ES2368089T3 - Derivados de 4-(3-benzoilaminofenil)-6,7-dimetoxi-2-metilaminoquinazolina. - Google Patents

Derivados de 4-(3-benzoilaminofenil)-6,7-dimetoxi-2-metilaminoquinazolina. Download PDF

Info

Publication number: ES2368089T3
Authority: ES; Spain
Prior art keywords: compound; salt; hydrate; dimethoxy; methylaminoquinazolin
Prior art date: 2006-02-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

ES07714569T

Other languages

English (en)

Spanish (es)

Inventor

Kazuki Miyazaki

Kazutomi Kusano

Yasutaka Takase

Osamu Asano

Manabu Shirato

Hisashi Wakita

Naoto Ishii

Takao Saeki

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eisai R&D Management Co Ltd

Original Assignee

Eisai R&D Management Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-02-21

Filing date

2007-02-20

Publication date

2011-11-14

2007-02-20 Application filed by Eisai R&D Management Co Ltd filed Critical Eisai R&D Management Co Ltd

2011-11-14 Application granted granted Critical

2011-11-14 Publication of ES2368089T3 publication Critical patent/ES2368089T3/es

Status Active legal-status Critical Current

2027-02-20 Anticipated expiration legal-status Critical

Links

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JCYWCSGERIELPG-UHFFFAOYSA-N imes Chemical group CC1=CC(C)=CC(C)=C1N1C=CN(C=2C(=CC(C)=CC=2C)C)[C]1 JCYWCSGERIELPG-UHFFFAOYSA-N 0.000 description 1
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239000003999 initiator Substances 0.000 description 1
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238000002955 isolation Methods 0.000 description 1
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239000007951 isotonicity adjuster Substances 0.000 description 1
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JMZFEHDNIAQMNB-UHFFFAOYSA-N m-aminophenylboronic acid Chemical compound NC1=CC=CC(B(O)O)=C1 JMZFEHDNIAQMNB-UHFFFAOYSA-N 0.000 description 1
229960003511 macrogol Drugs 0.000 description 1
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239000002207 metabolite Substances 0.000 description 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
CVXXHXPNTZBZEL-UHFFFAOYSA-N methyl 4-carbonochloridoylbenzoate Chemical compound COC(=O)C1=CC=C(C(Cl)=O)C=C1 CVXXHXPNTZBZEL-UHFFFAOYSA-N 0.000 description 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
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HZAXFHJVJLSVMW-UHFFFAOYSA-N monoethanolamine hydrochloride Natural products NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
239000004570 mortar (masonry) Substances 0.000 description 1
FEKRFYZGYUTGRY-UHFFFAOYSA-N n'-ethylmethanediimine Chemical compound CCN=C=N FEKRFYZGYUTGRY-UHFFFAOYSA-N 0.000 description 1
125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
239000007923 nasal drop Substances 0.000 description 1
229940100662 nasal drops Drugs 0.000 description 1
235000005152 nicotinamide Nutrition 0.000 description 1
239000011570 nicotinamide Substances 0.000 description 1
229960003966 nicotinamide Drugs 0.000 description 1
150000002825 nitriles Chemical class 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
239000002674 ointment Substances 0.000 description 1
238000011017 operating method Methods 0.000 description 1
239000002997 ophthalmic solution Substances 0.000 description 1
239000003538 oral antidiabetic agent Substances 0.000 description 1
125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 description 1
OTYPIDNRISCWQY-UHFFFAOYSA-L palladium(2+);tris(2-methylphenyl)phosphane;dichloride Chemical compound Cl[Pd]Cl.CC1=CC=CC=C1P(C=1C(=CC=CC=1)C)C1=CC=CC=C1C.CC1=CC=CC=C1P(C=1C(=CC=CC=1)C)C1=CC=CC=C1C OTYPIDNRISCWQY-UHFFFAOYSA-L 0.000 description 1
YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 description 1
MXQOYLRVSVOCQT-UHFFFAOYSA-N palladium;tritert-butylphosphane Chemical compound [Pd].CC(C)(C)P(C(C)(C)C)C(C)(C)C.CC(C)(C)P(C(C)(C)C)C(C)(C)C MXQOYLRVSVOCQT-UHFFFAOYSA-N 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
239000001814 pectin Substances 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
235000019477 peppermint oil Nutrition 0.000 description 1
230000002085 persistent effect Effects 0.000 description 1
239000012071 phase Substances 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
239000002587 phosphodiesterase IV inhibitor Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
235000011056 potassium acetate Nutrition 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
239000011698 potassium fluoride Substances 0.000 description 1
235000003270 potassium fluoride Nutrition 0.000 description 1
239000002243 precursor Substances 0.000 description 1
239000000651 prodrug Substances 0.000 description 1
229940002612 prodrug Drugs 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
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238000012797 qualification Methods 0.000 description 1
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239000004208 shellac Substances 0.000 description 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
229940113147 shellac Drugs 0.000 description 1
235000013874 shellac Nutrition 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
235000011083 sodium citrates Nutrition 0.000 description 1
QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
229940045902 sodium stearyl fumarate Drugs 0.000 description 1
239000012453 solvate Substances 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical compound O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 description 1
150000003462 sulfoxides Chemical class 0.000 description 1
239000000829 suppository Substances 0.000 description 1
230000002194 synthesizing effect Effects 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000003826 tablet Substances 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
238000010998 test method Methods 0.000 description 1
JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
229960005196 titanium dioxide Drugs 0.000 description 1
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
229960000984 tocofersolan Drugs 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
235000013337 tricalcium citrate Nutrition 0.000 description 1
WLPUWLXVBWGYMZ-UHFFFAOYSA-N tricyclohexylphosphine Chemical compound C1CCCCC1P(C1CCCCC1)C1CCCCC1 WLPUWLXVBWGYMZ-UHFFFAOYSA-N 0.000 description 1
229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
235000019798 tripotassium phosphate Nutrition 0.000 description 1
WXAZIUYTQHYBFW-UHFFFAOYSA-N tris(4-methylphenyl)phosphane Chemical compound C1=CC(C)=CC=C1P(C=1C=CC(C)=CC=1)C1=CC=C(C)C=C1 WXAZIUYTQHYBFW-UHFFFAOYSA-N 0.000 description 1
DLQYXUGCCKQSRJ-UHFFFAOYSA-N tris(furan-2-yl)phosphane Chemical compound C1=COC(P(C=2OC=CC=2)C=2OC=CC=2)=C1 DLQYXUGCCKQSRJ-UHFFFAOYSA-N 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
229910000406 trisodium phosphate Inorganic materials 0.000 description 1
235000019801 trisodium phosphate Nutrition 0.000 description 1
238000003828 vacuum filtration Methods 0.000 description 1
238000005406 washing Methods 0.000 description 1
CXNIUSPIQKWYAI-UHFFFAOYSA-N xantphos Chemical compound C=12OC3=C(P(C=4C=CC=CC=4)C=4C=CC=CC=4)C=CC=C3C(C)(C)C2=CC=CC=1P(C=1C=CC=CC=1)C1=CC=CC=C1 CXNIUSPIQKWYAI-UHFFFAOYSA-N 0.000 description 1
239000002076 α-tocopherol Substances 0.000 description 1
235000004835 α-tocopherol Nutrition 0.000 description 1
OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ES07714569T 2006-02-21 2007-02-20 Derivados de 4-(3-benzoilaminofenil)-6,7-dimetoxi-2-metilaminoquinazolina. Active ES2368089T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2006043273		2006-02-21
JP2006043273		2006-02-21

Publications (1)

Publication Number	Publication Date
ES2368089T3 true ES2368089T3 (es)	2011-11-14

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ES07714569T Active ES2368089T3 (es)	2006-02-21	2007-02-20	Derivados de 4-(3-benzoilaminofenil)-6,7-dimetoxi-2-metilaminoquinazolina.

Country Status (17)

Country	Link
JP (1)	JP4778550B2 (pt)
KR (1)	KR101278852B1 (pt)
AT (1)	ATE517875T1 (pt)
BR (1)	BRPI0708098B8 (pt)
CY (1)	CY1112554T1 (pt)
DK (1)	DK1992622T3 (pt)
ES (1)	ES2368089T3 (pt)
HR (1)	HRP20110604T1 (pt)
IL (1)	IL193322A (pt)
JO (1)	JO2726B1 (pt)
MY (1)	MY146275A (pt)
NZ (1)	NZ569936A (pt)
PT (1)	PT1992622E (pt)
RS (1)	RS51969B (pt)
RU (1)	RU2431632C2 (pt)
SI (1)	SI1992622T1 (pt)
TW (1)	TWI404709B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2123641A4 (en)	2007-02-16	2011-06-22	Eisai R&D Man Co Ltd	CRYSTAL, AMORPHOUS FORM AND METHYL N-Ý3- (6,7-DIMETHOXY-2-METHYLAMINOQUINAZOLINE-4-YL) PHENYLENE TEREPHTALIC ACID SALT
JP5060561B2 (ja)	2007-08-17	2012-10-31	エーザイ・アール・アンド・ディー・マネジメント株式会社	新規外用剤
WO2009025238A1 (ja)	2007-08-17	2009-02-26	Eisai R & D Management Co., Ltd.	キナゾリン誘導体の製造方法

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Publication number	Priority date	Publication date	Assignee	Title
AU661533B2 (en) *	1992-01-20	1995-07-27	Astrazeneca Ab	Quinazoline derivatives
DE69819349T2 (de) *	1997-08-29	2004-07-22	Tularik Ltd.	1-amino-7-isochinolin-derivate als serin protease inhibitoren
AR015966A1 (es) *	1997-10-17	2001-05-30	Smithkline Beecham Corp	Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito
JPH11209350A (ja)	1998-01-26	1999-08-03	Eisai Co Ltd	含窒素複素環誘導体およびその医薬
CN1934100A (zh) *	2004-03-23	2007-03-21	万有制药株式会社	取代喹唑啉或吡啶并嘧啶衍生物

2007
- 2007-02-16 TW TW096105966A patent/TWI404709B/zh not_active IP Right Cessation
- 2007-02-20 MY MYPI20083110A patent/MY146275A/en unknown
- 2007-02-20 DK DK07714569.6T patent/DK1992622T3/da active
- 2007-02-20 SI SI200730730T patent/SI1992622T1/sl unknown
- 2007-02-20 ES ES07714569T patent/ES2368089T3/es active Active
- 2007-02-20 NZ NZ569936A patent/NZ569936A/en not_active IP Right Cessation
- 2007-02-20 JO JO200752A patent/JO2726B1/en active
- 2007-02-20 KR KR1020087021869A patent/KR101278852B1/ko not_active Expired - Fee Related
- 2007-02-20 BR BRPI0708098A patent/BRPI0708098B8/pt not_active IP Right Cessation
- 2007-02-20 AT AT07714569T patent/ATE517875T1/de active
- 2007-02-20 PT PT07714569T patent/PT1992622E/pt unknown
- 2007-02-20 RS RS20110421A patent/RS51969B/sr unknown
- 2007-02-20 RU RU2008137654/04A patent/RU2431632C2/ru active
- 2007-02-20 JP JP2008501719A patent/JP4778550B2/ja not_active Expired - Fee Related
- 2007-02-20 HR HR20110604T patent/HRP20110604T1/hr unknown
2008
- 2008-08-07 IL IL193322A patent/IL193322A/en active IP Right Grant
2011
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Also Published As

Publication number	Publication date
DK1992622T3 (da)	2011-09-05
JO2726B1 (en)	2013-09-15
IL193322A (en)	2014-04-30
KR101278852B1 (ko)	2013-07-01
HRP20110604T1 (hr)	2011-09-30
BRPI0708098B8 (pt)	2021-05-25
NZ569936A (en)	2010-07-30
PT1992622E (pt)	2011-09-19
SI1992622T1 (sl)	2011-11-30
RU2431632C2 (ru)	2011-10-20
JP4778550B2 (ja)	2011-09-21
TWI404709B (zh)	2013-08-11
BRPI0708098A2 (pt)	2011-05-17
IL193322A0 (en)	2009-05-04
HK1122025A1 (en)	2009-05-08
CY1112554T1 (el)	2016-02-10
RU2008137654A (ru)	2010-03-27
KR20080094811A (ko)	2008-10-24
MY146275A (en)	2012-07-31
RS51969B (sr)	2012-02-29
BRPI0708098B1 (pt)	2019-08-06
TW200812980A (en)	2008-03-16
JPWO2007097317A1 (ja)	2009-07-16
ATE517875T1 (de)	2011-08-15

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