ATE555203T1 - Dicarbonsäureproduktion in eukaryonten - Google Patents
Dicarbonsäureproduktion in eukaryontenInfo
- Publication number
- ATE555203T1 ATE555203T1 AT08851601T AT08851601T ATE555203T1 AT E555203 T1 ATE555203 T1 AT E555203T1 AT 08851601 T AT08851601 T AT 08851601T AT 08851601 T AT08851601 T AT 08851601T AT E555203 T1 ATE555203 T1 AT E555203T1
- Authority
- AT
- Austria
- Prior art keywords
- eukaryones
- acid production
- dicarbonic acid
- eukaryotic cell
- present
- Prior art date
Links
- ZFTFAPZRGNKQPU-UHFFFAOYSA-N dicarbonic acid Chemical compound OC(=O)OC(O)=O ZFTFAPZRGNKQPU-UHFFFAOYSA-N 0.000 title 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 2
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 2
- 239000001384 succinic acid Substances 0.000 abstract 2
- 241000233866 Fungi Species 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 102000019259 Succinate Dehydrogenase Human genes 0.000 abstract 1
- 108010012901 Succinate Dehydrogenase Proteins 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 239000001530 fumaric acid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Fuel Cell (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07121117 | 2007-11-20 | ||
| EP07121113 | 2007-11-20 | ||
| EP07121120 | 2007-11-20 | ||
| EP08156961 | 2008-05-27 | ||
| EP08156960 | 2008-05-27 | ||
| EP08156959 | 2008-05-27 | ||
| PCT/EP2008/065588 WO2009065780A1 (en) | 2007-11-20 | 2008-11-14 | Dicarboxylic acid production in eukaryotes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE555203T1 true ATE555203T1 (de) | 2012-05-15 |
Family
ID=40268299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08851601T ATE555203T1 (de) | 2007-11-20 | 2008-11-14 | Dicarbonsäureproduktion in eukaryonten |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9340804B2 (de) |
| EP (3) | EP2220232B1 (de) |
| JP (2) | JP5641938B2 (de) |
| CN (3) | CN104818224A (de) |
| AT (1) | ATE555203T1 (de) |
| BR (2) | BRPI0819275B8 (de) |
| CA (2) | CA2704654C (de) |
| EA (1) | EA032726B1 (de) |
| ES (2) | ES2383473T3 (de) |
| WO (2) | WO2009065778A1 (de) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110039327A1 (en) * | 2007-05-18 | 2011-02-17 | Aaron Adriaan Winkler | Organic acid production by fungal cells |
| WO2009065778A1 (en) * | 2007-11-20 | 2009-05-28 | Dsm Ip Assets B.V. | Succinic acid production in a eukaryotic cell |
| CN102016053A (zh) * | 2008-02-15 | 2011-04-13 | 帝斯曼知识产权资产管理有限公司 | 生产二羧酸的方法 |
| CN102089436A (zh) | 2008-07-08 | 2011-06-08 | 帝斯曼知识产权资产管理有限公司 | 通过在低pH下发酵生产二羧酸 |
| RU2422526C2 (ru) * | 2009-01-30 | 2011-06-27 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов (ФГУП ГосНИИгенетика) | СПОСОБ ПОЛУЧЕНИЯ ЯНТАРНОЙ КИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ ДРОЖЖЕЙ, ПРИНАДЛЕЖАЩИХ К РОДУ Yarrowia |
| EP2419518A1 (de) * | 2009-04-15 | 2012-02-22 | DSM IP Assets B.V. | Dicarbonsäureherstellungsverfahren |
| UA108853C2 (uk) | 2009-07-10 | 2015-06-25 | Спосіб ферментації галактози | |
| EA026438B1 (ru) | 2009-08-27 | 2017-04-28 | ДСМ АйПи АССЕТС Б.В. | Способ ферментативного получения дикарбоновых кислот |
| MX2012002532A (es) * | 2009-09-01 | 2012-04-11 | Novozymes Inc | Metodos para mejorar la produccion de acido malico en hongos filamentosos. |
| WO2011064151A1 (en) | 2009-11-24 | 2011-06-03 | Dsm Ip Assets B.V. | Process for the crystallization of succinic acid |
| JP2011120508A (ja) * | 2009-12-09 | 2011-06-23 | Oji Paper Co Ltd | コハク酸を製造する方法 |
| EP2519491A4 (de) | 2009-12-31 | 2014-10-08 | Groupe Novasep Sas | Reinigung von bernsteinsäure aus der fermentierung von sprossen mit ammoniumsuccinat |
| JP5857954B2 (ja) | 2010-03-09 | 2016-02-10 | 三菱化学株式会社 | コハク酸の製造方法 |
| EP2371802A1 (de) | 2010-03-30 | 2011-10-05 | DSM IP Assets B.V. | Verfahren zur Kristallisierung von Bernsteinsäure |
| JP2013524797A (ja) | 2010-04-21 | 2013-06-20 | ディーエスエム アイピー アセッツ ビー．ブイ． | アラビノースを転化できる細胞を製造する方法 |
| EP2576606B1 (de) | 2010-06-04 | 2014-12-10 | Novozymes, Inc. | Produktion von c4-dicarboxylsäure bei fadenpilzen |
| CN102947458B (zh) | 2010-06-21 | 2016-05-04 | 诺维信股份有限公司 | 用于丝状真菌中c4-二羧酸的改善的产生的方法 |
| CA2803343C (en) | 2010-06-21 | 2018-08-07 | Novozymes, Inc. | Aspergillus aculeatus derived polypeptides having c4-dicarboxylic acid transporter activity and polynucleotides encoding same |
| US9187772B2 (en) * | 2010-09-01 | 2015-11-17 | University Of Florida Research Foundation, Inc. | L-malate production by metabolically engineered escherichia coli |
| EP2619314A1 (de) | 2010-09-24 | 2013-07-31 | DSM IP Assets B.V. | Verfahren zur herstellung von dicarbonsäure |
| CN103314098A (zh) * | 2010-10-28 | 2013-09-18 | 道达尔炼油与销售部 | 红曲霉在有机酸生产中的用途 |
| EP2495304A1 (de) | 2010-12-03 | 2012-09-05 | DSM IP Assets B.V. | Dikarbonsäure Produktion in Hefe Zellen |
| WO2012103261A2 (en) | 2011-01-25 | 2012-08-02 | Finley Kenneth R | Compositions and methods for succinate production |
| BR112013019036A2 (pt) | 2011-02-28 | 2017-04-04 | Novozymes Inc | célula hospedeira recombinante, e, método para produzir um ácido dicarboxílico. |
| PL2726624T3 (pl) | 2011-07-01 | 2017-06-30 | Dsm Ip Assets B.V. | Sposób wytwarzania kwasów dikarboksylowych komórki zatrudniających grzybiczych |
| DK2744904T3 (en) | 2011-08-19 | 2016-07-25 | Novozymes Inc | Recombinant microorganisms for the preparation of C4 dicarboxylic acids |
| CN102559518B (zh) * | 2011-12-20 | 2013-10-16 | 江南大学 | 一种高产延胡索酸米根霉及其应用 |
| US9885065B2 (en) * | 2012-01-25 | 2018-02-06 | Bioamber Inc. | Methods for succinate production |
| FR2987678B1 (fr) | 2012-03-02 | 2016-04-15 | Roquette Freres | Methode de mesure de la stabilite thermique d'un acide succinique cristallin destine a la fabrication de polymeres |
| FR2988733B1 (fr) | 2012-03-27 | 2016-02-05 | Carbios | Microorganisme recombinant |
| KR101464656B1 (ko) * | 2012-06-15 | 2014-12-02 | 한국생명공학연구원 | 발효산물 고생성능을 가지는 변이 미생물 및 이를 이용한 발효산물의 제조방법 |
| US10066246B2 (en) | 2012-07-25 | 2018-09-04 | Cargill, Incorporated | Yeast cells having NADP(H)-dependent reductive TCA pathway from pyruvate to succinate |
| EP3901248A1 (de) | 2012-07-25 | 2021-10-27 | Cargill, Incorporated | Hefezellen mit reduktivem tca-weg von pyruvat zu succinat und überexpression eines exogenen nad(p)+-transhydrogenase-enzyms |
| US20150211024A1 (en) * | 2012-08-28 | 2015-07-30 | Braskem S.A. | Methods for production of a terpene and a co-product |
| US11072807B2 (en) * | 2012-09-14 | 2021-07-27 | Ptt Global Chemical Public Company Limited | Production of organic acids by fermentation of genetically engineered yeast cells at low pH |
| EP2898082B1 (de) | 2012-09-20 | 2019-09-04 | LCY Bioscience Inc. | Pfade zu adipatsemialdehyd und anderen organischen produkten |
| WO2014135712A2 (en) | 2013-03-08 | 2014-09-12 | Dsm Ip Assets B.V. | Polyester |
| CN105378093A (zh) * | 2013-07-18 | 2016-03-02 | 帝斯曼知识产权资产管理有限公司 | 发酵方法 |
| EP3080251B1 (de) * | 2013-12-12 | 2020-03-04 | DSM IP Assets B.V. | Fumaratreduktasen |
| WO2016002680A1 (ja) * | 2014-06-30 | 2016-01-07 | 旭硝子株式会社 | 形質転換体およびその製造方法、ならびに炭素数４のジカルボン酸の製造方法 |
| US9882151B2 (en) | 2014-11-14 | 2018-01-30 | Universal Display Corporation | Organic electroluminescent materials and devices |
| US10189767B2 (en) | 2014-12-02 | 2019-01-29 | Dsm Ip Assets B.V. | Process for manufacturing succinic acid from a fermentation broth using nano filtration to purify recycled mother liquor |
| EP3067378A1 (de) | 2015-03-11 | 2016-09-14 | DSM IP Assets B.V. | Polyester |
| JP2018526969A (ja) | 2015-06-04 | 2018-09-20 | バイオアンバー インコーポレイテッドＢｉｏａｍｂｅｒ Ｉｎｃ． | 官能基化アルファ置換アクリレートおよびｃ４ジカルボキシレートのバイオベース産生 |
| ES2940213T3 (es) * | 2015-12-23 | 2023-05-04 | Technip Energies France | Células huésped para la producción de ácido dicarboxílico |
| JP2017121184A (ja) * | 2016-01-04 | 2017-07-13 | 花王株式会社 | 変異リゾプス属菌 |
| CA3030605A1 (en) | 2016-07-13 | 2018-01-18 | Dsm Ip Assets B.V. | Malate dehyrogenases |
| DE102016115425A1 (de) | 2016-08-19 | 2018-02-22 | Jacobs University Bremen Ggmbh | Gentechnisch veränderte Hefe zur Fermentation von Glycerol |
| US11548980B2 (en) | 2017-05-18 | 2023-01-10 | Avantium Knowledge Centre B.V. | Polyester copolymer |
| JP7159213B2 (ja) | 2017-05-18 | 2022-10-24 | アバンティウム・ナレッジ・センター・ベー・フェー | ポリエステルコポリマー |
| EP3652321B9 (de) * | 2017-07-11 | 2023-10-04 | Adisseo France S.A.S. | Saccharomyces cerevisiae mit erhöhter metabolitproduktion |
| CN118879519A (zh) * | 2018-05-25 | 2024-11-01 | 丹尼斯科美国公司 | 富马酸还原酶过表达导致酵母中增加的发酵速率 |
| KR102129379B1 (ko) * | 2018-10-10 | 2020-07-02 | 한국과학기술원 | 고활성의 말산 탈수소효소가 도입된 숙신산 생성용 변이 미생물 및 이를 이용한 숙신산 제조방법 |
| EP3883985A1 (de) | 2018-11-22 | 2021-09-29 | Avantium Knowledge Centre B.V. | Verfahren zur herstellung von einem oder mehreren polyestercopolymeren, verfahren zur herstellung von einem oder mehreren oligomeren, oligomerzusammensetzung und polyestercopolymer |
| CN113249238B (zh) * | 2021-05-07 | 2022-08-23 | 江南大学 | 一株耐酸酿酒酵母及其在有机酸制备中的应用 |
| CN114806913B (zh) * | 2022-04-15 | 2023-11-28 | 盛虹控股集团有限公司 | 具有线粒体定位还原tca途径的高产琥珀酸酵母工程菌株及其构建方法和应用 |
Family Cites Families (26)
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|---|---|---|---|---|
| DE3542861A1 (de) | 1985-12-04 | 1987-06-11 | Huels Chemische Werke Ag | Verfahren zur gewinnung von l-aepfelsaeure |
| US5643758A (en) * | 1987-03-10 | 1997-07-01 | New England Biolabs, Inc. | Production and purification of a protein fused to a binding protein |
| WO1990014423A1 (en) | 1989-05-18 | 1990-11-29 | The Infergene Company | Microorganism transformation |
| ATE160176T1 (de) | 1989-07-07 | 1997-11-15 | Unilever Nv | Verfahren zur herstellung eines proteins mittels eines durch mehrfachkopieintegrierung eines expressionsvektors transformierten pilzes |
| EP0635574B1 (de) | 1993-07-23 | 2003-04-23 | Dsm N.V. | Selektionmarker-genfreie rekombinante Stämme: Verfahren zur ihrer Herstellung und die Verwendung dieser Stämme |
| US6265186B1 (en) | 1997-04-11 | 2001-07-24 | Dsm N.V. | Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces |
| EP0979294B1 (de) | 1997-04-11 | 2015-05-27 | DSM IP Assets B.V. | Genkonversion als mittel zur herstellung von rekombinanten industriellen filamentösen pilzen |
| PL344863A1 (en) | 1998-05-19 | 2001-11-19 | Dsm Nv | Improved in vivo |
| EP1141372A2 (de) | 1998-12-22 | 2001-10-10 | Dsm N.V. | Verbesserte in vivo-produktion von cephalosporinen |
| EP1672077B1 (de) | 2003-08-28 | 2015-01-21 | Mitsubishi Chemical Corporation | Verfahren zur herstellung von bernsteinsäure |
| DE102004011248A1 (de) * | 2004-03-09 | 2005-09-22 | Degussa Ag | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
| US8119377B2 (en) * | 2004-12-22 | 2012-02-21 | Michigan Biotechnology Institute | Recombinant microorganisms for increased production of organic acids |
| US7435168B2 (en) * | 2005-01-14 | 2008-10-14 | Archer-Daniels-Midland Company | Compositions and methods for manipulating carbon flux in cells |
| DE102005031801B3 (de) * | 2005-07-07 | 2006-08-24 | Carsten Paulsen | Reinigungsanlage für Türme von Windkraftanlagen |
| BRPI0614716A2 (pt) * | 2005-08-05 | 2011-04-12 | Univ Michigan State | método para produção de um produto quìmico a partir da via c4 de a. succinogenes |
| KR100727054B1 (ko) | 2005-08-19 | 2007-06-12 | 한국과학기술원 | 푸마레이트 하이드라타제 ｃ를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법 |
| AU2006287257A1 (en) | 2005-09-09 | 2007-03-15 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of succinate |
| US20080090273A1 (en) * | 2005-11-21 | 2008-04-17 | Aaron Adriaan Winkler | Malic Acid Production in Recombinant Yeast |
| EP1867727A1 (de) | 2006-06-15 | 2007-12-19 | Danmarks Tekniske Universitet | Erhöhte Citratproduktion |
| ES2534282T3 (es) | 2006-06-29 | 2015-04-21 | Dsm Ip Assets B.V. | Un método para lograr la expresión polipeptídica mejorada |
| EP2147970B1 (de) * | 2007-04-17 | 2014-12-31 | Ajinomoto Co., Inc. | Verfahren zur herstellung einer sauren substanz mit einer carboxylgruppe |
| US20110039327A1 (en) | 2007-05-18 | 2011-02-17 | Aaron Adriaan Winkler | Organic acid production by fungal cells |
| US20110045559A1 (en) | 2007-05-18 | 2011-02-24 | Aaron Adriaan Winkler | Malic acid production in recombinant yeast |
| WO2009065778A1 (en) * | 2007-11-20 | 2009-05-28 | Dsm Ip Assets B.V. | Succinic acid production in a eukaryotic cell |
| US9885065B2 (en) | 2012-01-25 | 2018-02-06 | Bioamber Inc. | Methods for succinate production |
| US11072807B2 (en) | 2012-09-14 | 2021-07-27 | Ptt Global Chemical Public Company Limited | Production of organic acids by fermentation of genetically engineered yeast cells at low pH |
-
2008
- 2008-11-14 WO PCT/EP2008/065583 patent/WO2009065778A1/en not_active Ceased
- 2008-11-14 BR BRPI0819275A patent/BRPI0819275B8/pt active IP Right Grant
- 2008-11-14 AT AT08851601T patent/ATE555203T1/de active
- 2008-11-14 CN CN201510186003.3A patent/CN104818224A/zh active Pending
- 2008-11-14 ES ES08851601T patent/ES2383473T3/es active Active
- 2008-11-14 CN CN200880117105.8A patent/CN101903522B/zh active Active
- 2008-11-14 JP JP2010533596A patent/JP5641938B2/ja active Active
- 2008-11-14 WO PCT/EP2008/065588 patent/WO2009065780A1/en not_active Ceased
- 2008-11-14 EP EP08851178.7A patent/EP2220232B1/de active Active
- 2008-11-14 BR BRPI0819273A patent/BRPI0819273B8/pt active IP Right Grant
- 2008-11-14 EA EA201000837A patent/EA032726B1/ru not_active IP Right Cessation
- 2008-11-14 CN CN200880117129.3A patent/CN101978063B/zh active Active
- 2008-11-14 EP EP13170415.7A patent/EP2687602A1/de not_active Withdrawn
- 2008-11-14 CA CA2704654A patent/CA2704654C/en active Active
- 2008-11-14 EP EP08851601A patent/EP2220233B1/de active Active
- 2008-11-14 US US12/743,927 patent/US9340804B2/en active Active
- 2008-11-14 CA CA2875319A patent/CA2875319A1/en not_active Abandoned
- 2008-11-14 ES ES08851178.7T patent/ES2522622T3/es active Active
- 2008-11-14 US US12/743,106 patent/US20120165569A1/en not_active Abandoned
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2013
- 2013-10-02 US US14/044,722 patent/US9689005B2/en active Active
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2014
- 2014-07-25 JP JP2014151882A patent/JP2014236739A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011502524A (ja) | 2011-01-27 |
| CA2704654C (en) | 2015-02-10 |
| CN101978063B (zh) | 2018-10-16 |
| US20120165569A1 (en) | 2012-06-28 |
| BRPI0819275B8 (pt) | 2022-07-19 |
| US9340804B2 (en) | 2016-05-17 |
| EP2220233B1 (de) | 2012-04-25 |
| WO2009065778A1 (en) | 2009-05-28 |
| US20110081694A1 (en) | 2011-04-07 |
| CN101903522B (zh) | 2015-08-05 |
| BRPI0819273B8 (pt) | 2022-07-19 |
| CN101978063A (zh) | 2011-02-16 |
| EP2220233A1 (de) | 2010-08-25 |
| ES2383473T3 (es) | 2012-06-21 |
| JP5641938B2 (ja) | 2014-12-17 |
| EA032726B1 (ru) | 2019-07-31 |
| JP2014236739A (ja) | 2014-12-18 |
| BRPI0819275A2 (pt) | 2014-10-14 |
| ES2522622T3 (es) | 2014-11-17 |
| CA2875319A1 (en) | 2009-05-28 |
| US20140031587A1 (en) | 2014-01-30 |
| BRPI0819273A2 (pt) | 2014-10-14 |
| WO2009065780A1 (en) | 2009-05-28 |
| BRPI0819273B1 (pt) | 2022-05-17 |
| EP2220232B1 (de) | 2014-09-03 |
| EP2687602A1 (de) | 2014-01-22 |
| US9689005B2 (en) | 2017-06-27 |
| EP2220232A1 (de) | 2010-08-25 |
| EA201000837A1 (ru) | 2010-12-30 |
| CA2704654A1 (en) | 2009-05-28 |
| BRPI0819275B1 (pt) | 2022-05-17 |
| CN104818224A (zh) | 2015-08-05 |
| CN101903522A (zh) | 2010-12-01 |
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