BRPI0610206B8 - uso de misturas de polímeros para a produção de formulações farmacêuticas revestidas, e formulação farmacêutica com revestimento polimérico misto - Google Patents

uso de misturas de polímeros para a produção de formulações farmacêuticas revestidas, e formulação farmacêutica com revestimento polimérico misto

Info

Publication number
BRPI0610206B8
BRPI0610206B8 BRPI0610206A BRPI0610206A BRPI0610206B8 BR PI0610206 B8 BRPI0610206 B8 BR PI0610206B8 BR PI0610206 A BRPI0610206 A BR PI0610206A BR PI0610206 A BRPI0610206 A BR PI0610206A BR PI0610206 B8 BRPI0610206 B8 BR PI0610206B8
Authority
BR
Brazil
Prior art keywords
polymer
weight
pharmaceutical formulation
coated pharmaceutical
polymers
Prior art date
Application number
BRPI0610206A
Other languages
English (en)
Inventor
Meier Christian
Knuppen Karin
Petereit Hans-Ulrich
Original Assignee
Evonik Roehm Gmbh
Roehm Gmbh
Evonik Degussa Gmbh
Evonik Operations Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Roehm Gmbh, Roehm Gmbh, Evonik Degussa Gmbh, Evonik Operations Gmbh filed Critical Evonik Roehm Gmbh
Publication of BRPI0610206A2 publication Critical patent/BRPI0610206A2/pt
Publication of BRPI0610206B1 publication Critical patent/BRPI0610206B1/pt
Publication of BRPI0610206B8 publication Critical patent/BRPI0610206B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

USO DE MISTURAS DE POLÍMEROS PARA A PRODUÇÃO DE FORMULAÇÕES FARMACÊUTICAS REVESTIDAS E FORMULAÇÃO FARMACÊUTICA COM REVESTIMENTO POLIMÉRICO MISTO. A presente invenção refere-se ao uso de mistura de 2 a 60% em peso de um ou mais polímeros (I) com 40 a 98% em peso de um ou mais polímeros (II), onde o polímero (I) é um copolímero (met)acrilato, contendo 90 a 100% em peso polimerizado com radical de 40 a 95% em peso de C1-4 alquil ésteres de ácido acrílico ou metacrílico e 5 a 60% em peso de unidades de monômeros (met)acrilato com um grupo aniônico com O a 10% em peso de ainda monômeros vinílicos polimerizáveis e polímero (II) é um polímero vinila diferente de polímero (I) ou um polissacarídeo ou um derivado de um polissacarídeo, contendo 88 a 100% de unidades de monômero neutro e até 12% em peso de unidades de monômero polimerizável com grupos iônicos, para produção de uma formulação farmacêutica revestida, contendo um núcleo de agente ativo e um revestimento polimérico fabricado a partir de mistura de polímeros (I) e (II), caracterizada pelo fato de que a temperatura de transição vítrea de polímero (I) não é mais que 7000 e um perfil de liberação de agente ativo é obtido, pelo que a liberação de agente é retardada com relação a uma formulação farmacêutica com um revestimento fabricado exclusivamente de polímero (I), iniciando com o mesmo pH. A invenção ainda refere-se a uma formulação farmacêutica com um polímero (I) selecionado.
BRPI0610206A 2005-05-25 2006-03-03 uso de misturas de polímeros para a produção de formulações farmacêuticas revestidas, e formulação farmacêutica com revestimento polimérico misto BRPI0610206B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005024614.1 2005-05-25
DE102005024614A DE102005024614A1 (de) 2005-05-25 2005-05-25 Verwendung von Polymermischungen zur Herstellung von überzogenen Arzneiformen sowie Arzneiform mit polymerem Mischüberzug
PCT/EP2006/001949 WO2006125483A1 (de) 2005-05-25 2006-03-03 Verwendung vom polymermischungen zur herstellung von überzogenen arzneiformen sowie arzneiform mit

Publications (3)

Publication Number Publication Date
BRPI0610206A2 BRPI0610206A2 (pt) 2010-06-01
BRPI0610206B1 BRPI0610206B1 (pt) 2020-10-06
BRPI0610206B8 true BRPI0610206B8 (pt) 2022-07-05

Family

ID=36607494

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0610206A BRPI0610206B8 (pt) 2005-05-25 2006-03-03 uso de misturas de polímeros para a produção de formulações farmacêuticas revestidas, e formulação farmacêutica com revestimento polimérico misto

Country Status (15)

Country Link
US (1) US20080193522A1 (pt)
EP (1) EP1890682B1 (pt)
JP (1) JP5582701B2 (pt)
KR (1) KR101387835B1 (pt)
CN (1) CN101137354B (pt)
BR (1) BRPI0610206B8 (pt)
CA (1) CA2606587C (pt)
DE (1) DE102005024614A1 (pt)
ES (1) ES2628962T3 (pt)
HU (1) HUE032869T2 (pt)
IL (1) IL187535A0 (pt)
MX (1) MX363064B (pt)
PL (1) PL1890682T3 (pt)
SI (1) SI1890682T1 (pt)
WO (1) WO2006125483A1 (pt)

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JP5453434B2 (ja) 2008-09-24 2014-03-26 エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング エタノールの影響に対する耐性を有するオピオイドではないｐＨ依存の制御放出の医薬組成物
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WO2010105673A1 (en) * 2009-03-18 2010-09-23 Evonik Röhm Gmbh Controlled release pharmaceutical composition with resistance against the influence of ethanol employing a coating comprising a polymer mixture and excipients
US20100303920A1 (en) * 2009-05-27 2010-12-02 Johan Hjartstam Aqueous Film Coating Composition / 841
US8329208B2 (en) 2009-07-28 2012-12-11 Methylation Sciences International Srl Pharmacokinetics of S-adenosylmethionine formulations
WO2011047700A1 (en) * 2009-10-22 2011-04-28 Synthon B.V. Pharmaceutical compositions of sevelamer
CN103501768B (zh) * 2011-06-17 2016-11-09 赢创罗姆有限公司 具有抗乙醇影响抗性的抗胃酸的药物或营养组合物
EP2949331A1 (en) 2012-10-17 2015-12-02 Methylation Sciences International SRL Compositions comprising s-adenosylmethionine and a gallic acid ester
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US20170042806A1 (en) 2015-04-29 2017-02-16 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
JP6824197B2 (ja) 2015-06-05 2021-02-03 エボニック オペレーションズ ゲーエムベーハー エタノールの影響に対する耐性を有する医薬品組成物または栄養機能食品組成物
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
JP6739275B2 (ja) * 2016-08-02 2020-08-12 日本化薬株式会社 ゲフィチニブを有効成分とする医薬組成物
IT201700032367A1 (it) * 2017-03-23 2018-09-23 Lamberti Spa Dispersioni poliuretaniche acquose
JP2021515778A (ja) * 2018-03-09 2021-06-24 エボニック オペレーションズ ゲーエムベーハー エタノールの影響に対する耐性を有するポリマー混合物
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
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CN113950321A (zh) * 2019-06-13 2022-01-18 赢创运营有限公司 包含共聚物混合物和水溶性纤维素的粉末组合物
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CN111700871A (zh) * 2020-06-24 2020-09-25 杭州巴洛特生物科技有限公司 一种美沙拉嗪组合物及其制备方法
CN112237572A (zh) * 2020-10-28 2021-01-19 海南卫康制药(潜山)有限公司 一种富马酸沃诺拉赞片剂及其制备方法
CN114409998A (zh) * 2021-12-24 2022-04-29 浙江普利特新材料有限公司 一种蜂窝状咖啡炭复合隔音降噪聚丙烯材料及其制备方法
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Also Published As

Publication number Publication date
BRPI0610206A2 (pt) 2010-06-01
CN101137354B (zh) 2014-06-11
PL1890682T3 (pl) 2017-10-31
ES2628962T3 (es) 2017-08-04
JP5582701B2 (ja) 2014-09-03
HK1116341A1 (en) 2008-12-19
CN101137354A (zh) 2008-03-05
CA2606587A1 (en) 2006-11-30
WO2006125483A1 (de) 2006-11-30
JP2008542211A (ja) 2008-11-27
HUE032869T2 (en) 2017-11-28
KR101387835B1 (ko) 2014-04-25
DE102005024614A1 (de) 2006-11-30
EP1890682B1 (de) 2017-05-03
BRPI0610206B1 (pt) 2020-10-06
MX2007014024A (es) 2008-04-09
KR20080009213A (ko) 2008-01-25
CA2606587C (en) 2015-05-26
EP1890682A1 (de) 2008-02-27
SI1890682T1 (sl) 2017-10-30
US20080193522A1 (en) 2008-08-14
MX363064B (es) 2019-03-06
IL187535A0 (en) 2008-03-20

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