BRPI0703692A - método para se obter os cristais de um hidrocloreto de aminoácido básico de um caldo de fermentação de aminoácido básico ou na solução de reação enzimática - Google Patents
método para se obter os cristais de um hidrocloreto de aminoácido básico de um caldo de fermentação de aminoácido básico ou na solução de reação enzimáticaInfo
- Publication number
- BRPI0703692A BRPI0703692A BRPI0703692-2A BRPI0703692A BRPI0703692A BR PI0703692 A BRPI0703692 A BR PI0703692A BR PI0703692 A BRPI0703692 A BR PI0703692A BR PI0703692 A BRPI0703692 A BR PI0703692A
- Authority
- BR
- Brazil
- Prior art keywords
- amino acid
- basic amino
- crystals
- reaction solution
- fermentation broth
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title abstract 8
- 239000013078 crystal Substances 0.000 title abstract 7
- 238000006911 enzymatic reaction Methods 0.000 title abstract 6
- 238000000855 fermentation Methods 0.000 title abstract 5
- 230000004151 fermentation Effects 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- -1 amino acid hydrochloride Chemical class 0.000 title abstract 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 7
- 229910052751 metal Inorganic materials 0.000 abstract 5
- 239000002184 metal Substances 0.000 abstract 5
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052788 barium Inorganic materials 0.000 abstract 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/10—Citrulline; Arginine; Ornithine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/24—Proline; Hydroxyproline; Histidine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"MéTODO PARA SE OBTER OS CRISTAIS DE UM HIDROCLORETO DE AMINOáCIDO BáSICO DE UM CALDO DE FERMENTAçãO DE AMINOáCIDO BáSICO OU NA SOLUçãO DE REAçãO ENZIMáTICA". é um objeto da presente invenção prover um método para separar e obter um hidrocloreto de aminoácido básico de um caldo de fermentação de aminoácido básico ou na solução de reação enzimática, cuja reação enzimática tenha sido catalisada por células viáveis de um micróbio produtor de aminoácido básico, cada um contendo íons de sulfato, pela qual o método produz o produto, e as qualidades são quase as mesmas e são garantidas mais facilmente em comparação com a técnica convencional, método este que compreende as etapas de: (1) adicionar o cloreto de um metal selecionado do grupo consistindo em cálcio, potássio, magnésio e bário, ao caldo de fermentação de aminoácido básico, ou à solução de reação enzimática que contenha os tons de sulfato, para precipitar os tons de sulfato como cristais do sulfato de metal resultante, (2) remover os cristais de sulfato de metal da solução de aminoácido básico, (3) esfriar o caldo de fermentação de aminoácido básico ou a solução de reação enzimática, em que os cristais de sulfato de metal são removidos, enquanto se mantém a concentração do sulfato de metal abaixo da sua concentração saturada para precipitar o aminoácido básico como seus cristais de hidrocloreto, e (4) separar os cristais de hidrocloreto de aminoácido básico para coletá-los.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006347650 | 2006-12-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0703692A true BRPI0703692A (pt) | 2008-08-19 |
| BRPI0703692B1 BRPI0703692B1 (pt) | 2016-12-27 |
Family
ID=39562242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0703692A BRPI0703692B1 (pt) | 2006-12-25 | 2007-09-20 | método para se obter os cristais de um hidrocloreto de aminoácido básico compreendendo gerar um aminoácido básico usando células microbianas por fermentação em um caldo de fermentação ou por um método enzimático em uma solução de reação de enzima usando as células como catalisadores |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8372606B2 (pt) |
| EP (1) | EP2096176B1 (pt) |
| JP (1) | JPWO2008078448A1 (pt) |
| KR (1) | KR101046905B1 (pt) |
| CN (1) | CN101558164B (pt) |
| BR (1) | BRPI0703692B1 (pt) |
| CA (1) | CA2672714C (pt) |
| MX (1) | MX2009006932A (pt) |
| RU (1) | RU2460799C2 (pt) |
| WO (1) | WO2008078448A1 (pt) |
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|---|---|---|---|---|
| JP2011067095A (ja) | 2008-01-10 | 2011-04-07 | Ajinomoto Co Inc | 発酵法による目的物質の製造法 |
| BRPI1007069A2 (pt) | 2009-01-23 | 2015-08-25 | Ajinomoto Kk | Método para produzir um l-aminoácido. |
| JP2012196144A (ja) | 2009-08-03 | 2012-10-18 | Ajinomoto Co Inc | ビブリオ属細菌を用いたｌ−リジンの製造法 |
| JP2012223092A (ja) | 2009-08-28 | 2012-11-15 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| JP2013013329A (ja) | 2009-11-06 | 2013-01-24 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| RU2460793C2 (ru) | 2010-01-15 | 2012-09-10 | Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) | Способ получения l-аминокислот с использованием бактерий семейства enterobacteriaceae |
| JP2013074795A (ja) | 2010-02-08 | 2013-04-25 | Ajinomoto Co Inc | 変異型ｒｐｓＡ遺伝子及びＬ−アミノ酸の製造法 |
| JP2014036576A (ja) | 2010-12-10 | 2014-02-27 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| EP2695940B1 (en) | 2011-04-01 | 2016-11-30 | Ajinomoto Co., Inc. | Method for producing l-cysteine |
| JP2014131487A (ja) | 2011-04-18 | 2014-07-17 | Ajinomoto Co Inc | Ｌ−システインの製造法 |
| WO2013069634A1 (ja) | 2011-11-11 | 2013-05-16 | 味の素株式会社 | 発酵法による目的物質の製造法 |
| EP2868745B1 (en) | 2013-05-13 | 2017-06-21 | Ajinomoto Co., Inc. | Method for manufacturing an L-amino acid |
| CN104892437A (zh) * | 2015-05-15 | 2015-09-09 | 南通荣泰生物科技有限公司 | 一种l-盐酸赖氨酸的生产工艺 |
| CN105175275B (zh) * | 2015-07-01 | 2017-03-01 | 山东民强生物科技股份有限公司 | 一种l‑鸟氨酸的分离纯化方法 |
| JP6623690B2 (ja) | 2015-10-30 | 2019-12-25 | 味の素株式会社 | グルタミン酸系ｌ−アミノ酸の製造法 |
| JP7066977B2 (ja) | 2017-04-03 | 2022-05-16 | 味の素株式会社 | Ｌ－アミノ酸の製造法 |
| CN107963650A (zh) * | 2017-12-15 | 2018-04-27 | 湖南师范大学 | 一种氨基酸络合物合成工艺中的母液处理方法 |
| SE543703C2 (en) * | 2018-03-05 | 2021-06-15 | Arevo Ab | Separation of basic amino acids |
| JP7845187B2 (ja) | 2020-10-28 | 2026-04-14 | 味の素株式会社 | Ｌ－アミノ酸の製造法 |
| JPWO2023013655A1 (pt) | 2021-08-02 | 2023-02-09 | ||
| CN119012914A (zh) | 2022-04-04 | 2024-11-22 | 味之素株式会社 | 防治寄生植物的方法 |
| US20240117393A1 (en) | 2022-09-30 | 2024-04-11 | Ajinomoto Co., Inc. | Method for producing l-amino acid |
| CN118026894A (zh) * | 2022-11-14 | 2024-05-14 | 安徽华恒生物科技股份有限公司 | 一种瓜氨酸的分离纯化方法 |
| KR20250035158A (ko) * | 2023-09-05 | 2025-03-12 | 씨제이제일제당 (주) | 고순도 아르기닌의 제조방법 |
| EP4692312A1 (en) | 2023-12-28 | 2026-02-11 | Ajinomoto Co., Inc. | L-glutamic acid-producing bacterium and method for producing l-glutamic acid |
| JP7716823B1 (ja) | 2023-12-28 | 2025-08-01 | 味の素株式会社 | Ｌ－グルタミン酸生産菌およびｌ－グルタミン酸の製造方法 |
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2007
- 2007-09-20 BR BRPI0703692A patent/BRPI0703692B1/pt active IP Right Grant
- 2007-10-22 EP EP07830289.0A patent/EP2096176B1/en active Active
- 2007-10-22 MX MX2009006932A patent/MX2009006932A/es active IP Right Grant
- 2007-10-22 RU RU2009124135/10A patent/RU2460799C2/ru active
- 2007-10-22 KR KR1020097014763A patent/KR101046905B1/ko active Active
- 2007-10-22 WO PCT/JP2007/070555 patent/WO2008078448A1/ja not_active Ceased
- 2007-10-22 CN CN2007800458215A patent/CN101558164B/zh active Active
- 2007-10-22 JP JP2008550983A patent/JPWO2008078448A1/ja active Pending
- 2007-10-22 CA CA2672714A patent/CA2672714C/en active Active
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2009
- 2009-06-25 US US12/491,341 patent/US8372606B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2008078448A1 (ja) | 2010-04-15 |
| US20090291477A1 (en) | 2009-11-26 |
| MX2009006932A (es) | 2009-07-06 |
| KR20090100406A (ko) | 2009-09-23 |
| CN101558164A (zh) | 2009-10-14 |
| BRPI0703692B1 (pt) | 2016-12-27 |
| CN101558164B (zh) | 2012-05-09 |
| RU2460799C2 (ru) | 2012-09-10 |
| CA2672714C (en) | 2016-04-26 |
| WO2008078448A1 (ja) | 2008-07-03 |
| CA2672714A1 (en) | 2008-07-03 |
| EP2096176B1 (en) | 2017-04-12 |
| US8372606B2 (en) | 2013-02-12 |
| EP2096176A4 (en) | 2012-12-26 |
| KR101046905B1 (ko) | 2011-07-07 |
| EP2096176A1 (en) | 2009-09-02 |
| RU2009124135A (ru) | 2010-12-27 |
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