BRPI0708098B8 - derivados de 4-benzoilaminofenil)-6,7-dimetóxi-2-metilaminoquinazolina, composição farmacêutica e agente antiprurítico - Google Patents

derivados de 4-benzoilaminofenil)-6,7-dimetóxi-2-metilaminoquinazolina, composição farmacêutica e agente antiprurítico

Info

Publication number
BRPI0708098B8
BRPI0708098B8 BRPI0708098A BRPI0708098A BRPI0708098B8 BR PI0708098 B8 BRPI0708098 B8 BR PI0708098B8 BR PI0708098 A BRPI0708098 A BR PI0708098A BR PI0708098 A BRPI0708098 A BR PI0708098A BR PI0708098 B8 BRPI0708098 B8 BR PI0708098B8
Authority
BR
Brazil
Prior art keywords
methylaminoquinazoline
benzoylaminophenyl
dimethoxy
derivatives
pharmaceutical composition
Prior art date
Application number
BRPI0708098A
Other languages
English (en)
Inventor
Wakita Hisashi
Miyazaki Kazuki
Kusano Kazutomi
Shirato Manabu
Ishii Naoto
Asano Osamu
Saeki Takao
Takase Yasutaka
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Priority claimed from PCT/JP2007/053066 external-priority patent/WO2007097317A1/ja
Publication of BRPI0708098A2 publication Critical patent/BRPI0708098A2/pt
Publication of BRPI0708098B1 publication Critical patent/BRPI0708098B1/pt
Publication of BRPI0708098B8 publication Critical patent/BRPI0708098B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

derivados de 4-(3-benzoilaminofenil)-6-7-dimetóxi-2-metilaminoquinazolina. a presente invenção refere-se a um composto representado pela seguinte fórmula (i), seu sal, ou seu hidrato, pode eficazmente aliviar coceira causada por doença tópica ou semelhantes, em que r representa hidroxila, c1-6 alcóxi opcionalmente substituído com c1-6 alcóxi, ou amino opcionalmente substituído com c1-6 alquila.
BRPI0708098A 2006-02-21 2007-02-20 derivados de 4-benzoilaminofenil)-6,7-dimetóxi-2-metilaminoquinazolina, composição farmacêutica e agente antiprurítico BRPI0708098B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006043273 2006-02-21
JP2006-043273 2006-02-21
PCT/JP2007/053066 WO2007097317A1 (ja) 2006-02-21 2007-02-20 ４－（３－ベンゾイルアミノフェニル）－６，７－ジメトキシ－２－メチルアミノキナゾリン誘導体

Publications (3)

Publication Number Publication Date
BRPI0708098A2 BRPI0708098A2 (pt) 2011-05-17
BRPI0708098B1 BRPI0708098B1 (pt) 2019-08-06
BRPI0708098B8 true BRPI0708098B8 (pt) 2021-05-25

Family

ID=42137992

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0708098A BRPI0708098B8 (pt) 2006-02-21 2007-02-20 derivados de 4-benzoilaminofenil)-6,7-dimetóxi-2-metilaminoquinazolina, composição farmacêutica e agente antiprurítico

Country Status (17)

Country Link
JP (1) JP4778550B2 (pt)
KR (1) KR101278852B1 (pt)
AT (1) ATE517875T1 (pt)
BR (1) BRPI0708098B8 (pt)
CY (1) CY1112554T1 (pt)
DK (1) DK1992622T3 (pt)
ES (1) ES2368089T3 (pt)
HR (1) HRP20110604T1 (pt)
IL (1) IL193322A (pt)
JO (1) JO2726B1 (pt)
MY (1) MY146275A (pt)
NZ (1) NZ569936A (pt)
PT (1) PT1992622E (pt)
RS (1) RS51969B (pt)
RU (1) RU2431632C2 (pt)
SI (1) SI1992622T1 (pt)
TW (1) TWI404709B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2123641A4 (en) 2007-02-16 2011-06-22 Eisai R&D Man Co Ltd CRYSTAL, AMORPHOUS FORM AND METHYL N-Ý3- (6,7-DIMETHOXY-2-METHYLAMINOQUINAZOLINE-4-YL) PHENYLENE TEREPHTALIC ACID SALT
JP5060561B2 (ja) 2007-08-17 2012-10-31 エーザイ・アール・アンド・ディー・マネジメント株式会社 新規外用剤
WO2009025238A1 (ja) 2007-08-17 2009-02-26 Eisai R & D Management Co., Ltd. キナゾリン誘導体の製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU661533B2 (en) * 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
DE69819349T2 (de) * 1997-08-29 2004-07-22 Tularik Ltd. 1-amino-7-isochinolin-derivate als serin protease inhibitoren
AR015966A1 (es) * 1997-10-17 2001-05-30 Smithkline Beecham Corp Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito
JPH11209350A (ja) 1998-01-26 1999-08-03 Eisai Co Ltd 含窒素複素環誘導体およびその医薬
CN1934100A (zh) * 2004-03-23 2007-03-21 万有制药株式会社 取代喹唑啉或吡啶并嘧啶衍生物

Also Published As

Publication number Publication date
DK1992622T3 (da) 2011-09-05
JO2726B1 (en) 2013-09-15
IL193322A (en) 2014-04-30
KR101278852B1 (ko) 2013-07-01
HRP20110604T1 (hr) 2011-09-30
NZ569936A (en) 2010-07-30
PT1992622E (pt) 2011-09-19
SI1992622T1 (sl) 2011-11-30
RU2431632C2 (ru) 2011-10-20
JP4778550B2 (ja) 2011-09-21
TWI404709B (zh) 2013-08-11
BRPI0708098A2 (pt) 2011-05-17
IL193322A0 (en) 2009-05-04
HK1122025A1 (en) 2009-05-08
CY1112554T1 (el) 2016-02-10
RU2008137654A (ru) 2010-03-27
KR20080094811A (ko) 2008-10-24
MY146275A (en) 2012-07-31
RS51969B (sr) 2012-02-29
BRPI0708098B1 (pt) 2019-08-06
TW200812980A (en) 2008-03-16
JPWO2007097317A1 (ja) 2009-07-16
ES2368089T3 (es) 2011-11-14
ATE517875T1 (de) 2011-08-15

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B09X Republication of the decision to grant [chapter 9.1.3 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 06/08/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 06/08/2019, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/02/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 17A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2762 DE 12-12-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.