |
| WO2003079014A1 (en) | 2002-03-03 | 2003-09-25 | Activx Biosciences, Inc. | Tethered activity-based probes and uses thereof |
| US7375234B2 (en) | 2002-05-30 | 2008-05-20 | The Scripps Research Institute | Copper-catalysed ligation of azides and acetylenes |
| WO2004055160A2 (en) | 2002-12-13 | 2004-07-01 | The Trustees Of Columbia University In The City Of New York | Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry |
| KR100540509B1 (ko) | 2004-01-07 | 2006-01-11 | 학교법인 포항공과대학교 | 수화젤레이터로 사용되는 2'-데옥시우리딘 유도체 |
| US7745118B2 (en) * | 2004-04-08 | 2010-06-29 | Roche Nimblegen, Inc. | Comparative genomic resequencing |
| KR20080000620A (ko) * | 2005-04-27 | 2008-01-02 | 지멘스 메디컬 솔루션즈 유에스에이, 인크. | 분자 이미징 프로브를 합성하기 위한 클릭 화학 방법 |
| AU2006243370B2 (en) | 2005-05-02 | 2012-06-28 | Basf Aktiengesellschaft | New labelling strategies for the sensitive detection of analytes |
| EP1937849B1 (en) | 2005-10-27 | 2019-05-29 | The President and Fellows of Harvard College | Methods and compositions for labeling nucleic acids |
| ES2369299T3 (es) | 2006-10-31 | 2011-11-29 | Baseclick Gmbh | Química de click para la producción de moléculas informadoras. |
-
2006
- 2006-04-28 AU AU2006243370A patent/AU2006243370B2/en not_active Expired
- 2006-04-28 PT PT06742750T patent/PT1877415E/pt unknown
- 2006-04-28 WO PCT/EP2006/004017 patent/WO2006117161A2/en not_active Ceased
- 2006-04-28 DK DK06742750.0T patent/DK1877415T3/da active
- 2006-04-28 AT AT06742750T patent/ATE479699T1/de active
- 2006-04-28 AR ARP060101744A patent/AR053251A1/es active IP Right Grant
- 2006-04-28 DE DE602006016589T patent/DE602006016589D1/de not_active Expired - Lifetime
- 2006-04-28 JP JP2008509350A patent/JP4944098B2/ja not_active Expired - Lifetime
- 2006-04-28 MX MX2007013296A patent/MX2007013296A/es not_active Application Discontinuation
- 2006-04-28 SI SI200630838T patent/SI1877415T1/sl unknown
- 2006-04-28 EP EP10171611.6A patent/EP2256126B1/en not_active Expired - Lifetime
- 2006-04-28 TW TW095115452A patent/TWI406952B/zh not_active IP Right Cessation
- 2006-04-28 EP EP10171618.1A patent/EP2270228B1/en not_active Expired - Lifetime
- 2006-04-28 BR BRPI0610092A patent/BRPI0610092B8/pt active IP Right Grant
- 2006-04-28 CA CA2607530A patent/CA2607530C/en not_active Expired - Lifetime
- 2006-04-28 US US11/913,156 patent/US8129315B2/en active Active
- 2006-04-28 PL PL06742750T patent/PL1877415T3/pl unknown
- 2006-04-28 EP EP10177873A patent/EP2266996A3/en not_active Withdrawn
- 2006-04-28 EP EP06742750A patent/EP1877415B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| TW200720441A (en) | 2007-06-01 |
| US8129315B2 (en) | 2012-03-06 |
| AR053251A1 (es) | 2007-04-25 |
| US20090215635A1 (en) | 2009-08-27 |
| SI1877415T1 (sl) | 2011-01-31 |
| JP4944098B2 (ja) | 2012-05-30 |
| TWI406952B (zh) | 2013-09-01 |
| CA2607530A1 (en) | 2006-11-09 |
| EP1877415B1 (en) | 2010-09-01 |
| WO2006117161A3 (en) | 2007-01-11 |
| AU2006243370B2 (en) | 2012-06-28 |
| EP2270228B1 (en) | 2013-08-21 |
| EP2256126B1 (en) | 2015-07-01 |
| PT1877415E (pt) | 2010-12-09 |
| DE602006016589D1 (de) | 2010-10-14 |
| EP1877415A2 (en) | 2008-01-16 |
| EP2266996A2 (en) | 2010-12-29 |
| BRPI0610092B8 (pt) | 2021-07-27 |
| EP2270228A1 (en) | 2011-01-05 |
| JP2008539703A (ja) | 2008-11-20 |
| WO2006117161A2 (en) | 2006-11-09 |
| PL1877415T3 (pl) | 2011-02-28 |
| CA2607530C (en) | 2014-07-08 |
| EP2256126A1 (en) | 2010-12-01 |
| ATE479699T1 (de) | 2010-09-15 |
| DK1877415T3 (da) | 2010-12-20 |
| MX2007013296A (es) | 2007-12-13 |
| AU2006243370A1 (en) | 2006-11-09 |
| BRPI0610092B1 (pt) | 2018-03-27 |
| EP2266996A3 (en) | 2011-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B09X | Republication of the decision to grant [chapter 9.1.3 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] | ||
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
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