CR9652A - Moduladores de alquilquinolina y alquilquinazolina cinasa - Google Patents
Moduladores de alquilquinolina y alquilquinazolina cinasaInfo
- Publication number
- CR9652A CR9652A CR9652A CR9652A CR9652A CR 9652 A CR9652 A CR 9652A CR 9652 A CR9652 A CR 9652A CR 9652 A CR9652 A CR 9652A CR 9652 A CR9652 A CR 9652A
- Authority
- CR
- Costa Rica
- Prior art keywords
- compounds
- kit
- flt3
- trkb
- modulators
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 5
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 abstract 3
- 101150056950 Ntrk2 gene Proteins 0.000 abstract 3
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 230000002062 proliferating effect Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 abstract 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La invencion se refiere a compuestos alquinolina y alquinazolina de formula I: en donde R1, R2, R3, B, Z, G, Q, y X son como se define en la presente, el uso de dichos compuestos como moduladores de proteina tirosina cinasa, particularmente inhibidores de FLT3 y/o c-kit y/o TrkB, el uso de dichos compuestos para reducir o inhibir la actividad cinasa de FLT3 y/o c kit y/o TrkB en una celula o en un sujeto, y el uso de dichos compuestos para la prevencion o tratamiento en un sujeto de un trastorno proliferante celular y/o trastornos relacionados a FLT3 y/o c kit y/o TrkB; la presente invencion se refiere ademas a composiciones farmaceuticas que comprenden los compuestos de la presente invencion y a metodos para el tratamiento de condiciones tales como canceres y otros trastornos proliferantes celulares.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68938405P | 2005-06-10 | 2005-06-10 | |
| US73091905P | 2005-10-27 | 2005-10-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR9652A true CR9652A (es) | 2008-09-09 |
Family
ID=37038081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR9652A CR9652A (es) | 2005-06-10 | 2008-01-09 | Moduladores de alquilquinolina y alquilquinazolina cinasa |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8071768B2 (es) |
| EP (1) | EP1893598A1 (es) |
| JP (1) | JP2009501135A (es) |
| KR (1) | KR20080028912A (es) |
| AR (1) | AR054386A1 (es) |
| AU (1) | AU2006257945A1 (es) |
| BR (1) | BRPI0611964A2 (es) |
| CA (1) | CA2611242A1 (es) |
| CR (1) | CR9652A (es) |
| EA (1) | EA200800017A1 (es) |
| EC (1) | ECSP077997A (es) |
| GT (1) | GT200600251A (es) |
| IL (1) | IL187692A0 (es) |
| NO (1) | NO20080174L (es) |
| PE (1) | PE20070014A1 (es) |
| TW (1) | TW200716599A (es) |
| UY (1) | UY29588A1 (es) |
| WO (1) | WO2006135721A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7825244B2 (en) * | 2005-06-10 | 2010-11-02 | Janssen Pharmaceutica Nv | Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis |
| US8071768B2 (en) | 2005-06-10 | 2011-12-06 | Janssen Pharmaceutica, N.V. | Alkylquinoline and alkylquinazoline kinase modulators |
| US8760507B2 (en) * | 2008-08-05 | 2014-06-24 | Inspectron, Inc. | Light pipe for imaging head of video inspection device |
| CA2785284A1 (en) * | 2009-12-25 | 2011-06-30 | Tomoyuki Kamino | Novel aryl urea derivative |
| EP2621923B1 (en) | 2010-09-29 | 2017-03-29 | Intervet International B.V. | N-heteroaryl compounds with cyclic bridging unit for the treatment of parasitic diseases |
| PH12014500168A1 (en) | 2011-07-27 | 2014-02-24 | Ab Science | Selective protein kinase inhibitors |
| SG11201503959VA (en) * | 2012-11-20 | 2015-06-29 | Merial Inc | Anthelmintic compounds and compositions and method of using thereof |
| CN105683167B (zh) * | 2013-10-16 | 2018-10-23 | 富士胶片株式会社 | 含氮杂环化合物的盐或其结晶、药品组合物及flt3抑制剂 |
| EP3083602A1 (en) * | 2013-12-20 | 2016-10-26 | Pfizer Limited | N-acylpiperidine ether tropomyosin-related kinase inhibitors |
| JP2017538678A (ja) | 2014-11-05 | 2017-12-28 | フレクサス・バイオサイエンシーズ・インコーポレイテッドＦｌｅｘｕｓ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ． | 免疫調節剤 |
| UY36390A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
| JP6412471B2 (ja) * | 2015-07-15 | 2018-10-24 | 富士フイルム株式会社 | 含窒素複素環化合物の製造方法およびその中間体 |
| US12551478B2 (en) | 2018-09-27 | 2026-02-17 | Shenzhen Chipscreen Biosciences Co., Ltd. | Quinoline derivative having indoleamine-2,3-dioxygenase inhibitory activity |
| CA3128085A1 (en) * | 2018-12-21 | 2020-06-25 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Dna-pkcs inhibitors for increasing genome editing efficiency |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3517005A (en) * | 1967-10-26 | 1970-06-23 | Pfizer & Co C | Certain 2- and 4-substituted quinazolines |
| GB1460389A (en) * | 1974-07-25 | 1977-01-06 | Pfizer Ltd | 4-substituted quinazoline cardiac stimulants |
| JPS5976082A (ja) | 1982-10-23 | 1984-04-28 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体 |
| GB8320958D0 (en) * | 1983-08-03 | 1983-09-07 | Pfizer Ltd | Quinazoline cardiac stimulants |
| US5300515A (en) * | 1991-01-31 | 1994-04-05 | Kyorin Pharmaceutical Co., Ltd. | Carbamic acid derivatives and method for preparing the same |
| EP0627940B1 (en) * | 1992-03-05 | 2003-05-07 | Board of Regents, The University of Texas System | Use of immunoconjugates for the diagnosis and/or therapy of vascularized tumors |
| US5474765A (en) * | 1992-03-23 | 1995-12-12 | Ut Sw Medical Ctr At Dallas | Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells |
| GB9510757D0 (en) | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
| GB2295387A (en) | 1994-11-23 | 1996-05-29 | Glaxo Inc | Quinazoline antagonists of alpha 1c adrenergic receptors |
| CA2216943C (en) | 1995-04-19 | 2003-06-17 | Boston Scientific Limited | Drug release coated stent |
| WO1997028118A1 (en) | 1996-02-05 | 1997-08-07 | Hoechst Celanese Corporation | Process for preparing anthranilic acids |
| JP2001511764A (ja) | 1996-04-12 | 2001-08-14 | 住友製薬株式会社 | ピペリジニルピリミジン誘導体 |
| US5948786A (en) * | 1996-04-12 | 1999-09-07 | Sumitomo Pharmaceuticals Company, Limited | Piperidinylpyrimidine derivatives |
| US5869669A (en) * | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
| AU719392B2 (en) | 1996-10-01 | 2000-05-11 | Kyowa Hakko Kirin Co., Ltd. | Nitrogen-containing heterocyclic compounds |
| US5866562A (en) * | 1996-10-25 | 1999-02-02 | Bayer Aktiengesellschaft | Ring-bridged bis-quinolines |
| JP2002508366A (ja) | 1997-12-12 | 2002-03-19 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | キノリンピペラジンおよびキノリンピペリジン誘導体、それらの製造方法、ならびに複合的５−ｈｔ１ａ、５−ｈｔ１ｂおよび５−ｈｔ１ｄ受容体アンタゴニストとしてのそれらの用途 |
| DE19756388A1 (de) * | 1997-12-18 | 1999-06-24 | Hoechst Marion Roussel De Gmbh | Substituierte 2-Aryl-4-amino-chinazoline |
| GB9819382D0 (en) | 1998-09-04 | 1998-10-28 | Cerebrus Ltd | Chemical compounds I |
| ES2223705T3 (es) * | 1999-04-28 | 2005-03-01 | Board Of Regents, The University Of Texas System | Composiciones y metodos para el tratamiento de cancer mediante inhibi cion selectiva del vegf. |
| SV2002000205A (es) | 1999-11-01 | 2002-06-07 | Lilly Co Eli | Compuestos farmaceuticos ref. x-01095 |
| US6776796B2 (en) * | 2000-05-12 | 2004-08-17 | Cordis Corportation | Antiinflammatory drug and delivery device |
| WO2002016360A2 (en) | 2000-08-18 | 2002-02-28 | Cor Therapeutics, Inc. | Nitrogenous heterocyclic compounds |
| US6956039B2 (en) | 2000-08-18 | 2005-10-18 | Millennium Pharmaceuticals, Inc. | Nitrogenous heterocylic compounds |
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| DE10109866A1 (de) | 2001-03-01 | 2002-09-05 | Abbott Gmbh & Co Kg | Triazolverbindungen und deren Verwendung zur Prophylaxe und Therapie neurodegenerativer Erkrankungen, Hirntrauma und zerebraler Ischämie |
| DE60227794D1 (de) * | 2001-04-26 | 2008-09-04 | Eisai R&D Man Co Ltd | Stickstoffhaltige verbindung mit kondensiertem ring und pyrazolylgruppe als substituent und medizinische zusammensetzung davon |
| TWI238824B (en) | 2001-05-14 | 2005-09-01 | Novartis Ag | 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives |
| US7101884B2 (en) | 2001-09-14 | 2006-09-05 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| WO2003024931A1 (en) | 2001-09-14 | 2003-03-27 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| TWI259081B (en) | 2001-10-26 | 2006-08-01 | Sugen Inc | Treatment of acute myeloid leukemia with indolinone compounds |
| CN101703509A (zh) | 2001-10-30 | 2010-05-12 | 诺瓦提斯公司 | 作为flt3受体酪氨酸激酶活性抑制剂的星形孢菌素衍生物 |
| EP1458713B1 (en) | 2001-12-27 | 2005-08-24 | Theravance, Inc. | Indolinone derivatives useful as protein kinase inhibitors |
| DK1474420T3 (da) | 2002-02-01 | 2012-05-21 | Astrazeneca Ab | Quinazolinforbindelser |
| AR037647A1 (es) | 2002-05-29 | 2004-12-01 | Novartis Ag | Derivados de diarilurea utiles para el tratamiento de enfermedades dependientes de la cinasa de proteina |
| MY141867A (en) * | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
| IL165871A0 (en) | 2002-06-27 | 2006-01-15 | Schering Ag | Substituted quinoline CCR5 receptor antagonists |
| GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| EP1546117A2 (en) | 2002-08-14 | 2005-06-29 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors and uses thereof |
| BR0313743A (pt) | 2002-08-23 | 2005-07-05 | Chiron Corp | Benzimidazol quinolinonas e usos destas |
| US20080207617A1 (en) | 2002-10-29 | 2008-08-28 | Kirin Beer Kabushiki Kaisha | Quinoline Derivatives and Quinazoline Derivatives Inhibiting Autophosphrylation of Flt3 and Medicinal Compositions Containing the Same |
| MXPA05004754A (es) | 2002-11-13 | 2005-08-02 | Chiron Corp | Metodos para tratar cancer y metodos relacionados. |
| TWI335913B (en) | 2002-11-15 | 2011-01-11 | Vertex Pharma | Diaminotriazoles useful as inhibitors of protein kinases |
| WO2004058749A1 (en) | 2002-12-18 | 2004-07-15 | Vertex Pharmaceuticals Incorporated | Benzisoxazole derivatives useful as inhibitors of protein kinases |
| AU2003299791A1 (en) | 2002-12-20 | 2004-07-22 | Bayer Pharmaceuticals Corporation | Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity |
| TW200508224A (en) | 2003-02-12 | 2005-03-01 | Bristol Myers Squibb Co | Cyclic derivatives as modulators of chemokine receptor activity |
| US7163937B2 (en) | 2003-08-21 | 2007-01-16 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| ES2344007T3 (es) | 2003-10-14 | 2010-08-16 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Inhibidores proteina quinasa. |
| EP1684694A2 (en) | 2003-11-21 | 2006-08-02 | Array Biopharma, Inc. | Akt protein kinase inhibitors |
| US7825244B2 (en) | 2005-06-10 | 2010-11-02 | Janssen Pharmaceutica Nv | Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis |
| US8071768B2 (en) | 2005-06-10 | 2011-12-06 | Janssen Pharmaceutica, N.V. | Alkylquinoline and alkylquinazoline kinase modulators |
-
2006
- 2006-06-06 US US11/422,349 patent/US8071768B2/en active Active
- 2006-06-07 CA CA002611242A patent/CA2611242A1/en not_active Abandoned
- 2006-06-07 BR BRPI0611964-6A patent/BRPI0611964A2/pt not_active Application Discontinuation
- 2006-06-07 AU AU2006257945A patent/AU2006257945A1/en not_active Abandoned
- 2006-06-07 PE PE2006000627A patent/PE20070014A1/es not_active Application Discontinuation
- 2006-06-07 WO PCT/US2006/022414 patent/WO2006135721A1/en not_active Ceased
- 2006-06-07 EA EA200800017A patent/EA200800017A1/ru unknown
- 2006-06-07 EP EP06772652A patent/EP1893598A1/en not_active Withdrawn
- 2006-06-07 JP JP2008515954A patent/JP2009501135A/ja not_active Withdrawn
- 2006-06-07 KR KR1020087000405A patent/KR20080028912A/ko not_active Withdrawn
- 2006-06-08 GT GT200600251A patent/GT200600251A/es unknown
- 2006-06-08 UY UY29588A patent/UY29588A1/es unknown
- 2006-06-09 AR ARP060102422A patent/AR054386A1/es not_active Application Discontinuation
- 2006-06-09 TW TW095120477A patent/TW200716599A/zh unknown
-
2007
- 2007-11-27 IL IL187692A patent/IL187692A0/en unknown
- 2007-12-10 EC EC2007007997A patent/ECSP077997A/es unknown
-
2008
- 2008-01-09 CR CR9652A patent/CR9652A/es not_active Application Discontinuation
- 2008-01-10 NO NO20080174A patent/NO20080174L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2611242A1 (en) | 2006-12-21 |
| WO2006135721A1 (en) | 2006-12-21 |
| TW200716599A (en) | 2007-05-01 |
| EA200800017A1 (ru) | 2008-08-29 |
| JP2009501135A (ja) | 2009-01-15 |
| AR054386A1 (es) | 2007-06-20 |
| KR20080028912A (ko) | 2008-04-02 |
| IL187692A0 (en) | 2008-08-07 |
| PE20070014A1 (es) | 2007-03-08 |
| ECSP077997A (es) | 2008-01-23 |
| GT200600251A (es) | 2007-01-12 |
| UY29588A1 (es) | 2006-10-02 |
| US8071768B2 (en) | 2011-12-06 |
| BRPI0611964A2 (pt) | 2009-01-27 |
| US20060281772A1 (en) | 2006-12-14 |
| EP1893598A1 (en) | 2008-03-05 |
| NO20080174L (no) | 2008-02-19 |
| AU2006257945A1 (en) | 2006-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal (granting procedure) |