BRPI0613568A2 - Síntese de beta-lactama - Google Patents

Síntese de beta-lactama Download PDF

Info

Publication number
BRPI0613568A2
BRPI0613568A2 BRPI0613568-4A BRPI0613568A BRPI0613568A2 BR PI0613568 A2 BRPI0613568 A2 BR PI0613568A2 BR PI0613568 A BRPI0613568 A BR PI0613568A BR PI0613568 A2 BRPI0613568 A2 BR PI0613568A2
Authority
BR
Brazil
Prior art keywords
beta
synthesis
lactama
cyclocondensed
enolate
Prior art date
Application number
BRPI0613568-4A
Other languages
English (en)
Inventor
Vu Phong
A. Holton Robert
Original Assignee
Florida State University Research Foundation, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Florida State University Research Foundation, Inc. filed Critical Florida State University Research Foundation, Inc.
Publication of BRPI0613568A2 publication Critical patent/BRPI0613568A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SìNTESE DE BETA-LACTAMA. A presente invenção refere-se a um processo para a preparação de <225>-Iactamas. Em geral, uma imina é ciclocondensada com um ceteno acetal ou enolato para formar o produto de Beta-lactama em uma síntese de "one pot", este processo é geralmente realizado em uma temperalura mais alta do que processos convencionais.
BRPI0613568-4A 2005-06-10 2006-06-08 Síntese de beta-lactama BRPI0613568A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US68942505P 2005-06-10 2005-06-10
US60/689,425 2005-06-10
US70892905P 2005-08-17 2005-08-17
US60/708,929 2005-08-17
PCT/US2006/022267 WO2006135670A2 (en) 2005-06-10 2006-06-08 β-LACTAM SYNTHESIS

Publications (1)

Publication Number Publication Date
BRPI0613568A2 true BRPI0613568A2 (pt) 2012-03-20

Family

ID=37513838

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0613568-4A BRPI0613568A2 (pt) 2005-06-10 2006-06-08 Síntese de beta-lactama

Country Status (11)

Country Link
US (1) US7541458B2 (pt)
EP (1) EP1888522A2 (pt)
JP (1) JP2008545792A (pt)
KR (1) KR20080033249A (pt)
AU (1) AU2006258080A1 (pt)
BR (1) BRPI0613568A2 (pt)
CA (1) CA2610442A1 (pt)
IL (1) IL187856A0 (pt)
MX (1) MX2007015593A (pt)
TW (1) TW200716542A (pt)
WO (1) WO2006135670A2 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103808850A (zh) * 2012-11-15 2014-05-21 刘胜远 一种红豆杉中10-去乙酰基巴卡亭ⅲ的薄层色谱检测方法
CN103808851A (zh) * 2012-11-15 2014-05-21 刘胜远 一种红豆杉中10-去乙酰基紫杉醇的薄层色谱检测方法
CN103808854A (zh) * 2012-11-15 2014-05-21 刘胜远 一种红豆杉中巴卡亭ⅲ的薄层色谱检测方法
CN103808853A (zh) * 2012-11-15 2014-05-21 刘胜远 一种红豆杉中7-木糖-10-去乙酰基紫杉醇的薄层色谱检测方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
EP0442576A1 (en) * 1990-02-13 1991-08-21 Rijksuniversiteit Utrecht Synthesis of cis-beta-lactams with the aid of an alkali metal compound
US5284864A (en) * 1991-09-23 1994-02-08 Florida State University Butenyl substituted taxanes and pharmaceutical compositions containing them
US5294737A (en) 1992-02-27 1994-03-15 The Research Foundation State University Of New York Process for the production of chiral hydroxy-β-lactams and hydroxyamino acids derived therefrom
CA2501805C (en) 2002-10-09 2012-05-22 Phytogen Life Sciences, Inc. Novel taxanes and methods related to use and preparation thereof

Also Published As

Publication number Publication date
JP2008545792A (ja) 2008-12-18
WO2006135670A3 (en) 2007-04-19
AU2006258080A1 (en) 2006-12-21
WO2006135670A2 (en) 2006-12-21
MX2007015593A (es) 2008-03-07
CA2610442A1 (en) 2006-12-21
IL187856A0 (en) 2008-03-20
EP1888522A2 (en) 2008-02-20
KR20080033249A (ko) 2008-04-16
TW200716542A (en) 2007-05-01
US20060281914A1 (en) 2006-12-14
US7541458B2 (en) 2009-06-02

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A, 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012.