BRPI0613771A2 - derivado de heterociclideno acetamida - Google Patents

derivado de heterociclideno acetamida

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Publication number
BRPI0613771A2
BRPI0613771A2 BRPI0613771-7A BRPI0613771A BRPI0613771A2 BR PI0613771 A2 BRPI0613771 A2 BR PI0613771A2 BR PI0613771 A BRPI0613771 A BR PI0613771A BR PI0613771 A2 BRPI0613771 A2 BR PI0613771A2
Authority
BR
Brazil
Prior art keywords
group
compound
salt
isomer
solvate
Prior art date
Application number
BRPI0613771-7A
Other languages
English (en)
Inventor
Hideharu Uchida
Naoto Kosuga
Tsutomu Satoh
Daido Hotta
Tomoyuki Kamino
Yoshitaka Maeda
Ken-Ichi Amano
Yasushige Akada
Original Assignee
Mochida Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharm Co Ltd filed Critical Mochida Pharm Co Ltd
Publication of BRPI0613771A2 publication Critical patent/BRPI0613771A2/pt
Publication of BRPI0613771B1 publication Critical patent/BRPI0613771B1/pt

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
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  • Diabetes (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
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Abstract

DERIVADO DE HETEROCICLIDENO ACETAMIDA. Um composto representado pela fórmula (I') (em que m, n, e p cada um representa O a 2; q representa O ou 1; R¹ representa halogênio, um grupo hidrocarboneto, um grupo heterocíclico, um grupo alcoxi, um grupo alcoxicarbonil, um grupo sulfamoil, um grupo CN, um grupo NO~ 2~, ou outros; R² representa halogênio, amino, um grupo hidrocarboneto, um grupo heterocíclico aromático, ou um grupo oxo; X~ 1~ representa O, -NR³-, ou -S(O)r-; X~ 2~ representa um grupo metileno, O, -NR³-, ou -S(O)r-; Q' representa um grupo heteroaril, um grupo heteroarilalquil, um grupo aril substituído, ou um grupo aralquil; Porção de ciclo representa um anel aril ou um anel heteroaril; e a linha ondulada representa um E-isómero ou um Z-isómero), um sal do composto, ou um solvato do composto ou o sal. Uma composição farmacêutica e um Antagonista de receptor tipo I potencial de receptor transitório (TRPV1) cada um contendo, como um ingrediente ativo, pelo menos um do composto, um sal do composto e um solvato do composto ou o sal.
BRPI0613771-7A 2005-07-22 2006-07-24 Composto derivado de heterociclideno acetamida, composição farmacêutica e antagonista de receptor de tipo i vaniloide com potencial de receptor transitório (trpv1) BRPI0613771B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2005-213534 2005-07-22
JP2005213534 2005-07-22
JP2005-330890 2005-11-15
JP2005330890 2005-11-15
JP2006045985 2006-02-22
JP2006-045985 2006-02-22
PCT/IB2006/002016 WO2007010383A1 (ja) 2005-07-22 2006-07-24 新規なヘテロシクリデンアセトアミド誘導体

Publications (2)

Publication Number Publication Date
BRPI0613771A2 true BRPI0613771A2 (pt) 2009-05-19
BRPI0613771B1 BRPI0613771B1 (pt) 2021-11-23

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BRPI0613771-7A BRPI0613771B1 (pt) 2005-07-22 2006-07-24 Composto derivado de heterociclideno acetamida, composição farmacêutica e antagonista de receptor de tipo i vaniloide com potencial de receptor transitório (trpv1)

Country Status (14)

Country Link
US (2) US7910751B2 (pt)
EP (1) EP1908753B1 (pt)
JP (2) JP4754566B2 (pt)
KR (2) KR101136183B1 (pt)
AU (1) AU2006271297C1 (pt)
BR (1) BRPI0613771B1 (pt)
CA (1) CA2616079C (pt)
CR (1) CR9660A (pt)
EC (1) ECSP088129A (pt)
ES (1) ES2531621T3 (pt)
NO (1) NO341962B1 (pt)
NZ (1) NZ565080A (pt)
PT (1) PT1908753E (pt)
WO (1) WO2007010383A1 (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4754566B2 (ja) 2005-07-22 2011-08-24 持田製薬株式会社 新規なヘテロシクリデンアセトアミド誘導体
US20100016285A1 (en) * 2007-01-24 2010-01-21 Mochida Pharmaceutical Co., Ltd. Heterocyclidene-n-(aryl) acetamide derivative
PE20081692A1 (es) * 2007-01-24 2008-12-18 Mochida Pharm Co Ltd Nuevo derivado de heterocicliden acetamida
JP2011201776A (ja) * 2008-07-23 2011-10-13 Mochida Pharmaceut Co Ltd ヘテロシクリデン−ｎ−（３，４−ジヒドロ−２（１ｈ）−キナゾリノン−５−イル）アセトアミド誘導体
WO2009037707A2 (en) 2007-09-20 2009-03-26 Ramot At Tel Aviv University Ltd. N-phenyl anthranilic acid derivatives and uses thereof
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