BRPI0708095B8 - método para isolar uma fração bioativa, e, ingrediente bioativo - Google Patents
método para isolar uma fração bioativa, e, ingrediente bioativoInfo
- Publication number
- BRPI0708095B8 BRPI0708095B8 BRPI0708095A BRPI0708095A BRPI0708095B8 BR PI0708095 B8 BRPI0708095 B8 BR PI0708095B8 BR PI0708095 A BRPI0708095 A BR PI0708095A BR PI0708095 A BRPI0708095 A BR PI0708095A BR PI0708095 B8 BRPI0708095 B8 BR PI0708095B8
- Authority
- BR
- Brazil
- Prior art keywords
- bioactive
- present
- fraction
- gamma
- relates
- Prior art date
Links
- 230000000975 bioactive effect Effects 0.000 title abstract 12
- 239000004615 ingredient Substances 0.000 title abstract 3
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 abstract 4
- 235000008384 feverfew Nutrition 0.000 abstract 4
- 235000011389 fruit/vegetable juice Nutrition 0.000 abstract 4
- BUQLXKSONWUQAC-UHFFFAOYSA-N Parthenolide Natural products CC1C2OC(=O)C(=C)C2CCC(=C/CCC1(C)O)C BUQLXKSONWUQAC-UHFFFAOYSA-N 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- KTEXNACQROZXEV-PVLRGYAZSA-N parthenolide Chemical compound C1CC(/C)=C/CC[C@@]2(C)O[C@@H]2[C@H]2OC(=O)C(=C)[C@@H]21 KTEXNACQROZXEV-PVLRGYAZSA-N 0.000 abstract 3
- 229940069510 parthenolide Drugs 0.000 abstract 3
- 239000002028 Biomass Substances 0.000 abstract 2
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 abstract 2
- 244000192528 Chrysanthemum parthenium Species 0.000 abstract 2
- 241000196324 Embryophyta Species 0.000 abstract 2
- 241000602316 Tanacetum parthenium Species 0.000 abstract 2
- 210000002966 serum Anatomy 0.000 abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
ingrediente bioativo, método para isolar uma fração bioativa, e, composição bioativa. a presente invenção refere-se a ingredientes bioativos que incluem frações bioativas isoladas derivadas de suco de células de biomassa fresca de uma planta de matricária (tanacetum parthenium). as frações bioativas são ou livres de ou substancialmente livres de (gama)-lactonas (alfa)-insaturadas (por exemplo, partenolídeo). além disso, as frações bioativas tem atividade antiinflamatória e antioxidante. a presente invenção também refere-se a um método para isolar uma fração bioativa que é derivada de suco de células de biomassa fresca de uma planta de matricária (tanacetum parthenium) e que é pelo menos substancialmente livre de (gama)-lactonas (alfa)-insaturadas (por exemplo partenolídeo). a presente invenção também refere- se a um método para preparar uma fração de soro de suco de células estabilizada e uma fração de soro de suco de células concentrada estabilizada que são livres de (gama)-lactonas (gama)-insaturadas (por exemplo, partenolídeo). a presente invenção também refere-se a uma composição bioativa que inclui uma mistura de uma ou mais das frações bioativas isoladas da presente invenção.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77525706P | 2006-02-21 | 2006-02-21 | |
| US60/775257 | 2006-02-21 | ||
| PCT/US2007/062498 WO2007098471A2 (en) | 2006-02-21 | 2007-02-21 | Parthenolide free bioactive ingredients from feverfew (tanacetum parthenium) and processes for their production |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| BRPI0708095A2 BRPI0708095A2 (pt) | 2011-05-17 |
| BRPI0708095B1 BRPI0708095B1 (pt) | 2021-03-02 |
| BRPI0708095B8 true BRPI0708095B8 (pt) | 2021-03-23 |
| BRPI0708095C1 BRPI0708095C1 (pt) | 2021-05-25 |
Family
ID=38438098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0708095A BRPI0708095C1 (pt) | 2006-02-21 | 2007-02-21 | método para isolar uma fração bioativa, e, ingrediente bioativo |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7537791B2 (pt) |
| EP (1) | EP1991242B1 (pt) |
| JP (4) | JP5336859B2 (pt) |
| CN (1) | CN101453898B (pt) |
| AU (1) | AU2007217003B2 (pt) |
| BR (1) | BRPI0708095C1 (pt) |
| CA (1) | CA2643255A1 (pt) |
| ES (1) | ES2625848T3 (pt) |
| NZ (2) | NZ595600A (pt) |
| WO (1) | WO2007098471A2 (pt) |
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2007
- 2007-02-21 CA CA002643255A patent/CA2643255A1/en not_active Abandoned
- 2007-02-21 NZ NZ595600A patent/NZ595600A/xx not_active IP Right Cessation
- 2007-02-21 JP JP2008556525A patent/JP5336859B2/ja not_active Expired - Fee Related
- 2007-02-21 CN CN200780013469.7A patent/CN101453898B/zh active Active
- 2007-02-21 ES ES07757276.6T patent/ES2625848T3/es active Active
- 2007-02-21 EP EP07757276.6A patent/EP1991242B1/en active Active
- 2007-02-21 BR BRPI0708095A patent/BRPI0708095C1/pt active IP Right Grant
- 2007-02-21 WO PCT/US2007/062498 patent/WO2007098471A2/en not_active Ceased
- 2007-02-21 NZ NZ607880A patent/NZ607880A/en not_active IP Right Cessation
- 2007-02-21 AU AU2007217003A patent/AU2007217003B2/en not_active Ceased
- 2007-02-21 US US11/677,435 patent/US7537791B2/en active Active
-
2009
- 2009-03-26 US US12/412,126 patent/US8728548B2/en not_active Ceased
-
2013
- 2013-04-04 JP JP2013078229A patent/JP2013151544A/ja active Pending
-
2015
- 2015-06-26 JP JP2015128677A patent/JP6141912B2/ja active Active
-
2016
- 2016-05-20 US US15/161,134 patent/USRE46788E1/en active Active
- 2016-10-21 JP JP2016206859A patent/JP2017061476A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN101453898A (zh) | 2009-06-10 |
| US20090186109A1 (en) | 2009-07-23 |
| BRPI0708095A2 (pt) | 2011-05-17 |
| US20070196523A1 (en) | 2007-08-23 |
| CA2643255A1 (en) | 2007-08-30 |
| BRPI0708095B1 (pt) | 2021-03-02 |
| EP1991242A4 (en) | 2010-11-03 |
| JP2009527582A (ja) | 2009-07-30 |
| US8728548B2 (en) | 2014-05-20 |
| JP2017061476A (ja) | 2017-03-30 |
| NZ607880A (en) | 2014-11-28 |
| ES2625848T3 (es) | 2017-07-20 |
| BRPI0708095C1 (pt) | 2021-05-25 |
| AU2007217003B2 (en) | 2013-04-04 |
| AU2007217003A1 (en) | 2007-08-30 |
| US7537791B2 (en) | 2009-05-26 |
| JP6141912B2 (ja) | 2017-06-07 |
| JP5336859B2 (ja) | 2013-11-06 |
| WO2007098471A3 (en) | 2008-11-20 |
| JP2013151544A (ja) | 2013-08-08 |
| USRE46788E1 (en) | 2018-04-17 |
| JP2015205906A (ja) | 2015-11-19 |
| NZ595600A (en) | 2013-03-28 |
| EP1991242B1 (en) | 2017-04-26 |
| EP1991242A2 (en) | 2008-11-19 |
| WO2007098471A2 (en) | 2007-08-30 |
| CN101453898B (zh) | 2014-03-26 |
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