BRPI0615970A8 - Processo para preparar (s) (+)-10,11-dihidro-10-hidróxi-5h-dibenz/b,f/azepina-5-carboxamida, processo para preparar (s) - (-) -10-acetoxi-10,11 -dihidro-5h-dibenz/b,f/azepina-5-carboxamida e processo para preparar (r) - (+)-10-acetoxi-10,11-dihidro-5h-dibenz/b,f/azepina-5-carboxamida - Google Patents

Processo para preparar (s) (+)-10,11-dihidro-10-hidróxi-5h-dibenz/b,f/azepina-5-carboxamida, processo para preparar (s) - (-) -10-acetoxi-10,11 -dihidro-5h-dibenz/b,f/azepina-5-carboxamida e processo para preparar (r) - (+)-10-acetoxi-10,11-dihidro-5h-dibenz/b,f/azepina-5-carboxamida

Info

Publication number
BRPI0615970A8
BRPI0615970A8 BRPI0615970A BRPI0615970A BRPI0615970A8 BR PI0615970 A8 BRPI0615970 A8 BR PI0615970A8 BR PI0615970 A BRPI0615970 A BR PI0615970A BR PI0615970 A BRPI0615970 A BR PI0615970A BR PI0615970 A8 BRPI0615970 A8 BR PI0615970A8
Authority
BR
Brazil
Prior art keywords
carboxamide
azepine
preparing
dibenz
dihydro
Prior art date
Application number
BRPI0615970A
Other languages
English (en)
Inventor
Alexandra Grasa Gabriela
Zanotti-Gerosa Antonio
Alexander Learmonth David
Original Assignee
Portela & Ca Sa
Bial Portela & Ca Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34983785&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0615970(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Portela & Ca Sa, Bial Portela & Ca Sa filed Critical Portela & Ca Sa
Publication of BRPI0615970A2 publication Critical patent/BRPI0615970A2/pt
Publication of BRPI0615970A8 publication Critical patent/BRPI0615970A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)

Abstract

PROCESSO PARA PREPARAR (S) (+) lO,11-DIHIDROlO-HIDROXI-5H-DIBENZ/B, F/AZEPINA-5-CARBOXAMIDA, PROCESSO PARA PREPARAR(S) - (-) -10-ACETOXI-lO,llDIHIDRO5HDIBENZ/B,F/ AZEPINA-5-CARBOXAMIDA E PROCESSO PARA PREPARAR(R) - (+) -10-- ACETOXI-lO, 5H-DIHIDRO-5H~DIBENZ/B,F/AzEPINA-5- CARBOXAMIDA. É divulgado um processo para preparar (S)-(+)-lO,l1- dihidro- 10 -hidroxi-5H-dibeflZ/b, f/azepina-5-carboxamida, ou (R) - (-) -5-carboxamida, por redução de oxcarbazepifla na presença de um catalisador e uma fonte de hidreto. O catalisador é preparado a partir de uma combinação de [RuX~ 2~(L)]~ 2~ sendo que X é cloro, bromo ou iodo, e L é um ligante arila ou aril-alifático, com o ligante de fórmula (A) ou fórmula (B) onde R^ 1^ é selecionado de alcóxi e alquila C~ 1- 6~, n é um número de O a 5, e quando n é um número de 2 a 5, R^1^ poderá ser igual ou diferente, e R^ 2^ é alquila, alquila substituído, arila, arila substituído, alcarila ou alcarila substituído. A fonte de hidreto é ou NR3R4R5 e ácido fórmico, ou [R^ 3^R^ 4^R^ 5^NH] [OOCH] e opcionalmente ácido fórmico, ou [Ml [OOCH]X e ácido fórmico, sendo que R^ 3^, R^ 4^ e R^ 5^ são alquila C~ 1- 6~M é um metal alcalino ou um metal alcalino-terroso e x é 1 ou 2. É mantido um pH de 6,5 a 8 durante o processo.
BRPI0615970A 2005-07-29 2006-04-21 Processo para preparar (s) (+)-10,11-dihidro-10-hidróxi-5h-dibenz/b,f/azepina-5-carboxamida, processo para preparar (s) - (-) -10-acetoxi-10,11 -dihidro-5h-dibenz/b,f/azepina-5-carboxamida e processo para preparar (r) - (+)-10-acetoxi-10,11-dihidro-5h-dibenz/b,f/azepina-5-carboxamida BRPI0615970A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0515690.6 2005-07-29
GBGB0515690.6A GB0515690D0 (en) 2005-07-29 2005-07-29 Asymmetric catalytic reduction
PCT/GB2006/001473 WO2007012793A1 (en) 2005-07-29 2006-04-21 Asymmetric catalytic reduction of oxcarbazepine

Publications (2)

Publication Number Publication Date
BRPI0615970A2 BRPI0615970A2 (pt) 2011-05-31
BRPI0615970A8 true BRPI0615970A8 (pt) 2017-08-22

Family

ID=34983785

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0615970A BRPI0615970A8 (pt) 2005-07-29 2006-04-21 Processo para preparar (s) (+)-10,11-dihidro-10-hidróxi-5h-dibenz/b,f/azepina-5-carboxamida, processo para preparar (s) - (-) -10-acetoxi-10,11 -dihidro-5h-dibenz/b,f/azepina-5-carboxamida e processo para preparar (r) - (+)-10-acetoxi-10,11-dihidro-5h-dibenz/b,f/azepina-5-carboxamida

Country Status (23)

Country Link
US (4) US8288532B2 (pt)
EP (2) EP1915346B1 (pt)
JP (2) JP5295765B2 (pt)
KR (1) KR101362281B1 (pt)
CN (1) CN101277937B (pt)
AR (1) AR055917A1 (pt)
AT (1) ATE520665T1 (pt)
AU (1) AU2006273874B2 (pt)
BR (1) BRPI0615970A8 (pt)
CA (1) CA2616984C (pt)
CY (1) CY1111988T1 (pt)
DK (1) DK1915346T3 (pt)
ES (2) ES2371556T3 (pt)
GB (1) GB0515690D0 (pt)
IL (1) IL189062A0 (pt)
MX (1) MX2008001291A (pt)
NZ (1) NZ565462A (pt)
PL (1) PL1915346T3 (pt)
PT (1) PT103467B (pt)
RU (1) RU2439060C2 (pt)
SI (1) SI1915346T1 (pt)
WO (1) WO2007012793A1 (pt)
ZA (1) ZA200800986B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060252745A1 (en) 2005-05-06 2006-11-09 Almeida Jose L D Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use
GB0515690D0 (en) 2005-07-29 2005-09-07 Portela & Ca Sa Asymmetric catalytic reduction
GB0700773D0 (en) 2007-01-15 2007-02-21 Portela & Ca Sa Drug therapies
US8372431B2 (en) 2007-10-26 2013-02-12 Bial-Portela & C.A., S.A. Pharmaceutical composition comprising licarbazepine acetate
EP2414335A4 (en) 2009-04-02 2012-02-08 Glenmark Generics Ltd PROCESS FOR PURIFYING ESLICARBAZEPINACETATE
RU2012106827A (ru) 2009-07-27 2013-09-10 БИАЛ-ПОРТЕЛА энд КА., С.А. Применение производных 5н-дибенз/в, f/азепин-5-карбоксамида для лечения фибромиалгии
WO2011091131A2 (en) * 2010-01-23 2011-07-28 Dr. Reddy's Laboratories Ltd. Eslicarbazepine acetate and its polymorphs
EP2383261B1 (en) 2010-04-23 2013-09-04 Euticals GmbH Process for the asymmetric hydrogenation of ketones
WO2011138795A2 (en) * 2010-05-03 2011-11-10 Msn Laboratories Limited Process for preparing (s)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f] azepine-5-carboxamide
CN102250005B (zh) * 2010-05-19 2015-04-08 浙江九洲药物科技有限公司 艾利西平的制备方法
WO2012120356A2 (en) 2011-03-08 2012-09-13 Jubilant Life Sciences Limited Process for the preparation of (s)-(+)-or (r)-(-)-10 hydroxy dihydrodibenz[b,f]azepines by enantioselective reduction of 10, 11-dihydro-10-oxo-5h-dibenz[b,f]azepines and polymorphs thereof
HUE038800T2 (hu) 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
US20150065704A1 (en) 2011-07-13 2015-03-05 Ketan Hirpara Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof
IN2015DN02296A (pt) 2012-09-26 2015-08-21 Ranbaxy Lab Ltd
EP3042902B1 (en) 2013-09-06 2018-10-10 Nippon Soda Co., Ltd. Method for producing endo-9-azabicyclo[3.3.1]nonan-3-ol derivative
EP3064490A1 (en) 2015-03-06 2016-09-07 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Improved process for the preparation of eslicarbazepine and eslicarbazepine acetate
MX388586B (es) 2016-12-16 2025-03-20 Idorsia Pharmaceuticals Ltd Combinacion farmaceutica que comprende un bloqueador del canal de calcio de tipo t.

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT101732B (pt) * 1995-06-30 1997-12-31 Portela & Ca Sa Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso
WO1997020789A1 (en) 1995-12-06 1997-06-12 Japan Science And Technology Corporation Process for preparating optically active compounds
JP2003502296A (ja) 1999-06-15 2003-01-21 ロディア・シミ スルホニルアミド及びカルボキサミド並びに不斉触媒作用におけるそれらの使用
GB0111566D0 (en) 2001-05-11 2001-07-04 Portela & Ca Sa Method for preparation of (s)-(+)-and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azephine-5-carboxamide
GB0112812D0 (en) 2001-05-25 2001-07-18 Portela & Ca Sa Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom
JP3504254B2 (ja) 2001-10-31 2004-03-08 関東化学株式会社 光学活性アミノアルコールおよびその中間体の製造方法
US6972275B2 (en) 2002-06-28 2005-12-06 Exxonmobil Research And Engineering Company Oil-in-oil emulsion lubricants for enhanced lubrication
GB0223224D0 (en) * 2002-10-07 2002-11-13 Novartis Ag Organic compounds
JP4309686B2 (ja) 2003-01-17 2009-08-05 関東化学株式会社 光学活性化合物の製造方法
GB2401605A (en) 2003-05-12 2004-11-17 Portela & Ca Sa Method for racemisation of (S)-(+)- and (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide and optically enriched mixtures thereof
CN1328252C (zh) * 2003-06-12 2007-07-25 中国科学院成都有机化学研究所 新型光学纯水溶性二胺和衍生物及其制备方法和用途
JP4744091B2 (ja) 2003-09-05 2011-08-10 関東化学株式会社 光学活性ニトロ化合物およびシアノ化合物の製造方法
GB2416167A (en) 2004-07-13 2006-01-18 Portela & Ca Sa Chiral inversion and esterification of (S)- and (R)-10-hydroxy-dibenzazepine carboxamides
GB2422149A (en) 2005-01-14 2006-07-19 Portela & Ca Sa Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
GB0515690D0 (en) * 2005-07-29 2005-09-07 Portela & Ca Sa Asymmetric catalytic reduction

Also Published As

Publication number Publication date
JP2013173764A (ja) 2013-09-05
US20130041146A1 (en) 2013-02-14
AU2006273874A8 (en) 2008-03-06
CA2616984A1 (en) 2007-02-01
US9206135B2 (en) 2015-12-08
DK1915346T3 (da) 2011-12-05
AU2006273874A1 (en) 2007-02-01
KR20080036212A (ko) 2008-04-25
RU2008107718A (ru) 2009-09-10
GB0515690D0 (en) 2005-09-07
PL1915346T3 (pl) 2012-01-31
US20160176823A1 (en) 2016-06-23
IL189062A0 (en) 2008-08-07
KR101362281B1 (ko) 2014-02-12
CN101277937B (zh) 2010-12-08
EP2319836A1 (en) 2011-05-11
US20090203902A1 (en) 2009-08-13
CN101277937A (zh) 2008-10-01
EP1915346A1 (en) 2008-04-30
NZ565462A (en) 2010-02-26
EP2319836B1 (en) 2015-11-25
ATE520665T1 (de) 2011-09-15
ES2562816T3 (es) 2016-03-08
JP2009502893A (ja) 2009-01-29
WO2007012793A1 (en) 2007-02-01
PT103467A (pt) 2007-01-31
EP1915346B1 (en) 2011-08-17
PT103467B (pt) 2009-03-19
ES2371556T3 (es) 2012-01-05
AR055917A1 (es) 2007-09-12
RU2439060C2 (ru) 2012-01-10
BRPI0615970A2 (pt) 2011-05-31
ZA200800986B (en) 2010-02-24
MX2008001291A (es) 2008-03-18
US8288532B2 (en) 2012-10-16
US20170190668A1 (en) 2017-07-06
US9643929B2 (en) 2017-05-09
JP5295765B2 (ja) 2013-09-18
AU2006273874B2 (en) 2013-01-10
CY1111988T1 (el) 2015-11-04
CA2616984C (en) 2017-09-26
SI1915346T1 (sl) 2011-12-30

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Legal Events

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B25D Requested change of name of applicant approved

Owner name: BIAL-PORTELA AND CA, S.A. (PT)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]