BRPI0621544A2 - biossensores para mensuração de produto de análise em fluido e de nìveis de glicose no sangue e respectivo método de produção - Google Patents

biossensores para mensuração de produto de análise em fluido e de nìveis de glicose no sangue e respectivo método de produção Download PDF

Info

Publication number: BRPI0621544A2
Authority: BR; Brazil
Prior art keywords: biosensor; measurement; product according; analysis product; fluid analysis
Prior art date: 2006-04-18

Application number

BRPI0621544-0A

Other languages

English (en)

Portuguese (pt)

Inventor

Dennis Slomski

Natasha Popovich

Original Assignee

Home Doagnostics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-04-18

Filing date

2006-04-18

Publication date

2011-12-13

2006-04-18 Application filed by Home Doagnostics Inc filed Critical Home Doagnostics Inc

2011-12-13 Publication of BRPI0621544A2 publication Critical patent/BRPI0621544A2/pt

Links

238000004458 analytical method Methods 0.000 title claims abstract description 51
238000005259 measurement Methods 0.000 title claims abstract description 48
239000012530 fluid Substances 0.000 title claims abstract description 33
238000004519 manufacturing process Methods 0.000 title claims abstract description 27
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 24
239000008103 glucose Substances 0.000 title claims abstract description 24
210000004369 blood Anatomy 0.000 title claims abstract description 20
239000008280 blood Substances 0.000 title claims abstract description 20
239000000463 material Substances 0.000 claims abstract description 86
125000006850 spacer group Chemical group 0.000 claims abstract description 58
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239000012044 organic layer Substances 0.000 claims abstract description 8
238000006243 chemical reaction Methods 0.000 claims description 34
239000000523 sample Substances 0.000 claims description 33
238000000034 method Methods 0.000 claims description 22
239000004065 semiconductor Substances 0.000 claims description 20
XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 16
239000011230 binding agent Substances 0.000 claims description 14
-1 polyethylene terephthalate Polymers 0.000 claims description 14
239000012491 analyte Substances 0.000 claims description 13
KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims description 12
229910052707 ruthenium Inorganic materials 0.000 claims description 12
108090000790 Enzymes Proteins 0.000 claims description 11
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229940088598 enzyme Drugs 0.000 claims description 11
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 10
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229910003437 indium oxide Inorganic materials 0.000 claims description 10
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LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 10
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YAGKRVSRTSUGEY-UHFFFAOYSA-N ferricyanide Chemical compound [Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] YAGKRVSRTSUGEY-UHFFFAOYSA-N 0.000 claims description 9
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239000002736 nonionic surfactant Substances 0.000 claims description 9
230000033116 oxidation-reduction process Effects 0.000 claims description 9
WXTMDXOMEHJXQO-UHFFFAOYSA-N 2,5-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC(O)=CC=C1O WXTMDXOMEHJXQO-UHFFFAOYSA-N 0.000 claims description 8
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 8
239000004372 Polyvinyl alcohol Substances 0.000 claims description 8
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 8
238000000151 deposition Methods 0.000 claims description 8
239000000975 dye Substances 0.000 claims description 8
AMWRITDGCCNYAT-UHFFFAOYSA-L hydroxy(oxo)manganese;manganese Chemical compound [Mn].O[Mn]=O.O[Mn]=O AMWRITDGCCNYAT-UHFFFAOYSA-L 0.000 claims description 8
229910052738 indium Inorganic materials 0.000 claims description 8
APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 claims description 8
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BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 8
229920002451 polyvinyl alcohol Polymers 0.000 claims description 8
XOLBLPGZBRYERU-UHFFFAOYSA-N tin dioxide Chemical compound O=[Sn]=O XOLBLPGZBRYERU-UHFFFAOYSA-N 0.000 claims description 8
229910001887 tin oxide Inorganic materials 0.000 claims description 8
229910052723 transition metal Inorganic materials 0.000 claims description 8
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239000011787 zinc oxide Substances 0.000 claims description 8
UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 7
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HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 6
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ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims description 6
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 5
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GPRSOIDYHMXAGW-UHFFFAOYSA-N cyclopenta-1,3-diene cyclopentanecarboxylic acid iron Chemical compound [CH-]1[CH-][CH-][C-]([CH-]1)C(=O)O.[CH-]1C=CC=C1.[Fe] GPRSOIDYHMXAGW-UHFFFAOYSA-N 0.000 claims description 5
KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical class [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 claims description 5
235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 5
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UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 5
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229910000160 potassium phosphate Inorganic materials 0.000 claims description 5
235000011009 potassium phosphates Nutrition 0.000 claims description 5
239000000661 sodium alginate Substances 0.000 claims description 5
235000010413 sodium alginate Nutrition 0.000 claims description 5
229940005550 sodium alginate Drugs 0.000 claims description 5
239000002888 zwitterionic surfactant Substances 0.000 claims description 5
BRRSNXCXLSVPFC-UHFFFAOYSA-N 2,3,4-Trihydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C(O)=C1O BRRSNXCXLSVPFC-UHFFFAOYSA-N 0.000 claims description 4
239000005711 Benzoic acid Substances 0.000 claims description 4
ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims description 4
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 4
229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 4
229910000831 Steel Inorganic materials 0.000 claims description 4
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
150000001413 amino acids Chemical class 0.000 claims description 4
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229910052796 boron Inorganic materials 0.000 claims description 4
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125000000853 cresyl group Chemical group C1(=CC=C(C=C1)C)* 0.000 claims description 4
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GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 claims description 4
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229910052757 nitrogen Inorganic materials 0.000 claims description 4
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229910052703 rhodium Inorganic materials 0.000 claims description 4
239000010948 rhodium Substances 0.000 claims description 4
MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 claims description 4
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WDJHALXBUFZDSR-UHFFFAOYSA-N Acetoacetic acid Natural products CC(=O)CC(O)=O WDJHALXBUFZDSR-UHFFFAOYSA-N 0.000 claims description 3
VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims description 3
102000001554 Hemoglobins Human genes 0.000 claims description 3
108010054147 Hemoglobins Proteins 0.000 claims description 3
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 3
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
235000012000 cholesterol Nutrition 0.000 claims description 3
238000001514 detection method Methods 0.000 claims description 3
WOWBFOBYOAGEEA-UHFFFAOYSA-N diafenthiuron Chemical compound CC(C)C1=C(NC(=S)NC(C)(C)C)C(C(C)C)=CC(OC=2C=CC=CC=2)=C1 WOWBFOBYOAGEEA-UHFFFAOYSA-N 0.000 claims description 3
150000002576 ketones Chemical class 0.000 claims description 3
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238000003556 assay Methods 0.000 claims description 2
229940116332 glucose oxidase Drugs 0.000 claims description 2
235000019420 glucose oxidase Nutrition 0.000 claims description 2
238000010030 laminating Methods 0.000 claims description 2
BPEVHDGLPIIAGH-UHFFFAOYSA-N ruthenium(3+) Chemical compound [Ru+3] BPEVHDGLPIIAGH-UHFFFAOYSA-N 0.000 claims description 2
125000002524 organometallic group Chemical group 0.000 claims 3
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
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238000005534 hematocrit Methods 0.000 description 4
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238000004080 punching Methods 0.000 description 3
239000010409 thin film Substances 0.000 description 3
229920001007 Nylon 4 Polymers 0.000 description 2
ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 2
238000013459 approach Methods 0.000 description 2
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150000001875 compounds Chemical class 0.000 description 2
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238000007254 oxidation reaction Methods 0.000 description 2
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229920000642 polymer Polymers 0.000 description 2
SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 2
238000006479 redox reaction Methods 0.000 description 2
230000027756 respiratory electron transport chain Effects 0.000 description 2
238000001878 scanning electron micrograph Methods 0.000 description 2
JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
NECRQCBKTGZNMH-UHFFFAOYSA-N 3,5-dimethylhex-1-yn-3-ol Chemical compound CC(C)CC(C)(O)C#C NECRQCBKTGZNMH-UHFFFAOYSA-N 0.000 description 1
241000238876 Acari Species 0.000 description 1
229920002799 BoPET Polymers 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
239000007995 HEPES buffer Substances 0.000 description 1
239000007987 MES buffer Substances 0.000 description 1
239000007993 MOPS buffer Substances 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
239000007983 Tris buffer Substances 0.000 description 1
ZUQAPLKKNAQJAU-UHFFFAOYSA-N acetylenediol Chemical compound OC#CO ZUQAPLKKNAQJAU-UHFFFAOYSA-N 0.000 description 1
230000004913 activation Effects 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000002210 biocatalytic effect Effects 0.000 description 1
239000001045 blue dye Substances 0.000 description 1
230000003139 buffering effect Effects 0.000 description 1
239000003575 carbonaceous material Substances 0.000 description 1
230000002596 correlated effect Effects 0.000 description 1
230000007547 defect Effects 0.000 description 1
230000002950 deficient Effects 0.000 description 1
239000003599 detergent Substances 0.000 description 1
238000011161 development Methods 0.000 description 1
206010012601 diabetes mellitus Diseases 0.000 description 1
MWYMHZINPCTWSB-UHFFFAOYSA-N dimethylsilyloxy-dimethyl-trimethylsilyloxysilane Chemical class C[SiH](C)O[Si](C)(C)O[Si](C)(C)C MWYMHZINPCTWSB-UHFFFAOYSA-N 0.000 description 1
238000001035 drying Methods 0.000 description 1
239000012992 electron transfer agent Substances 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
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238000007689 inspection Methods 0.000 description 1
230000003993 interaction Effects 0.000 description 1
239000000787 lecithin Substances 0.000 description 1
235000010445 lecithin Nutrition 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
AJDUTMFFZHIJEM-UHFFFAOYSA-N n-(9,10-dioxoanthracen-1-yl)-4-[4-[[4-[4-[(9,10-dioxoanthracen-1-yl)carbamoyl]phenyl]phenyl]diazenyl]phenyl]benzamide Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2NC(=O)C(C=C1)=CC=C1C(C=C1)=CC=C1N=NC(C=C1)=CC=C1C(C=C1)=CC=C1C(=O)NC1=CC=CC2=C1C(=O)C1=CC=CC=C1C2=O AJDUTMFFZHIJEM-UHFFFAOYSA-N 0.000 description 1
239000002105 nanoparticle Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
239000002985 plastic film Substances 0.000 description 1
229920006255 plastic film Polymers 0.000 description 1
229920001281 polyalkylene Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
235000011056 potassium acetate Nutrition 0.000 description 1
238000001314 profilometry Methods 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
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239000000080 wetting agent Substances 0.000 description 1
239000001043 yellow dye Substances 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
Electrochemistry (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Immunology (AREA)
Pathology (AREA)
Investigating Or Analysing Biological Materials (AREA)
Investigating Or Analyzing Materials Using Thermal Means (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)

BRPI0621544-0A 2006-04-18 2006-04-18 biossensores para mensuração de produto de análise em fluido e de nìveis de glicose no sangue e respectivo método de produção BRPI0621544A2 (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2006/014753 WO2007120149A1 (en)	2006-04-18	2006-04-18	Biosensors comprising heat sealable spacer materials

Publications (1)

Publication Number	Publication Date
BRPI0621544A2 true BRPI0621544A2 (pt)	2011-12-13

Family

ID=37782001

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0621544-0A BRPI0621544A2 (pt)	2006-04-18	2006-04-18	biossensores para mensuração de produto de análise em fluido e de nìveis de glicose no sangue e respectivo método de produção

Country Status (6)

Country	Link
EP (1)	EP2016400A1 (no)
AU (1)	AU2006342199A1 (no)
BR (1)	BRPI0621544A2 (no)
MX (1)	MX2008013231A (no)
NO (1)	NO20084811L (no)
WO (1)	WO2007120149A1 (no)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2010099507A1 (en) *	2009-02-26	2010-09-02	Abbott Diabetes Care Inc.	Improved analyte sensors and methods of making and using the same
CN109200059B (zh) *	2017-07-07	2021-03-30	昆山新蕴达生物科技有限公司	氮掺杂纳米碳球的类超氧化物歧化酶活性及其用途

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1078813A (en) *	1965-03-11	1967-08-09	Ici Ltd	Heat seal coated polyester films
US6755949B1 (en) *	2001-10-09	2004-06-29	Roche Diagnostics Corporation	Biosensor
JP4458802B2 (ja) *	2003-10-02	2010-04-28	パナソニック株式会社	血液中のグルコースの測定方法およびそれに用いるセンサ
CN100472210C (zh) *	2003-12-04	2009-03-25	松下电器产业株式会社	血液成分的测定方法及该方法中使用的传感器和测定装置

2006
- 2006-04-18 MX MX2008013231A patent/MX2008013231A/es not_active Application Discontinuation
- 2006-04-18 EP EP06750726A patent/EP2016400A1/en not_active Withdrawn
- 2006-04-18 AU AU2006342199A patent/AU2006342199A1/en not_active Abandoned
- 2006-04-18 WO PCT/US2006/014753 patent/WO2007120149A1/en not_active Ceased
- 2006-04-18 BR BRPI0621544-0A patent/BRPI0621544A2/pt not_active IP Right Cessation
2008
- 2008-11-14 NO NO20084811A patent/NO20084811L/no unknown

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Publication number	Publication date
AU2006342199A1 (en)	2007-10-25
WO2007120149A1 (en)	2007-10-25
EP2016400A1 (en)	2009-01-21
MX2008013231A (es)	2008-10-22
NO20084811L (no)	2009-01-14

Legal Events

Date	Code	Title	Description
2012-06-05	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 5A E 6A ANUIDADES.
2013-07-02	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012.

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