BRPI0611964A2 - moduladores de alquilquinolina e alquilquinazolina cinase - Google Patents

moduladores de alquilquinolina e alquilquinazolina cinase

Info

Publication number
BRPI0611964A2
BRPI0611964A2 BRPI0611964-6A BRPI0611964A BRPI0611964A2 BR PI0611964 A2 BRPI0611964 A2 BR PI0611964A2 BR PI0611964 A BRPI0611964 A BR PI0611964A BR PI0611964 A2 BRPI0611964 A2 BR PI0611964A2
Authority
BR
Brazil
Prior art keywords
compounds
kit
alkylquinazoline
alkylquinoline
kinase modulators
Prior art date
Application number
BRPI0611964-6A
Other languages
English (en)
Inventor
Nand Baindur
Michael David Gaul
Kevin Douglas Kreutter
Guozhang Xu
Robert W Tuman
Christian Andrew Baumann
Alexander J Kim
Dana L Johnson
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0611964A2 publication Critical patent/BRPI0611964A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

MODULADORES DE ALQUILQUINOLINA E AL QUILQUINAZOLINA CINASE. A invenção está direcionada a compostos de alquilquinolina e alquilquinazolina de Fórmula 1: em que R~ 1~, R~ 2~, R~ 3~, B, Z, G, Q e X são como definidos aqui, o uso de tais compostos como moduladores de proteína tirosina cinase, particularmente inibidores de FLT3 e/ou c-kit e/ou TrkB, o uso de tais compostos para reduzir ou inibir atividade de cinase de FLT3 e/ou c-kit e/ou TrkB em uma célula ou um indivíduo, e o uso de tais compostos para prevenir ou tratar em um indivíduo um distúrbio proliferativo celular e/ou distúrbios relacionadas a FLT3 e/ou c-kit e/ou TrkB. A presente invenção está direcionada à composições farmacêuticas compreendendo os compostos da presente invenção e a métodos para tratar condições tais como cânceres e outros distúrbios proliferativos celulares.
BRPI0611964-6A 2005-06-10 2006-06-07 moduladores de alquilquinolina e alquilquinazolina cinase BRPI0611964A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68938405P 2005-06-10 2005-06-10
US73091905P 2005-10-27 2005-10-27
PCT/US2006/022414 WO2006135721A1 (en) 2005-06-10 2006-06-07 Alkylquinoline and alkylquinazoline kinase modulators

Publications (1)

Publication Number Publication Date
BRPI0611964A2 true BRPI0611964A2 (pt) 2009-01-27

Family

ID=37038081

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0611964-6A BRPI0611964A2 (pt) 2005-06-10 2006-06-07 moduladores de alquilquinolina e alquilquinazolina cinase

Country Status (18)

Country Link
US (1) US8071768B2 (pt)
EP (1) EP1893598A1 (pt)
JP (1) JP2009501135A (pt)
KR (1) KR20080028912A (pt)
AR (1) AR054386A1 (pt)
AU (1) AU2006257945A1 (pt)
BR (1) BRPI0611964A2 (pt)
CA (1) CA2611242A1 (pt)
CR (1) CR9652A (pt)
EA (1) EA200800017A1 (pt)
EC (1) ECSP077997A (pt)
GT (1) GT200600251A (pt)
IL (1) IL187692A0 (pt)
NO (1) NO20080174L (pt)
PE (1) PE20070014A1 (pt)
TW (1) TW200716599A (pt)
UY (1) UY29588A1 (pt)
WO (1) WO2006135721A1 (pt)

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EP2518064A1 (en) * 2009-12-25 2012-10-31 Mochida Pharmaceutical Co., Ltd. Novel aryl urea derivative
US8883791B2 (en) 2010-09-29 2014-11-11 Intervet Inc. N-heteroaryl compounds with cyclic bridging unit for the treatment of parasitic diseases
EP2736904B1 (en) 2011-07-27 2016-03-16 AB Science Oxazole and thiazole derivatives as selective protein kinase inhibitors (c-kit)
NZ723198A (en) * 2012-11-20 2018-11-30 Boehringer Ingelheim Animal Health Usa Inc Anthelmintic compounds and compositions and methods of using thereof
CN105683167B (zh) * 2013-10-16 2018-10-23 富士胶片株式会社 含氮杂环化合物的盐或其结晶、药品组合物及flt3抑制剂
US20170305857A1 (en) * 2013-12-20 2017-10-26 Pfizer Limited N-acylpiperidine ether tropomyosin-related kinase inhibitors
MX2017005462A (es) 2014-11-05 2017-07-28 Flexus Biosciences Inc Agentes inmunorreguladores.
UY36390A (es) * 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
JP6412471B2 (ja) * 2015-07-15 2018-10-24 富士フイルム株式会社 含窒素複素環化合物の製造方法およびその中間体
KR102833434B1 (ko) * 2018-09-27 2025-07-15 쉔젠 칩스크린 바이오사이언스 씨오., 엘티디. 인돌아민-2,3-디옥시게나아제 억제 활성을 갖는 퀴놀린 유도체
WO2020127738A1 (en) * 2018-12-21 2020-06-25 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Dna-pkcs inhibitors for increasing genome editing efficiency

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Also Published As

Publication number Publication date
CR9652A (es) 2008-09-09
EA200800017A1 (ru) 2008-08-29
ECSP077997A (es) 2008-01-23
CA2611242A1 (en) 2006-12-21
NO20080174L (no) 2008-02-19
PE20070014A1 (es) 2007-03-08
KR20080028912A (ko) 2008-04-02
EP1893598A1 (en) 2008-03-05
JP2009501135A (ja) 2009-01-15
AR054386A1 (es) 2007-06-20
AU2006257945A1 (en) 2006-12-21
IL187692A0 (en) 2008-08-07
GT200600251A (es) 2007-01-12
US20060281772A1 (en) 2006-12-14
UY29588A1 (es) 2006-10-02
WO2006135721A1 (en) 2006-12-21
US8071768B2 (en) 2011-12-06
TW200716599A (en) 2007-05-01

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: JOHNSON AND JOHNSON (US)

Free format text: TRANSFERIDO DE: JANSSEN PHARMACEUTICA N.V.

B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]