BRPI0714439A2 - Processos para a preparação de d-1,2,4-butanotriol de trinitrato de 1,2,4-butanotriol, de ácido d-3,4-diidroxibutanóico, de ácido 3-desoxi-d-gliceropentanóico, de ácido (4s)-2-amino-4,5-diidroxipentanóico; d-1,2,4-butanotriol trinitrato de d-1,2,4-butanotriol, d-xilose desidrogenase, ácido d-xilônico, desidratase, ácido 3-desoxi-gliceropentanóico, ácido d-3-4-diidroxibutanóico, ácido (4s)-2-amino-4,5-diidroxipentanóico; ácidos nucléicos codificadores de uma d-xilose ou recombinantes, para biossíntese de 1,2,4-butanotriol, do ácido (4s)-2-amino-4,5-diidroxipentanóico, do ácido d-3-4-diidroxibutanóico, do ácido (4s)-2-amino-4,5-diidroxipentanóico; vetor knock-out de uma 3-desoxi-d-glicero-pentulossonato aldolase, entidade celular recombinante, célula recombinate, processo para investigação de polinucleotídeos candidatos codificadores de enzimas, anticorpo. - Google Patents

Processos para a preparação de d-1,2,4-butanotriol de trinitrato de 1,2,4-butanotriol, de ácido d-3,4-diidroxibutanóico, de ácido 3-desoxi-d-gliceropentanóico, de ácido (4s)-2-amino-4,5-diidroxipentanóico; d-1,2,4-butanotriol trinitrato de d-1,2,4-butanotriol, d-xilose desidrogenase, ácido d-xilônico, desidratase, ácido 3-desoxi-gliceropentanóico, ácido d-3-4-diidroxibutanóico, ácido (4s)-2-amino-4,5-diidroxipentanóico; ácidos nucléicos codificadores de uma d-xilose ou recombinantes, para biossíntese de 1,2,4-butanotriol, do ácido (4s)-2-amino-4,5-diidroxipentanóico, do ácido d-3-4-diidroxibutanóico, do ácido (4s)-2-amino-4,5-diidroxipentanóico; vetor knock-out de uma 3-desoxi-d-glicero-pentulossonato aldolase, entidade celular recombinante, célula recombinate, processo para investigação de polinucleotídeos candidatos codificadores de enzimas, anticorpo.

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Publication number
BRPI0714439A2
BRPI0714439A2 BRPI0714439-3A2A BRPI0714439A BRPI0714439A2 BR PI0714439 A2 BRPI0714439 A2 BR PI0714439A2 BR PI0714439 A BRPI0714439 A BR PI0714439A BR PI0714439 A2 BRPI0714439 A2 BR PI0714439A2
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Prior art keywords
acid
butanotriol
amino
diidroxipentanic
deoxy
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BRPI0714439-3A2A
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English (en)
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John W Frost
Wei Niu
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Univ Michigan State
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Publication date
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Publication of BRPI0714439A2 publication Critical patent/BRPI0714439A2/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/16—Butanols
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Chemical & Material Sciences (AREA)
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  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
BRPI0714439-3A2A 2006-07-19 2007-07-19 Processos para a preparação de d-1,2,4-butanotriol de trinitrato de 1,2,4-butanotriol, de ácido d-3,4-diidroxibutanóico, de ácido 3-desoxi-d-gliceropentanóico, de ácido (4s)-2-amino-4,5-diidroxipentanóico; d-1,2,4-butanotriol trinitrato de d-1,2,4-butanotriol, d-xilose desidrogenase, ácido d-xilônico, desidratase, ácido 3-desoxi-gliceropentanóico, ácido d-3-4-diidroxibutanóico, ácido (4s)-2-amino-4,5-diidroxipentanóico; ácidos nucléicos codificadores de uma d-xilose ou recombinantes, para biossíntese de 1,2,4-butanotriol, do ácido (4s)-2-amino-4,5-diidroxipentanóico, do ácido d-3-4-diidroxibutanóico, do ácido (4s)-2-amino-4,5-diidroxipentanóico; vetor knock-out de uma 3-desoxi-d-glicero-pentulossonato aldolase, entidade celular recombinante, célula recombinate, processo para investigação de polinucleotídeos candidatos codificadores de enzimas, anticorpo. BRPI0714439A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83196406P 2006-07-19 2006-07-19
PCT/US2007/016384 WO2008091288A2 (en) 2006-07-19 2007-07-19 Microbial synthesis of d-1,2,4-butanetriol

Publications (1)

Publication Number Publication Date
BRPI0714439A2 true BRPI0714439A2 (pt) 2014-04-08

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BRPI0714439-3A2A BRPI0714439A2 (pt) 2006-07-19 2007-07-19 Processos para a preparação de d-1,2,4-butanotriol de trinitrato de 1,2,4-butanotriol, de ácido d-3,4-diidroxibutanóico, de ácido 3-desoxi-d-gliceropentanóico, de ácido (4s)-2-amino-4,5-diidroxipentanóico; d-1,2,4-butanotriol trinitrato de d-1,2,4-butanotriol, d-xilose desidrogenase, ácido d-xilônico, desidratase, ácido 3-desoxi-gliceropentanóico, ácido d-3-4-diidroxibutanóico, ácido (4s)-2-amino-4,5-diidroxipentanóico; ácidos nucléicos codificadores de uma d-xilose ou recombinantes, para biossíntese de 1,2,4-butanotriol, do ácido (4s)-2-amino-4,5-diidroxipentanóico, do ácido d-3-4-diidroxibutanóico, do ácido (4s)-2-amino-4,5-diidroxipentanóico; vetor knock-out de uma 3-desoxi-d-glicero-pentulossonato aldolase, entidade celular recombinante, célula recombinate, processo para investigação de polinucleotídeos candidatos codificadores de enzimas, anticorpo.

Country Status (6)

Country Link
US (1) US20110076730A1 (pt)
EP (1) EP2054518A2 (pt)
KR (1) KR20090039738A (pt)
CN (1) CN101512004A (pt)
BR (1) BRPI0714439A2 (pt)
WO (1) WO2008091288A2 (pt)

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WO2005068642A2 (en) 2003-10-01 2005-07-28 Board Of Trustees Operating Michigan State University Bacterial synthesis of 1,2,4-butanetriol enantiomers
FI20095278A0 (fi) 2009-03-18 2009-03-18 Valtion Teknillinen Ksylonihapon valmistus
WO2013069634A1 (ja) * 2011-11-11 2013-05-16 味の素株式会社 発酵法による目的物質の製造法
KR101351879B1 (ko) * 2012-02-06 2014-01-22 명지대학교 산학협력단 에탄―１，２―디올 생산 미생물 및 이를 이용한 에탄―１，２―디올 생산 방법
US20130316416A1 (en) * 2012-02-23 2013-11-28 Massachusetts Institute Of Technology Engineering microbes and metabolic pathways for the production of ethylene glycol
CN102965401B (zh) * 2012-11-14 2014-01-01 中国科学院微生物研究所 1，2，4-丁三醇的生物合成方法
CN104450798B (zh) * 2014-11-24 2018-02-02 中国科学院青岛生物能源与过程研究所 一种体外酶反应生成1,2,4‑丁三醇的方法及应用
EP3050970B1 (en) 2015-01-28 2019-09-18 Metabolic Explorer Modified microorganism for optimized production of 1,4-butanediol
CN107690482B (zh) 2015-04-07 2022-11-29 代谢探索者公司 用于2,4-二羟基丁酸的优化生产的经修饰的微生物
ES2811337T3 (es) 2015-04-07 2021-03-11 Metabolic Explorer Sa Microorganismo modificado para la producción optimizada de 2,4-dihidroxibutirato con eflujo de 2,4- dihidroxibutirato aumentado
CN105132400B (zh) * 2015-07-24 2018-10-12 中国科学院天津工业生物技术研究所 具有催化甲醛合成1,3-二羟基丙酮功能的酶及其制备方法
CN106148429B (zh) * 2016-08-25 2020-01-10 南京工业大学 一种生物转化纤维素水解液生产d-1,2,4-丁三醇的方法
CN107674889B (zh) * 2017-11-24 2020-11-03 南京工业大学 一种酶反应合成1,2,4-丁三醇的方法
CN107988128B (zh) * 2017-11-27 2021-02-05 南京工业大学 一种产d-1,2,4-丁三醇的基因工程菌及其应用
CN108148796B (zh) * 2017-12-29 2021-01-01 北京理工大学 一种重组大肠杆菌、制备方法及其合成d-1,2,4-丁三醇的方法
KR102241682B1 (ko) * 2018-12-26 2021-04-19 명지대학교 산학협력단 D-자일론산 반응성 프로모터, 이를 포함하는 d-자일론산 감지용 재설계 유전자 회로 및 이를 이용한 d-자일론산의 감지방법
CN111172143B (zh) * 2020-01-10 2021-09-24 南京工业大学 D-木糖酸脱水酶及其应用
CN113337546B (zh) * 2021-06-04 2023-09-12 上海启讯医药科技有限公司 一种(s)-1，2，4-丁三醇的制备方法
CN115094016B (zh) * 2022-06-30 2024-02-23 山东大学 敲除葡萄糖-6-磷酸异构酶基因的重组大肠杆菌及其在生产1,2,4-丁三醇中的应用
CN120796243B (zh) * 2025-09-10 2026-03-06 北京化工大学 乙醇醛合成酶突变体及其在提高乙醇醛合成酶热稳定性中的应用

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WO2008091288A3 (en) 2009-03-19
WO2008091288A2 (en) 2008-07-31
CN101512004A (zh) 2009-08-19
KR20090039738A (ko) 2009-04-22
EP2054518A2 (en) 2009-05-06
US20110076730A1 (en) 2011-03-31

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