BRPI0618374A2 - uso de um composto ou um derivado do mesmo farmaceuticamente aceitável, métodos para matar microorganismos clinicamente latentes em um mamìfero, para tratar ou prevenir uma infecção microbiana em um mamìfero, para esterilizar um objeto, para preservar um material inorgánico ou orgánico, para tratar uma doença, para reduzir a dose de agente antimicrobiano convencional requerida para tratar uma infecção microbiana e para tratar uma doença de protozoário em um mamìfero, produto combinado, formulação, uso de um produto combinado, composto, e, processo para a preparação do mesmo - Google Patents

uso de um composto ou um derivado do mesmo farmaceuticamente aceitável, métodos para matar microorganismos clinicamente latentes em um mamìfero, para tratar ou prevenir uma infecção microbiana em um mamìfero, para esterilizar um objeto, para preservar um material inorgánico ou orgánico, para tratar uma doença, para reduzir a dose de agente antimicrobiano convencional requerida para tratar uma infecção microbiana e para tratar uma doença de protozoário em um mamìfero, produto combinado, formulação, uso de um produto combinado, composto, e, processo para a preparação do mesmo Download PDF

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Publication number
BRPI0618374A2
BRPI0618374A2 BRPI0618374-3A BRPI0618374A BRPI0618374A2 BR PI0618374 A2 BRPI0618374 A2 BR PI0618374A2 BR PI0618374 A BRPI0618374 A BR PI0618374A BR PI0618374 A2 BRPI0618374 A2 BR PI0618374A2
Authority
BR
Brazil
Prior art keywords
mammal
treat
treating
compound
combined product
Prior art date
Application number
BRPI0618374-3A
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English (en)
Inventor
Petra Helga Beck
Marc Barry Brown
David Edward Clark
Hazel Joan Dyke
Anthony Coates
Yanmin Hu
Derek John Londesbrough
Gary Patrick Reid
Keith Mills
Thomas David Pallin
Gerlinda Stoddart
Original Assignee
Helperby Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helperby Therapeutics Ltd filed Critical Helperby Therapeutics Ltd
Publication of BRPI0618374A2 publication Critical patent/BRPI0618374A2/pt

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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Abstract

USO DE UM COMPOSTO OU UM DERIVADO DO MESMO FARMACEUTICAMENTE ACEITáVEL, MéTODOS PARA MATAR MICROORGANISMOS CLINICAMENTE LATENTES EM UM MAMìFERO, PARA TRATAR OU PREVENIR UMA INFECçãO MICROBIANA EM UM MAMìFERO, PARA ESTERILIZAR UM OBJETO, PARA PRESERVAR UM MATERIAL INORGáNICO OU ORGáNICO, PARA TRATAR UMA DOENçA, PARA REDUZIR A DOSE DE AGENTE ANTIMICROBIANO CONVENCIONAL REQUERIDA PARA TRATAR UMA INFECçãO MICROBIANA E PARA TRATAR UMA DOENçA DE PROTOZOáRIO EM UM MAMìFERO, PRODUTO COMBINADO, FORMULAçãO, USO DE UM PRODUTO COMBINADO, COMPOSTO, E, PROCESSO PARA A PREPARAçãO DO MESMO. é fornecido o uso de compostos da fórmula (I), em que R^2^ R^3^ e X têm os significados dados na descrição, para a preparação de um medicamento para matar microorganismos clinicamente latentes. Também é fornecido o uso de compostos da fórmula (I) para tratar infecções microbianas, assim como certos compostos da fórmula (I) por si.
BRPI0618374-3A 2005-11-08 2006-11-08 uso de um composto ou um derivado do mesmo farmaceuticamente aceitável, métodos para matar microorganismos clinicamente latentes em um mamìfero, para tratar ou prevenir uma infecção microbiana em um mamìfero, para esterilizar um objeto, para preservar um material inorgánico ou orgánico, para tratar uma doença, para reduzir a dose de agente antimicrobiano convencional requerida para tratar uma infecção microbiana e para tratar uma doença de protozoário em um mamìfero, produto combinado, formulação, uso de um produto combinado, composto, e, processo para a preparação do mesmo BRPI0618374A2 (pt)

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GBGB0522715.2A GB0522715D0 (en) 2005-11-08 2005-11-08 New use
PCT/GB2006/004178 WO2007054693A1 (en) 2005-11-08 2006-11-08 Use of pyrroloquinoline compounds to kill clinically latent microorganisms

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HR (1) HRP20160043T1 (pt)
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PT (1) PT1945211E (pt)
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Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0522715D0 (en) 2005-11-08 2005-12-14 Helperby Therapeutics Ltd New use
GB0709513D0 (en) * 2007-05-17 2007-06-27 Helperby Therapeutics Ltd Topical formulations
US8759348B2 (en) * 2007-05-17 2014-06-24 Helperby Therapeutics Limited Use of 4-(pyrrolidin-1-yl)quinoline compounds to kill clinically latent microorganisms
AU2008316830B2 (en) 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
CN107854477A (zh) 2008-10-24 2018-03-30 森普拉制药公司 使用含三唑的大环内酯治疗抗性疾病的方法
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
RU2457208C2 (ru) * 2009-07-06 2012-07-27 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО "ПГФА Росздрава") 1H-ПИРРОЛО[3,4-b]ХИНОЛИН-3,9(2H,4H)-ДИОНЫ, ОБЛАДАЮЩИЕ ПРОТИВОТУБЕРКУЛЕЗНОЙ АКТИВНОСТЬЮ, И СПОСОБ ИХ ПОЛУЧЕНИЯ
SI2552440T1 (sl) * 2010-03-30 2019-03-29 Helperby Therapeutics Limited Nove kombinacije in uporaba
WO2012017215A1 (en) 2010-08-05 2012-02-09 Helperby Therapeutics Limited Combination of a pyrroloquinoline compound and a beta-lactam antimicrobial agent, mupirocin or chlorhexidine
GB201013207D0 (en) * 2010-08-05 2010-09-22 Helperby Therapeutics Ltd Novel combination
GB201015079D0 (en) 2010-09-10 2010-10-27 Helperby Therapeutics Ltd Novel use
EP2624817A1 (en) 2010-10-08 2013-08-14 Helperby Therapeutics Limited Novel composition
KR101254038B1 (ko) * 2011-01-12 2013-04-12 한국화학연구원 퀴놀린올 화합물을 유효성분으로 포함하는 항진균 조성물
GB201107755D0 (en) 2011-05-10 2011-06-22 Helperby Therapeutics Ltd Novel compounds
WO2013148891A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
AU2014233240B2 (en) 2013-03-15 2018-08-09 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
PL3027613T3 (pl) * 2013-07-25 2018-10-31 Uniwersytet Jagielloński Pochodne pirolochinoliny jako antagonisty 5-HT6, sposób wytwarzania i ich zastosowanie
US20170119793A1 (en) * 2014-06-12 2017-05-04 Cem-102 Pharmaceuticals, Inc. Compositions and methods for treating bone and joint infections
GB201416351D0 (en) * 2014-09-16 2014-10-29 Shire Internat Gmbh Heterocyclic derivatives
JP6804096B2 (ja) * 2015-04-11 2020-12-23 ヘルパービー セラピューティクス リミテッドＨｅｌｐｅｒｂｙ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 口腔用組成物
WO2016179231A1 (en) * 2015-05-04 2016-11-10 Board Of Trustees Of Michigan State University Compositions and methods for inhibiting bacterial growth
GB201518969D0 (en) * 2015-10-27 2015-12-09 Helperby Therapeutics Ltd Triple combination
GB201703898D0 (en) 2017-03-10 2017-04-26 Helperby Therapeautics Ltd Method
CN108660189B (zh) * 2018-05-30 2021-09-07 杭州千基生物科技有限公司 一种用于尿路感染病原体的量子点核酸检测的试剂盒
CN109503569B (zh) * 2019-01-03 2021-01-15 山东大学 噻唑类衍生物及其制备方法和应用
US11896612B2 (en) 2019-03-29 2024-02-13 Board Of Trustees Of Michigan State University Resurrection of antibiotics that MRSA resists by silver-doped bioactive glass-ceramic particles
CN111297852B (zh) * 2019-12-05 2022-03-29 宁波大学 一种促进三疣梭子蟹雌蟹卵黄积累与卵巢发育的方法
WO2021150613A1 (en) 2020-01-20 2021-07-29 Incyte Corporation Spiro compounds as inhibitors of kras
WO2021231526A1 (en) 2020-05-13 2021-11-18 Incyte Corporation Fused pyrimidine compounds as kras inhibitors
GB202012797D0 (en) 2020-08-17 2020-09-30 Helperby Therapeautics Ltd Disinfectant composition
WO2022047093A1 (en) 2020-08-28 2022-03-03 Incyte Corporation Vinyl imidazole compounds as inhibitors of kras
WO2022072783A1 (en) 2020-10-02 2022-04-07 Incyte Corporation Bicyclic dione compounds as inhibitors of kras
WO2022204112A1 (en) 2021-03-22 2022-09-29 Incyte Corporation Imidazole and triazole kras inhibitors
WO2023283213A1 (en) 2021-07-07 2023-01-12 Incyte Corporation Tricyclic compounds as inhibitors of kras
CA3224841A1 (en) 2021-07-14 2023-01-19 Zhenwu Li Tricyclic compounds as inhibitors of kras
CA3229855A1 (en) 2021-08-31 2023-03-09 Incyte Corporation Naphthyridine compounds as inhibitors of kras
US12030883B2 (en) 2021-09-21 2024-07-09 Incyte Corporation Hetero-tricyclic compounds as inhibitors of KRAS
US12030884B2 (en) 2021-10-01 2024-07-09 Incyte Corporation Pyrazoloquinoline KRAS inhibitors
KR20240101561A (ko) 2021-10-14 2024-07-02 인사이트 코포레이션 Kras의 저해제로서의 퀴놀린 화합물
US11926627B1 (en) 2023-08-30 2024-03-12 King Faisal University Substituted 7-methyl quinoline derivatives as antitubercular agents

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US725745A (en) * 1902-07-09 1903-04-21 Edwin A Moore Coke-oven door.
DE831249C (de) * 1948-02-09 1952-02-11 Ciba A G Verfahren zur Herstellung heterocyclisch substituierter Diaminochinazoline
US2691024A (en) * 1952-05-26 1954-10-05 Schenley Ind Inc Dihydropyrrolo-(3.2-c) quinoline derivatives
US2714593A (en) * 1952-05-26 1955-08-02 Schenley Ind Inc Dihydropyrrolo-(3.2-c) quinoline derivatives
US2691023A (en) * 1952-05-26 1954-10-05 Schenley Ind Inc Dihydropyrrolo-(3.2-c) quinoline derivatives
GB725745A (en) 1952-05-26 1955-03-09 Bayer Ag Pyrrolinoquinolines and processes for making same
SU726097A1 (ru) * 1977-10-10 1980-04-05 Донецкий государственный университет Гетероциклические производные пирролохинолина как стабилизаторы полимерных материалов
EP0226508A1 (fr) 1985-12-02 1987-06-24 Sanofi Dérivés de l'indolo(3,2-c)quinoléine, leur procédé de préparation et leur activité antitumorale
US4771052A (en) * 1987-02-05 1988-09-13 Hoechst-Roussel Pharmaceuticals, Inc. Tetrahydropyrido[3',4':4,5]pyrrolo[2,3-c]quinolines and their use as hypotensive agents
GB8717644D0 (en) * 1987-07-24 1987-09-03 Smithkline Beckman Intercredit Compounds
US5190951A (en) 1990-10-19 1993-03-02 Ss Pharmaceutical Co., Ltd. Quinoline derivatives
JPH062963A (ja) 1992-06-23 1994-01-11 Mitsubishi Heavy Ind Ltd 空気調和機
JP2997828B2 (ja) 1992-07-30 2000-01-11 株式会社大塚製薬工場 キノリン及びナフチリジン誘導体
FR2695126B1 (fr) 1992-08-27 1994-11-10 Sanofi Elf Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant.
TW593317B (en) * 1993-06-21 2004-06-21 Janssen Pharmaceutica Nv Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
US5578315A (en) * 1993-12-01 1996-11-26 Rutgers, The State University Of New Jersey Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity
KR100187475B1 (ko) 1996-05-17 1999-05-01 이서봉 1-아릴-4-옥소 피롤로(3,2-c)퀴놀린 유도체의 제조방법
GB2316072B (en) 1996-08-05 2000-05-10 Pharmacia Spa Pyrrolo[3,2-c]quinoline derivatives
KR100251522B1 (ko) 1997-08-13 2000-08-01 김충섭 할로알콕시기를 함유하는 피롤[3,2-c]퀴놀린 유도체 및 약학적으로 허용되는 그의 염
US6180640B1 (en) * 1998-06-25 2001-01-30 Sepracor, Inc. Di- and tetra-hydroquinoline-indole antimicrobial agents, uses and compositions related thereto
JP2002519424A (ja) * 1998-07-02 2002-07-02 コリア リサーチ インスティチュート オブ ケミカル テクノロジイ ３−アルキルピロロ〔３，２−ｃ〕キノリン誘導体
AU1061100A (en) 1998-11-09 2000-05-29 St. George's Enterprises Limited Screening process for antibacterial agents
JP4100865B2 (ja) * 1999-12-13 2008-06-11 エーザイ・アール・アンド・ディー・マネジメント株式会社 三環式縮合異項環化合物、その製造法およびその医薬
TWI271406B (en) * 1999-12-13 2007-01-21 Eisai Co Ltd Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same
JP4387804B2 (ja) * 2001-04-06 2009-12-24 アフィニアム・ファーマシューティカルズ・インコーポレイテッド ＦａｂＩ阻害剤
EP2048142A3 (en) * 2001-04-26 2009-04-22 Eisai R&D Management Co., Ltd. Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof
CA2489560A1 (en) 2002-06-27 2004-01-08 Schering Aktiengesellschaft Substituted quinoline ccr5 receptor antagonists
CL2004000409A1 (es) 2003-03-03 2005-01-07 Vertex Pharma Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu
CA2555132A1 (en) * 2004-02-04 2005-08-25 University Of Virginia Patent Foundation Compounds that inhibit hiv particle formation
RU2384571C2 (ru) 2004-04-28 2010-03-20 Такеда Фармасьютикал Компани Лимитед Конденсированное хинолиновое производное и его применение
US20060074105A1 (en) 2004-09-20 2006-04-06 Serenex, Inc. Substituted quinoline and quinazoline inhibitors of quinone reductase 2
US20060183763A1 (en) 2004-12-31 2006-08-17 Pfizer Inc Novel pyrrolidyl derivatives of heteroaromatic compounds
GB0522715D0 (en) * 2005-11-08 2005-12-14 Helperby Therapeutics Ltd New use
WO2012017215A1 (en) * 2010-08-05 2012-02-09 Helperby Therapeutics Limited Combination of a pyrroloquinoline compound and a beta-lactam antimicrobial agent, mupirocin or chlorhexidine

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AU2006313590B2 (en) 2010-07-15
CN101351203A (zh) 2009-01-21
ES2558685T3 (es) 2016-02-08
US8207187B2 (en) 2012-06-26
US10493071B2 (en) 2019-12-03
RU2404982C2 (ru) 2010-11-27
US9694006B2 (en) 2017-07-04
CN101351203B (zh) 2013-12-04
JP2009514936A (ja) 2009-04-09
PT1945211E (pt) 2016-02-08
EP1945211A1 (en) 2008-07-23
AU2006313590B9 (en) 2010-07-29
HK1127551A1 (en) 2009-10-02
WO2007054693A1 (en) 2007-05-18
CA2628729A1 (en) 2007-05-18
CA2628729C (en) 2011-05-24
AU2006313590C1 (en) 2011-03-10
KR20080081910A (ko) 2008-09-10
DK1945211T3 (en) 2016-01-25
RU2008122912A (ru) 2009-12-20
KR101148049B1 (ko) 2012-05-29
IL191260A (en) 2015-11-30
NZ568035A (en) 2011-05-27
HUE026568T2 (hu) 2016-06-28
EP1945211B1 (en) 2015-10-21
US20090137622A1 (en) 2009-05-28
US20120231995A1 (en) 2012-09-13
ZA200804454B (en) 2009-08-26
US20170258784A1 (en) 2017-09-14
GB0522715D0 (en) 2005-12-14
SI1945211T1 (sl) 2016-03-31
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HRP20160043T1 (hr) 2016-02-12
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