BRPI0611909A2 - biossÍntese aperfeiÇoada de aminoÁcido e metabàlito - Google Patents

biossÍntese aperfeiÇoada de aminoÁcido e metabàlito

Info

Publication number
BRPI0611909A2
BRPI0611909A2 BRPI0611909-3A BRPI0611909A BRPI0611909A2 BR PI0611909 A2 BRPI0611909 A2 BR PI0611909A2 BR PI0611909 A BRPI0611909 A BR PI0611909A BR PI0611909 A2 BRPI0611909 A2 BR PI0611909A2
Authority
BR
Brazil
Prior art keywords
amino acid
nucleic acid
polypeptide
increase
biosynthesis
Prior art date
Application number
BRPI0611909-3A
Other languages
English (en)
Inventor
Kevin T Madden
Michael J Walbridge
Peter S Yorgey
Reed Doten
Original Assignee
Microbia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbia Inc filed Critical Microbia Inc
Publication of BRPI0611909A2 publication Critical patent/BRPI0611909A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

BIOSSÍNTESE APERFEIÇOADA DE AMINOÁCIDO E METABàLITO. A presente invenção refere-se a linhagens bacterianas que são projetadas para aumento de produção de aminoácidos, incluindo aminoácidos derivados de aspartato (por exemplo, metionina, usina, treonina, isoleuema, e S-adenosil metionina (S-AM) e cisteina, e metabólitos relacionados são descritos. As cepas podem ser geneticamente engenheiradas para abrigarem uma ou mais moléculas de ácido nucléico (por exemplo, moléculas de ácido nucléico recombinante) codificando um polipeptídeo (por exemplo, um polipeptídeo que é heterólogo ou homólogo para a célula hospedeira) e/ou elas podem ser engenheiradas para aumentar ou diminuir expressão e/ou atividade de polipeptídeos (por exemplo, através de mutação de seqúências de ácido nucléico endógenas).
BRPI0611909-3A 2005-06-17 2006-06-19 biossÍntese aperfeiÇoada de aminoÁcido e metabàlito BRPI0611909A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69203705P 2005-06-17 2005-06-17
US75059205P 2005-12-15 2005-12-15
PCT/US2006/023694 WO2006138689A2 (en) 2005-06-17 2006-06-19 Improved amino acid and metabolite biosynthesis

Publications (1)

Publication Number Publication Date
BRPI0611909A2 true BRPI0611909A2 (pt) 2009-01-20

Family

ID=37571275

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0611909-3A BRPI0611909A2 (pt) 2005-06-17 2006-06-19 biossÍntese aperfeiÇoada de aminoÁcido e metabàlito

Country Status (8)

Country Link
US (1) US20070026505A1 (pt)
EP (1) EP1891226A4 (pt)
JP (1) JP2009501512A (pt)
KR (1) KR20080028940A (pt)
AU (1) AU2006261356A1 (pt)
BR (1) BRPI0611909A2 (pt)
CA (1) CA2611513A1 (pt)
WO (1) WO2006138689A2 (pt)

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Also Published As

Publication number Publication date
EP1891226A4 (en) 2010-03-24
AU2006261356A1 (en) 2006-12-28
KR20080028940A (ko) 2008-04-02
CA2611513A1 (en) 2006-12-28
WO2006138689A3 (en) 2009-06-11
EP1891226A2 (en) 2008-02-27
US20070026505A1 (en) 2007-02-01
WO2006138689A9 (en) 2008-01-17
WO2006138689A2 (en) 2006-12-28
JP2009501512A (ja) 2009-01-22

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