BRPI0713380A2 - Métodos para determinar in vitro a quantidade de ácidos nucleicos nucleares em pelo menos uma célula, e para diagnosticar e/ou prognosticar câncer em um indivíduo humano ou animal - Google Patents

Métodos para determinar in vitro a quantidade de ácidos nucleicos nucleares em pelo menos uma célula, e para diagnosticar e/ou prognosticar câncer em um indivíduo humano ou animal Download PDF

Info

Publication number
BRPI0713380A2
BRPI0713380A2 BRPI0713380-4A BRPI0713380A BRPI0713380A2 BR PI0713380 A2 BRPI0713380 A2 BR PI0713380A2 BR PI0713380 A BRPI0713380 A BR PI0713380A BR PI0713380 A2 BRPI0713380 A2 BR PI0713380A2
Authority
BR
Brazil
Prior art keywords
vitro
human
diagnosing
determining
cell
Prior art date
Application number
BRPI0713380-4A
Other languages
English (en)
Inventor
Hendrikus Wilhelmus Hendriks Bernardus
Robert Vossenaar Erik
Spekowius Gerhard
Cornelis Van Der Vaart Nijs
Kuiper Stein
Original Assignee
Koninklijke Philips Electonics N. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electonics N. V. filed Critical Koninklijke Philips Electonics N. V.
Publication of BRPI0713380A2 publication Critical patent/BRPI0713380A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/33—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5035—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on sub-cellular localization
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/40—Analysis of texture
    • G06T7/41—Analysis of texture based on statistical description of texture
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/693—Acquisition
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10056—Microscopic image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Genetics & Genomics (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Quality & Reliability (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Multimedia (AREA)
  • Probability & Statistics with Applications (AREA)

Abstract

MéTODOS PARA DETERMINAR IN VITRO A QUANTIDADE DE áCIDOS NUCLEICOS NUCLEARES EM PELO MENOS UMA CéLULA, E PARA DIAGNOSTICAR E/OU PROGNOSTICAR CáNCER EM UM INDIVìDUO HUMANO OU ANIMAL. A invenção refere-se a um método para determinar in vitro a quantidade de DNA nuclear dentro de uma célula humana ou animal, empregando-se medição de absorção UV com luz UV. A invenção também refere-se a um método para detectar in vitro células cancerosas em uma amostra biológica com base nos princípios acima mencionados. A invenção também se refere a um método in vitro de diagnosticar ou prognosticar a ocorrência provável de câncer em um indivíduo humano ou animal.
BRPI0713380-4A 2006-06-29 2007-05-14 Métodos para determinar in vitro a quantidade de ácidos nucleicos nucleares em pelo menos uma célula, e para diagnosticar e/ou prognosticar câncer em um indivíduo humano ou animal BRPI0713380A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP06116336.6 2006-06-29
EP06116336 2006-06-29
EP06118438 2006-08-04
EP06118438.8 2006-08-04
PCT/IB2007/051810 WO2008001235A2 (en) 2006-06-29 2007-05-14 An in vitro method of detecting and/or diagnosing cancer using uv light based dna image cytometry

Publications (1)

Publication Number Publication Date
BRPI0713380A2 true BRPI0713380A2 (pt) 2012-03-20

Family

ID=38617949

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0713380-4A BRPI0713380A2 (pt) 2006-06-29 2007-05-14 Métodos para determinar in vitro a quantidade de ácidos nucleicos nucleares em pelo menos uma célula, e para diagnosticar e/ou prognosticar câncer em um indivíduo humano ou animal

Country Status (7)

Country Link
US (1) US9057729B2 (pt)
EP (1) EP2038651B1 (pt)
JP (1) JP2009542200A (pt)
CN (1) CN104849228B (pt)
BR (1) BRPI0713380A2 (pt)
RU (1) RU2009102834A (pt)
WO (1) WO2008001235A2 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017107348B4 (de) 2017-04-05 2019-03-14 Olympus Soft Imaging Solutions Gmbh Verfahren zur zytometrischen Analyse von Zellproben
MX2022004703A (es) 2019-10-22 2022-05-11 S D Sight Diagnostics Ltd Contabilidad de errores en mediciones opticas.
MX2022007121A (es) * 2019-12-12 2022-07-11 S D Sight Diagnostics Ltd Imagenes microscopicas desenfocadas de una muestra.
BR112022011233A2 (pt) 2019-12-12 2022-08-30 S D Sight Diagnostics Ltd Detecção de plaquetas em uma amostra sanguínea
US11551360B2 (en) 2020-04-28 2023-01-10 QATAR UNIVERSITY, Office of Academic Research Device and method for cancer detection

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3327119A (en) * 1964-03-26 1967-06-20 Ibm Method and apparatus for detecting cancer cells
US3675768A (en) * 1969-03-17 1972-07-11 Gildardo Legorreta Sanchez Method and apparatus for classifying and segregating particles with electrical and optical means
US3699336A (en) * 1969-08-15 1972-10-17 Hycel Inc Biological cell analyzing system
US4767717A (en) * 1985-05-02 1988-08-30 Baisden C Robert Method of detecting and quantitating cell malignancy in biological tissue
SU1451598A1 (ru) 1986-05-29 1989-01-15 Северо-Кавказский научно-исследовательский институт фитопатологии Способ определени целостности дер в срезах биологической ткани на цитологическом препарате
US5932872A (en) * 1994-07-01 1999-08-03 Jeffrey H. Price Autofocus system for scanning microscopy having a volume image formation
US5871902A (en) * 1994-12-09 1999-02-16 The Gene Pool, Inc. Sequence-specific detection of nucleic acid hybrids using a DNA-binding molecule or assembly capable of discriminating perfect hybrids from non-perfect hybrids
US6165734A (en) * 1995-12-12 2000-12-26 Applied Spectral Imaging Ltd. In-situ method of analyzing cells
WO2000003033A1 (en) * 1998-07-08 2000-01-20 The Regents Of The University Of California Use of fluorescent reagents in identification of cancerous cells and activated lymphocytes
US7218764B2 (en) * 2000-12-04 2007-05-15 Cytokinetics, Inc. Ploidy classification method
US6944322B2 (en) * 2001-03-28 2005-09-13 Visiongate, Inc. Optical tomography of small objects using parallel ray illumination and post-specimen optical magnification
CN1659439A (zh) * 2001-09-07 2005-08-24 伯斯坦技术公司 利用光学生物盘系统基于细胞核形态学的白血细胞类型的识别和定量
US20040197839A1 (en) * 2003-04-04 2004-10-07 Bioview Ltd. Methods of detecting cancer cells in biological samples
EP1760454A4 (en) * 2004-06-24 2008-09-03 Olympus Corp PHOTOMETRIC FLUORESCENT METHOD

Also Published As

Publication number Publication date
CN104849228B (zh) 2018-04-13
EP2038651A2 (en) 2009-03-25
CN104849228A (zh) 2015-08-19
WO2008001235A2 (en) 2008-01-03
JP2009542200A (ja) 2009-12-03
RU2009102834A (ru) 2010-08-10
EP2038651B1 (en) 2017-03-29
WO2008001235A3 (en) 2008-02-21
US20090197272A1 (en) 2009-08-06
US9057729B2 (en) 2015-06-16

Similar Documents

Publication Publication Date Title
NO20083461L (no) Genekspresjonsmarkorer for kolorektal cancer-prognose
BRPI0516005A (pt) determinação de concentração em uma camada-barreira de difusão
BRPI0707645B8 (pt) métodos in vitro para detecção de câncer em um indivíduo e para avaliação de prognóstico de um indivíduo tendo, ou suspeito de ter, câncer ovariano
AU2016216744A1 (en) Novel Biomarkers
BRPI0915619A2 (pt) métodos para determinar uma probabilidade de que um sujeito tenha contribuído com material genético para amostra de teste de material genético, para caracterizar amostra de teste de material genético e para determinar se uma pessoa de interesse contribuiu com material genético para uma amostra de teste de material genético, kit para análise de amostra de teste de material genético e sistema para determinar se um sujeito contribuiu com material genético para uma amostra
WO2010005991A3 (en) Circulating tumor and tumor stem cell detection using genomic specific probes
EP2405022A3 (en) Gene expression profiling for predicting the survivability of prostate cancer subjects
BR112012009481A2 (pt) método e dispositivo para detectar uma pluralidade de alvos em uma amostra biológica, e, kit para detectar uma pluralidade de alvos múltiplos em uma amostra biológica
ATE526333T1 (de) Reagentien zum nachweis von hypochloriger säure
MX2008009592A (es) Metodos y composiciones para identificar pacientes con una probabilidad incrementada de tener cancer de ovario.
NZ593514A (en) p-mTOR and p-AKT as Ratio Based Biomarkers for the Prognosis and/or Diagnosis of Cancer
ATE437216T1 (de) Schnellnachweis replizierender zellen
PL2386860T3 (pl) Przewidywanie śmiertelności i wykrywanie poważnej choroby
MX2010010465A (es) Metodo para la deteccion de igf1r/chr 15 en celulas tumorales circulantes mediante hibridacion fluorescente in situ.
BR112014016313A2 (pt) medições precisas de analito para tira de teste eletroquímico com base em característica(s) física(s) detectada(s) da amostra contendo o analito e parâmetros de biossensores derivados
BRPI1013896A2 (pt) Célula de levedura, e, métodos para produzir um composto isoprenóide e para detectar em uma amostra biológica a presença ou ausência de uma célula microbiana geneticamente.
WO2012151105A3 (en) Basophil analysis system and method
AR053251A1 (es) Estrategias nuevas de etiquetado para la deteccion sensible de analitos
WO2007038754A3 (en) Gene expression profiling for identification monitoring and treatment of rheumatoid arthritis
RU2011106957A (ru) Онкоген nrf2 и его применение
BRPI0515223A (pt) dispositivo integrado para análises diagnósticas e método relativo
DK2038430T3 (da) Toll-Like-Receptor-4-dysfunktion og de biologiske anvendelser deraf
WO2011008814A3 (en) Multiplexed measurement of exogenous and endogenous dna
DE602006021777D1 (de) Diagnoseverfahren für präeklampsie
WO2005032347A3 (en) Determining the chemosensitivity of cells to cytotoxic agents

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A E 5A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 4A E 5A ANUIDADES.