BRPI0707559A8 - sal de ácido succínico de 1-[2-(2-cloro-4-{[(r)-2-hidróxi-2-(8-hidróxi-2-oxo-1,2-diidroquinolin-5-il) etilamino]metil]}-5-metoxifenilcarbamoil)etil]piperidin-4-il éster de ácido bifenil-2-ilcarbâmico ou um solvato do mesmo, composição farmacêutica, combinação, uso de um sal de ácido succínico, e, processo para preparar um sal de succinato de forma 1 - Google Patents

sal de ácido succínico de 1-[2-(2-cloro-4-{[(r)-2-hidróxi-2-(8-hidróxi-2-oxo-1,2-diidroquinolin-5-il) etilamino]metil]}-5-metoxifenilcarbamoil)etil]piperidin-4-il éster de ácido bifenil-2-ilcarbâmico ou um solvato do mesmo, composição farmacêutica, combinação, uso de um sal de ácido succínico, e, processo para preparar um sal de succinato de forma 1

Info

Publication number
BRPI0707559A8
BRPI0707559A8 BRPI0707559A BRPI0707559A BRPI0707559A8 BR PI0707559 A8 BRPI0707559 A8 BR PI0707559A8 BR PI0707559 A BRPI0707559 A BR PI0707559A BR PI0707559 A BRPI0707559 A BR PI0707559A BR PI0707559 A8 BRPI0707559 A8 BR PI0707559A8
Authority
BR
Brazil
Prior art keywords
hydroxy
succinic acid
salt
acid salt
combination
Prior art date
Application number
BRPI0707559A
Other languages
English (en)
Inventor
Kennedy Andrew
Patrick Mallet Franck
Jane Kindon Leanda
Chudasama Reshma
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36119909&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0707559(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BRPI0707559A2 publication Critical patent/BRPI0707559A2/pt
Publication of BRPI0707559A8 publication Critical patent/BRPI0707559A8/pt
Publication of BRPI0707559B1 publication Critical patent/BRPI0707559B1/pt
Publication of BRPI0707559B8 publication Critical patent/BRPI0707559B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

composto, composição farmacêutica, combinação, métodos para tratar um distúrbio pulmonar, para produzir broncodilatação em um paciente, e para tratar doença pulmonar obstrutiva crônica ou asma, usos de um composto e de uma combinação, e, processo para preparar um composto. um sal de ácido succínico de 1- [2-(2-cloro-4- { [(r)-2-hidróxi-2-(8-hidróxi-2-oxo-1,2-diidroquinolin-5 -il)etilamino] metil]}-5 -metoxifenil-carbamoil)etil] piperidin-4-il éster do ácido bifenil-2-ilcarbâmico e ou um solvato do mesmo, para uso no tratamento de distúrbios pulmonares"
BRPI0707559A 2006-02-10 2007-02-08 polimorfo de forma i do sal de ácido succínico de 1- [2- (2- cloro- 4- {[(r)- 2- hidróxi- 2- (8- hidróxi- 2- oxo- 1,2- diidroquinolin- 5- il) etilamino] meti1]}- 5- metoxifenilcarbamoil) etil] piperidin- 4- il éster de ácido bifenil- 2- il- carbâmico, seu processo de preparo e usos BRPI0707559B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0602778.3 2006-02-10
GBGB0602778.3A GB0602778D0 (en) 2006-02-10 2006-02-10 Novel compound
PCT/EP2007/051196 WO2007090859A1 (en) 2006-02-10 2007-02-08 Succinic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{ [ (r)-2-hydroxy-2- (8-hydroxy-2-oxo-1, 2-dihydroquinolin-5-yl) eth ylaminoimethyl] } -5-methoxyphenylcarbamoyl) ethyl] piperidin-4-yl ester and its use for the treatment of pulmonary disorders

Publications (4)

Publication Number Publication Date
BRPI0707559A2 BRPI0707559A2 (pt) 2011-05-10
BRPI0707559A8 true BRPI0707559A8 (pt) 2019-01-29
BRPI0707559B1 BRPI0707559B1 (pt) 2021-01-12
BRPI0707559B8 BRPI0707559B8 (pt) 2021-05-25

Family

ID=36119909

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0707559A BRPI0707559B8 (pt) 2006-02-10 2007-02-08 polimorfo de forma i do sal de ácido succínico de 1- [2- (2- cloro- 4- {[(r)- 2- hidróxi- 2- (8- hidróxi- 2- oxo- 1,2- diidroquinolin- 5- il) etilamino] meti1]}- 5- metoxifenilcarbamoil) etil] piperidin- 4- il éster de ácido bifenil- 2- il- carbâmico, seu processo de preparo e usos

Country Status (33)

Country Link
US (1) US7960551B2 (pt)
EP (1) EP1981872B1 (pt)
JP (1) JP5616021B2 (pt)
KR (1) KR101488691B1 (pt)
CN (1) CN101379057B (pt)
AR (2) AR059409A1 (pt)
AU (1) AU2007213767B2 (pt)
BR (1) BRPI0707559B8 (pt)
CA (1) CA2641769C (pt)
CR (1) CR10227A (pt)
CY (1) CY1119238T1 (pt)
DK (1) DK1981872T3 (pt)
EA (1) EA016580B1 (pt)
ES (1) ES2640226T3 (pt)
GB (1) GB0602778D0 (pt)
HR (1) HRP20171304T1 (pt)
HU (1) HUE034315T2 (pt)
IL (1) IL193103A (pt)
JO (1) JO3389B1 (pt)
LT (1) LT1981872T (pt)
MA (1) MA30273B1 (pt)
MY (1) MY153656A (pt)
NO (1) NO341343B1 (pt)
NZ (1) NZ570242A (pt)
PE (2) PE20071249A1 (pt)
PL (1) PL1981872T3 (pt)
PT (1) PT1981872T (pt)
SG (1) SG169404A1 (pt)
SI (1) SI1981872T1 (pt)
TW (1) TWI401251B (pt)
UA (1) UA100364C2 (pt)
WO (1) WO2007090859A1 (pt)
ZA (1) ZA200806782B (pt)

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EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
US9518050B2 (en) * 2012-12-18 2016-12-13 Almirall, S.A. Cyclohexyl and quinuclidinyl carbamate derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activity
TWI643853B (zh) 2013-02-27 2018-12-11 阿爾米雷爾有限公司 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類
TWI641373B (zh) 2013-07-25 2018-11-21 阿爾米雷爾有限公司 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽
TW201517906A (zh) 2013-07-25 2015-05-16 Almirall Sa 含有ｍａｂａ化合物和皮質類固醇之組合
TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物
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Also Published As

Publication number Publication date
MA30273B1 (fr) 2009-03-02
UA100364C2 (xx) 2012-12-25
JO3389B1 (ar) 2019-03-13
TW200800948A (en) 2008-01-01
WO2007090859A1 (en) 2007-08-16
PL1981872T3 (pl) 2017-11-30
LT1981872T (lt) 2017-09-11
HRP20171304T1 (hr) 2017-10-20
KR20080114723A (ko) 2008-12-31
US7960551B2 (en) 2011-06-14
CA2641769C (en) 2014-02-04
ZA200806782B (en) 2009-10-28
CN101379057B (zh) 2013-02-13
KR101488691B1 (ko) 2015-02-02
PT1981872T (pt) 2017-09-13
SI1981872T1 (sl) 2017-10-30
EP1981872B1 (en) 2017-06-21
ES2640226T3 (es) 2017-11-02
EP1981872A1 (en) 2008-10-22
EA200801691A1 (ru) 2009-02-27
HUE034315T2 (en) 2018-02-28
PE20110120A1 (es) 2011-03-08
AR104288A2 (es) 2017-07-12
DK1981872T3 (en) 2017-09-11
AU2007213767A1 (en) 2007-08-16
CR10227A (es) 2008-10-29
GB0602778D0 (en) 2006-03-22
AU2007213767B2 (en) 2012-04-26
SG169404A1 (en) 2011-03-30
JP5616021B2 (ja) 2014-10-29
EA016580B1 (ru) 2012-06-29
PE20071249A1 (es) 2008-01-16
BRPI0707559A2 (pt) 2011-05-10
CA2641769A1 (en) 2007-08-16
IL193103A0 (en) 2009-02-11
NO341343B1 (no) 2017-10-16
MY153656A (en) 2015-03-13
BRPI0707559B8 (pt) 2021-05-25
IL193103A (en) 2013-06-27
TWI401251B (zh) 2013-07-11
BRPI0707559B1 (pt) 2021-01-12
JP2009526018A (ja) 2009-07-16
CN101379057A (zh) 2009-03-04
NZ570242A (en) 2011-09-30
NO20083425L (no) 2008-09-09
AR059409A1 (es) 2008-04-09
CY1119238T1 (el) 2018-02-14
US20070281971A1 (en) 2007-12-06

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