DK1478650T3 - Nye boronatestere - Google Patents

Nye boronatestere

Info

Publication number: DK1478650T3
Authority: DK; Denmark
Prior art keywords: new; boronate esters; pitavastatin; cerivastatin; rosuvastatin
Prior art date: 2002-02-25

Application number

DK02707083.8T

Other languages

English (en)

Inventor

Tom Thomas Puthiaprampil

Sumithra Srinath

Madhavan Sridharan

Sambasivam Ganesh

Original Assignee

Biocon Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-25

Filing date

2002-02-25

Publication date

2010-01-25

2002-02-25 Application filed by Biocon Ltd filed Critical Biocon Ltd

2010-01-25 Application granted granted Critical

2010-01-25 Publication of DK1478650T3 publication Critical patent/DK1478650T3/da

Links

ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical class OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 title abstract 2
FJLGEFLZQAZZCD-MCBHFWOFSA-N (3R,5S)-fluvastatin Chemical compound C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 FJLGEFLZQAZZCD-MCBHFWOFSA-N 0.000 abstract 1
CABVTRNMFUVUDM-VRHQGPGLSA-N (3S)-3-hydroxy-3-methylglutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](O)(CC(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CABVTRNMFUVUDM-VRHQGPGLSA-N 0.000 abstract 1
XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 abstract 1
XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 abstract 1
229960005370 atorvastatin Drugs 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
229960005110 cerivastatin Drugs 0.000 abstract 1
SEERZIQQUAZTOL-ANMDKAQQSA-N cerivastatin Chemical compound COCC1=C(C(C)C)N=C(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 SEERZIQQUAZTOL-ANMDKAQQSA-N 0.000 abstract 1
239000002532 enzyme inhibitor Substances 0.000 abstract 1
229960003765 fluvastatin Drugs 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
229960002797 pitavastatin Drugs 0.000 abstract 1
VGYFMXBACGZSIL-MCBHFWOFSA-N pitavastatin Chemical compound OC(=O)C[C@H](O)C[C@H](O)\C=C\C1=C(C2CC2)N=C2C=CC=CC2=C1C1=CC=C(F)C=C1 VGYFMXBACGZSIL-MCBHFWOFSA-N 0.000 abstract 1
229960000672 rosuvastatin Drugs 0.000 abstract 1
BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pyrrole Compounds (AREA)

DK02707083.8T 2002-02-25 2002-02-25 Nye boronatestere DK1478650T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/IN2002/000032 WO2003070733A1 (en)	2002-02-25	2002-02-25	Novel boronate esters
EP02707083A EP1478650B1 (en)	2002-02-25	2002-02-25	Novel boronate esters

Publications (1)

Publication Number	Publication Date
DK1478650T3 true DK1478650T3 (da)	2010-01-25

Family

ID=27742233

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02707083.8T DK1478650T3 (da)	2002-02-25	2002-02-25	Nye boronatestere

Country Status (21)

Country	Link
US (2)	US7301046B2 (da)
EP (1)	EP1478650B1 (da)
JP (1)	JP4139334B2 (da)
KR (1)	KR100598079B1 (da)
AT (1)	ATE444299T1 (da)
AU (1)	AU2002241235B2 (da)
BR (1)	BR0215602A (da)
CA (1)	CA2475586C (da)
CZ (1)	CZ2004863A3 (da)
DE (1)	DE60233899D1 (da)
DK (1)	DK1478650T3 (da)
ES (1)	ES2332881T3 (da)
HR (1)	HRP20040888B1 (da)
HU (1)	HUP0500125A3 (da)
IL (1)	IL163333A (da)
NO (1)	NO20043223L (da)
NZ (1)	NZ534688A (da)
PT (1)	PT1478650E (da)
RO (1)	RO122095B1 (da)
SK (1)	SK288093B6 (da)
WO (1)	WO2003070733A1 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0011120D0 (en) *	2000-05-09	2000-06-28	Avecia Ltd	Process
NL1015744C2 (nl) *	2000-07-19	2002-01-22	Dsm Nv	Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
US7135978B2 (en)	2001-09-14	2006-11-14	Calypso Medical Technologies, Inc.	Miniature resonating marker assembly
EP1323717A1 (en) *	2001-12-27	2003-07-02	Dsm N.V.	Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
PT1478650E (pt)	2002-02-25	2010-01-04	Biocon Ltd	Novos ésteres boronato
KR20090039738A (ko) *	2006-07-19	2009-04-22	보드 오브 트러스티즈 오브 미시건 스테이트 유니버시티	Ｄ－１，２，４－부탄트리올의 미생물 합성
US7879585B2 (en)	2006-10-02	2011-02-01	Codexis, Inc.	Ketoreductase enzymes and uses thereof
KR100933172B1 (ko)	2007-11-30	2009-12-21	씨제이제일제당 (주)	아토르바스타틴 칼슘염의 개선된 제조방법
KR101339648B1 (ko) *	2012-05-10	2013-12-09	(주) 에프엔지리서치	신규한 아토바스타틴 중간체 및 이를 이용한 아토바스타틴의 제조 방법
KR101292743B1 (ko) *	2012-05-17	2013-08-02	(주) 에프엔지리서치	신규한 스타틴 중간체 및 이를 이용한 피타바스타틴, 로수바스타틴, 세리바스타틴 및 플루바스타틴의 제조 방법
KR101528359B1 (ko) *	2013-04-24	2015-06-15	(주) 성운파마코피아	스타틴 화합물 제조를 위한 신규한 보로네이트 에테르 화합물, 그 제조방법 및 상기 보로네이트 에테르 화합물을 이용한 스타틴 화합물 제조방법
CN108033899B (zh) *	2017-12-06	2020-04-10	浙江科技学院	一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4474034A (en)	1982-09-23	1984-10-02	Avery Jr Richard J	Refrigerant accumulator and charging apparatus and method for vapor-compression refrigeration system
DE3741509A1 (de) *	1987-12-08	1989-06-22	Hoechst Ag	Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
DE69329221D1 (de) *	1992-06-10	2000-09-21	Chisso Corp	Optisch aktives, 1,5-disubstituiertes 2,4-0-Isopropyliden-2,4-dihydroxypentan und ein Verfahren zu seiner Herstellung
SG44830A1 (en) *	1992-07-02	1997-12-19	Hoechst Ag	Process for preparing tert-butyl 93R,5S) -6 Hydroxy-3,5-O-Isopropylidene-3, 5-Dihydroxyhexanoate
KR950005791A (ko) *	1993-08-09	1995-03-20	후꾸야마 마사루	카르복실산 에스테르-유도체의 제조방법 및 그 방법에 사용되는 4- 플루오로비페닐 유도체
AU3515497A (en) *	1996-07-29	1998-02-20	Warner-Lambert Company	Improved process for the synthesis of protected esters of (s)-3,4-dihydroxybutyric acid
JPH11171850A (ja) *	1997-12-12	1999-06-29	Kanegafuchi Chem Ind Co Ltd	酪酸エステル誘導体の製造方法
WO2001072706A1 (en) *	2000-03-28	2001-10-04	Biocon India Limited	Synthesis of [r-(r,r)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin)
WO2002057229A1 (en)	2001-01-19	2002-07-25	Biocon India Limited	FORM V CRYSTALLINE [R-(R,R)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
PT1478650E (pt)	2002-02-25	2010-01-04	Biocon Ltd	Novos ésteres boronato

2002
- 2002-02-25 PT PT02707083T patent/PT1478650E/pt unknown
- 2002-02-25 DE DE60233899T patent/DE60233899D1/de not_active Expired - Lifetime
- 2002-02-25 HU HU0500125A patent/HUP0500125A3/hu unknown
- 2002-02-25 CA CA2475586A patent/CA2475586C/en not_active Expired - Fee Related
- 2002-02-25 AU AU2002241235A patent/AU2002241235B2/en not_active Ceased
- 2002-02-25 EP EP02707083A patent/EP1478650B1/en not_active Expired - Lifetime
- 2002-02-25 NZ NZ534688A patent/NZ534688A/en not_active IP Right Cessation
- 2002-02-25 KR KR1020047012639A patent/KR100598079B1/ko not_active Expired - Fee Related
- 2002-02-25 DK DK02707083.8T patent/DK1478650T3/da active
- 2002-02-25 SK SK305-2004A patent/SK288093B6/sk not_active IP Right Cessation
- 2002-02-25 ES ES02707083T patent/ES2332881T3/es not_active Expired - Lifetime
- 2002-02-25 WO PCT/IN2002/000032 patent/WO2003070733A1/en not_active Ceased
- 2002-02-25 HR HR20040888 patent/HRP20040888B1/xx not_active IP Right Cessation
- 2002-02-25 AT AT02707083T patent/ATE444299T1/de not_active IP Right Cessation
- 2002-02-25 BR BR0215602-4A patent/BR0215602A/pt not_active Application Discontinuation
- 2002-02-25 CZ CZ2004863A patent/CZ2004863A3/cs unknown
- 2002-02-25 US US10/505,528 patent/US7301046B2/en not_active Expired - Fee Related
- 2002-02-25 JP JP2003569640A patent/JP4139334B2/ja not_active Expired - Fee Related
- 2002-02-25 RO ROA200400728A patent/RO122095B1/ro unknown
2004
- 2004-07-29 NO NO20043223A patent/NO20043223L/no not_active Application Discontinuation
- 2004-08-03 IL IL163333A patent/IL163333A/en not_active IP Right Cessation
- 2004-08-23 US US10/923,934 patent/US7238826B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CZ2004863A3 (cs)	2004-12-15
KR100598079B1 (ko)	2006-07-07
NZ534688A (en)	2005-04-29
NO20043223L (no)	2004-09-28
AU2002241235A1 (en)	2003-09-09
SK3052004A3 (sk)	2005-02-04
EP1478650B1 (en)	2009-09-30
US7301046B2 (en)	2007-11-27
BR0215602A (pt)	2004-12-07
DE60233899D1 (de)	2009-11-12
US20050154213A1 (en)	2005-07-14
CA2475586C (en)	2011-07-05
KR20040084915A (ko)	2004-10-06
CA2475586A1 (en)	2003-08-28
JP2005518427A (ja)	2005-06-23
US20060040898A1 (en)	2006-02-23
AU2002241235B2 (en)	2009-04-23
HUP0500125A2 (hu)	2005-04-28
HRP20040888B1 (en)	2012-12-31
EP1478650A4 (en)	2008-02-13
WO2003070733A1 (en)	2003-08-28
ES2332881T3 (es)	2010-02-15
ATE444299T1 (de)	2009-10-15
EP1478650A1 (en)	2004-11-24
HRP20040888A2 (en)	2005-04-30
SK288093B6 (sk)	2013-07-02
PT1478650E (pt)	2010-01-04
RO122095B1 (ro)	2008-12-30
JP4139334B2 (ja)	2008-08-27
US7238826B2 (en)	2007-07-03
HUP0500125A3 (en)	2008-03-28
IL163333A (en)	2009-05-04

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