DK1478650T3 - Nye boronatestere - Google Patents

Nye boronatestere

Info

Publication number: DK1478650T3
Authority: DK; Denmark
Prior art keywords: new; boronate esters; pitavastatin; cerivastatin; rosuvastatin
Prior art date: 2002-02-25

Application number

DK02707083.8T

Other languages

English (en)

Inventor

Tom Thomas Puthiaprampil

Sumithra Srinath

Madhavan Sridharan

Sambasivam Ganesh

Original Assignee

Biocon Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-25

Filing date

2002-02-25

Publication date

2010-01-25

2002-02-25 Application filed by Biocon Ltd filed Critical Biocon Ltd

2010-01-25 Application granted granted Critical

2010-01-25 Publication of DK1478650T3 publication Critical patent/DK1478650T3/da

Links

ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical class OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 title abstract 2
FJLGEFLZQAZZCD-MCBHFWOFSA-N (3R,5S)-fluvastatin Chemical compound C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 FJLGEFLZQAZZCD-MCBHFWOFSA-N 0.000 abstract 1
CABVTRNMFUVUDM-VRHQGPGLSA-N (3S)-3-hydroxy-3-methylglutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](O)(CC(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CABVTRNMFUVUDM-VRHQGPGLSA-N 0.000 abstract 1
XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 abstract 1
XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 abstract 1
229960005370 atorvastatin Drugs 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
229960005110 cerivastatin Drugs 0.000 abstract 1
SEERZIQQUAZTOL-ANMDKAQQSA-N cerivastatin Chemical compound COCC1=C(C(C)C)N=C(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 SEERZIQQUAZTOL-ANMDKAQQSA-N 0.000 abstract 1
239000002532 enzyme inhibitor Substances 0.000 abstract 1
229960003765 fluvastatin Drugs 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
229960002797 pitavastatin Drugs 0.000 abstract 1
VGYFMXBACGZSIL-MCBHFWOFSA-N pitavastatin Chemical compound OC(=O)C[C@H](O)C[C@H](O)\C=C\C1=C(C2CC2)N=C2C=CC=CC2=C1C1=CC=C(F)C=C1 VGYFMXBACGZSIL-MCBHFWOFSA-N 0.000 abstract 1
229960000672 rosuvastatin Drugs 0.000 abstract 1
BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pyrrole Compounds (AREA)

DK02707083.8T 2002-02-25 2002-02-25 Nye boronatestere DK1478650T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02707083A EP1478650B1 (en)	2002-02-25	2002-02-25	Novel boronate esters
PCT/IN2002/000032 WO2003070733A1 (en)	2002-02-25	2002-02-25	Novel boronate esters

Publications (1)

Publication Number	Publication Date
DK1478650T3 true DK1478650T3 (da)	2010-01-25

Family

ID=27742233

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02707083.8T DK1478650T3 (da)	2002-02-25	2002-02-25	Nye boronatestere

Country Status (21)

Country	Link
US (2)	US7301046B2 (da)
EP (1)	EP1478650B1 (da)
JP (1)	JP4139334B2 (da)
KR (1)	KR100598079B1 (da)
AT (1)	ATE444299T1 (da)
AU (1)	AU2002241235B2 (da)
BR (1)	BR0215602A (da)
CA (1)	CA2475586C (da)
CZ (1)	CZ2004863A3 (da)
DE (1)	DE60233899D1 (da)
DK (1)	DK1478650T3 (da)
ES (1)	ES2332881T3 (da)
HR (1)	HRP20040888B1 (da)
HU (1)	HUP0500125A3 (da)
IL (1)	IL163333A (da)
NO (1)	NO20043223L (da)
NZ (1)	NZ534688A (da)
PT (1)	PT1478650E (da)
RO (1)	RO122095B1 (da)
SK (1)	SK288093B6 (da)
WO (1)	WO2003070733A1 (da)

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GB0011120D0 (en) *	2000-05-09	2000-06-28	Avecia Ltd	Process
NL1015744C2 (nl) *	2000-07-19	2002-01-22	Dsm Nv	Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
US7135978B2 (en)	2001-09-14	2006-11-14	Calypso Medical Technologies, Inc.	Miniature resonating marker assembly
EP1323717A1 (en) *	2001-12-27	2003-07-02	Dsm N.V.	Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
DK1478650T3 (da)	2002-02-25	2010-01-25	Biocon Ltd	Nye boronatestere
BRPI0714439A2 (pt) *	2006-07-19	2014-04-08	Univ Michigan State	Processos para a preparação de d-1,2,4-butanotriol de trinitrato de 1,2,4-butanotriol, de ácido d-3,4-diidroxibutanóico, de ácido 3-desoxi-d-gliceropentanóico, de ácido (4s)-2-amino-4,5-diidroxipentanóico; d-1,2,4-butanotriol trinitrato de d-1,2,4-butanotriol, d-xilose desidrogenase, ácido d-xilônico, desidratase, ácido 3-desoxi-gliceropentanóico, ácido d-3-4-diidroxibutanóico, ácido (4s)-2-amino-4,5-diidroxipentanóico; ácidos nucléicos codificadores de uma d-xilose ou recombinantes, para biossíntese de 1,2,4-butanotriol, do ácido (4s)-2-amino-4,5-diidroxipentanóico, do ácido d-3-4-diidroxibutanóico, do ácido (4s)-2-amino-4,5-diidroxipentanóico; vetor knock-out de uma 3-desoxi-d-glicero-pentulossonato aldolase, entidade celular recombinante, célula recombinate, processo para investigação de polinucleotídeos candidatos codificadores de enzimas, anticorpo.
CN101528917B (zh)	2006-10-02	2015-07-29	科德克希思公司	用于制备立体异构纯的他汀类及其合成中间体的组合物和方法
KR100933172B1 (ko)	2007-11-30	2009-12-21	씨제이제일제당 (주)	아토르바스타틴 칼슘염의 개선된 제조방법
KR101339648B1 (ko) *	2012-05-10	2013-12-09	(주) 에프엔지리서치	신규한 아토바스타틴 중간체 및 이를 이용한 아토바스타틴의 제조 방법
KR101292743B1 (ko) *	2012-05-17	2013-08-02	(주) 에프엔지리서치	신규한 스타틴 중간체 및 이를 이용한 피타바스타틴, 로수바스타틴, 세리바스타틴 및 플루바스타틴의 제조 방법
KR101528359B1 (ko) *	2013-04-24	2015-06-15	(주) 성운파마코피아	스타틴 화합물 제조를 위한 신규한 보로네이트 에테르 화합물, 그 제조방법 및 상기 보로네이트 에테르 화합물을 이용한 스타틴 화합물 제조방법
CN108033899B (zh) *	2017-12-06	2020-04-10	浙江科技学院	一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4474034A (en)	1982-09-23	1984-10-02	Avery Jr Richard J	Refrigerant accumulator and charging apparatus and method for vapor-compression refrigeration system
DE3741509A1 (de) *	1987-12-08	1989-06-22	Hoechst Ag	Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
EP0909757A3 (en) *	1992-06-10	1999-04-28	Chisso Corporation	Process for producing optically active pentanetetraols
SG44830A1 (en) *	1992-07-02	1997-12-19	Hoechst Ag	Process for preparing tert-butyl 93R,5S) -6 Hydroxy-3,5-O-Isopropylidene-3, 5-Dihydroxyhexanoate
US5481009A (en) *	1993-08-09	1996-01-02	Fujirebio Inc.	Methods of producing carboxylic acid ester derivatives and intermediates for use in the methods
WO1998004543A1 (en) *	1996-07-29	1998-02-05	Warner-Lambert Company	Improved process for the synthesis of protected esters of (s)-3,4-dihydroxybutyric acid
JPH11171850A (ja)	1997-12-12	1999-06-29	Kanegafuchi Chem Ind Co Ltd	酪酸エステル誘導体の製造方法
WO2001072706A1 (en) *	2000-03-28	2001-10-04	Biocon India Limited	Synthesis of [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin)
WO2002057229A1 (en)	2001-01-19	2002-07-25	Biocon India Limited	FORM V CRYSTALLINE [R-(R,R)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
DK1478650T3 (da) *	2002-02-25	2010-01-25	Biocon Ltd	Nye boronatestere

2002
- 2002-02-25 DK DK02707083.8T patent/DK1478650T3/da active
- 2002-02-25 US US10/505,528 patent/US7301046B2/en not_active Expired - Fee Related
- 2002-02-25 HU HU0500125A patent/HUP0500125A3/hu unknown
- 2002-02-25 AU AU2002241235A patent/AU2002241235B2/en not_active Ceased
- 2002-02-25 BR BR0215602-4A patent/BR0215602A/pt not_active Application Discontinuation
- 2002-02-25 CA CA2475586A patent/CA2475586C/en not_active Expired - Fee Related
- 2002-02-25 NZ NZ534688A patent/NZ534688A/en not_active IP Right Cessation
- 2002-02-25 EP EP02707083A patent/EP1478650B1/en not_active Expired - Lifetime
- 2002-02-25 CZ CZ2004863A patent/CZ2004863A3/cs unknown
- 2002-02-25 WO PCT/IN2002/000032 patent/WO2003070733A1/en not_active Ceased
- 2002-02-25 RO ROA200400728A patent/RO122095B1/ro unknown
- 2002-02-25 DE DE60233899T patent/DE60233899D1/de not_active Expired - Lifetime
- 2002-02-25 HR HR20040888 patent/HRP20040888B1/xx not_active IP Right Cessation
- 2002-02-25 ES ES02707083T patent/ES2332881T3/es not_active Expired - Lifetime
- 2002-02-25 JP JP2003569640A patent/JP4139334B2/ja not_active Expired - Fee Related
- 2002-02-25 PT PT02707083T patent/PT1478650E/pt unknown
- 2002-02-25 SK SK305-2004A patent/SK288093B6/sk not_active IP Right Cessation
- 2002-02-25 KR KR1020047012639A patent/KR100598079B1/ko not_active Expired - Fee Related
- 2002-02-25 AT AT02707083T patent/ATE444299T1/de not_active IP Right Cessation
2004
- 2004-07-29 NO NO20043223A patent/NO20043223L/no not_active Application Discontinuation
- 2004-08-03 IL IL163333A patent/IL163333A/en not_active IP Right Cessation
- 2004-08-23 US US10/923,934 patent/US7238826B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2475586C (en)	2011-07-05
HUP0500125A3 (en)	2008-03-28
EP1478650A4 (en)	2008-02-13
AU2002241235B2 (en)	2009-04-23
NZ534688A (en)	2005-04-29
US20050154213A1 (en)	2005-07-14
WO2003070733A1 (en)	2003-08-28
US20060040898A1 (en)	2006-02-23
CZ2004863A3 (cs)	2004-12-15
US7238826B2 (en)	2007-07-03
BR0215602A (pt)	2004-12-07
EP1478650B1 (en)	2009-09-30
ATE444299T1 (de)	2009-10-15
SK288093B6 (sk)	2013-07-02
IL163333A (en)	2009-05-04
RO122095B1 (ro)	2008-12-30
JP4139334B2 (ja)	2008-08-27
HRP20040888B1 (en)	2012-12-31
HRP20040888A2 (en)	2005-04-30
AU2002241235A1 (en)	2003-09-09
KR100598079B1 (ko)	2006-07-07
SK3052004A3 (sk)	2005-02-04
US7301046B2 (en)	2007-11-27
HUP0500125A2 (hu)	2005-04-28
JP2005518427A (ja)	2005-06-23
KR20040084915A (ko)	2004-10-06
EP1478650A1 (en)	2004-11-24
NO20043223L (no)	2004-09-28
ES2332881T3 (es)	2010-02-15
PT1478650E (pt)	2010-01-04
CA2475586A1 (en)	2003-08-28
DE60233899D1 (de)	2009-11-12

Publication	Publication Date	Title
NO20043223L (no)	2004-09-28	Nye boronatestere
CY1109006T1 (el)	2014-07-02	Παραγωγα πουρινης ως αναστολεις κινασης
EP1625223A4 (en)	2009-11-11	CHEMOENZYMATIC PROCEDURES FOR SYNTHESIS OF STATINES AND STATIN INTERCONNECTIONS
WO2012002741A3 (en)	2012-06-21	Process for the preparation of hmg-coa reductase inhibitors and intermediates thereof
DK1578733T3 (da)	2011-06-14	Fremgangsmåde til fremstilling af rosuvastatin
ATE499097T1 (de)	2011-03-15	Monozyklische heterozyklen als kinase-hemmer
EA200701257A1 (ru)	2007-12-28	Пирролопиразолы в качестве сильнодействующих ингибиторов киназы
EA200801291A1 (ru)	2008-12-30	Карбониламинопирролопиразолы в качестве эффективных ингибиторов киназ
PL372926A1 (en)	2005-08-08	Piperidine-pyridazones and phthalazones as pde4 inhibitors
BRPI0413468A (pt)	2006-10-17	inibidores de hmg-coa redutase baseados em pirrol
DE602005010413D1 (de)	2008-11-27	Phosphonatanaloga von hiv-integrasehemmerverbindungen
WO2000048626A3 (en)	2000-12-07	Aerosol compositions of hmg-coa reductase inhibitors for inhibiting inflammation associated with pulmonary disease
ATE404536T1 (de)	2008-08-15	Substituierte chinolinderivate als inhibitoren von mitotischem kinesin
AU2001230395A1 (en)	2001-08-14	Use of cox-2 inhibitors as gastroprokinetics
ATE428417T1 (de)	2009-05-15	Derivate von piperidinylalkylcarbamaten, herstellungsverfahren davon und verwendung derselben als faah-enzym-inhibitoren
WO2004039803A3 (en)	2004-09-16	Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use
MXPA05006368A (es)	2006-02-08	Inhibidores aminocianopiridina de proteina cinasa-2 activada por proteina cinasa activada por mitogeno.
EA200601678A1 (ru)	2007-04-27	Новые имидазолы
BRPI0417138A (pt)	2007-02-21	n-alquil-pirroles como inibidores de hmg-coa-redutase
EA200501900A1 (ru)	2006-06-30	Новый способ синтеза периндоприла и его фармацевтически приемлемых солей
AU2003281220A1 (en)	2004-01-23	N-benzyl-3-phenyl-3-heterocyclyl-propionamide compounds as tachykinin and/ or serotonin reuptake inhibitors
ATE496025T1 (de)	2011-02-15	Magnesiumsalze von hmg-coa-reduktase-hemmern
PE20070603A1 (es)	2007-06-22	COMPOSICION FARMACEUTICA QUE COMPRENDE UN INHIBIDOR DE ESCUALENO SINTASA Y UN INHIBIDOR DE 3-HIDROXI-3-METILGLUTARIL-CoA-REDUCTASA (HMG-CoA)
EA200800916A1 (ru)	2008-10-30	СПОСОБ СИНТЕЗА ИНГИБИТОРОВ HMG-CoA РЕДУКТАЗЫ
EA200600455A1 (ru)	2006-08-25	Новый способ синтеза периндоприла и его фармацевтически приемлемых солей