BRPI0611400B1 - formulações contendo xiloglicano muco-adesivas úteis em dispositivos médicos e em formulações farmacêuticas - Google Patents

formulações contendo xiloglicano muco-adesivas úteis em dispositivos médicos e em formulações farmacêuticas Download PDF

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Publication number
BRPI0611400B1
BRPI0611400B1 BRPI0611400A BRPI0611400A BRPI0611400B1 BR PI0611400 B1 BRPI0611400 B1 BR PI0611400B1 BR PI0611400 A BRPI0611400 A BR PI0611400A BR PI0611400 A BRPI0611400 A BR PI0611400A BR PI0611400 B1 BRPI0611400 B1 BR PI0611400B1
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Brazil
Prior art keywords
formulations
adhesive
xyloglycan
medical devices
useful
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BRPI0611400A
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English (en)
Inventor
Giuseppe Bottoni
Maffei Paola
Annalisa Sforzini
Federici Mascia
Carla Caramella
Silvia Rossi
Giuseppe Claudio Viscomi
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Alfasigma S.P.A.
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Publication of BRPI0611400A2 publication Critical patent/BRPI0611400A2/pt
Publication of BRPI0611400A8 publication Critical patent/BRPI0611400A8/pt
Publication of BRPI0611400B1 publication Critical patent/BRPI0611400B1/pt
Publication of BRPI0611400B8 publication Critical patent/BRPI0611400B8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Otolaryngology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)

Abstract

formulações contendo xiloglicano muco-adesivas úteis em dispositivos médicos e em formulações farmacêuticas. o objeto da invenção são formulações muco-adesivas e de liberação controlada consistindo em soluções aquosas contendo 0,05% a 5% em peso de um polímero purificado natural tendo estrutura xiloglicano e 10% a 70% em peso de glicerol. estas formulações são apropriadas para aplicação sobre membranas de mucosas humanas, tais como membranas de mucosas nasal, oral e vaginal, como agentes umectantes e amaciantes ou como sistema de liberação farmacêutica. ainda objetos da invenção são formulações farmacêuticas e dispositivos médicos apropriados para a aplicação a membranas de mucosas humanas, contendo as formulações muco-adesivas e de liberação controlada junto com ingredientes ativos e excipientes.
BRPI0611400A 2005-06-06 2006-06-01 formulações contendo xiloglicano muco-adesivas úteis em dispositivos médicos e em formulações farmacêuticas BRPI0611400B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000388A ITBO20050388A1 (it) 2005-06-06 2005-06-06 Formulazione mucoadesive utili in dispositivi medici in preparazioni farmaceutiche
ITBO2005A000388 2005-06-06
PCT/EP2006/005240 WO2006131262A1 (en) 2005-06-06 2006-06-01 Mucoadhesive xyloglucan-containing formulations useful in medical devices and in pharmaceutical formulations

Publications (4)

Publication Number Publication Date
BRPI0611400A2 BRPI0611400A2 (pt) 2010-09-08
BRPI0611400A8 BRPI0611400A8 (pt) 2017-12-26
BRPI0611400B1 true BRPI0611400B1 (pt) 2020-04-28
BRPI0611400B8 BRPI0611400B8 (pt) 2021-05-25

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ID=36954507

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Application Number Title Priority Date Filing Date
BRPI0611400A BRPI0611400B8 (pt) 2005-06-06 2006-06-01 formulações contendo xiloglicano muco-adesivas úteis em dispositivos médicos e em formulações farmacêuticas

Country Status (22)

Country Link
US (3) US20090081133A1 (pt)
EP (1) EP1898876B1 (pt)
JP (1) JP5118633B2 (pt)
KR (1) KR101337578B1 (pt)
CN (2) CN101180036B (pt)
AT (1) ATE418324T1 (pt)
BR (1) BRPI0611400B8 (pt)
CA (1) CA2604768C (pt)
CY (1) CY1108875T1 (pt)
DE (1) DE602006004451D1 (pt)
DK (1) DK1898876T3 (pt)
ES (1) ES2318756T3 (pt)
IL (1) IL186655A (pt)
IT (1) ITBO20050388A1 (pt)
MX (1) MX2007015074A (pt)
NO (1) NO338991B1 (pt)
PL (1) PL1898876T3 (pt)
PT (1) PT1898876E (pt)
RU (1) RU2403012C2 (pt)
SI (1) SI1898876T1 (pt)
UA (1) UA90507C2 (pt)
WO (1) WO2006131262A1 (pt)

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Publication number Publication date
BRPI0611400A8 (pt) 2017-12-26
RU2007143998A (ru) 2009-07-20
CA2604768A1 (en) 2006-12-14
WO2006131262A1 (en) 2006-12-14
BRPI0611400B8 (pt) 2021-05-25
BRPI0611400A2 (pt) 2010-09-08
CN101180036A (zh) 2008-05-14
KR101337578B1 (ko) 2013-12-09
MX2007015074A (es) 2008-01-24
IL186655A0 (en) 2008-01-20
ES2318756T3 (es) 2009-05-01
ITBO20050388A1 (it) 2006-12-07
DK1898876T3 (da) 2009-03-02
US20130183325A1 (en) 2013-07-18
JP5118633B2 (ja) 2013-01-16
RU2403012C2 (ru) 2010-11-10
NO20076083L (no) 2007-11-26
PL1898876T3 (pl) 2009-06-30
CN102079794A (zh) 2011-06-01
US20090081133A1 (en) 2009-03-26
ATE418324T1 (de) 2009-01-15
NO338991B1 (no) 2016-11-07
CN101180036B (zh) 2011-07-27
EP1898876A1 (en) 2008-03-19
CA2604768C (en) 2013-07-30
SI1898876T1 (sl) 2009-04-30
UA90507C2 (uk) 2010-05-11
KR20080016596A (ko) 2008-02-21
PT1898876E (pt) 2009-03-05
IL186655A (en) 2010-12-30
US20120088726A1 (en) 2012-04-12
DE602006004451D1 (de) 2009-02-05
CY1108875T1 (el) 2014-07-02
JP2008542324A (ja) 2008-11-27
EP1898876B1 (en) 2008-12-24
CN102079794B (zh) 2012-03-28

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