BRPI0614716A2 - método para produção de um produto quìmico a partir da via c4 de a. succinogenes - Google Patents

método para produção de um produto quìmico a partir da via c4 de a. succinogenes Download PDF

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Publication number
BRPI0614716A2
BRPI0614716A2 BRPI0614716-0A BRPI0614716A BRPI0614716A2 BR PI0614716 A2 BRPI0614716 A2 BR PI0614716A2 BR PI0614716 A BRPI0614716 A BR PI0614716A BR PI0614716 A2 BRPI0614716 A2 BR PI0614716A2
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BR
Brazil
Prior art keywords
succinogenes
enzymes
pyruvate
pathway
group
Prior art date
Application number
BRPI0614716-0A
Other languages
English (en)
Portuguese (pt)
Inventor
J Gregory Zeikus
Original Assignee
Univ Michigan State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan State filed Critical Univ Michigan State
Publication of BRPI0614716A2 publication Critical patent/BRPI0614716A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/14—Glutamic acid; Glutamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/20—Aspartic acid; Asparagine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/50—Polycarboxylic acids having keto groups, e.g. 2-ketoglutaric acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BRPI0614716-0A 2005-08-05 2006-08-04 método para produção de um produto quìmico a partir da via c4 de a. succinogenes BRPI0614716A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70584105P 2005-08-05 2005-08-05
US60/705.841 2005-08-05
PCT/US2006/030425 WO2007019301A2 (fr) 2005-08-05 2006-08-04 Genes issus de d'actinobacillus succinogenes 130z (atcc 55618) pour la production d'agents chimiques issus de la voie c4 d'a. succinogenes

Publications (1)

Publication Number Publication Date
BRPI0614716A2 true BRPI0614716A2 (pt) 2011-04-12

Family

ID=37727918

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0614716-0A BRPI0614716A2 (pt) 2005-08-05 2006-08-04 método para produção de um produto quìmico a partir da via c4 de a. succinogenes

Country Status (7)

Country Link
EP (1) EP1922405A4 (fr)
KR (1) KR20080031504A (fr)
CN (1) CN101278041A (fr)
BR (1) BRPI0614716A2 (fr)
CA (1) CA2618694A1 (fr)
MX (1) MX2008001716A (fr)
WO (1) WO2007019301A2 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0819717B1 (pt) 2007-11-20 2022-05-17 Dsm Ip Assets B.V. Levedura recombinante e processo para a produção de ácido succínico
ATE555203T1 (de) 2007-11-20 2012-05-15 Dsm Ip Assets Bv Dicarbonsäureproduktion in eukaryonten
WO2013163628A2 (fr) 2012-04-27 2013-10-31 Duke University Correction génétique de gènes ayant subi une mutation
BE1021047B1 (fr) * 2013-01-18 2015-02-25 Man To Tree S.A. Actinobacillus succinogenes genetiquement modifiee et son utilisation pour la production d'acide succinique
CN103981203B (zh) * 2013-02-07 2018-01-12 中国科学院天津工业生物技术研究所 5‑氨基乙酰丙酸高产菌株及其制备方法和应用
US9828582B2 (en) 2013-03-19 2017-11-28 Duke University Compositions and methods for the induction and tuning of gene expression
CN105849555B (zh) * 2013-12-18 2019-05-14 加利福尼亚太平洋生物科学股份有限公司 用于错误校正的序列读数迭代聚类
CN103695364B (zh) * 2014-01-14 2018-02-02 中国科学院天津工业生物技术研究所 通过弱化5‑氨基乙酰丙酸脱水酶活性获得5‑氨基乙酰丙酸高产菌株及其应用
CN103710374B (zh) * 2014-01-14 2018-02-06 中国科学院天津工业生物技术研究所 一种5‑氨基乙酰丙酸产生菌株及其制备方法与应用
KR20160117572A (ko) 2014-02-07 2016-10-10 바스프 에스이 수크로스 상의 정밀 화학물질의 개선된 생산을 위한 변형된 미생물
CN104357497B (zh) * 2014-10-22 2018-04-27 江南大学 一种提高产酸丙酸杆菌丙酸产量的方法
WO2016130600A2 (fr) 2015-02-09 2016-08-18 Duke University Compositions et procédés pour l'édition de l'épigénome
EP4089175A1 (fr) 2015-10-13 2022-11-16 Duke University Ingénierie génomique avec systèmes crispr de type i dans des cellules eucaryotes
KR102787119B1 (ko) 2015-11-30 2025-03-27 듀크 유니버시티 유전자 편집에 의한 인간 디스트로핀 유전자의 교정을 위한 치료용 표적 및 사용 방법
US20190127713A1 (en) 2016-04-13 2019-05-02 Duke University Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
JP7490211B2 (ja) 2016-07-19 2024-05-27 デューク ユニバーシティ Ｃｐｆ１に基づくゲノム編集の治療適用
US10428359B2 (en) * 2016-10-03 2019-10-01 Ajinomoto Co, Inc. Method for producing L-amino acid
KR20200009010A (ko) * 2017-05-19 2020-01-29 바스프 에스이 유기 화합물 제조 방법
EP3740580A4 (fr) 2018-01-19 2021-10-20 Duke University Ingénierie génomique avec des systèmes crispr-cas dans des eucaryotes
CN108517327B (zh) * 2018-04-20 2020-10-30 中国科学院天津工业生物技术研究所 5-氨基乙酰丙酸高产菌株及其制备方法和应用
CN110904018B (zh) * 2018-09-14 2022-09-09 中国科学院天津工业生物技术研究所 5-氨基乙酰丙酸生产菌株及其构建方法和应用
US20230383297A1 (en) * 2020-10-09 2023-11-30 Duke University Novel targets for reactivation of prader-willi syndrome-associated genes
WO2023095896A1 (fr) * 2021-11-26 2023-06-01 Dic株式会社 Micro-organisme génétiquement modifié et procédé de production d'asparagine
IL317874A (en) 2022-06-24 2025-02-01 Tune Therapeutics Inc Compounds, systems and methods for reducing low density lipoproteins through targeted gene suppression

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696561B1 (en) * 1909-07-09 2004-02-24 Basf Aktiengesellschaft Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport
US20030087381A1 (en) * 1998-04-13 2003-05-08 University Of Georgia Research Foundation, Inc. Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals
US6495023B1 (en) * 1998-07-09 2002-12-17 Michigan State University Electrochemical methods for generation of a biological proton motive force and pyridine nucleotide cofactor regeneration
US6599732B1 (en) * 1999-06-29 2003-07-29 Archer-Daniels-Midland Company Regulation of carbon assimilation
WO2004044210A2 (fr) * 2002-11-06 2004-05-27 University Of Florida Materiaux et procedes permettant une bonne production d'acetate et d'autres produits
AU2004245988A1 (en) * 2003-05-30 2004-12-16 Microbia, Inc. Methods and compositions for amino acid production
US7393669B2 (en) * 2003-07-07 2008-07-01 Fluxome Sciences A/S Metabolically engineered micro-organisms having improved galactose uptake
US7163812B2 (en) * 2003-08-06 2007-01-16 Board Of Trustees Of Michigan State University Actinobacillus succinogenes shuttle vector and methods of use

Also Published As

Publication number Publication date
WO2007019301A2 (fr) 2007-02-15
EP1922405A4 (fr) 2009-04-01
CN101278041A (zh) 2008-10-01
WO2007019301A3 (fr) 2007-07-12
KR20080031504A (ko) 2008-04-08
CA2618694A1 (fr) 2007-02-15
MX2008001716A (es) 2008-04-07
EP1922405A2 (fr) 2008-05-21

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012.